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This meeting took place in 2022



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Engineering Multi-Cellular Living Systems (X7)


Organizer(s) Roger D. Kamm, Nuria Montserrat Pulido and Jianping Fu
April 3—6, 2022
Keystone Resort • Keystone, CO USA
Abstract Deadline: Jan 6, 2022
Scholarship Deadline: Jan 6, 2022
Discounted Registration Deadline: Feb 3, 2022

Sponsored by Biogen and Novo Nordisk A/S


Summary of Meeting:
Developing the capability to design, engineer and produce complex, multi-cellular engineered living systems (M-CELS) to emulate natural processes (development, regeneration, and disease) or to create new functionality is a grand challenge facing the scientific community. The manufacturing and design of these complex multicellular machines and systems (e.g., organ-on-chip models, biological robots, and organoids) require fundamental understanding of interactions between cells and their environment, their control by biochemical and mechanical cues, and coordinated behavior of functional cell clusters through computational and experimental methods. Cell interactions, controls across scales (from subcellular structures to multi-cellular systems) and behaviors will be central themes of the conference. The primary aim of this conference is to bring together a multidisciplinary group of forward-looking researchers seeking to explore these complex biological interactions and the emergent behaviors they produce, with the goal of creating responsibly engineered multi-cellular systems with specific functions.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, April 3 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, April 6 with a closing plenary session from 17:00 to 19:15, followed by a social hour. We recommend return travel on Thursday, April 7 in order to fully experience the meeting.

SUNDAY, APRIL 3

16:00—20:00
Arrival and Registration

Longs Peak Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer

MONDAY, APRIL 4

07:00—08:00
Breakfast

Quandary Peak
08:00—09:30
Welcome and Keynote Session (Joint)

Grays/Longs Peaks
* Roger D. Kamm, Massachusetts Institute of Technology, USA

* Jason R. Spence, University of Michigan Health System, USA

Paola Arlotta, Harvard University, USA
Programming, Reprogramming and Modeling of the Mammalian Cerebral Cortex

Matthias Lutolf, EPF Lausanne, Switzerland
Engineering Epithelial Organoid Development

Coffee Break

09:50—12:00
Embryoids and Gastruloids for Early Development (Joint)

Grays/Longs Peaks
* Nuria Montserrat Pulido, Institute for Bioengineering of Catalonia, Spain

* Todd C. McDevitt, Gladstone Institutes, USA

Jianping Fu, University of Michigan, Ann Arbor, USA
Building Synthetic Human Embryo-Like Structures

Magdalena D. Zernicka-Goetz, Caltech and University of Cambridge, UK
Development of Cell Lineages and Patterning in the Early Mammalian Embryo

Xufeng Xue, University of Michigan, USA
Short Talk: A Patterned Human Neural Tube Model Using Microfluidics

Xufeng Xue, University of Michigan, USA
Short Talk: A Patterned Human Neural Tube Model Using Microfluidics

Sunghee Estelle Park, University of Pennsylvania, USA
Short Talk: Geometric Engineering of Organoid Culture for Enhanced Organogenesis in a Dish

12:00—17:00
On Own for Lunch

12:00—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Engineering Principles of Developmental Biology and Regeneration

Longs Peak
* Ron Weiss, Massachusetts Institute of Technology, USA
Mammalian Synthetic Biology, Programmable Organoids, and Neuromorphic Computing in Cells

Kevin Kit Parker, Harvard University, USA
Building Cardiac Anatomy and Physiology into Muscular Pumps

Alex Hughes, University of Pennsylvania, USA
Short Talk: Extracting and Building with the Engineering Principles of Kidney Development

Katharine Goodwin, Princeton University, USA
Short Talk: On Fate and Form: Branching Morphogenesis Instructs Spatial Patterns of Epithelial Differentiation in the Developing Lung

17:00—19:00
High Content Screening with Organoids

Grays Peak
Jason R. Spence, University of Michigan Health System, USA
Complex Cell-Cell Interactions in the Developing Human Lung and Gut

Athanasia Apostolou, Emulate Inc, USA
Next Generation in vitro Systems for Drug Discovery

* Shuibing Chen, Weill Cornell Medical College, USA
A Multi-organoid Platform, SARS-CoV-2 Infection and Drug Screening

Filippo Cipriani, New York Stem Cell Foundation Research Institute, USA
Short Talk: Automated Platform to Derive iPSC-pancreatic Organoids for Population-scale Modeling of Type 2 Diabetes

Jack Song, USC, USA
Short Talk: Pluripotent Stem Cell-directed Model of Autosomal Dominant Polycystic Kidney Disease for Disease Mechanism and Drug Discovery

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Quandary Peak
19:30—22:00
Poster Session 1

Quandary Peak

TUESDAY, APRIL 5

07:00—08:00
Breakfast

Quandary Peak
08:00—11:15
Microphysiological Systems and Drug Discovery Platforms

Longs Peak
* Adam W. Feinberg, Carnegie Mellon University, USA

* Alex Hughes, University of Pennsylvania, USA

Christine L. Mummery, Leiden University Medical Center, Netherlands
Remote Presentation: Characterization and Functional Analysis of Cardiovascular Derivatives of Human Pluripotent Stem Cells

Roger D. Kamm, Massachusetts Institute of Technology, USA
Microphysiological Models for Neurological Disease

Coffee Break

Sandra J. Engle, Biogen, USA
In vitro Models to Enable Drug Discovery

Danilo A. Tagle, NCATS, National Institutes of Health, USA
Tissue Chips for Drug Screening

Sylvia F. Boj, Hubrecht Organoid Technology, Netherlands
Patient-Derived Organoids for Drug Development and Screening

Alice Stanton, MIT, USA
Short Talk: Engineering Vascularized Mini-Brain-Tissue for Accelerating Drug Discovery and Translation with Cell-Instructive Materials

08:00—11:00
Increasing Complexity in Organoids by Leveraging Development

Grays Peak
Barbara Treutlein, ETH Zürich, Switzerland
Remote Presentation: Single Cell Genomics to Guide Human Stem Cell and Tissue Engineering

Prisca Liberali, Friedrich Miescher Institute for Biomedical Research, Switzerland
Remote Presentation: Regenerative Landscape of Intestinal Organoids

Coffee Break

* Giorgia Quadrato, University of Southern California, USC Stem Cell, USA
Modeling Human Brain Development and Disease at Single Cell Resolution with Brain Organoids

* Madeline Lancaster, Medical Research Council Laboratory of Molecular Biology, UK
Using Brain Organoids to Identify Conserved or Unique Factors in Human Brain Size Evolution

Anna Meier, Technical University of Munich, Germany
Short Talk: Epicardioid Single-cell Genomics Uncover Principles of Human Epicardium Biology in Heart Development and Disease

Nicole Pek, Cincinnati Childrens Hospital Medical Center, USA
Short Talk: Reconstructing Pulmonary Circulation to Study Lung Alveologenesis in a Dish

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak
14:30—16:30
Career Roundtable (Joint)

Castle Peaks 1-2
Sandra J. Engle, Biogen, USA

Anjelica L. Gonzalez, Yale University, USA

Meritxell Huch, Max Planck Institute of Molecular Cell Biology and Genetics, Germany

Adriana Harbuzariu, Emory University, USA

Nuria Montserrat Pulido, Institute for Bioengineering of Catalonia, Spain

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Advanced Technologies for Engineering Multi Cellular Living Systems: Computation

Longs Peak
* Rashid Bashir, University of Illinois, USA

Yoshihiro Morishita, RIKEN, Japan
Remote Presentation: Quantitative Analysis of Tissue and Cell Dynamics Towards Revealing Design Principles for Organ Morphogenesis

* Melissa L. Kemp, Georgia Institute of Technology, USA
Modeling Self-Organization in Multi-Cellular Engineered Living Systems

Elebeoba E. May, University of Houston, USA
Multiscale Models of Spatiotemporal Response to Mycobacterium Infection

Dennis A. Norfleet, Georgia Institute of Technology, USA
Short Talk: Model-driven Prediction of Novel Emergent Bioelectric Patterns in hiPSCs

Aric Lu, Harvard University, USA
Short Talk: Orthogonal Induced Differentiation for Programming Stem Cells, Organoids, and Printed Tissues

17:00—19:00
Improvements in Organoid Maturation

Grays Peak
* J. Gray Camp, University of Basel, Switzerland
Interrogating Evolution using Single Cell Genomics and Genome Engineering

* James M. Wells, Cincinnati Children's Hospital Research Foundation, USA
Engineering Complexity into PSC-derived Gastrointestinal Organoids

Meghan Capeling, University of Michigan, USA
Short Talk: Suspension Culture Promotes Serosal Mesothelial Development in Human Intestinal Organoids

Ana Uzquiano Lopez, Harvard University, USA
Short Talk: Single-cell Atlas of Human Cortical Development in vitro and in vivo Reveals Longitudinal Molecular Programs of Human Cortex Diversification

Julien G. Roth, Stanford University, USA
Short Talk: Spatially Controlled Construction of Multi-organoid Neural Tissues using Bioprinting

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Quandary Peak
19:30—22:00
Poster Session 2

Quandary Peak

WEDNESDAY, APRIL 6

07:00—08:00
Breakfast

Quandary Peak
08:00—11:00
Advanced Technologies for Engineering Multi-Cellular Living Systems: Imaging, Biomaterials, and 3D Printing

Longs Peak
* Matthias Lutolf, EPF Lausanne, Switzerland

* Kevin Kit Parker, Harvard University, USA

Rashid Bashir, University of Illinois, USA
3D Printed Cellular Machines for Engineering and Biology

Adam W. Feinberg, Carnegie Mellon University, USA
3D Bioprinting of Collagen to Rebuild Components of the Human Heart

Coffee Break

Anjelica L. Gonzalez, Yale University, USA
Development of Biomaterials for Use As Investigational Tools

Michael Blatchley, University of Colorado Boulder, USA
Short Talk: In Situ Super-resolution Imaging of Organoids and Extracellular Matrix Interactions via Photo-expansion Microscopy

Sarah M. Hull, Stanford University, USA
Short Talk: UNIversal Orthogonal Network (UNION) Bioinks Enable Multi-material, Multi-cellular 3D Bioprinting

08:00—11:00
Organoids for Disease Modeling

Grays Peak
Samira Musah, Duke University, USA
Remote Presentation: Stem Cell-Derived Organ Chips for Disease Modeling

* Meritxell Huch, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Liver Organoids for Human Biology and Disease

Coffee Break

Mina Gouti, Max-Delbrück Center for Molecular Medicine, Germany
Neuromuscular Organoids to Model Human Development and Disease

Pleun Hombrink, Hubrecht Organoid Technology, Netherlands
Short Talk: Organoid Co-cultures with Autologous TIL to Model Personalized Tumor Specific Immune-responses

Jean-Paul Urenda, University of Southern California, USA
Short Talk: A Next-generation Human Multi-organoids-based Platform to Model Neurodevelopmental Disorders Following Physiological Stimulation

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Bioengineering of Organoids (Joint)

Grays/Longs Peaks
* Jianping Fu, University of Michigan, Ann Arbor, USA

Nuria Montserrat Pulido, Institute for Bioengineering of Catalonia, Spain
Engineering Solutions for Pluripotent Stem Cell Derived Kidney Organoids

Ryuji Morizane, Harvard Medical School, USA
Vascularized Kidney Organoids for Disease Modeling and Regenerative Medicine

* Todd C. McDevitt, Gladstone Institutes, USA
Talk Title to be Announced

Deepak Mishra, Massachusetts Institute of Technology, USA
Short Talk: Genetically Engineered Human Pluripotent Stem Cells Utilizing Multi-step Automated Differentiation for Development of 3D Liver Bud-like Organoids

Adriana Mulero-Russe, Georgia Tech, USA
Short Talk: Engineered Synthetic Platform for Human Intestinal Organoid Delivery

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (Joint)

Longs Peak/Grays Peak
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Quandary Peak

THURSDAY, APRIL 7

08:00—08:00
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

Novo Nordisk A/S

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13EB033176-01

Funding for this conference was made possible (in part) by 1R13EB033176-01 from the National Institute of Biomedical Imaging and Bioengineering with co-funding provided by the National Center for Advancing Translational Science . The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Biogen


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Phone:+1 970-262-2690

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Phone:+1 970-262-1179