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This meeting took place in 2019



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Why So Many Ways to Die? Apoptosis, Necroptosis, Pyroptosis and Beyond (T3)


Organizer(s) Karina R. Bortoluci, Vishva M. Dixit and Andreas E. Strasser
November 19—23, 2019
Casa Grande Hotel • Guarujá, São Paulo Brazil
Discounted Abstract Deadline: Jul 18, 2019
Abstract Deadline: Aug 20, 2019
Scholarship Deadline: Jul 30, 2019
Discounted Registration Deadline: Sep 19, 2019

Organized in collaboration with the São Paulo Research Foundation (FAPESP)
Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation

Supported by a grant from Genentech

Summary of Meeting:
Cell death is linked to diverse physiological and pathological conditions. In addition to the well-defined apoptosis versus accidental necrosis paradigm, novel processes of programmed cell death, necroptosis and pyroptosis, in particular, have been described over the last years. Our knowledge about the molecular machineries that control these cell death processes has expanded substantially with the discovery of key regulators and effectors, such as the gasdermins, mixed-lineage kinase domain-like protein (MLKL), and receptor-interacting protein (RIP) kinases. We have learned that apoptosis, pyroptosis, necroptosis, ferroptosis, autophagic cell death and other cell death processes are all equipped with individual sets of regulatory and effector molecules but can also share constituents that can interconnect the distinct cell death pathways. Moreover, several alternative cell death programs may operate in any given circumstances with distinct consequences to the immune response and to the development of inflammatory disorders. Last, but not least, cell death may not be the sole or even the major fate/purpose of cells that engage inflammatory cell death pathways. Understanding of the role of the different regulators and effectors of each cell death processes is essential for the development of therapeutic tools for cancer, autoimmune diseases and inflammatory pathologies. Thus, this conference proposes to bring together specialists from diverse areas of cell death research from around world to explore these crucial issues to develop a better understanding of the relative, additive and/or redundant contributions of the distinct cell death pathways in health and disease.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Tuesday, November 19 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, November 23 with a keynote address and closing plenary session from 17:00 to 19:30, followed by a social hour and entertainment. We recommend return travel on Sunday, November 24 in order to fully experience the meeting.

TUESDAY, NOVEMBER 19

16:00—20:00
Arrival and Registration

Imperial Ballroom Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Imperial Ballroom Terrace

WEDNESDAY, NOVEMBER 20

08:30—09:30
Welcome and Keynote Address

Imperial Ballroom
* Karina R. Bortoluci, Federal University of São Paulo, Brazil

Kim Newton, Genentech, Inc., USA
The Cut that Makes the Difference – A Caspase-8 Story

09:30—12:00
Advances in Molecular Control of Cell Death I

Imperial Ballroom
* Jonathan C. Kagan, Boston Children's Hospital, USA

Hao Wu, Harvard Medical School, Boston Children's Hospital, USA
Inflammasomes: NLRP3 and Gasdermin D (GSDMD)

Coffee Break

Veit Hornung, Ludwig-Maximilians-University Munich, Germany
Inflammasome Signaling in the Human System

Daniel Kastner, National Institutes of Health, USA
Inflammasomes in Auto-Inflammatory Diseases

Niklas A. Schmacke, Ludwig-Maximilians-University Munich, Germany
Short Talk: Priming Enables a NEK7-Independent Route of NLRP3 Activation

Bart Tummers, St. Jude Children's Research Hospital, USA
Short Talk: A Non-Apoptotic Function of Caspase-8 Mediates Inflammation and Blocks the Development of ALPS

12:00—17:00
On Own for Lunch

12:00—13:00
Poster Setup

Imperial Ballroom
13:00—22:00
Poster Viewing

Imperial Ballroom
14:30—16:30
Workshop 1: Host Defense

Imperial Ballroom
* Russell E. Vance, University of California, Berkeley, USA

Youssef Aachoui, University of Arkansas for Medical Sciences, USA
Innate Lymphocytes Prime Caspase-11 in Neutrophils to Defend against a Cytosol Invasive Bacterium

Thomas Burke, University of California, Berkeley, USA
Inflammasome-Mediated Antagonism of Type I Interferon Enhances Rickettsia Pathogenesis

Laura Migliari Branco, University of São Paulo, Brazil
Molecular Mechanisms Involved in NAIP/NLRC4 Inflammasome Activation

Alejandro Rodriguez Gama, Stowers Institute for Medical Research, USA
The Inflammasome-Nucleating Interactome Reveals Specificity and Crosstalk in Cell Death Signaling

Lucas Secchim Ribeiro, University of Bonn, Germany
Inflammasome Activation and Pyroptosis Drive the Formation of Nuclear Filaments between Macrophages

Kateryna Shkarina, University of Lausanne, Switzerland
Optogenetic Control of Programmed Cell Death Reveals Differential Responses towards Apoptotic and Necrotic Cells

Monica Varela, Leiden University, Netherlands
Mycobacteria Exploit Host Caspase 11 and Gasdermin D Tandem for Phagosome Permeabilization, Macrophage Pyroptosis and Infection Dissemination

16:30—17:00
Coffee Available

Imperial Ballroom Terrace
17:00—19:00
Advances in Molecular Control of Cell Death II

Imperial Ballroom
* Domagoj Vucic, Genentech, Inc., USA

Feng Shao, National Institute of Biological Sciences, China
Mechanism and Function of Gasdermin-Mediated Pyroptosis

Eicke Latz, University of Bonn, Germany
Cellular Responses to Pyroptosis

Oliver Florey, Babraham Institute, UK
Eaten Alive! - Mechanisms and Consequences of Cell Cannibalism

Catherine L. Day, University of Otago, New Zealand
Short Talk: Regulation of Ubiquitin Transfer by TRAF E3 Ligases

Megan H. Orzalli, University of Massachusetts Medical School, USA
Short Talk: Apoptotic Caspases Activate Pro-Inflammatory Cell Death Pathways in Barrier Epithelial Cells

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Imperial Ballroom Terrace
19:30—22:00
Poster Session 1

Imperial Ballroom

THURSDAY, NOVEMBER 21

08:30—11:45
Cell Death and Cancer

Imperial Ballroom
* Gustavo P. Amarante-Mendes, Universidade de São Paulo, Brazil

Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
Towards Targeting Mutant p53 for Cancer Therapy

Henning Walczak, University College London, Cancer Institute, UK
Cell Death and Ubiquitin in Cancer

Coffee Break

Ricardo Weinlich, Hospital Israelita Albert Einstein, Brazil
Necroptosis, Inflammation and Cancer

Ruth M. Kluck, Walter and Eliza Hall Institute of Medical Research, Australia
BAK and BAX in Cancer

Gabriela Brumatti, Walter and Eliza Hall Institute, Australia
Short Talk: RIPping Leukaemias Apart: The Role of RIP Kinase 1 in Acute Myeloid Leukaemia

Dhyan Chandra, Roswell Park Comprehensive Cancer Center, USA
Short Talk: Novel Nuclear-Mitochondrial Crosstalk Regulates Cell Death and Survival in Cancer

Eli Arama, Weizmann Institute of Science, Israel
Short Talk: Parthanatos Steps Out of the Shadows of Cell Death and into the Developmental Spotlight

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Imperial Ballroom
13:00—22:00
Poster Viewing

Imperial Ballroom
16:30—17:00
Coffee Available

Imperial Ballroom Terrace
17:00—19:15
Consequences of Cell Death

Imperial Ballroom
* Kim Newton, Genentech, Inc., USA

Vishva M. Dixit, Genentech, Inc., USA
The Non-Canonical Inflammasome Pathway

Jonathan C. Kagan, Boston Children's Hospital, USA
Regulation of Innate Immunity

John Silke, Walter and Eliza Hall Institute of Medical Research, Australia
Mutations that Prevent Caspase Cleavage of RIPK1 Cause Inflammatory Disease

Konrad Aden, University Hospital Kiel, Germany
Short Talk: XBP-1 Coordinates DNA Damage Induced Stem Cell Repression in the Intestinal Epithelium via p53-Ddit4l-Dependent mTOR Inhibition

Randal Halfmann, Stowers Institute for Medical Research, USA
Short Talk: Waiting to Die: Signalosome Nucleation Kinetically Controls Cell Fate

Caitlin Schneider, McGill University, Canada
Short Talk: Migration-Induced Cell Shattering Due to DOCK8 Deficiency Causes a Type-2 Biased T Helper Response

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Imperial Ballroom Terrace
19:30—22:00
Poster Session 2

Imperial Ballroom

FRIDAY, NOVEMBER 22

08:30—11:30
Cell Death and Host Defense I

Imperial Ballroom
* Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA

Petr Broz, University of Lausanne, Switzerland
Cell Death during Bacteria Infections

Ricardo T. Gazzinelli, Fundação Oswaldo Cruz-CPqRR, Brazil
Caspase 8 Mediates Experimental Cerebral Malaria

Coffee Break

Russell E. Vance, University of California, Berkeley, USA
Inflammasome-Dependent Cell Death in Response to Bacterial Pathogens

Karina R. Bortoluci, Federal University of São Paulo, Brazil
Inflammasomes: Cell Death, Cytokines and Beyond

Katie Deets, University of California, Berkeley, USA
Short Talk: Investigating a Role for the NAIP/NLCR4 Inflammasome in Adaptive T Cell Responses

Sergio Costa Oliveira, Universidade Federal de Minas Gerais, Brazil
Short Talk: Guanylate-Binding Protein 5 Licenses Caspase-11 for Gasdermin-D Mediated Host Resistance to Intracellular Bacterial Infection

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Imperial Ballroom
13:00—22:00
Poster Viewing

Imperial Ballroom
16:30—17:00
Coffee Available

Imperial Ballroom Terrace
17:00—19:00
Cell Death and Host Defense II

Imperial Ballroom
* Ricardo T. Gazzinelli, Fundação Oswaldo Cruz-CPqRR, Brazil

Edward A. Miao, University of North Carolina at Chapel Hill, USA
Infectious Models Reveal a Unique Role for Caspase-7 after Cytotoxic Lymphocyte Attack

Dario S. Zamboni, University of São Paulo, Brazil
Inflammasomes in Host Response to Pathogenic Microbes

Larissa D. Cunha, Ribeirao Preto Medical School, University of Sao Paulo, Brazil
Short Talk: Regulation of Macrophage Function by LC3-Associated Phagocytosis

Marcel Doerflinger, Walter and Eliza Hall Institute, Australia
Short Talk: Functional Overlap of Different Cell Death Pathways Ensures Host Protection against Intracellular Bacterial Pathogens

Antonia R. Bass, University of Pennsylvania, USA
Short Talk: Human Noncanonical Inflammasome Responses to Legionella Pneumophila

Kshiti Meera Phulphagar, Max Planck Institute of Biochemistry, Germany
Short Talk: Quantitative Spatial Proteomics Reveals Specific Nlrp3 and Cell Death Mediated Reprogramming of Essential Cellular Functions and Organelles

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Imperial Ballroom Terrace
19:30—22:00
Poster Session 3

Imperial Ballroom

SATURDAY, NOVEMBER 23

08:30—11:45
Manipulating Cell Death for Therapeutic Intervention

Imperial Ballroom
* Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia

Andrew W. Roberts, Walter and Eliza Hall Institute of Medical Research, Australia
Translational and Clinical Updates on Targeting BCL2 and MCL-1

Ksenija Slavic Obradovic, Boehringer Ingelheim RCV GmBH & Co KG, Austria
Short Talk: Enabling Cell Death: Genetic Dissection of Cellular Responses to SMAC Mimetic Treatment

Opher Shai Kornfeld, Genentech, Inc., USA
Short Talk: IRF2 Transcriptionally Induces GSDMD Expression for Pyroptosis

Coffee Break

Domagoj Vucic, Genentech, Inc., USA
Regulation of Inflammatory Cell Death Signaling by RIP Kinases

Wenlin Shao, AstraZeneca, USA
Broad Opportunity of Cell Death Agents as Mono- and Combination Therapies in Haematological and Solid Cancers

Pedro Elias Marques, KU Leuven, Belgium
Short Talk: Displacement of Necrotic Cell Debris In Vivo by a Chemokine-Based Peptide Dampens Tissue Inflammation

Jun Sun, University of Illinois at Chicago, USA
Short Talk: Intestinal Vitamin D Receptor Determines Cell Fate via Apoptosis and Autophagy

Lynn Wong, University of Zurich, Switzerland
Short Talk: TNFR2 Induced Priming of NLRP3-Inflammasome via RIPK1 Leads to Pyroptosis in XIAP Deficient Cells

11:45—17:00
On Own for Lunch

14:30—16:30
Workshop 2: Cancer

Imperial Ballroom
* Laura D. Attardi, Stanford University School of Medicine, USA

Silvina Odete Bustos, Instituto do Câncer do Estado de São Paulo, Brazil
A New Imidazacridine Derivate with Antineoplasic Activity in Melanoma

Annette Jacobsen, Walter and Eliza Hall Institute, Australia
Up Close and Personal with the Necroptotic Death Effector, MLKL: Lessons Learned from Mutagenesis Studies

Bruna dos Santos Mendonça, Brazilian National Cancer Institute, Brazil
Nuclear Localization of X-Linked Inhibitor of Apoptosis Protein (XIAP): Impact on Drug Resistance, Cell Growth and Prognosis in Breast Cancer

Ancely F. dos Santos, University of São Paulo, Brazil
Ferroptosis Contributes to MB-PDT Efficacy on Killing Human PDAC Cells

Maria Tanzer, Max Planck Institute of Biochemistry, Germany
Phosphoproteome and Secretome Analysis Reveal Differences between TNF-Induced Apoptosis and Necroptosis

Angelica Beate Winter Boldt, Universidade Federal do Paraná, Brazil
At the Edge of Survival: Genetic Associations for Cell Death in Pemphigus Foliaceus

Mikaela Catherine Coleman, University of Sydney, Australia
Dissecting the Ways to Die: A Single-Cell Assay to Simultaneously Quantify Cell Loss and Discriminate Death Program

16:30—17:00
Coffee Available

Imperial Ballroom Terrace
17:00—17:45
Keynote Address

Imperial Ballroom
* Vishva M. Dixit, Genentech, Inc., USA

Shigekazu Nagata, IFReC, Osaka University, Japan
Phosphatidylserine-Dependent Efferocytosis and Entosis

17:45—19:15
Cell Death in Inflammatory Diseases

Imperial Ballroom
* John Silke, Walter and Eliza Hall Institute of Medical Research, Australia

Francis Ka-Ming Chan, Duke University, USA
RIPK3 in Anti-Viral Immunity and Tissue Homeostasis

Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Regulation of Inflammasome Activation and Cell Death

Laura D. Attardi, Stanford University School of Medicine, USA
Deconstructing p53 Cellular Responses and Transcriptional Programs in Tumor Suppression and Developmental Syndromes

19:15—19:30
Meeting Wrap-Up: Outcomes and Future Directions

Imperial Ballroom
* Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia

19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Duque de Caxias/Thereza Cristina
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Duque de Caxias/Thereza Cristina

SUNDAY, NOVEMBER 24

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Bill & Melinda Gates Foundation Genentech, Inc.
São Paulo Research Foundation (FAPESP) - Brazil
 

We gratefully acknowledge additional support for this conference from:

AdipoGen Life Sciences

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


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