Keystone Symposia

Beaver Run Conference Center Floorplan

This meeting took place in 2023


Here are the related meetings in 2024:
Regulation of Barrier Immunity (X8)

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Skin-Immune Crosstalk (Q3)


Organizer(s) Anna Di Nardo, Daniel H. Kaplan and Nathalie Boulanger
February 13—16, 2023
Beaver Run Conference Center • Breckenridge, CO USA
Abstract Deadline: Nov 28, 2022
Scholarship Deadline: Nov 28, 2022
Discounted Registration Deadline: Dec 14, 2022

Supported by the Directors' Fund


Summary of Meeting:
Skin is a barrier environment where immune cells interact with the unique skin environment to maintain tissue homeostasis and induce immune responses. Skin immune cells can be recruited from the circulation, but many reside in the skin where they are strategically located at the barrier interface within a complex stromal matrix in proximity with commensal bacteria and the external environment. Recent discoveries have radically changed our knowledge of the skin immune system including the interplay between different skin-resident immune cell types and the realization that skin immune cells interact with non-immune compartments in the skin. Skin-resident immune cells are shaped by the cutaneous microbiome and interact with the peripheral nervous system. These complex interactions result in efficient host defense against many pathogens, but some bacteria, fungi, viruses and vector-borne pathogens have evolved mechanisms to evade these systems. This conference will bring together immunologists, skin biologists, and dermatologists to introduce all groups to these new discoveries, challenges, and therapeutic opportunities. We will provide the attendees with a clear understanding that the host skin is a complex environment designed to tolerate commensals and respond to pathogens. Joining with a concurrent vector-borne disease meeting will enable microbiologists and vector biologists to exchange knowledge with immunologists and skin biologists, allowing for consideration of how new discoveries regarding skin-immune cross talk can inform our understanding of vector-borne pathogen transmission.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Monday, February 13 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 16 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Friday, February 17 in order to fully experience the meeting.

MONDAY, FEBRUARY 13

16:00—20:00
Arrival and Registration (4pm Start)

Colorado Ballroom Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Colorado Ballroom Foyer

TUESDAY, FEBRUARY 14

07:00—08:00
Breakfast

Summit Gallery
08:00—09:00
Welcoming Remarks from Organizers and Keynote Address (8am Start)

Peaks 4 & 5
Lisa A. Beck, University of Rochester Medical Center, USA
Success Story Going from the Basic Science of Atopic Dermatitis all the way Through to the Development of Game Changing New Therapy

08:00—09:00
Welcome and Keynote Address (8am Start)

Peaks 1-3
* João Pedra, University of Maryland School of Medicine, USA

Manu Prakash, Stanford University, USA
Remote Presentation: Mosquitoes Meet Microfluidics: High Throughout Low-Cost Tools for Molecular Surveillance of Vectors and Pathogens

09:00—11:15
Immune Microbiome Crosstalk at the Skin (9am Start)

Peaks 4 & 5
* Tiffany C. Scharschmidt, University of California, San Francisco, USA
Early Life Bacterial-Immune Interactions in Skin

Coffee Break

Richard L. Gallo, University of California, San Diego, USA
Microbial Control of Skin Innate Immunity

Roberto Ricardo Gonzalez, University of California, San Francisco, USA
Immune Control of Demodex Mites

Victoria Lovins, University of Pennsylvania, USA
Short Talk: Investigating the Role of Staphylococcus Aureus Strain-level Diversity on Neutrophil Recruitment and Wound Healing in a Cutaneous Leishmaniasis Infection

09:00—11:15
Transgenesis, Synthetic Biology and Machine Learning (9am Start)

Peaks 1-3
Omar S. Akbari, University of California, San Diego, USA
Synthetic Biology and Mosquitoes

Coffee Break

* Monika Gulia-Nuss, University of Nevada, USA
Genetic Tools for Tick and Tick-Borne Diseases Management

Felix Hol, Radboud University Medical Center, Netherlands
Short Talk: High-throughput Deep Behavioral Phenotyping of Dengue-virus infected Aedes Aegypti Reveals Transmission-enhancing Changes in Blood Feeding Behavior

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
14:30—16:30
Workshop 1: Skin Antibiotics and the Immune System (2:30pm Start)

Peaks 4 & 5
* Richard L. Gallo, University of California, San Diego, USA
Session Chair

Alexandria Wells, NIAID/NIH, USA
Adaptive Immunity to Ancient Retroelements Controls the Skin Tissue Threshold of Activation

Najla Nasr, Westmead Institute for Medical Research, University of Sydney, Australia
Characterising Plasmacytoid and Myeloid AXL SIGLEC6 Dendritic Cells Responses in Initial HIV Infection

Xintong Dong, University of Texas Dallas, USA
Genetic Dissection of Antimicrobial Peptide Signaling in Skin Infection and Inflammation

Sang Hun Lee, NIAID, National Institutes of Health, USA
MRhiMHCII- dermis Resident Macrophages Orchestrate Localized ILC2-eosinophil Circuitries to Maintain M2-like Properties in Cutaneous Leishmaniasis

Michael Battaglia, SUNY at Buffalo, USA
Ets1 Cooperates with IL17RA Signaling to Control Staphylococcus Aureus Skin Infection

Imke Visser, Erasmus MC, Netherlands
Differential Effect of Mosquito Saliva from Distinct Species on Human Dermal Endothelial Cell Function

Sam Verwimp, Rega Institute for Medical Research, KU Leuven, Belgium
Depletion of Host Skin Bacteria by Topical Antibiotic Treatment of the Skin Aggravates the Disease Outcome of Zika Virus Infections in Mice

Charlotte Cook, Pirbright Institute, UK
Stomoxys Calcitrans Feeding Activity Influences the Kinetics of Lumpy Skin Disease

14:30—16:30
Workshop 1: Immunobiology and Metabolism (2:30pm Start)

Peaks 1-3
* Dana K. Shaw, Washington State University, USA

Patricia Y. Scaraffia, Tulane University, USA
Advancing our Understanding of Aedes Aegypti Metabolism using Classical and Cutting-edge Technologies

Agustin Rolandelli, University of Maryland School of Medicine, USA
The Gene Expression Landscape of Ixodes Scapularis Hemocytes at Single-cell Resolution

Oshani Chathurangika Ratnayake, Colorado State University, USA
Investigating Remodeling of Metabolic Homeostasis in the Mosquito Vector during Arbovirus Infections

Yu-Min Chuang, Yale University, USA
Signaling Between Mammalian Adiponectin and a Mosquito Adiponectin Receptor Reduces Plasmodium Transmission

Paolo Gabrieli, Università degli Studi di Milano, Italy
The Insect Saliva as Modulator of the Mosquito Biting Behavior

Alan G. Goodman, Washington State University, USA
Anti-viral Insulin Signaling during Zika and West Nile Virus Infections

16:30—17:00
Coffee Available

Colorado Ballroom Foyer
17:00—19:00
Dermal Mechanism of Host Defense: Mast Cells (5pm Start)

Peaks 4 & 5
Stephen J. Galli, Stanford University, USA
Mast Cell Biology at the Skin Interface: Combating Venoms and Bacteria

Xinzhong Dong, Johns Hopkins University, USA
MrgprB2 in Mast Cells Detects Bacterial Quorum Sensing Molecules and Mediates Antibacterial Immunity

* Anna Di Nardo, University of California, San Diego, USA
Dermal Mast Cell and Skin Microbiome

Tina L. Sumpter, University of Pittsburgh, USA
Short Talk: Blockade of the ATP Binding Cassette Subfamily A Member 1 Reduces Mast Cell-initiated Inflammation in the Skin

Yue Xing, NYU Grossman School of Medicine, USA
Short Talk: Hyperactive γ𝛅T17 Cells Uniquely Drive Neonatal Hypersensitivity to Allergens

17:00—19:00
Microbial Ecology and Vector Genetics (5pm Start)

Peaks 1-3
Utpal Pal, University of Maryland College Park, USA
Mammal-arthropod Crosstalk Integrates Tick Immunity and Development

* Louis Lambrechts, Institut Pasteur, France
Mosquito-Arbovirus Interactions

Pamela Pennington, Universidad del Valle de Guatemala, Guatemala
Kissing Bugs and Chagas Disease

João Trindade Marques, Universidade Federal de Minas Gerais, Brazil
Short Talk: Mosquito Vector Competence for Dengue is Modulated by Insect Specific Viruses

Paola Carrillo-Bustamante, Max Planck Institute for Infection Biology, Germany
Short Talk: How Does Climate Affect the Evolution of Mosquito-transmitted Pathogens?

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
19:30—22:00
Poster Session 1 (7:30pm Start)

Breckenridge Ballroom

WEDNESDAY, FEBRUARY 15

07:00—08:00
Breakfast

Summit Gallery
08:00—11:00
Vector-Borne Pathogens at the Skin Interface (Joint) (8am Start)

Colorado Ballroom
* Nathalie Boulanger, Institut de Bacteriologie, France

Guy Caljon, University of Antwerp, Belgium
Tsetse Transmitted Trypanosomes: From the Skin to a Systemic Infection

* Sukanya Narasimhan, Yale School of Medicine, USA
The Sweet Side of Tick-host Interactions

Coffee Break

Jesus G. Valenzuela, NIAID, National Institutes of Health, USA
Skin Responses to Vector Derived Factors

Julien Pompon, IRD, France
Short Talk: Phospholipids in Mosquito Saliva are a New Class of Transmission Enhancing compounds for flaviviruses

Hacène Medkour, CNRS, France
Short Talk: Mosquito Bite-Initiated Skin Infection by Flaviviruses at the Single Cell Level

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
14:30—16:30
Workshop 2: MRG Receptors and Skin Immunity (2:30pm Start)

Peaks 4 & 5
* Xinzhong Dong, Johns Hopkins University, USA
Session Chair

Dustin P. Green, UTMB, USA
Connective Tissue Mast Cells and their Role in Pain

Sabrina de Souza, Michigan State University, USA
Mast Cells are Necessary for the Resolution of Pain Hypersensitivity after Surgical Skin Incision or Skin Inflammation

Naina Gour, Johns Hopkins University, USA
GPCR-neuropeptide Axis Regulates Neutrophil Polarization

Juan Manuel Leyva-Castillo, Boston Children's Hospital, Harvard Medical School, USA
Basophils Play a Protective Role in Skin Barrier Function Recovery

Caterina Curato, German Federal Institute for Risk Assessment, Germany
Induction of Type IV Hypersensitivity in a Red Tattoo Induced by Subcutaneous immunotherapy: a case report

Laura Marie Gail, Medical University of Vienna, Austria
Regulation of T Cell Tissue Residency in the Skin after Hematopoietic Stem Cell Transplantation

Eric Smith Weiss, University of Pittsburgh, USA
Cognate Antigen Encounter in Skin is Required for Full Differentiation of Epidermal Resident Memory T Cells

14:30—16:30
Workshop 2: Microbiome, Symbionts and Pathogens (2:30pm Start)

Peaks 1-3
Rebecca M. Johnson, Connecticut Agricultural Experiment Station, USA
Blood Feeding Dynamics Reflective of Mosquito Behavior in the Wild Alter Dengue Virus Dissemination in Aedes Aegypti

* Eric Caragata, University of Florida, USA
Larval Competition Stress and Wolbachia Infection Shape Fitness and West Nile Virus Infection in Culex Guinquefasciatus

Emily Gallichotte, Colorado State University, USA
WNV and SLEV Coinfection in Avian and Mosquito Hosts: Virus Replication, Virus Competition, and Virus-virus Interactions

Cassandra Koh, Institut Pasteur, France
Decoding rRNA Sequences for Improved Metagenomics of Sylvatic Mosquito Species

Rachel E. Lange, UAlbany School of Public Health, USA
Role of Ixodes Scapularis in Powassan Virus Host-specificity and Adaptation

Fatalmoudou Tandina, Université des Sciences Techniques et des Technologies de Bamako, Mali
The Impact of Feeding Method on Anopheles Mosquito Midgut Microbiota and Plasmodium falciparum Infection Rates

16:30—17:00
Coffee Available

Colorado Ballroom Foyer
17:00—19:00
Cutaneous T Cell-Dendritic Cell interactions (5pm Start)

Peaks 4 & 5
Muzlifah A. Haniffa, Wellcome Sanger Institute, UK
Human Mononuclear Phagocytes and Dendritic Cells in Human Health and Disease

Christina Elisabeth Zielinski, Leibniz Institute for Natural Product Research & Infection Biology, Germany
Human T Cells in Skin Lockdown - Lessons from Clinical Models

* Niroshana Anandasabapathy, Weill Cornell Medicine, USA
Peripheral Immune Tolerance and DC:T Cell Cross Talk

Jiang Zhang, Brigham And Women's Hospital, USA
Short Talk: Nociceptor Sensory Neurons Promote CD8 T cell Response to VACV Infection

Michela Frascoli, University of Massachusetts Chan Medical School, USA
Short Talk: Crosstalk between Skin Homing Innate T Cells and Epithelial Cells via Cholesterol Byproduct Messengers is Required for Tissue Immunity

17:00—19:00
Immunobiology and Metabolism (5pm Start)

Peaks 1-3
* Meghan Hermance, University of South Alabama, USA

Elena A. Levashina, Max Planck Institute for Infection Biology, Germany
Mosquito Immunity

Maria-Carla Saleh, Institut Pasteur, France
Antiviral Immunity in Insects

João Pedra, University of Maryland School of Medicine, USA
Tick Extracellular Vesicles and Skin Immunity

Anya J. O'Neal, University of Maryland, Baltimore, USA
Short Talk: The CD36 Homolog Croquemort Binds Infection-derived Lipids and Initiates Antibacterial Immunity in Ixodes Scapularis

Kevin Maringer, Pirbright Institute, UK
Short Talk: Flavivirus Evasion of Mosquito NF-κB-mediated Innate Immunity Defines Vector Specificity and Emergence Potential

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
19:30—22:00
Poster Session 2 (7:30pm Start)

Breckenridge Ballroom

THURSDAY, FEBRUARY 16

07:00—08:00
Breakfast

Summit Gallery
08:00—11:00
Skin-Vector Borne Diseases: Novel Approaches to Diagnosis, Vaccines and Therapeutics (Joint) (8am Start)

Colorado Ballroom
* Saravanan Thangamani, SUNY Upstate Medical University, USA

Yasmine Belkaid, Pasteur Institut, France
The Influence of Skin Microbiota at the Cutaneous Immunity

Nathalie Boulanger, Institut de Bacteriologie, France
Proteomics to Identify Pathogen Candidates for Vaccines and Diagnosis at the Skin Interface

Coffee Break

Fiona Kuo, RAPT Therapeutics, USA
Novel Therapeutic Approaches to Atopic Dermatitis

* Anne C. Moore, University College Cork, Ireland
Microarray Patches to Vaccinate at the Skin Interface

Alexandra Francian, University of New Mexico, USA
Short Talk: VLP-based Vaccines Targeting Mosquito Salivary Co-factors for Disease Transmission

Shrey A. Shah, University of Maryland, USA
Short Talk: Profiling the Immune Interaction between Microneedle Matrices and Cargo with the Skin

11:00—17:00
On Own for Lunch

15:00—16:30
Career Roundtable (Joint) (3pm Start)

Peaks 4 & 5
Jesus G. Valenzuela, NIAID, National Institutes of Health, USA

Fiona Kuo, RAPT Therapeutics, USA

Kevin R. Macaluso, University of South Alabama, USA

Christina Elisabeth Zielinski, Leibniz Institute for Natural Product Research & Infection Biology, Germany

16:30—17:00
Coffee Available

Colorado Ballroom Foyer
17:00—18:45
Neuroimmune Crosstalk in the Skin (5pm Start)

Peaks 4 & 5
Isaac Chiu, Harvard Medical School, USA
Recognition of Pathogens by Cutaneous Nociceptors

* Daniel H. Kaplan, University of Pittsburgh, USA
Immune Function of Cutaneous Sensory Neurons

Brian Kim, Mount Sinai, USA
Neuroimmune Regulation of Itch

Juan Inclan Rico, University of Pennsylvania, School of Veterinary Medicine, USA
Short Talk: MrgprA3 neurons Selectively Control Myeloid-derived IL-33 for IL-17 Dependent Cutaneous Immunity

17:00—18:45
Behavior, Physiology and Reproduction (5pm Start)

Peaks 1-3
Leah Houri-Zeevi, Rockefeller University, USA
Mosquitoes, Love, Memory: Genetic Programs Towards a Lifetime of Behavior in Aedes Aegypti Females

* Geoffrey Michael Attardo, University of California, Davis, USA
Tsetse Reproduction and Metabolism

Kevin R. Macaluso, University of South Alabama, USA
Rickettsial Influence on Vector Physiology

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (6:45pm Start)

Peaks 4 & 5
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (6:45pm Start)

Peaks 1-3
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom

FRIDAY, FEBRUARY 17

08:00—08:00
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AR078065-01

Funding for this conference was made possible (in part) by 1R13AR078065-01 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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