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This meeting took place in 2020



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Pain: Aligning the Target (J7)


Organizer(s) Laura M. Bohn, William K. Schmidt and Allan I. Basbaum
February 2—5, 2020
Keystone Resort • Keystone, CO USA
Discounted Abstract Deadline: Oct 17, 2019
Abstract Deadline: Nov 22, 2019
Scholarship Deadline: Oct 17, 2019
Discounted Registration Deadline: Dec 4, 2019

Sponsored by Vertex Pharmaceuticals Incorporated


Summary of Meeting:
The Keystone Symposia on Pain: Aligning the Target will bring together researchers from diverse disciplines to examine the complex problem of pain and to shed light on mechanistic underpinnings and molecular approaches towards treatment. Topics will range from understanding neurotransmission and the anatomy of pain, structural features of molecular targets for modulating pain, and novel approaches, including drug development, optogenetic and genetic approaches to controlling pain. Most conferences on pain discuss pain management (clinical focus), neuroanatomical transmission of pain (neuroscience), or the mechanism by which analgesics/anesthetics work with a focus on particular molecular targets (pharmacology). Our goal is to bring these disciplines together to aid in a more efficient design of preclinical studies and drug development by educating each other in the individual challenges and offerings of our disciplines. Ultimately, this conference should inspire researchers from diverse backgrounds to examine this fundamental health problem via many new angles. Importantly, researchers that focus on the neurocircuitry and cause of pain and those that focus on drug development for the treatment of pain generally, are not often attending the same conferences. Finally, the pairing of this conference with the conference on Somatosensation: from Detection to Perception, which will focus more on the neurobiology of pain sensation, will allow participants to intermingle at poster sessions and dinners, enabling the cross-fostering of ideas. Collectively, these events will provide a forum for the convergence of insights into the diverse causes of pain and the approaches to treatment.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, February 2 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, February 5 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Thursday, February 6 in order to fully experience the meeting.

SUNDAY, FEBRUARY 2

16:00—20:00
Arrival and Registration

Longs Peak Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer

MONDAY, FEBRUARY 3

07:00—08:00
Breakfast

Quandary Peak
08:00—09:00
Welcome and Keynote Address

Grays Peak
* Laura M. Bohn, The Scripps Research Institute, USA

* William K. Schmidt, Helixmith Co., Ltd, Seoul, South Korea, and San Diego, USA

* Allan I. Basbaum, University of California, San Francisco, USA

Irene Tracey, University of Oxford, UK
Brain Imaging of Acute and Chronic Human Pain: From Cause to Perception

08:00—08:10
Opening Remarks

Longs Peak
09:00—11:15
Learning from Our Patients

Grays Peak
* Allan I. Basbaum, University of California, San Francisco, USA

Christin Veasley, Chronic Pain Research Alliance, USA
A Patient’s Perspective on the Critical Need to Align the Target

Coffee Break

Lauren Charlotte Heathcote, Stanford University, USA
Pain and Somatic Sensation as Bodily Threat

Chas Bountra, University of Oxford, UK
Using Epigenetics to Discover New Pain Targets

Deborah Schechtman, University of São Paulo, Brazil
Short Talk: Genetic Mutations in Patients with Congenital Insensitivity to Pain Guide Development of a New Analgesic

08:10—11:00
Molecules and Cells for Touch, Temperature and Pain

Longs Peak
* Alexander Chesler, National Institutes of Health, USA

Ardem Patapoutian, The Scripps Research Institute, USA
Moleculez 4 Touch

Diana Bautista, University of California, Berkeley, USA
S1P Signaling in Inflammatory Itch and Pain

Ellen A. Lumpkin, University of California, Berkeley, USA
The Epithelial and Neural Connections Mediating Touch

Coffee Break

John King, University of California, San Francisco, USA
Gating Mechanisms of the Wasabi Receptor, TRPA1—From Atomic Structure to Pain Physiology

Joriene C. de Nooij, Columbia University, USA
Short Talk: Transcriptional and Physiological Analysis of Adult Muscle Spindle and Golgi Tendon Organ Sensory Afferents

Hakan William Olausson, Linkoping University, Sweden
Short Talk: Human Social Touch As Encoded by First-Order Aβ and C-Tactile Afferents

11:15—11:45
NIH HEAL Initiative and Efforts

Longs Peak
Amir Tamiz, NINDS, National Institutes of Health, USA

11:00—11:15
NCCIH and BRAIN Funding Opportunities for Circuits Studies
Program Officers from NCCIH and the BRAIN Initiative will be available to inform the community of funding opportunities. BRAIN Circuits FOAs emphasize the use of cutting-edge methods of activation and recording to address circuit function in the context of specific neural systems such as sensation, perception, attention, decision-making, emotion, communication, or homeostasis. NCCIH basic and mechanistic research FOAs focus on fundamental science of mind and body approaches, including the neurocircuitry of body-based approaches involving mechanosensation (e.g., peripheral mechanical stimulation, massage, spinal manipulation/mobilization) in health and disease.

Longs Peak
Karen K. David, NINDS, National Institutes of Health, USA

Merav Sabri, NCCIH, National Institutes of Health, USA

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak
14:30—15:30
Workshop: New Resources for Therapeutic Discovery

Grays Peak
* William K. Schmidt, Helixmith Co., Ltd, Seoul, South Korea, and San Diego, USA

Patricia Labosky, National Institutes of Health, USA
The NIH Common Fund Acute to Chronic Pain Signatures (A2CPS) Program

Jennifer Beierlein, NINDS, National Institutes of Health, USA
NIH HEAL Initiative: National Institute of Neurological Disorders and Stroke’s Early Phase Pain Investigation Clinical Network (EPPIC-Net)

Ilyas Singec, National Institutes of Health, USA
Scalable Differentiation of Human iPSC-Derived Pseudo-Unipolar Nociceptors With In Vivo-like Properties and Translational Applicability

Sarah Woller, NINDS, National Institutes of Health, USA
National Institute of Neurological Disorders and Stroke Preclinical Screening Platform for Pain

15:00—16:30
Workshop

Longs Peak
* Ellen A. Lumpkin, University of California, Berkeley, USA

John S. Del Rosario, Rutgers University, New Jersey Medical School, USA
Gi-Coupled Receptor Activation Potentiates Piezo2 Currents via Gβγ

Sonali S. Mali, University of California, Berkeley, USA
The Role of Epidermal Cells in Drosophila Melanogaster Nociception

Fred Schwaller, Max Delbruck Centrum, Germany
USH2A Is a Skin End-Organ Protein Necessary for Vibration Sensing in Mice and Humans

Nivanthika K. Wimalasena, Harvard University, USA
Scratching and Sensory Deficits in an Nav1.7 Gain-of-Function Mouse Model

Shanni Yamaki, University of Southern California, USA
Phenotyping of TRPA1 Afferents Suggests the Channel Induces Cold Pain Upstream of the Neurotrophin Receptor GFRα3 and TRPM8

Xin Zhang, Duke University, USA
The Role of Keratinocyte β2ARs in Mechanical Pain Sensation

15:30—16:30
Panel Discussion

Grays Peak
* Amir Tamiz, NINDS, National Institutes of Health, USA

Patricia Labosky, National Institutes of Health, USA

Jennifer Beierlein, NINDS, National Institutes of Health, USA

Ilyas Singec, National Institutes of Health, USA
New Stem Cell Models for Pain Research and the NIH HEAL Initiative

Sarah Woller, NINDS, National Institutes of Health, USA
Preclinical Screening Platform for Pain

Smriti Iyengar, National Institute of Neurological Disorders and Stroke, USA

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Developing More Informative Pain Models

Grays Peak
* Cheryl L. Stucky, Medical College of Wisconsin, USA

Allan I. Basbaum, University of California, San Francisco, USA
General Anesthetic Influences on Neuronal Activity Provide Insight into Cortical Pain Processing

Jose Moron-Concepcion, Washington University School of Medicine, USA
Dissecting the Neural Circuits Driving Pain-Induced Negative Affect

Annemieke Kavelaars, University of Texas MD Anderson Cancer Center, USA
Fibroblasts Control Vascular Permeability, Leukocyte Infiltration and Chronic Pain

Levi P. Sowers, University of Iowa, USA
Short Talk: Development and Use of Automated Facial Pain Detection to Explore the Role of CGRP and Amylin in a Preclinical Mouse Model of Migraine

Ishmail John Abdus-Saboor, University of Pennsylvania, USA
Short Talk: Automated Measurement of Pain at Millisecond Resolution

17:00—19:00
Spinal Cord

Longs Peak
* Sarah Ross, University of Pittsburgh, USA

Patrik Ernfors, Karolinska Institutet, Sweden
The Cellular Basis for Somatosensation and Pain

Rebecca Seal, University of Pittsburgh, USA
Cross Species Analysis of the Molecular and Cellular Organization of the Mammalian Dorsal Horn: Functional Implications and Future Directions

David D. Ginty, HHMI/Harvard Medical School, USA
Mechanosensory Neuron Subtypes and the Central Representation of Touch

Eric V. Brown, Thomas Jefferson University, USA
Short Talk: Differential Activation of Dorsal Horn Neuron Subtypes in a Mouse Model of Spinal Cord Injury Induced Neuropathic Pain

Wenqin Luo, University of Pennsylvania, USA
Short Talk: Synaptic Transmission of MrgprA3+ Itch-sensing Afferents in the Spinal Cord

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Quandary Peak
19:30—22:00
Poster Session 1

Quandary Peak

TUESDAY, FEBRUARY 4

07:00—08:00
Breakfast

Quandary Peak
08:00—11:00
New Tech for Managing Pain

Grays Peak
* Jose Moron-Concepcion, Washington University School of Medicine, USA

Robert W. Gereau, Washington University Pain Center, USA
Optogenetic Silencing of Nociceptors

Karen Wagner, EicOsis, USA
A Novel Target for Analgesia: Small Molecule Inhibition of the Soluble Epoxide Hydrolase

Coffee Break

Sunyoung Kim, Helixmith Co., Ltd., South Korea
New Concept Regenerative Medicine for Neuropathic Pain Using Plasmid DNA Encoding Human Hepatocyte Growth Factor (HGF), Engensis® (VM202): Scientific Basis and Results from Clinical Studies

Gregory Nachtrab, Stanford University, USA
Short Talk: Role of Descending µ-Opioid Receptor Neurons in Nociception and Chronic Pain

Dustin Green, Johns Hopkins, USA
Short Talk: The Mast Cell Receptor Mrgprb2 Mediates Neurogenic Inflammation and Pain

Bryan Copits, Washington University School of Medicine, USA
Short Talk: A Photoswitchable GPCR-Based Opsin for Presynaptic Inhibition

Bethany Fitzsimmons, Ionis Pharmaceuticals, USA
Short Talk: Antisense Oligonucleotides Selectively Suppress Target RNA in DRG and Can Ameliorate Mechanical Pain

08:00—11:00
Subcortical Circuits

Longs Peak
* Jan Siemens, University of Heidelberg, Germany

Sarah Ross, University of Pittsburgh, USA
Neural Circuits for Itch

Alexander Chesler, National Institutes of Health, USA
Cells and Circuits for Touch and Pain

Coffee Break

Yarimar Carrasquillo, National Institutes of Health, USA
Dialing Pain Up and Down in the Amygdala

Victoria Abraira, Rutgers University, USA
Wired for Touch: The Neurons and Circuits of the Somatosensory System

Chen Ran, Harvard University, USA
Short Talk: The Coding of Internal Senses in the Brainstem

11:00—12:00
Panel Discussion: Inclusivity and Diversity in the Field: What Works and How to Do Better (Joint)

Longs Peak
* Ishmail John Abdus-Saboor, University of Pennsylvania, USA

Michael D. Burton, University of Texas at Dallas, USA

John S. Del Rosario, Rutgers University, New Jersey Medical School, USA

Yarimar Carrasquillo, National Institutes of Health, USA

Diana Bautista, University of California, Berkeley, USA

Celine Santiago, Harvard Medical School, USA

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
New Approaches to Modulating Known Targets

Grays Peak
Wendy L. Imlach, Monash University, Australia
Targeting Spinal Adenosine Signalling to Treat Neuropathic Pain

Laura M. Bohn, The Scripps Research Institute, USA
Using Biased Agonism to Refine Pain Therapeutics

Venetia Zachariou, Icahn School of Medicine at Mount Sinai, USA
The “Complex” Role of RGS Proteins in Chronic Pain and Opioid Analgesia

Evangelia Semizoglou, King's College London, UK
Short Talk: Kappa Opioid Receptors Mediate the Analgesic Effects of TRPA1 Inactivation

Scott A. Scarneo, Duke University School of Medicine, USA
Short Talk: Pharmacological Inhibition of TAK1 Reduces TNF-Mediated Pain and Inflammation

17:00—19:00
Internal States

Longs Peak
* Rebecca Seal, University of Pittsburgh, USA

Richard D. Palmiter, HHMI/University of Washington, USA
Parabrachial CGRP-Expressing Neurons Establish and Maintain Threat Memories

Jan Siemens, University of Heidelberg, Germany
Deep Brain vs. Ambient Temperature Detection: Who Has the Say in Thermoregulation?

Yuki Oka, California Institute of Technology, USA
Neural Mechanisms of Body Fluid Regulation

Ricardo Paricio Montesinos, Max Delbruck Center For Molecular Medicine, Germany
Short Talk: The Sensory Encoding of Warm Perception

Kara Marshall, The Scripps Research Institute, USA
Short Talk: Under Pressure: The Role of PIEZO2 in Urination

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Quandary Peak
19:30—22:00
Poster Session 2

Quandary Peak

WEDNESDAY, FEBRUARY 5

07:00—08:00
Breakfast

Quandary Peak
08:00—11:00
New Targets

Grays Peak
* Venetia Zachariou, Icahn School of Medicine at Mount Sinai, USA

Nikita Gamper, University of Leeds, UK
GABAergic Signaling within Dorsal Root Ganglia

Biafra Ahanonu, University of California, San Francisco, USA
An Amygdalar Neural Ensemble that Encodes the Unpleasantness of Pain

Coffee Break

Daniela Salvemini, Saint Louis University, USA
Adenosine Receptors Modulating Neuropathic Pain

Cheryl L. Stucky, Medical College of Wisconsin, USA
Transient Receptor Potential Canonical 5 (TRPC5): A Novel Target for Inflammatory and Migraine Pain

08:00—11:00
Somatosensory Cortex

Longs Peak
Carl CH Petersen, École Polytechnique Fédérale de Lausanne, Switzerland
Neural Circuits for Goal-Directed Sensorimotor Transformation

Daniel O'Connor, Johns Hopkins University, USA
A Functional Cortical Network for Sensorimotor Sequence Generation

Coffee Break

James Poulet, Max-Delbrück-Centrum für Molekulare Medizin, Germany
Cortical Circuits of Thermal Perception

Jeff Yau, Baylor College of Medicine, USA
Short Talk: Bimanual Touch and Cortical Encoding Models of Sensory Cue Integration

John Tuthill, University of Washington, USA
Short Talk: Neural Coding of Leg Proprioception in Central Circuits of Drosophila

11:00—17:00
On Own for Lunch

14:30—16:30
Career Roundtable
Interested participants must sign up at the registration desk on a first-come, first-serve basis. Maximum attendance: 60.

Castle Peaks 1-2
Laura M. Bohn, The Scripps Research Institute, USA

Alexander Chesler, National Institutes of Health, USA

Yarimar Carrasquillo, National Institutes of Health, USA

William K. Schmidt, Helixmith Co., Ltd, Seoul, South Korea, and San Diego, USA

Karen Wagner, EicOsis, USA

Michael D. Burton, University of Texas at Dallas, USA

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—18:30
Cannabis for Managing Pain?

Grays Peak
* William K. Schmidt, Helixmith Co., Ltd, Seoul, South Korea, and San Diego, USA

Aron H. Lichtman, Virginia Commonwealth University, USA
Targeting Endocannabinoid-Regulating Enzymes in Mouse Models of Neuropathic Pain: The 2-AG Paradox

Andrea Hohmann, Indiana University, USA
CB2 Cannabinoid Receptor as a Therapeutic Target

David Shurtleff, NCCIH, National Institutes of Health, USA
Natural Products for the Treatment of Chronic Pain

17:00—18:45
Cortical Processes for Somatosensation

Longs Peak
* Daniel O'Connor, Johns Hopkins University, USA

Michael Brecht, Humboldt University Berlin, Germany
Tickling, Self-Touch and Mirroring

Sliman J. Bensmaia, University of Chicago, USA
The Neural Basis of Touch and Proprioception in Non-Human Primates

* Soohyun Lee, NIMH, National Institutes of Health, USA
Functional Connectivity of Diverse Long-Range Inputs to the Primary Somatosensory Cortex

Alan J. Emanuel, Harvard Medical School, USA
Short Talk: Subcortical Integration of Signals from Peripheral Mechanoreceptor Subtypes

18:30—18:45
Panel Discussion: Future Directions

18:45—19:00
Meeting Wrap-Up

Grays Peak
Laura M. Bohn, The Scripps Research Institute, USA

William K. Schmidt, Helixmith Co., Ltd, Seoul, South Korea, and San Diego, USA

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Longs Peak
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Quandary Peak
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Quandary Peak

THURSDAY, FEBRUARY 6

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

Vertex Pharmaceuticals Incorporated

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health
National Center for Complementary and Integrative Health (NCCIH)

Grant No. 1R13AT010563-01

Funding for this conference was made possible (in part) by 1R13AT010563-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Cayman Chemical Company Helixmith Co., Ltd.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Helixmith Co., Ltd.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-1179