Keystone Symposia

Fairmont Banff Springs Floorplan

This meeting was rescheduled and may have a different Meeting Program and Scholarships/Awards



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MEETING POSTPONED: The Human Microbiome: Ecology and Evolution (Q3)


Organizer(s) Ruth E. Ley, Alejandro Reyes and C. Jessica Metcalf
February 13—16, 2022
Fairmont Banff Springs • Banff, AB Canada
Abstract Deadline: Nov 12, 2021
Scholarship Deadline: Nov 12, 2021
Discounted Registration Deadline: Dec 14, 2021

Sponsored by Astellas Pharma Inc.


Summary of Meeting:
This Keystone Symposia conference will explore the evolutionary and ecological forces shaping the interplay between the human host and microbiome. The microbiome is implicated in a widening set of disease conditions, yet many questions remain as to how its diversity and composition are assembled and maintained. This program is designed to take on the topic of the microbiome across scales, integrating the latest understanding of human microbiome diversity across time and space, and delving into the molecular interactions that shape the associations. This conference aims to understand how movement of human populations, past and present, shape patterns of microbiome diversity. The program will include sessions on deciphering evolutionary dynamics linking microbiota to the human host, as well as discussions on understanding the co-evolution of humans with the microbiome at level of interactions at the molecular scale. Other topics will assess how interactions between host and microbiome can be harnessed for health. Through integration of patterns, processes and theory derived from human and non-human systems, attendees will gain an integrated view of microbiome diversity across modern human populations, and their interactions in host health.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, February 13 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, February 16 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, February 17 in order to fully experience the meeting.

SUNDAY, FEBRUARY 13

16:00—20:00
Arrival and Registration

Van Horne Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Van Horne Foyer

MONDAY, FEBRUARY 14

07:00—08:00
Breakfast

Van Horne C/President's Hall
08:00—09:00
Welcome and Keynote Address

Van Horne A
Howard Ochman, University of Texas at Austin, USA
Evolution of the Human Microbiome

08:00—09:00
Welcome and Keynote Address

Van Horne B
Eric G. Pamer, University of Chicago, USA
Impact of Antibiotic on Resistance Development, the Microbiome and Human Health

09:00—11:15
Host Factors and the Microbiome

Van Horne A
Alexandra Zhernakova, University Medical Center Groningen, Netherlands
Host Genetics in Relation to the Microbiome

Coffee Break

C. Jessica Metcalf, Princeton University, USA
Demographics and the Human Microbiome

Nandita Garud, University of California, Los Angeles, USA
Comparative Population Genetics in the Human Gut Microbiome

Qijun Zhang, University of Wisconsin-Madison, USA
Short Talk: Systems Genetics Uncovers Microbe-Lipid-Host Connections in the Murine Gut

Faye Chleilat, Stanford University, USA
Short Talk: Paternal High Protein Diet-induced Intergenerational Effects on Body Composition, Insulin Sensitivity, Epigenetics and the Gut Microbiota

09:00—11:15
Expanding the Source of Chemical Space for Antimicrobial

Van Horne B
Man-Wah Tan, Genentech, Inc., USA
DNA Encoded Macrocycles and Metagenomic Mining for Antibiotic Discovery

Coffee Break

David Bikard, Pasteur Institute and Eligo Bioscience, France
Engineering CRISPR-CAS Systems to Kill Bacteria

Davide Corti, Vir Biotechnology, Switzerland
Advances and Challenges in the Development of Anti-Infective Monoclonal Antibodies

Paola Estrada†, Princeton University, USA
Short Talk: Discovery of Aromatic Polyketides from the Human Microbiome

Noam Adir†, Technion, Israel
Short Talk: Lethal Sequences: Development of a Platform for Novel Peptide Antibiotics

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Van Horne C/President's Hall
13:00—22:00
Poster Viewing

Van Horne C/President's Hall
14:30—16:30
Panel Discussion

Van Horne B
* Deborah T. Hung, Broad Institute of MIT & Harvard, USA

Man-Wah Tan, Genentech, Inc., USA

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Co-Evolution and Co-Diversification of Microbiota and their Hosts

Van Horne A
Andrew Moeller, Cornell University, USA
Coevolution of Hominids and their Microbiomes

Katherine R. Amato, Northwestern University, USA
Diet and the Evolution of the Human Microbiome

Ran Blekhman, University of Minnesota, USA
Human Genomics and the Human Microbiome

Samuel Zimmerman, Harvard University, USA
Short Talk: Tracking Vertical or Horizontal Transmission History of Human Gut Symbionts with Ancient Microbial Genomes

Taichi A. Suzuki, Max Planck Institute for Developmental Biology, Germany
Short Talk: Codiversification of Gut Microbiota with Humans

17:00—19:00
Novel Approaches to Discover Therapeutics and Overcome AMR

Van Horne B
Deborah T. Hung, Broad Institute of MIT & Harvard, USA
Systems Approach to Antimicrobial Discovery

Jonathan M. Stokes, McMaster University, Canada
AI-Driven Antibiotic Discovery: New Weapons Against Old Foes

Houra Merrikh, Vanderbilt University, USA
Blocking the Evolution of Resistance

David S. Weiss, Emory University, USA
Novel Ways to Treat MDR Microbes

Tommaso Biancalani, Genentech, USA
Short Talk: GNEprop: State of the Art Deep Learning Framework for Antibiotic Discovery

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Van Horne C/President's Hall
19:30—22:00
Poster Session 1

Van Horne C/President's Hall

TUESDAY, FEBRUARY 15

07:00—08:00
Breakfast

Van Horne C/President's Hall
08:00—11:00
Controlling the Microbiome for Health

Van Horne A
Fredrik Bäckhed, University of Gothenburg, Sweden
The Microbiome in Metabolic Disease

Lisa Maier, University of Tübingen, Germany
Microbe-Drug Interactions

Coffee Break

Sandrine Claus, Ysopia Bioscience, France
A New Strain of Christensenella minuta as a Potential Biotherapy for Obesity and Associated Metabolic Diseases

Jens Walter, APC Microbiome Ireland, University College Cork, Ireland
Applying Ecological Theory in Controlling Microbiomes

Marie Wende, Helmholtz Centre for Infection Research, Germany
Short Talk: Promoting Gut Decolonization of Multi-Drug Resistant Bacteria via the Microbiome

Soumaya Zlitni, Stanford University, USA
Short Talk: Microbial Chatter: A Novel Quorum Sensing System in the Gut Bacterium and Pathogen E. Faecalis

Mackenzie Gutierrez, University of Calgary, Canada
Short Talk: Early-life Fungal Colonization Mediates Host Metabolism and White Adipose Tissue Inflammation in Mice

08:00—11:00
Alternatives Approaches to tackle AMR

Van Horne B
Annette Vogel, BioNTech, Germany
TB Vaccine based on mRNA Technology

Cesar de la Fuente†, University of Pennsylvania, USA
Talk Title to be Announced

Coffee Break

Kimberly Kline, University of Geneva, Switzerland
Biofilm and AMR

Heather Pinkett, Northwestern University, USA
Transporters in AMR

Uyen Thy Nguyen, University of Wisconsin Madison, USA
Short Talk: Mining Sustainable Antimicrobials in the Human Skin Microbiome

Dalton T. Ham, University Of Western Ontario, Canada
Short Talk: Characterizing Cleavage Activity of CRISPR Guide RNAs in Bacteria to Enhance Strain-specific Elimination from Complex Microbial Populations

Jaroslav Zelenka, University of Chemistry and Technology Prague, Czech Republic
Short Talk: Elimination of Bacterial Biofilms with Antimicrobial Photodynamic Therapy

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Van Horne C/President's Hall
13:00—22:00
Poster Viewing

Van Horne C/President's Hall
14:30—16:30
Career Roundtable (Joint)

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Host-Virus-Microbiome Interactions (Joint)

Van Horne A/B
Andrew T. Gewirtz, Georgia State University / Frontiers, USA
Host-Virus-Microbiome Interactions

Alejandro Reyes, Los Andes University, Colombia
Bioinformatics Approaches to Phage-Host Interactions

Matthew Henn, Seres Therapeutics, USA
Microbiome Therapeutics to Combat Antimicrobial Resistance and Modulate Host Immunity

Lindsay R. Kalan, University of Wisconsin Madison, USA
Short Talk: Antifungal Potential of the Skin Microbiome

Julia Berkson†, FDA, USA
Short Talk: Immunological and Microbial Responses to Bacteriophage Therapy Targeting Vancomycin-Resistant Enterococcus Colonization

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Van Horne C/President's Hall
19:30—22:00
Poster Session 2

Van Horne C/President's Hall

WEDNESDAY, FEBRUARY 16

07:00—08:00
Breakfast

Van Horne C/President's Hall
08:00—11:00
Microbe-Microbe Interactions in Shaping the Microbiome

Van Horne A
Britt Koskella, University of California, Berkeley, USA
How Microbial Interactions Maintain Diversity

Carolina Tropini, University of British Columbia, Canada
How the Host Physical Environment Shapes the Gut Microbiota in Health and Disease

Coffee Break

Jeff Gore, Massachusetts Institute of Technology, USA
Modeling Interactions

Kevin Foster, University of Oxford, UK
Cooperation and Competition in Microbes and the Microbiome

Anna Sophie Weiss, Max von Pettenkofer Institute, Germany
Short Talk: Exploring the Interaction Network of a Synthetic Gut Bacterial Community

Matthew Barber, University of Oregon, USA
Short Talk: Evolution of Microbial-Host Cell Adherence at Epithelial Barriers

Caitlin H. Kowalski, University of Oregon, USA
Short Talk: Antimicrobial Activity of Skin-Resident Fungi Alters Pathogen Adaptation

08:00—11:00
Innovations in Rapid Diagnostic to Combat AMR

Van Horne B
Pierre Mahé, Biomerieux, France
Diagnosing AMR through Sequencing

Julie A. Segre, National Institutes of Health, USA
Tracking an Emerging Pathogen Candida auris in Nursing Homes with Genomic-Epidemiology

Coffee Break

Kelly Flentie, Selux Diagnostics, Inc, USA
Rapid Phenotypic Antibiotic Susceptibility Testing

Yoelkys Morales, Tufts University School of Medicine, USA
Short Talk: Impact of Tissue Mimetic Conditions on Combination Therapy in the Treatment of Multi-drug Resistant Klebsiella

Skylar Martin, Harvard School of Public Health, USA
Short Talk: Optimizing Molecular Antimicrobial Susceptibility Tests for Neisseria Gonorrhoeae

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—18:45
Molecular Cross Talk

Van Horne A
Elizabeth L. Johnson, Cornell University, USA
Sphingolipids in the Infant Gut Microbiome

Ruth E. Ley, Max Planck Institute for Developmental Biology, Germany
The Interactions between Bacterial Flagellins and Toll-Like Receptor 5

Eric C. Martens, University of Michigan Medical School, USA
The Bacteroides Capsule in Microbiome Interactions

Tamia Alisha Harris-Tryon, University of Texas Southwestern Medical Center, USA
Short Talk: Small Proline-rich Proteins (SPRRs) are Epidermally Produced Antimicrobial Proteins that Defend the Cutaneous Barrier by Direct Bacterial Membrane Disruption

17:00—18:45
Challenges and Novel Pathways to Develop Alternative Therapies

Van Horne B
Sumathi Nambiar, Johnson and Johnson, USA
Regulatory Paths and Novel Clinical Endpoints

Jennifer Schneider, Global Antibiotic R&D Partnership, USA
Talk Title to be Announced

Timothy Jinks, Wellcome Trust, UK
Novel Antimicrobials to Patient: Creating Sustainable R&D and Marketplace for Antimicrobials

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Van Horne A
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Van Horne B
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Van Horne C/President's Hall

THURSDAY, FEBRUARY 17

08:00—08:00
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

Astellas Pharma Inc.

We gratefully acknowledge additional support from these exhibitors at this conference:

Anaerobe Systems CosmosID
Microba Life Sciences, Ltd
 
Please stop by to meet these exhibitors during the conference.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: John Monson, Director of Corporate Relations, Email: johnm@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Josh May, Director, Technology and Digital Media, Email: joshuam@keystonesymposia.org,
Phone:+1 970-262-1179