Keystone Symposia

Keystone Resort Floorplan

This meeting took place in 2023


Here are the related meetings in 2024:
Single-Cell Biology: Tissue Genomics, Technologies and Disease (A2)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Single Cell Biology: From Development to Cancer (E4)


Organizer(s) Mario Suva and Itay Tirosh
June 18—22, 2023
Keystone Resort • Keystone, CO USA
Abstract Deadline: Mar 29, 2023
Scholarship Deadline: Mar 29, 2023
Discounted Registration Deadline: Apr 18, 2023

Sponsored by Chinese Society for Cell Biology, (Cell Research) and Janssen R&D: Pharmaceutical Companies of Johnson & Johnson

Summary of Meeting:
Single cell genomics has become a central method for analysis of biological systems and its utility will further expand in the next few years. While the initial focus in single cell genomics was on generation of methods and atlases, we are now witnessing the integration of single cell approaches in various fields of biology, with a growing number of studies that provide deep biological insights. In this meeting we will focus on cellular heterogeneity, plasticity and spatial interactions, in the context of development and cancer, two areas in which single cell biology is having an important impact. Moreover, single cell studies are providing a renewed demonstration that cancer hijacks mechanisms of development, highlighting the need to bring together researchers from both fields. The meeting will primarily include sessions that focus on single cell analysis of particular tissues, in each case highlighting recent insights into the development and cancer of these tissues and the connections between these processes. We will also have sessions on computational analysis and recent technology developments in single-cell genomics. Speakers include a combination of experts in cancer research, development and physiology of specific organs, and the single cell community.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, June 18 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, June 22 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Friday, June 23 in order to fully experience the meeting.

SUNDAY, JUNE 18

16:00—20:00
Arrival and Registration

Longs Peak Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer

MONDAY, JUNE 19

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—09:00
Welcome and Keynote Address

Grays Peak
* Mario Suva, Harvard University, USA

* Itay Tirosh, Weizmann Institute of Science, Israel

Sohrab Shah, Memorial Sloan Kettering Cancer Center, USA

09:00—11:15
Hematopoiesis and Leukemia

Grays Peak
Andreas Trumpp, German Cancer Research Center, Germany
Leukemic Stem Cells

Coffee Break

Dan A. Landau, Weill Cornell Medicine, USA
Mapping Genotype-phenotype Relationships in Human Clonal Mosaicism

* Fernando D. Camargo, Boston Children's Hospital, USA
Single-Cell Lineage Tracing in Hematopoiesis

Ruslan Soldatov, MSKCC, USA
Short Talk: Transcriptional Signatures of Stem Cell Phenotypes in Normal and Clonal Hematopoiesis

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks
14:30—16:30
Workshop

Grays Peak
* Itay Tirosh, Weizmann Institute of Science, Israel

Tatyana Lev, University of California, Irvine, USA
Tumorigenesis and Progression of BRCA1-mutant Basal-like Breast Cancer

Antonios Somarakis, The Jackson Laboratory, Greece
Exploring the Molecular Profile and Cellular Diversity of Endometriosis using Spatial Transcriptomics

Siddharth S. Dey, University of California, Santa Barbara, USA
Photo-sensitive Barcodes Combined with Topologically Imposed Light Gradients Enable Spatially-resolved Single-cell Transcriptomics and Epigenomics

Benjamin K. Johnson, Van Andel Institute, USA
Single-cell Total RNA Miniaturized Sequencing (STORM-seq) Reveals Differentiation Trajectories of Primary Human Fallopian Tube Epithelium

Ignas Masilionis, Memorial Sloan Kettering Cancer Center, USA
Impact of Nuclei Isolation Methods on snRNAseq

Kairavee Thakkar, University of Cincinnati, USA
De Novo Patient Subtype and Phenotype Discovery from Single-cell Data Using UDON

Doris Fu, Cellarity Inc., USA
Predicting Small Molecule Modulator for Megakaryocyte Progenitor Potential: Application in Chemotherapy Induced Thrombocytopenia

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Development and Cancer of the Skin and Liver

Grays Peak
Anna Christina Obenauf, Research Institute of Molecular Pathology, Austria
Remote Presentation: Mechanisms of Metastasis and Drug Resistance in Melanoma

* Meritxell Huch, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Cellular Heterogeneity in Liver Regeneration and Cancer

Dylan Schaff, University of Pennsylvania, USA
Short Talk: Clonal Differences Underlie Differential Responses to Initial, Sequential and Prolonged Drug Treatment

Peter Renz, University of Zurich, Switzerland
Short Talk: Tissue-wide Single-cell CRISPR Uncovers Distinct TNFa Modes in Clonal Expansion and Transformation in the Skin

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
19:30—22:00
Poster Session 1

Longs/Quandary Peaks

TUESDAY, JUNE 20

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:00
Brain Development and Cancer

Grays Peak
* Mario Suva, Harvard University, USA
Heterogeneity in Glioma by scRNA-seq

Arnold R. Kriegstein, University of California, San Francisco, USA
Radial Glia in Development and Glioma

Coffee Break

Gioele La Manno, École Polytechnique Fédérale de Lausanne, Switzerland
A Single Cell Analysis of Neurodevelopment

Ian Cheong, Ontario Institute for Cancer Research, Canada
Short Talk: Uncovering Unique Human Gene Regulatory Networks in Hindbrain Development and Group 3 and 4 Medulloblastoma

Mary ONEILL, Brotman Baty Institute, USA
Short Talk: Five Years of Single-Cell Combinatorial Indexing at the BBI Advanced Technology Laboratory (BAT-Lab) at the University of Washington

Karthik Shekhar, University of California, Berkeley, USA
Short Talk: Multimodal Single-cell Insights into Experience-dependent and -Independent Specification of Neural Diversity

Alissa Greenwald, Weizmann Institute of Science, Israel
Short Talk: A Multi-layered Model of Glioma Spatial Organization

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks
15:00—16:30
Career Roundtable

Grays Peak
Andreas Trumpp, German Cancer Research Center, Germany

Andrea H. Bild, City of Hope Comprehensive Cancer Institute, USA

Fred P. Davis, Celsius Therapeutics, USA

Sidharth V. Puram, Washington University School of Medicine, USA

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Technology Development

Grays Peak
Jean Fan, Johns Hopkins University, USA
Integrative Spatial Transcriptomics Analyses

* Itai Yanai, New York University School of Medicine, USA
Spatial Analyses in Cancer

* Samantha A. Morris, Washington University School of Medicine in St Louis, USA
New Genomic Technologies to Deconstruct and Control Cell Identity

Jackson Weir, Harvard University, USA
Short Talk: Slide-tags: Scalable Single-nucleus Barcoding for Multi-modal Spatial Genomics

Nathan Spix, Van Andel Institute, USA
Short Talk: Deep Characterization of Single-Cell Epigenomes in Health and Disease with scDEEP-MeC

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
19:30—22:00
Poster Session 2

Longs/Quandary Peaks

WEDNESDAY, JUNE 21

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:00
Integrative Analyses and Comp. Methods

Grays Peak
* Itay Tirosh, Weizmann Institute of Science, Israel
Pan-Cancer Analysis of Cellular Heterogeneity

Aaron Newman, Stanford University, USA
Developmental States and Spatial Phenotypes in Cancer

Coffee Break

Tali Raveh-Sadka, Immunai, Israel
Single-cell Data at Scale, from Exploration to Decision Making

Antony David Rose, Newcastle University, UK
Short Talk: Single Cell Atlas of Whole Human Embryos with Pseudo-spatial Visualisation

Kyoung Won, Cedars-Sinai Medical Center, USA
Short Talk: CellNeighborEX: Deciphering Neighbor-Dependent Gene Expression from Spatial Transcriptomics Data

Joshua D. Campbell, Boston University, USA
Short Talk: Novel Approaches for Detecting Gene Programs Associated with Lineage Plasticity and Tumor Aggressiveness in Lung Cancer Cells from 12 Datasets

Guanming Wu, OHSU, USA
Short Talk: A Computational Workflow to Construct Regulatory Networks of Transcription factors and Pathways Using scRNA-seq Data for Mathematical Modeling

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks
14:30—16:30
Panel Discussion: Beyond the Bench – Career and Interpersonal Skills

Grays Peak
* Dana Silverbush, Broad institute of MIT and Harvard, USA

* Chris Mount, MGH, USA

Melissa Hirose Wong, Oregon Health & Science University, USA
Resilience

Karthik Shekhar, University of California, Berkeley, USA
Mentorship

Jean Fan, Johns Hopkins University, USA
Time Management

Aaron Newman, Stanford University, USA
Launching and Running a Data-Science Focused Research Group

Mark A. Krasnow, Stanford University School of Medicine, USA
How to Choose (or Invent) Model Systems for Your Science

Paivi Pihlajamaa, University of Helsinki, Finland
Pivoting from Dead-End to a Successful Project

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Gynecological Development and Cancer

Grays Peak
Andrea H. Bild, City of Hope Comprehensive Cancer Institute, USA
Evolution of Endocrine and Cell Cycle Therapy Resistance Driven by Tumor Cell Communication in Breast Cancer

* Devon A. Lawson, University of California, Irvine, USA
Microenvironment Influence on Metastatic Spread in Breast Cancer

* Nicholas Navin, University of Texas MD Anderson Cancer Center, USA
Clonal Diversity and Evolution in Breast Cancer

Melissa Saichi, Institut Curie, France
Short Talk: Pre-neoplastic States in BRCA1 Carriers

Yihan Wang, UT Southwestern, USA
Short Talk: Enhancer Regulatory Networks Globally Connect Non-coding Breast Cancer Loci to Cancer Genes

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
19:30—22:00
Poster Session 3

Longs/Quandary Peaks

THURSDAY, JUNE 22

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:00
Gastrointestinal Development and Cancer

Grays Peak
Moshe Biton, Weizmann Institute of Science, Israel
Epithelial-Immune Interaction in the Gut

* Karuna Ganesh, Memorial Sloan Kettering Cancer Center, USA
Targeting Regenerative Plasticity in Metastasis

Coffee Break

* Sidharth V. Puram, Washington University School of Medicine, USA
Heterogeneity in Head and Neck Cancer

Fred P. Davis, Celsius Therapeutics, USA
Single-Cell Analysis for Drug Development

Ashley N. Anderson, Oregon Health and Science University, USA
Short Talk: Multi-omic and Imaging Single Cell Analyses Identify Neoplastic-immune Hybrid Cell Properties for Metastatic Progression in Colorectal Cancer

Paivi Pihlajamaa, University of Helsinki, Finland
Short Talk: Dissecting Transcription Factor Binding Events Essential for Proliferation of Colon Cancer Cells Using a CRISPR/Cas9-based Genome Editing Methods

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—18:45
Lung Development and Cancer

Grays Peak
* Ashley M. Laughney, Weill Cornell Medicine, USA
Tackling the Genotype-to-phenotype Problem in Lung Cancer Evolution

Mark A. Krasnow, Stanford University School of Medicine, USA
Single Cell Analysis of Alveolar Development and Stem Cells

Dian Yang, Whitehead Institute, USA
Short Talk: Lineage Tracing Reveals the Phylodynamics, Plasticity and Paths of Tumor Evolution

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Grays Peak
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks

FRIDAY, JUNE 23

08:00—08:00
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

Chinese Society for Cell Biology, (Cell Research) Janssen R&D: Pharmaceutical Companies of Johnson & Johnson

We gratefully acknowledge additional support from these exhibitors at this conference:

BioLegend, Inc.
Please stop by to meet these exhibitors during the conference.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: John Monson, Director of Corporate Relations, Email: johnm@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Josh May, Director, Technology and Digital Media, Email: joshuam@keystonesymposia.org,
Phone:+1 970-262-1179