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This meeting took place in 2020



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Tissue Immunity (A6)


Organizer(s) Bana Jabri, Daniel Mucida and Ramnik Xavier
January 26—29, 2020
Embassy Suites by Hilton Boulder • Boulder, CO USA
Discounted Abstract Deadline: Sep 26, 2019
Abstract Deadline: Oct 24, 2019
Scholarship Deadline: Sep 26, 2019
Discounted Registration Deadline: Nov 21, 2019

Sponsored by AbbVie Inc., Akebia Therapeutics, BioLegend, Inc., Merck & Co., Inc. and Pfizer Inc.

Summary of Meeting:
How tissues integrate host-microbial signals and regulate immune responses has a critical impact on health and disease. However, our understanding of tissue immunity is limited because of difficulties in accessing the different organs and also due to the inherent complexity and individuality of the cellular circuits present in different tissues. This conference will bring together scientists in the fields of mucosal immunology, neurology, microbiology, metabolism and systems biology. The conference will discuss (i) the diversity of tissue resident T cell subsets and their function and regulation, (ii) the regulation and role of mucosal B cell responses, (iii) the role of the nervous system in the regulation of tissue immunity, (iii) how tissues integrate metabolic and microbial cues to determine which type of immune response to mount, (iv) the existence of innate memory and its role in pathophysiology, and (v) new approaches in the study of tissue immunity. Because of the interdisciplinary nature of the conference and its focus on tissue immunity across organs and cell types, the conference will give investigators a broad perspective on tissue immunity and encourage them to go beyond the traditional disciplinary boundaries. An interactive workshop engage will engage industrial partners to define new approaches to prevent and treat inflammatory disorders and cancer and will highlight new frontiers in tissue immunity, cellular networks and inter-tissue communication in health and disease.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 26 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, January 29 with a closing plenary session and keynote address from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Thursday, January 30 in order to fully experience the meeting.

SUNDAY, JANUARY 26

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

MONDAY, JANUARY 27

08:30—09:30
Welcome and Keynote Address

Pearl Street Ballroom
* Piotr Bielecki, Celsius Therapeutics, USA

Richard M. Locksley, HHMI/University of California, San Francisco, USA
Type 2 Immunity and Tissue Resilience

09:30—12:00
Tissue-Resident T Cells

Pearl Street Ballroom
* Daniel Mucida, Rockefeller University, USA

David B. Masopust, University of Minnesota, USA
Functions of Tissue Resident T Cells

Coffee Break

Laura K. Mackay, University of Melbourne, Australia
Targeting Tissue-Resident Memory T Cell Subsets

Ivaylo I. Ivanov, Columbia University, USA
Dissecting the Differential Roles of ILC3 and T Cells in Mucosal Immunity

Toufic Mayassi, University of Chicgao, USA
Insights into Tissue-Resident Immunity and Intraepithelial gamma delta Biology from Celiac Disease

12:00—17:00
On Own for Lunch

12:00—13:00
Poster Setup

Pearl Street Ballroom
13:00—22:00
Poster Viewing

Pearl Street Ballroom
14:30—16:30
Workshop 1: Immune Responses across Tissues

Pearl Street Ballroom
* Daria Esterházy, University of Chicago, USA

* Xingbin AI, Brigham & Women's Hospital, USA

Nicholas Bessman, Weill Cornell Medicine, USA
Dendritic Cell-Derived Hepcidin Sequesters Iron from the Microbiota to Promote Mucosal Healing

Quynh Nguyen, University of California, San Diego, USA
Transcriptional Programming of Intestinal CD4+ Tissue-Resident Memory T Cells

Susan Christo, University of Melbourne, Australia
The Local Microenvironment Drives the Identity of Tissue-Resident Memory T Cells

Jack McGinty, University of Washington, USA
Tuft Cell-Derived Leukotrienes Drive Rapid Activation of Anti-Helminth Immunity in the Small Intestine

Zachary Earley, University of Chicago, USA
GATA4 Controls Regionalization of Intestinal Immunity Through Restricting Bacterial Colonization

Angelina Bilate, Rockefeller University, USA
Instructive Role of the T Cell Receptor on Lymphocyte Plasticity at the Intestinal Border

Madelene W. Dahlgren, University of California, San Francisco, USA
Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches

Emily E. Thornton, University of Oxford, UK
Commensal-Reactive, IL-23 Responsive T Cells Promote Gut Barrier Immunity

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Innate Memory in Tissues

Pearl Street Ballroom
* Fiona M. Powrie, University of Oxford, UK

Mihai G. Netea, Radboud University, Netherlands
Trained Immunity: A Memory for Innate Host Defense

Marco Colonna, Washington University School of Medicine, USA
Tissue Imprinting of Innate-Like-Lymphocytes

Shruti Naik, New York University, USA
Inflammatory Memory in Epithelial Stem Cells

Michael G. Constantinides, NIAID, National Institutes of Health, USA
Short Talk: MAIT Cells are Imprinted by the Microbiota in Early Life and Promote Tissue Repair

Judith Agudo, Dana-Farber Cancer Institute, USA
Short Talk: Quiescent Tissue-Resident Stem Cells Evade Immune Surveillance

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pearl Street Ballroom
19:30—22:00
Poster Session 1

Pearl Street Ballroom

TUESDAY, JANUARY 28

08:30—11:30
Neuronal Control of Tissue Immunity

Pearl Street Ballroom
* Ramnik Xavier, Massachusetts General Hospital, USA
Microbial Metabolites in Health and Disease

Gloria Choi, Massachusetts Institute of Technology, USA
Neural Circuits and the Immune System

Coffee Break

Daniel Mucida, Rockefeller University, USA
Adrenergic Signaling in Muscularis Macrophages Limits Neuronal Death Following Enteric Infection

Lorena Riol Blanco, Genentech, Inc., USA
Nodose Sensory Neurons Require TMC3 to Restrain Lung Damage

William Khoury-Hanold, Yale University, USA
Short Talk: Bitter Taste Sensing in the Gastrointestinal Tract Controls Allergic Sensitization

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Pearl Street Ballroom
13:00—22:00
Poster Viewing

Pearl Street Ballroom
14:30—16:30
Career Roundtable

Pearl Street Ballroom
Shruti Naik, New York University, USA

David B. Masopust, University of Minnesota, USA

Daria Esterházy, University of Chicago, USA

Dan A. Erkes, American Association for Cancer Research, USA

Ramnik Xavier, Massachusetts General Hospital, USA

Melissa Marie Walker, Bolder Biopath, USA

Fiona M. Powrie, University of Oxford, UK

Ursula Weiss, Nature Publishing Group, UK

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Mucosal B Cell Responses

Pearl Street Ballroom
Matteo Iannacone, Fondazione Centro San Raffaele, Italy
Spatiotemporal Dynamics and Genomic Landscape of CD8+ T Cells Undergoing Intrahepatic Priming

* Ludvig M. Sollid, University of Oslo, Norway
Antigen-Specific B Cell Responses Implicated in Celiac Disease

Valerie Abadie, University of Chicago, USA
Contribution of the Humoral Response to the Pathogenesis of Celiac Disease

Priyadharshini Devarajan, University of Massachusetts Medical School, USA
Short Talk: Generation of Tissue-Restricted CD4 Effectors, TFH and ThCTL, Requires Signals from Antigen in the Tissue Site and from Infection at an Effector Checkpoint

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pearl Street Ballroom
19:30—22:00
Poster Session 2

Pearl Street Ballroom

WEDNESDAY, JANUARY 29

08:30—11:45
Molecular and Metabolic Control of Inflammation

Pearl Street Ballroom
* Ramnik Xavier, Massachusetts General Hospital, USA

Daria Esterházy, University of Chicago, USA
Compartmentalization of Intestinal Immune Responses

Fiona M. Powrie, University of Oxford, UK
Talk Title to be Announced

Coffee Break

Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Krebs Cycle Reborn in Macrophages

Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Influence of Nutrient Availability on Tissue Metabolism

Graham Barlow, Stanford University, USA
Short Talk: Hierarchical Tissue Factors Orchestrate Autoimmune Insulitis in Human Type I Diabetes

Jacqueline W. Mays, NIDCR, National Institutes of Health, USA
Short Talk: Tissue-Resident Memory T Cells May Drive the Pathogenesis of Exocrine Gland Chronic Graft-Versus-Host Disease

Eric Brown, Broad Institute of MIT and Harvard, USA
Short Talk: Intestinal Microbiome Sphingolipid Signaling Mediates Inflammation and Mucosal Immunity

11:45—17:00
On Own for Lunch

14:30—16:30
Workshop 2: New Approaches to Target Tissue Immunity in Autoimmunity and Cancer

Pearl Street Ballroom
* Shruti Naik, New York University, USA

* Ricardo R. Cibotti, NIAMS, National Institutes of Health, USA

Rafael Sanguinetti Czepielewski, Washington University School of Medicine, USA
Mesenteric Tertiary Lymphoid Organs Block Leukocyte Migration from the Intestine in a Crohn’s Disease-Like Mouse Model

Michel Enamorado, NIAID, National Institutes of Health, USA
Immunity - or Lack of - to Staphylococcus aureus

Yisu Gu, University of Oxford, UK
Spatial Compartmentalisation of Pathobiont-Reactive T Cell Differentiation in Gut Tissue

Duncan McKenzie, Francis Crick Institute, UK
A Two-Step Molecular Mechanism for Immune Discrimination of Tissue Dysregulation from Normality

Martina Damo, Yale University, USA
Tissue Type Determines the Outcome of Peripheral T Cell Tolerance Induction

Bernardo S. Reis, Rockefeller University, USA
Role of Intraepithelial gamma delta Lymphocytes during Colon Cancer Development and Progression

Zuri Sullivan, Yale University, USA
Gammadelta T-Cells Regulate Intestinal Epithelial Response to Nutrient Sensing

Shiqun Zhang, University of Pittsburgh, USA
MrgprD-Expressing Neurons Maintain Cutaneous Mast Cell Homeostasis

16:30—17:00
Coffee Available

Foyer
17:00—18:00
Microbiota and Tissue Immunity

Pearl Street Ballroom
* Ivaylo I. Ivanov, Columbia University, USA

Dan R. Littman, HHMI/New York University School of Medicine, USA
Gut Microbiota and Systemic Immunity

Jun R. Huh, Harvard Medical School, USA
Immune Modulatory Roles of Bile Acid Metabolites

18:00—18:45
Closing Keynote Address

Pearl Street Ballroom
* Ramnik Xavier, Massachusetts General Hospital, USA

Yasmine Belkaid, NIAID, National Institutes of Health, USA
Innate Resident T Cells in Skin Immunity

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Pearl Street Ballroom
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pearl Street Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Pearl Street Ballroom

THURSDAY, JANUARY 30

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

AbbVie Inc. Akebia Therapeutics
BioLegend, Inc. Merck & Co., Inc.
Pfizer Inc.
 

We gratefully acknowledge additional support from these exhibitors at this conference:

Bolder BioPATH, Inc.
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI147688-01

Funding for this conference was made possible (in part) by 1R13AI147688-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

American Association for Cancer Research (AACR)

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179