Keystone Resort Floorplan
This meeting took place in 2023
Here are the related meetings in 2024:
Single-Cell Biology: Tissue Genomics, Technologies and Disease (A2)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Single Cell Biology: From Development to Cancer (E4)
Organizer(s) Mario Suva and Itay Tirosh
June 18—22, 2023
Keystone Resort • Keystone, CO USA
Abstract Deadline: Mar 29, 2023
Scholarship Deadline: Mar 29, 2023
Discounted Registration Deadline: Apr 18, 2023
Sponsored by Chinese Society for Cell Biology, (Cell Research) and Janssen R&D: Pharmaceutical Companies of Johnson & Johnson
Summary of Meeting:
Single cell genomics has become a central method for analysis of biological systems and its utility will further expand in the next few years. While the initial focus in single cell genomics was on generation of methods and atlases, we are now witnessing the integration of single cell approaches in various fields of biology, with a growing number of studies that provide deep biological insights. In this meeting we will focus on cellular heterogeneity, plasticity and spatial interactions, in the context of development and cancer, two areas in which single cell biology is having an important impact. Moreover, single cell studies are providing a renewed demonstration that cancer hijacks mechanisms of development, highlighting the need to bring together researchers from both fields. The meeting will primarily include sessions that focus on single cell analysis of particular tissues, in each case highlighting recent insights into the development and cancer of these tissues and the connections between these processes. We will also have sessions on computational analysis and recent technology developments in single-cell genomics. Speakers include a combination of experts in cancer research, development and physiology of specific organs, and the single cell community.
View Scholarships/Awards
Single cell genomics has become a central method for analysis of biological systems and its utility will further expand in the next few years. While the initial focus in single cell genomics was on generation of methods and atlases, we are now witnessing the integration of single cell approaches in various fields of biology, with a growing number of studies that provide deep biological insights. In this meeting we will focus on cellular heterogeneity, plasticity and spatial interactions, in the context of development and cancer, two areas in which single cell biology is having an important impact. Moreover, single cell studies are providing a renewed demonstration that cancer hijacks mechanisms of development, highlighting the need to bring together researchers from both fields. The meeting will primarily include sessions that focus on single cell analysis of particular tissues, in each case highlighting recent insights into the development and cancer of these tissues and the connections between these processes. We will also have sessions on computational analysis and recent technology developments in single-cell genomics. Speakers include a combination of experts in cancer research, development and physiology of specific organs, and the single cell community.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, June 18 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, June 22 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Friday, June 23 in order to fully experience the meeting.
SUNDAY, JUNE 18
MONDAY, JUNE 19
TUESDAY, JUNE 20
WEDNESDAY, JUNE 21
THURSDAY, JUNE 22
FRIDAY, JUNE 23
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, June 18 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, June 22 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Friday, June 23 in order to fully experience the meeting.
SUNDAY, JUNE 18
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
*
Mario Suva,
Harvard University, USA
*
Itay Tirosh,
Weizmann Institute of Science, Israel
Sohrab Shah,
Memorial Sloan Kettering Cancer Center, USA
09:00—11:15
Hematopoiesis and Leukemia
Andreas Trumpp,
German Cancer Research Center, Germany
Leukemic Stem Cells
Leukemic Stem Cells
Coffee Break
Dan A. Landau,
Weill Cornell Medicine, USA
Mapping Genotype-phenotype Relationships in Human Clonal Mosaicism
Mapping Genotype-phenotype Relationships in Human Clonal Mosaicism
*
Fernando D. Camargo,
Boston Children's Hospital, USA
Single-Cell Lineage Tracing in Hematopoiesis
Single-Cell Lineage Tracing in Hematopoiesis
Ruslan Soldatov,
MSKCC, USA
Short Talk: Transcriptional Signatures of Stem Cell Phenotypes in Normal and Clonal Hematopoiesis
Short Talk: Transcriptional Signatures of Stem Cell Phenotypes in Normal and Clonal Hematopoiesis
14:30—16:30
Workshop
*
Itay Tirosh,
Weizmann Institute of Science, Israel
Tatyana Lev,
University of California, Irvine, USA
Tumorigenesis and Progression of BRCA1-mutant Basal-like Breast Cancer
Tumorigenesis and Progression of BRCA1-mutant Basal-like Breast Cancer
Antonios Somarakis,
The Jackson Laboratory, Greece
Exploring the Molecular Profile and Cellular Diversity of Endometriosis using Spatial Transcriptomics
Exploring the Molecular Profile and Cellular Diversity of Endometriosis using Spatial Transcriptomics
Siddharth S. Dey,
University of California, Santa Barbara, USA
Photo-sensitive Barcodes Combined with Topologically Imposed Light Gradients Enable Spatially-resolved Single-cell Transcriptomics and Epigenomics
Photo-sensitive Barcodes Combined with Topologically Imposed Light Gradients Enable Spatially-resolved Single-cell Transcriptomics and Epigenomics
Benjamin K. Johnson,
Van Andel Institute, USA
Single-cell Total RNA Miniaturized Sequencing (STORM-seq) Reveals Differentiation Trajectories of Primary Human Fallopian Tube Epithelium
Single-cell Total RNA Miniaturized Sequencing (STORM-seq) Reveals Differentiation Trajectories of Primary Human Fallopian Tube Epithelium
Ignas Masilionis,
Memorial Sloan Kettering Cancer Center, USA
Impact of Nuclei Isolation Methods on snRNAseq
Impact of Nuclei Isolation Methods on snRNAseq
Kairavee Thakkar,
University of Cincinnati, USA
De Novo Patient Subtype and Phenotype Discovery from Single-cell Data Using UDON
De Novo Patient Subtype and Phenotype Discovery from Single-cell Data Using UDON
Doris Fu,
Cellarity Inc., USA
Predicting Small Molecule Modulator for Megakaryocyte Progenitor Potential: Application in Chemotherapy Induced Thrombocytopenia
Predicting Small Molecule Modulator for Megakaryocyte Progenitor Potential: Application in Chemotherapy Induced Thrombocytopenia
17:00—19:00
Development and Cancer of the Skin and Liver
Anna Christina Obenauf,
Research Institute of Molecular Pathology, Austria
Remote Presentation: Mechanisms of Metastasis and Drug Resistance in Melanoma
Remote Presentation: Mechanisms of Metastasis and Drug Resistance in Melanoma
*
Meritxell Huch,
Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Cellular Heterogeneity in Liver Regeneration and Cancer
Cellular Heterogeneity in Liver Regeneration and Cancer
Dylan Schaff,
University of Pennsylvania, USA
Short Talk: Clonal Differences Underlie Differential Responses to Initial, Sequential and Prolonged Drug Treatment
Short Talk: Clonal Differences Underlie Differential Responses to Initial, Sequential and Prolonged Drug Treatment
Peter Renz,
University of Zurich, Switzerland
Short Talk: Tissue-wide Single-cell CRISPR Uncovers Distinct TNFa Modes in Clonal Expansion and Transformation in the Skin
Short Talk: Tissue-wide Single-cell CRISPR Uncovers Distinct TNFa Modes in Clonal Expansion and Transformation in the Skin
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Brain Development and Cancer
*
Mario Suva,
Harvard University, USA
Heterogeneity in Glioma by scRNA-seq
Heterogeneity in Glioma by scRNA-seq
Arnold R. Kriegstein,
University of California, San Francisco, USA
Radial Glia in Development and Glioma
Radial Glia in Development and Glioma
Coffee Break
Gioele La Manno,
École Polytechnique Fédérale de Lausanne, Switzerland
A Single Cell Analysis of Neurodevelopment
A Single Cell Analysis of Neurodevelopment
Ian Cheong,
Ontario Institute for Cancer Research, Canada
Short Talk: Uncovering Unique Human Gene Regulatory Networks in Hindbrain Development and Group 3 and 4 Medulloblastoma
Short Talk: Uncovering Unique Human Gene Regulatory Networks in Hindbrain Development and Group 3 and 4 Medulloblastoma
Mary ONEILL,
Brotman Baty Institute, USA
Short Talk: Five Years of Single-Cell Combinatorial Indexing at the BBI Advanced Technology Laboratory (BAT-Lab) at the University of Washington
Short Talk: Five Years of Single-Cell Combinatorial Indexing at the BBI Advanced Technology Laboratory (BAT-Lab) at the University of Washington
Karthik Shekhar,
University of California, Berkeley, USA
Short Talk: Multimodal Single-cell Insights into Experience-dependent and -Independent Specification of Neural Diversity
Short Talk: Multimodal Single-cell Insights into Experience-dependent and -Independent Specification of Neural Diversity
Alissa Greenwald,
Weizmann Institute of Science, Israel
Short Talk: A Multi-layered Model of Glioma Spatial Organization
Short Talk: A Multi-layered Model of Glioma Spatial Organization
15:00—16:30
Career Roundtable
Andreas Trumpp,
German Cancer Research Center, Germany
Andrea H. Bild,
City of Hope Comprehensive Cancer Institute, USA
Fred P. Davis,
Celsius Therapeutics, USA
Sidharth V. Puram,
Washington University School of Medicine, USA
17:00—19:00
Technology Development
Jean Fan,
Johns Hopkins University, USA
Integrative Spatial Transcriptomics Analyses
Integrative Spatial Transcriptomics Analyses
*
Itai Yanai,
New York University School of Medicine, USA
Spatial Analyses in Cancer
Spatial Analyses in Cancer
*
Samantha A. Morris,
Washington University School of Medicine in St Louis, USA
New Genomic Technologies to Deconstruct and Control Cell Identity
New Genomic Technologies to Deconstruct and Control Cell Identity
Jackson Weir,
Harvard University, USA
Short Talk: Slide-tags: Scalable Single-nucleus Barcoding for Multi-modal Spatial Genomics
Short Talk: Slide-tags: Scalable Single-nucleus Barcoding for Multi-modal Spatial Genomics
Nathan Spix,
Van Andel Institute, USA
Short Talk: Deep Characterization of Single-Cell Epigenomes in Health and Disease with scDEEP-MeC
Short Talk: Deep Characterization of Single-Cell Epigenomes in Health and Disease with scDEEP-MeC
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Integrative Analyses and Comp. Methods
*
Itay Tirosh,
Weizmann Institute of Science, Israel
Pan-Cancer Analysis of Cellular Heterogeneity
Pan-Cancer Analysis of Cellular Heterogeneity
Aaron Newman,
Stanford University, USA
Developmental States and Spatial Phenotypes in Cancer
Developmental States and Spatial Phenotypes in Cancer
Coffee Break
Tali Raveh-Sadka,
Immunai, Israel
Single-cell Data at Scale, from Exploration to Decision Making
Single-cell Data at Scale, from Exploration to Decision Making
Antony David Rose,
Newcastle University, UK
Short Talk: Single Cell Atlas of Whole Human Embryos with Pseudo-spatial Visualisation
Short Talk: Single Cell Atlas of Whole Human Embryos with Pseudo-spatial Visualisation
Kyoung Won,
Cedars-Sinai Medical Center, USA
Short Talk: CellNeighborEX: Deciphering Neighbor-Dependent Gene Expression from Spatial Transcriptomics Data
Short Talk: CellNeighborEX: Deciphering Neighbor-Dependent Gene Expression from Spatial Transcriptomics Data
Joshua D. Campbell,
Boston University, USA
Short Talk: Novel Approaches for Detecting Gene Programs Associated with Lineage Plasticity and Tumor Aggressiveness in Lung Cancer Cells from 12 Datasets
Short Talk: Novel Approaches for Detecting Gene Programs Associated with Lineage Plasticity and Tumor Aggressiveness in Lung Cancer Cells from 12 Datasets
Guanming Wu,
OHSU, USA
Short Talk: A Computational Workflow to Construct Regulatory Networks of Transcription factors and Pathways Using scRNA-seq Data for Mathematical Modeling
Short Talk: A Computational Workflow to Construct Regulatory Networks of Transcription factors and Pathways Using scRNA-seq Data for Mathematical Modeling
14:30—16:30
Panel Discussion: Beyond the Bench – Career and Interpersonal Skills
*
Dana Silverbush,
Broad institute of MIT and Harvard, USA
*
Chris Mount,
MGH, USA
Melissa Hirose Wong,
Oregon Health & Science University, USA
Resilience
Resilience
Karthik Shekhar,
University of California, Berkeley, USA
Mentorship
Mentorship
Jean Fan,
Johns Hopkins University, USA
Time Management
Time Management
Aaron Newman,
Stanford University, USA
Launching and Running a Data-Science Focused Research Group
Launching and Running a Data-Science Focused Research Group
Mark A. Krasnow,
Stanford University School of Medicine, USA
How to Choose (or Invent) Model Systems for Your Science
How to Choose (or Invent) Model Systems for Your Science
Paivi Pihlajamaa,
University of Helsinki, Finland
Pivoting from Dead-End to a Successful Project
Pivoting from Dead-End to a Successful Project
17:00—19:00
Gynecological Development and Cancer
Andrea H. Bild,
City of Hope Comprehensive Cancer Institute, USA
Evolution of Endocrine and Cell Cycle Therapy Resistance Driven by Tumor Cell Communication in Breast Cancer
Evolution of Endocrine and Cell Cycle Therapy Resistance Driven by Tumor Cell Communication in Breast Cancer
*
Devon A. Lawson,
University of California, Irvine, USA
Microenvironment Influence on Metastatic Spread in Breast Cancer
Microenvironment Influence on Metastatic Spread in Breast Cancer
*
Nicholas Navin,
University of Texas MD Anderson Cancer Center, USA
Clonal Diversity and Evolution in Breast Cancer
Clonal Diversity and Evolution in Breast Cancer
Melissa Saichi,
Institut Curie, France
Short Talk: Pre-neoplastic States in BRCA1 Carriers
Short Talk: Pre-neoplastic States in BRCA1 Carriers
Yihan Wang,
UT Southwestern, USA
Short Talk: Enhancer Regulatory Networks Globally Connect Non-coding Breast Cancer Loci to Cancer Genes
Short Talk: Enhancer Regulatory Networks Globally Connect Non-coding Breast Cancer Loci to Cancer Genes
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Gastrointestinal Development and Cancer
Moshe Biton,
Weizmann Institute of Science, Israel
Epithelial-Immune Interaction in the Gut
Epithelial-Immune Interaction in the Gut
*
Karuna Ganesh,
Memorial Sloan Kettering Cancer Center, USA
Targeting Regenerative Plasticity in Metastasis
Targeting Regenerative Plasticity in Metastasis
Coffee Break
*
Sidharth V. Puram,
Washington University School of Medicine, USA
Heterogeneity in Head and Neck Cancer
Heterogeneity in Head and Neck Cancer
Fred P. Davis,
Celsius Therapeutics, USA
Single-Cell Analysis for Drug Development
Single-Cell Analysis for Drug Development
Ashley N. Anderson,
Oregon Health and Science University, USA
Short Talk: Multi-omic and Imaging Single Cell Analyses Identify Neoplastic-immune Hybrid Cell Properties for Metastatic Progression in Colorectal Cancer
Short Talk: Multi-omic and Imaging Single Cell Analyses Identify Neoplastic-immune Hybrid Cell Properties for Metastatic Progression in Colorectal Cancer
Paivi Pihlajamaa,
University of Helsinki, Finland
Short Talk: Dissecting Transcription Factor Binding Events Essential for Proliferation of Colon Cancer Cells Using a CRISPR/Cas9-based Genome Editing Methods
Short Talk: Dissecting Transcription Factor Binding Events Essential for Proliferation of Colon Cancer Cells Using a CRISPR/Cas9-based Genome Editing Methods
17:00—18:45
Lung Development and Cancer
*
Ashley M. Laughney,
Weill Cornell Medicine, USA
Tackling the Genotype-to-phenotype Problem in Lung Cancer Evolution
Tackling the Genotype-to-phenotype Problem in Lung Cancer Evolution
Mark A. Krasnow,
Stanford University School of Medicine, USA
Single Cell Analysis of Alveolar Development and Stem Cells
Single Cell Analysis of Alveolar Development and Stem Cells
Dian Yang,
Whitehead Institute, USA
Short Talk: Lineage Tracing Reveals the Phylodynamics, Plasticity and Paths of Tumor Evolution
Short Talk: Lineage Tracing Reveals the Phylodynamics, Plasticity and Paths of Tumor Evolution
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
*Session Chair †Invited, not yet responded.
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