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This meeting took place in 2020



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AAA+ Proteins: From Atomic Structures to Organisms (A5)


Organizer(s) Walid A. Houry, James Shorter, Antonina Roll-Mecak and Phyllis I. Hanson
January 26—29, 2020
Granlibakken Tahoe • Tahoe City, CA USA
Discounted Abstract Deadline: Sep 26, 2019
Abstract Deadline: Nov 6, 2019
Scholarship Deadline: Sep 26, 2019
Discounted Registration Deadline: Nov 21, 2019

Supported by the Directors' Fund

Summary of Meeting:
AAA+ proteins are ATPases Associated with Diverse Cellular Activities. They form a large superfamily and have been found to carry out a very diverse range of functions including DNA replication, chromatin remodeling, rRNA processing, and membrane fusion. In recent years, there has been substantial progress in identifying the structure and cellular function of a large number of AAA+ proteins. However, little is known of the unique features underlying this mechano-chemical coupling mechanism used to apply forces to various substrates. There is also a lack of understanding for many AAA+ proteins regarding how substrates are recognized, regulation of their activities in vivo, and how their functions are coordinated with other competing and overlapping reactions. Recent findings demonstrate the importance of AAA+ proteins in the biology of cancer and neurodegeneration and as virulence factors in pathogenic microorganisms. However, we know very little of the biochemical pathways leading to diseases arising from mutations in these proteins. The conference will bring together an interdisciplinary group of scientists interested in understanding the structure, function, and disease aspects of these proteins. The conference comes at an opportune time of great developments in structural biology, especially cryoEM, and cell biology. We aim to provide a very interactive and collegial atmosphere to discuss the latest advances in this important field. In addition to having invited speakers, we will also provide the opportunity to many attendees to give an oral presentation about their research. Poster sessions will also be held for all attendees.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 26 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Wednesday, January 29 with a closing plenary session from 17:00 to 19:00, followed by dinner and entertainment. We recommend return travel on Thursday, January 30 in order to fully experience the meeting.

SUNDAY, JANUARY 26

16:00—20:00
Arrival and Registration

Pre Function
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Granhall
18:00—20:00
Light Meal - Provided by Granlibakken

Granhall

MONDAY, JANUARY 27

07:00—08:00
Breakfast

Granhall
08:00—09:00
Welcome and Keynote Address

Mountain/Lake
* Walid A. Houry, University of Toronto, Canada

* James Shorter, University of Pennsylvania, USA

* Antonina Roll-Mecak, DHHS/NINDS, National Institutes of Health, USA

* Phyllis I. Hanson, University of Michigan, USA

Bob T. Sauer, Massachusetts Institute of Technology, USA
Is ClpXP Unique or a Model for Other AAA+ Proteases and Protein Remodelers?

09:00—11:30
Insights into AAA+ Mechanism of Function by CryoEM

Mountain/Lake
* Antonina Roll-Mecak, DHHS/NINDS, National Institutes of Health, USA

Daniel Southworth, University of California, San Francisco, USA
Structures and Mechanisms of Protein Unfolding Machines by Cryo-EM

Coffee Break

Axel T. Brunger, Stanford University, USA
SNARE Complex Recycling and Quality Control by the AAA+ NSF ATPase

Andreas Martin, University of California, Berkeley, USA
Mechanisms of ATPase-Coupled Substrate Translocation by the 26S Proteasome and Related AAA+ Motors

Carol Soomin Cho, Korea Advanced Institute of Science and Technology, South Korea
Short Talk: Nucleotide-Dependent Structural Changes of the Abo1 AAA+ Histone Chaperone

Steven E. Glynn, Stony Brook University, USA
Short Talk: Structure of the AFG3L2 Mitochondrial AAA+ Protease Reveals the Molecular Basis for Activity in Health and Disease

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
14:30—16:30
Workshop 1

Mountain/Lake
* Phyllis I. Hanson, University of Michigan, USA

Kevin D. Corbett, University of California, San Diego, USA
Regulation of a Bacterial Innate-Immune Pathway by a TRIP13-Like ATPase

Ryan R. Cupo, University of Pennsylvania, USA
Function of Skd3, a Mitochondrial AAA+ Protein

Stephanie Gates, University of California, Berkeley, USA
VCP/p97 N-Terminal Domain Conformational Switching Regulates Cofactor Binding and Substrate Processing

Irina Gutsche, Institut de Biologie Structurale, France
An Enterobacterial Stress Response Triad from a Cryo-EM Perspective

Julia Kardon, Brandeis University, USA
Directed Unfolding by Mitochondrial ClpX Controls an Essential Biosynthetic Enzyme

Saikrishnan Kayarat, Indian Institute of Science Education and Research, India
Mechanism of Activation of the AAA+ GTPase McrB by the Endonuclease McrC

Teru Ogura, IMEG, Kumamoto University, Japan
Function of the p97-20S Proteasome and Nanodynamics of Novel and Canonical Proteasomal Pathway Components

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
AAA+ Proteins of the Cytoskeleton

Mountain/Lake
* James Shorter, University of Pennsylvania, USA

Antonina Roll-Mecak, DHHS/NINDS, National Institutes of Health, USA
Mechanism and Regulation of Microtubule Severing Enzymes

David W. Ehrhardt, Stanford University, USA
Mechanisms of Acentrosomal Microtubule Array Organization in Higher Plants

Arne Gennerich, Albert Einstein College of Medicine, USA
Short Talk: Force Generation of Mammalian Dynein-Dynactin is Augmented by Lis1

Chun-che Tseng, Mayo Clinic Graduate School of Biomedical Sciences, USA
Short Talk: Conserved Regulation of AAA-ATPase Vps4 by V Domain of Bro1 Family Proteins Contributes to ESCRT-III Function

19:00—20:00
Dinner

Granhall
19:00—20:00
Social Hour
No registration fees are used to fund alcohol served at this function.

Granhall
19:30—22:00
Poster Session 1

Bay

TUESDAY, JANUARY 28

07:00—08:00
Breakfast

Granhall
08:00—11:00
Role of AAA+ Proteins in Cellular Remodeling

Mountain/Lake
* Teru Ogura, IMEG, Kumamoto University, Japan

Tarun M. Kapoor, Rockefeller University, USA
Chemical Probes for AAA+ Proteins

Conrad C. Weihl, Washington University School of Medicine, USA
Multisystem Proteinopathy Mutations Define New Functions for p97/VCP

Coffee Break

James H. Hurley, University of California, Berkeley, USA
Roles of VPS4 and Spastin in ESCRT-III Membrane Scission and Disassembly

Xiaodong Zhang, Imperial College London, UK
Mechanistic Insights into Non-Translocating AAA ATPases: From INO80 Chromatin Remodeller to Transcription Activators

Aaron L. Lucius, University of Alabama at Birmingham, USA
Short Talk: Falling Off: ClpB and Hsp104 Operate as Non-Processive Translocases

Zev A. Ripstein, Hospital for Sick Children, Canada
Short Talk: A Processive Rotary Mechanism Couples Substrate Unfolding and Proteolysis in the ClpXP Degradation Machinery

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Role of AAA+ Proteins in Regulating DNA and RNA Complexes

Mountain/Lake
* Andreas Martin, University of California, Berkeley, USA

Robin E. Stanley, NIEHS, National Institutes of Health, USA
Role of AAA-ATPases in Ribosome Assembly

James M. Berger, Johns Hopkins University School of Medicine, USA
Conformational Coupling and Substrate-Recognition Plasticity in Replicative AAA+ ATPases

Matt J. Jaremko, Cold Spring Harbor Laboratory, USA
Short Talk: The Dynamic Conformations of the Human Origin Recognition Complex

Helmut Bergler, Karl-Franzens University Graz, Austria
Short Talk: Mechanism of Chemical Inhibition of the Essential Ribosome Assembly

Andrew Frank Neuwald, University of Maryland School of Medicine, USA
Short Talk: Deep Analysis of Residue Constraints (DARC): Identifying Determinants of AAA+ ATPase Functional Specificity

19:00—20:00
Dinner

Granhall
19:00—20:00
Social Hour
No registration fees are used to fund alcohol served at this function.

Granhall
19:30—22:00
Poster Session 2

Bay

WEDNESDAY, JANUARY 29

07:00—08:00
Breakfast

Granhall
08:00—11:15
AAA+ Proteins in Disease Pathways

Mountain/Lake
* Arne Gennerich, Albert Einstein College of Medicine, USA

Walid A. Houry, University of Toronto, Canada
Role of the ClpXP Protease in Pathogenesis

Rose E. Goodchild, VIB/ KU Leuven, Belgium
How Torsins Regulate Cellular Lipid Metabolism

Coffee Break

Christopher P. Hill, University of Utah, USA
Translocation Mechanism of AAA Unfoldases

Tania A. Baker, Massachusetts Institute of Technology, USA
Are Two Rings Better than One? Deciphering Roles of the ATPase Modules in the Double Ring AAA+ Unfoldase ClpA

Daisuke Morito, Showa University, Japan
Short Talk: The 591 kDa AAA+/Ubiquitin Ligase Regulates the Cellular Fat Metabolism

Nina Marie Wolf, University of Illinois, Chicago, USA
Short Talk: Structures of ClpC1 from Mycobacterium Tuberculosis in Complex with Macrocyclic Inhibitors from Natural Products Reveal Critical Binding Interactions

Minglei Zhao, University of Chicago, USA
Short Talk: Mechanistic Insights into p97 Inhibition through Disulfiram Derivative

11:15—17:00
On Own for Lunch

14:30—16:30
Workshop 2

Mountain/Lake
* Xiaodong Zhang, Imperial College London, UK

Kyle E. Lopez, University of California, San Francisco, USA
Conformational Plasticity of the ClpAP AAA+ Protease Couples Protein Unfolding and Proteolysis

Ying Lu, Harvard Medical School, USA
An Empirical Free-Energy Landscape Reveals the Global Conformational Dynamics of Proteasomal ATPases

Wen Ma, University of California, San Diego, USA
Molecular Mechanism of Polypeptide Translocation by an AAA+ Unfoldase Studied by Long Timescale Atomistic Simulations

Oliver Mueller-Cajar, Nanyang Technological University, Singapore
Insights into the Mechanism and Regulation of the CbbQO-type Rubisco Activase, a MoxR AAA+ ATPase

Thomas U. Schwartz, Massachusetts Institute of Technology, USA
On the Unusual Assembly States of the AAA+ ATPase TorsinA

Mia Shin, The Scripps Research Institute, USA
Structural Basis for Distinct Operational Modes and Protease Activation in Lon Protease

David Smith, West Virginia University School of Medicine, USA
Functional and Regulatory Roles Played by the N-Domain of the Proteasomal ATPase PAN

16:30—17:00
Coffee Available

Pre Function
17:00—18:45
AAA+ Proteins and Therapeutics

Mountain/Lake
James Shorter, University of Pennsylvania, USA
AAA+ Disaggregases as Therapeutic Agents

Phyllis I. Hanson, University of Michigan, USA
Role of AAA+ Protein in Late Endosomes

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Mountain/Lake
19:00—20:00
Dinner

Granhall
19:00—20:00
Social Hour
No registration fees are used to fund alcohol served at this function.

Granhall
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Granhall

THURSDAY, JANUARY 30

 
Departure


*Session Chair †Invited, not yet responded.



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