Taos Convention Center (meeting only) Floorplan
Registered Attendees
Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:
- Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting
(You can edit your own abstract from My Account page as well)
NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.
- Full participant list, including joint meeting participants
- Printable Invoices and Invitation Letters
- Scholarship Information
- Lodging Information
Login to My Account page
This meeting took place in 2001
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Cell Cycle 2001 (J1)
Organizer(s) William G. Kaelin, Jr. and Helen Piwnica-Worms
January 9—14, 2001
Taos Convention Center (meeting only) • Taos, NM USA
Abstract Deadline: Sep 8, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 9, 2000
Sponsored by Novartis Pharmaceuticals Corporation
Summary of Meeting:
Understanding cell-cycle control is central to understanding diseases characterized by abnormal cellular proliferation such as cancer. Recent developments in this area relate to molecular pathways that govern whether cells proceed through the cell cycle, as well as to the mechanics of DNA replication and mitosis. Timely changes in protein phosphorylation at the hands of specific kinases/phosphatases, as well as changes in protein stability mediated by specific ubiquitin ligases, play central roles in these processes. Finally, ‘checkpoints’ exist to monitor the fidelity and completion of these events. Activation of checkpoints leads to cell-cycle arrest or death and perturbations in checkpoint pathways is characteristic of cancers. Current problems include understanding how the molecular pathways alluded to above network with one another, determining how cell-cycle exit is coupled to cell fate decisions, and understanding of the biochemistry of both DNA replication and mitosis in higher eukaryotes. The goal of this meeting is to facilitate communication among a diverse group of investigators who apply genetic, biological and biochemical approaches to understand cell cycle regulation in a variety of model organisms. A secondary goal will be to ask whether there are specific therapeutic opportunities related to the cell cycle based on our current state of knowledge.
View Scholarships/Awards
Understanding cell-cycle control is central to understanding diseases characterized by abnormal cellular proliferation such as cancer. Recent developments in this area relate to molecular pathways that govern whether cells proceed through the cell cycle, as well as to the mechanics of DNA replication and mitosis. Timely changes in protein phosphorylation at the hands of specific kinases/phosphatases, as well as changes in protein stability mediated by specific ubiquitin ligases, play central roles in these processes. Finally, ‘checkpoints’ exist to monitor the fidelity and completion of these events. Activation of checkpoints leads to cell-cycle arrest or death and perturbations in checkpoint pathways is characteristic of cancers. Current problems include understanding how the molecular pathways alluded to above network with one another, determining how cell-cycle exit is coupled to cell fate decisions, and understanding of the biochemistry of both DNA replication and mitosis in higher eukaryotes. The goal of this meeting is to facilitate communication among a diverse group of investigators who apply genetic, biological and biochemical approaches to understand cell cycle regulation in a variety of model organisms. A secondary goal will be to ask whether there are specific therapeutic opportunities related to the cell cycle based on our current state of knowledge.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, JANUARY 9
WEDNESDAY, JANUARY 10
THURSDAY, JANUARY 11
FRIDAY, JANUARY 12
SATURDAY, JANUARY 13
SUNDAY, JANUARY 14
Conference Program Print | View meeting in 12 hr (am/pm) time
TUESDAY, JANUARY 9
19:30—21:30
Keynote Address (Joint)
Gerard I. Evan,
University of Cambridge, UK
Apoptosis and Cancer
Apoptosis and Cancer
08:00—11:00
DNA Replication
Stephen P. Bell,
Massachusetts Institute of Technology, USA
ORC-Dependent Nucleosome Positioning Stimulates the Initiation of DNA Replication
ORC-Dependent Nucleosome Positioning Stimulates the Initiation of DNA Replication
Michael Botchan,
University of California, Berkeley, USA
Targeting the Drosophila ORC to DNA
Targeting the Drosophila ORC to DNA
Ronald A. Laskey,
Hutchison/MRC Research Centre, UK
Control of DNA Replication in Normal and Neoplastic Cells
Control of DNA Replication in Normal and Neoplastic Cells
08:00—11:00
Apoptosis/Death Receptors
*
Gerard I. Evan,
University of Cambridge, UK
Avi Ashkenazi,
Genentech, Inc., USA
Death Receptors: Signaling and Modulation
Death Receptors: Signaling and Modulation
J. Marie Hardwick,
Johns Hopkins University Schools of Public Health and Medicine, USA
Regulating the Pro- and Anti-Apoptotic Functions of Bcl-2 Family Proteins
Regulating the Pro- and Anti-Apoptotic Functions of Bcl-2 Family Proteins
Hermann Steller,
Rockefeller University, USA
Control of Apoptosis in Drosophila
Control of Apoptosis in Drosophila
David Ching Huang,
Walter and Eliza Hall Institute of Medical Research, Australia
BH3-Only Proteins, Essential Initiators of Apoptotic Cell Death
BH3-Only Proteins, Essential Initiators of Apoptotic Cell Death
18:30—20:30
Cell-Cycle Transitions I
*
Douglas Dean,
Washington University School of Medicine, USA
Mechanism of Action of the Rb Tumor Suppressor
Mechanism of Action of the Rb Tumor Suppressor
Terry L. Orr-Weaver,
Massachusetts Institute of Technology, USA
Developmental Regulation of DNA Replication
Developmental Regulation of DNA Replication
J. Wade Harper,
Harvard Medical School, USA
Control of S-phase Events by Cyclin E/Cdk2
Control of S-phase Events by Cyclin E/Cdk2
18:30—20:30
Survival Signals/Growth Signals
*
Christopher Marshall,
Institute of Cancer Research, UK
Signaling Through Ras and Rho
Signaling Through Ras and Rho
Michael Karin,
University of California, San Diego, USA
Pro- and Anti-Apoptotic Activity of the JNK and IKK Signaling Pathways
Pro- and Anti-Apoptotic Activity of the JNK and IKK Signaling Pathways
Gerard I. Evan,
University of Cambridge, UK
Apoptosis and Cancer
Apoptosis and Cancer
08:00—11:00
Checkpoints and Cancer (Joint)
Joseph R. Nevins,
Duke University Medical Center, USA
Synergy in Pathways that Regulate G1 Cell Cycle Progression
Synergy in Pathways that Regulate G1 Cell Cycle Progression
*
Helen Piwnica-Worms,
Washington University School of Medicine, USA
Checkpoint Control in Normal and Cancer Cell Cycles
Checkpoint Control in Normal and Cancer Cell Cycles
Jerry W. Shay,
University of Texas Southwestern Medical Center, USA
The Role of Telomeres in Cell Cycle Checkpoint Responses
The Role of Telomeres in Cell Cycle Checkpoint Responses
18:30—21:00
Tumor Suppression (Joint)
*
Carol L. Prives,
Columbia University, USA
Regulation of p53 and its Relatives
Regulation of p53 and its Relatives
Leonard I. Zon,
HHMI/Boston Children's Hospital, USA
Screens in Zebrafish for Genes Related to the Cell Cycle and Cancer
Screens in Zebrafish for Genes Related to the Cell Cycle and Cancer
Edward Harlow,
Constellation Pharmaceuticals, USA
Nuclear Organization of DNA Replication in Primary Mammalian Cells
Nuclear Organization of DNA Replication in Primary Mammalian Cells
08:00—11:00
Cell-Cycle Transitions II
William G. Kaelin, Jr.,
Dana-Farber Cancer Institute, USA
Control of Cell Death and Differentiation by the Retinoblastoma Protein
Control of Cell Death and Differentiation by the Retinoblastoma Protein
*
Steven I. Reed,
The Scripps Research Institute, USA
Cell Cycle Control, Proteolysis, and Genetic Instability
Cell Cycle Control, Proteolysis, and Genetic Instability
Angelika Amon,
Massachusetts Institute of Technology, USA
Regulation of Exit from Mitosis in Yeast
Regulation of Exit from Mitosis in Yeast
Jan-Michael Peters,
Research Institute of Molecular Pathology, Austria
Regulation of Anaphase by the APC-Separase Pathway
Regulation of Anaphase by the APC-Separase Pathway
08:00—11:00
Signaling
Ann Marie Pendergast,
Duke University Medical Center, USA
Novel Roles of ABL Tyrosine Kinases and Associated Adaptors
Novel Roles of ABL Tyrosine Kinases and Associated Adaptors
Anita B. Roberts,
National Institutes of Health, USA
Role of the Smad Pathway in Pathogenetic Mechanisms Dependent on TGF-beta
Role of the Smad Pathway in Pathogenetic Mechanisms Dependent on TGF-beta
Stanley J. Korsmeyer,
Harvard University, USA
Integrating the Cell Death Pathway
Integrating the Cell Death Pathway
*
Moshe Oren,
Weizmann Institute of Science, Israel
Signaling to the p53 Pathway
Signaling to the p53 Pathway
18:30—20:30
Cell-Cycle Transitions III
Mark Winey,
University of California Davs, USA
MPS1 Family Kinases Regulate Centrosome Duplication
MPS1 Family Kinases Regulate Centrosome Duplication
*
David Pellman,
Dana-Farber Cancer Institute, USA
Spindle Attachments and Chromosomal Stability
Spindle Attachments and Chromosomal Stability
Stephen A. Osmani,
Geisinger Clinic, USA
Location of Protein Kinases and Mitosis
Location of Protein Kinases and Mitosis
18:30—20:30
Regulation of Gene Expression by Oncogenes/Tumor Suppressors
Robert N. Eisenman,
Fred Hutchinson Cancer Research Center, USA
The Mad Protein Family: Biological Functions and the Structural Basis for Transcription Repression
The Mad Protein Family: Biological Functions and the Structural Basis for Transcription Repression
Joan W. Conaway,
Stowers Institute for Medical Research, USA
Elongin BC and the VHL Tumor Suppressor Complex
Elongin BC and the VHL Tumor Suppressor Complex
Tony Kouzarides,
University of Cambridge, UK
Histone Methylation and Transcriptional Silencing
Histone Methylation and Transcriptional Silencing
08:00—11:00
Therapeutic Opportunities (Joint)
*
Allen Ira Oliff,
DuPont Pharmaceuticals Company, USA
Molecular Targets Versus Empirical Cytotoxics
Molecular Targets Versus Empirical Cytotoxics
Julian Adams,
Vedantra Pharmaceuticals, Inc., USA
Therapeutic Opportunities Related to Ubiquitination Pathways
Therapeutic Opportunities Related to Ubiquitination Pathways
Leisa K. Johnson,
Genentech, Inc., USA
Adenoviruses Targeting Deregulation of the RB Tumor Suppressor Pathway in Cancer Cells Demonstrate Potent Anti-Tumor Activity
Adenoviruses Targeting Deregulation of the RB Tumor Suppressor Pathway in Cancer Cells Demonstrate Potent Anti-Tumor Activity
Nicholas B. Lydon,
, USA
Structure-Based Approaches to the Discovery and Optimization of Selective Protein Kinase Inhibitors
Structure-Based Approaches to the Discovery and Optimization of Selective Protein Kinase Inhibitors
15:00—17:00
Proteolysis
*
Raymond J. Deshaies,
Amgen, Inc., USA
Standing at the Intersection of Cell Cycle Control and Ubiquitin-Dependent Proteolysis
Standing at the Intersection of Cell Cycle Control and Ubiquitin-Dependent Proteolysis
Michael Tyers,
, Canada
Multi-Site Phosphorylation of a CDK Inhibitor Sets a Threshold for S-Phase Onset
Multi-Site Phosphorylation of a CDK Inhibitor Sets a Threshold for S-Phase Onset
Wilhelm Krek,
Institute of Molecular Health Sciences, ETH Zürich, Switzerland
Roles of the F-Box Protein Skp2 in Cell Cycle Control
Roles of the F-Box Protein Skp2 in Cell Cycle Control
15:00—17:00
Tumor Progression
*
Terry A. Van Dyke,
National Cancer Institute, National Institutes of Health, USA
Modeling Cancer Mechanisms in the Mouse
Modeling Cancer Mechanisms in the Mouse
Allan Balmain,
University of California, San Francisco, USA
Genetic Control of Tumor Susceptibility in the Mouse
Genetic Control of Tumor Susceptibility in the Mouse
George F. Vande Woude,
Van Andel Research Institute, USA
Met-HGF/SF: Tumorigenesis, Invasion and Metastasis
Met-HGF/SF: Tumorigenesis, Invasion and Metastasis
*Session Chair †Invited, not yet responded.
We gratefully acknowledge the generous grant for this conference provided by:
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
Click here to view more of these organizations
|
If your organization is interested in joining these entities in support of Keystone
Symposia, please contact: Sarah Lavicka,
Director of Corporate Relations, Email: sarahl@keystonesymposia.org, Phone:+1 970-262-2690 Click here for more information on Industry Support and Recognition Opportunities. If you are interested in becoming an advertising/marketing in-kind partner, please contact: Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org, Phone:+1 970-262-1179 |
