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This meeting took place in 2005
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Cancer and Development (J6)
Organizer(s) Matthew Scott and Roeland Nusse
February 5—10, 2005
Fairmont Banff Springs • Banff, AB Canada
Abstract Deadline: Oct 5, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 6, 2004
Supported by The Director's Fund
Summary of Meeting:
Genes critical for development have been implicated in cancer processes in rapidly increasing numbers. This meeting will bring together leading researchers in both cancer and development to facilitate mutual learning. Scientific areas to be included will be cancer progression steps, telomeres and telomerase, signal transduction pathways, chromatin machines, mouse models of human cancer, transcriptional regulators, extracellular matrix, cell cycle and DNA repair, stem cells, and cell cycle.
View Scholarships/Awards
Genes critical for development have been implicated in cancer processes in rapidly increasing numbers. This meeting will bring together leading researchers in both cancer and development to facilitate mutual learning. Scientific areas to be included will be cancer progression steps, telomeres and telomerase, signal transduction pathways, chromatin machines, mouse models of human cancer, transcriptional regulators, extracellular matrix, cell cycle and DNA repair, stem cells, and cell cycle.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SATURDAY, FEBRUARY 5
SUNDAY, FEBRUARY 6
MONDAY, FEBRUARY 7
TUESDAY, FEBRUARY 8
WEDNESDAY, FEBRUARY 9
THURSDAY, FEBRUARY 10
Conference Program Print | View meeting in 12 hr (am/pm) time
SATURDAY, FEBRUARY 5
19:30—21:30
Keynote Session: Development, Cancer, and the Microenvironment (Joint)
Zena Werb,
University of California, San Francisco, USA
Historical Perspective and What Development Tells Us about Cancer
Historical Perspective and What Development Tells Us about Cancer
19:30—21:30
Keynote Session: Development, Cancer, and the Microenvironment (Joint)
Zena Werb,
University of California, San Francisco, USA
Historical Perspective and What Development Tells Us about Cancer
Historical Perspective and What Development Tells Us about Cancer
08:00—11:00
Signal Transduction Pathways in Development and Cancer
*
Mariann Bienz,
MRC Laboratory of Molecular Biology, UK
Wnt Signaling and Dishevelled Function
Wnt Signaling and Dishevelled Function
Matthew P. Scott,
Stanford University, USA
Development and Cancer of the Cerebellum
Development and Cancer of the Cerebellum
Matthias Hebrok,
University of California, San Francisco, USA
Embryonic Signaling Pathways in Pancreatic Cancer
Embryonic Signaling Pathways in Pancreatic Cancer
JoMichelle D. Corrales,
Impact Communications, USA
Short Talk: Gli2 Mediates the Mitogenic Function of Sonic Hedgehog in the Developing Mouse Cerebellum
Short Talk: Gli2 Mediates the Mitogenic Function of Sonic Hedgehog in the Developing Mouse Cerebellum
08:00—11:00
Angiogenesis and the Microenvironment
*
Luisa Iruela-Arispe,
University of California, Los Angeles, USA
Microenvironmental Regulation of Vascular Patterning
Microenvironmental Regulation of Vascular Patterning
Nancy J. Boudreau,
NCI, National Institutes of Health, USA
Co-Ordinate Loss of Hox D10 in Breast Tumor Progression and Angiogenesis; Bi-Directional Communication between Breast Tumor Epithelium and Angiogenic Stroma
Co-Ordinate Loss of Hox D10 in Breast Tumor Progression and Angiogenesis; Bi-Directional Communication between Breast Tumor Epithelium and Angiogenic Stroma
Randall S. Johnson,
University of Cambridge, UK
The Role of Endothelial Cell Hypoxic Response in Tumor Formation
The Role of Endothelial Cell Hypoxic Response in Tumor Formation
Mary J.C. Hendrix,
Children's Memorial Research Center at Northwestern University, USA
The Epigenetic Effect of the Metastatic Microenvironment on Tumor Cell Plasticity
The Epigenetic Effect of the Metastatic Microenvironment on Tumor Cell Plasticity
Gavin O. Thurston,
Regeneron Pharmaceuticals Inc., USA
Short Talk
Short Talk
17:00—19:00
Cell Cycle
*
Iswar K. Hariharan,
University of California, Berkeley, USA
Pathways that Regulate Growth and Cell Proliferation in Drosophila and Humans
Pathways that Regulate Growth and Cell Proliferation in Drosophila and Humans
Tian Xu,
Yale University School of Medicine, USA
Deciphering Genetic Basis of Tumor Growth and Metastasis in Drosophila
Deciphering Genetic Basis of Tumor Growth and Metastasis in Drosophila
Michael A. Dyer,
HHMI/St. Jude Children's Research Hospital, USA
The Role of the Rb Family in Retinal Development and Retinoblastoma
The Role of the Rb Family in Retinal Development and Retinoblastoma
Erica L. Jackson,
University of California, San Francisco, USA
Short Talk: PDGF Signaling in Neural Stem Cells and Glioma Formation
Short Talk: PDGF Signaling in Neural Stem Cells and Glioma Formation
17:00—19:00
Microenvironmental Influence on Metastasis
Jeffrey W. Pollard,
Queen's Medical Research Institute, UK
Macrophages Promote Mammary Tumor Progression and Metastasis.
Macrophages Promote Mammary Tumor Progression and Metastasis.
Kenneth J. Pienta,
Cue Biopharma, Inc., USA
Metastatic Cancer is a Heterogeneous Group of Diseases
Metastatic Cancer is a Heterogeneous Group of Diseases
Pepper Jo Schedin,
Oregon Health & Science University, USA
Short Talk: Remodeling of the Mammary Tumor Microenvironment Following Pregnancy Promotes Tumor Cell Metastasis; a Plausible Mechanism for Poor Prognosis of Pregnancy-Associated Breast Cancer
Short Talk: Remodeling of the Mammary Tumor Microenvironment Following Pregnancy Promotes Tumor Cell Metastasis; a Plausible Mechanism for Poor Prognosis of Pregnancy-Associated Breast Cancer
08:00—11:00
Cancer Gene Functions
Dean Walton Felsher,
Stanford University, USA
Conditional Transgenic Mouse Models of Oncogenesis in a Developmental Context
Conditional Transgenic Mouse Models of Oncogenesis in a Developmental Context
*
Owen N. Witte,
HHMI/University of California, Los Angeles, USA
Prostate Stem Cells and Prostate Cancer Development
Prostate Stem Cells and Prostate Cancer Development
Thomas Curran,
Children's Hospital of Philadelphia, USA
Mouse Models and Molecular Targeted Therapies: Sonic Hedgehog Pathway Antagonist in Medulloblastoma
Mouse Models and Molecular Targeted Therapies: Sonic Hedgehog Pathway Antagonist in Medulloblastoma
Robert B. Clarke,
University of Manchester, UK
Short Talk: Isolation and Characterization of Human Mammary Stem Cells
Short Talk: Isolation and Characterization of Human Mammary Stem Cells
08:00—11:00
Stromal-Epithelial and Heterotypic Interactions
*
Harold L. Moses,
Vanderbilt University, USA
Stromal and Epithelial TGF-ß Signaling in Carcinoma Initiation and Progression
Stromal and Epithelial TGF-ß Signaling in Carcinoma Initiation and Progression
Mary Helen Barcellos-Hoff,
New York School of Medicine, USA
Modulation of Mammary Stromal-Epithelial Interactions During Radiation Carcinogenesis
Modulation of Mammary Stromal-Epithelial Interactions During Radiation Carcinogenesis
Terry A. Van Dyke,
National Cancer Institute, National Institutes of Health, USA
Selective Inactivation of P53 in Prostate Stroma in Response to Epithelial Tumorigenesis; Coevolution of Both Compartments During Tumor Progression
Selective Inactivation of P53 in Prostate Stroma in Response to Epithelial Tumorigenesis; Coevolution of Both Compartments During Tumor Progression
Leland W.K. Chung,
Emory University School of Medicine, USA
Stromal-Epithelial Interaction in Prostate Cancer Bone Metastasis
Stromal-Epithelial Interaction in Prostate Cancer Bone Metastasis
Olivier De Wever,
University of Ghent, Belgium
Short Talk: Implication of Stromal Myofibroblasts in Cancer Invasion
Short Talk: Implication of Stromal Myofibroblasts in Cancer Invasion
17:00—19:00
Cancer Origins
*
Elizabeth H. Blackburn,
University of California, San Francisco, USA
Distinct growth responses of human cancer cells to perturbing telomeres and telomerase
Distinct growth responses of human cancer cells to perturbing telomeres and telomerase
Robert J. Coffey, Jr.,
Vanderbilt University Medical Center, USA
Identification of Developmentally Regulated Genes in Human Colorectal Cancer (CRC)
Identification of Developmentally Regulated Genes in Human Colorectal Cancer (CRC)
Ling-Jie Kong,
Merck Research Laboratories, USA
Short Talk: The Role of the Rb Family Protein p130 in Telomere Length Control
Short Talk: The Role of the Rb Family Protein p130 in Telomere Length Control
Sumana Datta,
Texas A & M University, USA
Short Talk: Brain Development and Prostate Cancer: From Flies to Humans
Short Talk: Brain Development and Prostate Cancer: From Flies to Humans
Ellen E. McCarthy,
Columbia University, USA
Short Talk: Bard1 and Mammary Tumorigenesis
Short Talk: Bard1 and Mammary Tumorigenesis
17:00—19:00
Recent Advances in Signaling in 3D Microenvironments
Valerie M. Weaver,
University of California, San Francisco, USA
Tissue Polarity and the Mechanism of Epithelial Resistance to Chemotherapy
Tissue Polarity and the Mechanism of Epithelial Resistance to Chemotherapy
Edna Cukierman,
Fox Chase Cancer Center, USA
Primed Stroma 3D-Adhesions; Inciters of Tumor Permissiveness
Primed Stroma 3D-Adhesions; Inciters of Tumor Permissiveness
John L. Muschler,
California Pacific Medical Center, USA
Short Talk: Loss of dystroglycan function alters responses to laminin-1 in carcinoma cells
Short Talk: Loss of dystroglycan function alters responses to laminin-1 in carcinoma cells
08:00—11:00
Cancer Models (Joint)
*
Ronald A. DePinho,
University of Texas MD Anderson Cancer Center, USA
Genetics and Biology of Pancreas Cancer
Genetics and Biology of Pancreas Cancer
Rudolf Jaenisch,
Whitehead Institute for Biomedical Research, USA
Epigenetic Changes in Cancer and the Reversibility of the Malignant Phenotype
Epigenetic Changes in Cancer and the Reversibility of the Malignant Phenotype
James F. Amatruda,
University of Texas Southwestern Medical Center, USA
Short Talk: A Genetic Model of Testicular Cancer in the Zebrafish
Short Talk: A Genetic Model of Testicular Cancer in the Zebrafish
14:30—16:30
Workshop: Cancer, Aging and the Microenvironment
*
Judith Campisi,
Buck Institute for Research on Aging, USA
Cancer and Aging: Role of the Senescent Microenvironment
Cancer and Aging: Role of the Senescent Microenvironment
Irmgard Irminger-Finger,
University of Geneva, Switzerland
Short Talk: Function of BARD1 in Tumor Suppression and Aging
Short Talk: Function of BARD1 in Tumor Suppression and Aging
S. Ruby Chan,
Washington University, USA
Short Talk: Characterization of Mammary Adenocarcinomas that Spontaneously Develop in Aged STAT1-Deficient Female Mice
Short Talk: Characterization of Mammary Adenocarcinomas that Spontaneously Develop in Aged STAT1-Deficient Female Mice
Babett Bartling,
Martin Luther University, Germany
Short Talk: RAGE Diminishes the Proliferative Effect of Fibroblasts on Human Lung Cancer Cells
Short Talk: RAGE Diminishes the Proliferative Effect of Fibroblasts on Human Lung Cancer Cells
Thea D. Tlsty,
University of California, San Francisco, USA
Epigenetic and Genetic Changes Control Tumorigenic Phenotypes and Occur in vivo in Human Mammary Epithelia
Epigenetic and Genetic Changes Control Tumorigenic Phenotypes and Occur in vivo in Human Mammary Epithelia
17:00—19:15
Signaling Pathways and Cancer
Philip A. Beachy,
HHMI/Stanford University, USA
Hedgehog Signal Transduction
Hedgehog Signal Transduction
Pier Paolo Pandolfi,
Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Oncogenesis and Developmental Control
Oncogenesis and Developmental Control
Lee L. Rubin,
Harvard University, USA
The Hedgehog Signaling Pathway and Cancer: Therapeutic Use of Small Molecule Antagonists
The Hedgehog Signaling Pathway and Cancer: Therapeutic Use of Small Molecule Antagonists
Robert J. Wechsler-Reya,
Sanford-Burnham Medical Research Institute, USA
Short Talk: Molecular and Cellular Origins of Medulloblastoma
Short Talk: Molecular and Cellular Origins of Medulloblastoma
17:00—19:00
The Extracellular Matrix and its Degrading Enzymes in Tumor Progression and Metastasis
*
Lynn M. Matrisian,
Vanderbilt University School of Medicine, USA
MMPs in Cancer
MMPs in Cancer
Raghu Kalluri,
University of Texas MD Anderson Cancer Center, USA
Extracellular Matrix Degradome Contributes to a Novel Class of Tumor Suppressors
Extracellular Matrix Degradome Contributes to a Novel Class of Tumor Suppressors
Seth L. Schor,
University of Dundee, UK
Migration Stimulating Factor (MSF): A Potent Bi-Directional Mediator of Tumor-Stromal Interactions
Migration Stimulating Factor (MSF): A Potent Bi-Directional Mediator of Tumor-Stromal Interactions
James P. Quigley,
The Scripps Research Institute, USA
Short Talk: Janus Nature of Tumor Microenvironment: MMPs from the Stromal Face and the Tumor Face
Short Talk: Janus Nature of Tumor Microenvironment: MMPs from the Stromal Face and the Tumor Face
08:00—11:00
Growth Control
Max S. Wicha,
University of Michigan, USA
Stem Cells in Human Human Breast Development and Cancer
Stem Cells in Human Human Breast Development and Cancer
Gary B. Ruvkun,
Massachusetts General Hospital, Harvard Medical School, USA
Growth Control in C. elegans
Growth Control in C. elegans
*
Anton J. M. Berns,
Netherlands Cancer Institute, Netherlands
Mouse Models for Cancer
Mouse Models for Cancer
A. Thomas Look,
Dana-Farber Cancer Institute, USA
Genetics of T-Cell Acute Lymphoblastic Leukemia: The Role of Notch
Genetics of T-Cell Acute Lymphoblastic Leukemia: The Role of Notch
Johannes L. Bos,
University Medical Center Utrecht, Netherlands
Short Talk: Genetic Mapping of Notch1 Activity in vivo
Short Talk: Genetic Mapping of Notch1 Activity in vivo
08:00—11:00
Role of Inflammatory Cells and Cytokines in the Tissue and Tumor Microenvironment
Douglas Hanahan,
ISREC, Switzerland
Immune Enhancement and Therapy of Cancer
Immune Enhancement and Therapy of Cancer
Lisa M. Coussens,
Oregon Health & Science University, USA
Innate and Adaptive Immune Interactions Regulate Cancer Development
Innate and Adaptive Immune Interactions Regulate Cancer Development
Kornelia Polyak,
Dana-Farber Cancer Institute, Harvard Medical School, USA
Molecular Profile of the Tumor Microenvironment in Breast Cancer
Molecular Profile of the Tumor Microenvironment in Breast Cancer
Julia L. Wilson,
, UK
Short Talk: Expression of the Chemokine Receptor CXCR4 Alters the Behavior of Ovarian Cancer Cells in vitro and in vivo
Short Talk: Expression of the Chemokine Receptor CXCR4 Alters the Behavior of Ovarian Cancer Cells in vitro and in vivo
17:00—19:00
Checkpoints and Signal Transduction
Anindya Dutta,
University of Virginia, USA
Checkpoint Pathways Monitor Levels of Replication Initiators in Cancer Cells
Checkpoint Pathways Monitor Levels of Replication Initiators in Cancer Cells
*
Garry P. Nolan,
Stanford University, USA
Single Cell Proteomics of Cancer: Remodeling of Networks on a Patient by Patient Basis
Single Cell Proteomics of Cancer: Remodeling of Networks on a Patient by Patient Basis
Esther M. Verheyen,
Simon Fraser University, Canada
Short Talk: Control of Wnt and BMP Signaling by the Nemo-like Kinase during Drosophila Development
Short Talk: Control of Wnt and BMP Signaling by the Nemo-like Kinase during Drosophila Development
Johannes L. Bos,
University Medical Center Utrecht, Netherlands
Short Talk: The Small GTPase Rap1, the cAMP Target Epac and Integrin- and Cadherin-Mediated Cell Adhesion
Short Talk: The Small GTPase Rap1, the cAMP Target Epac and Integrin- and Cadherin-Mediated Cell Adhesion
17:00—19:00
Concluding Session
M. Judah Folkman,
Children's Hospital Boston, USA
How Early Can Cancer be Treated?
How Early Can Cancer be Treated?
Mina J. Bissell,
Lawrence Berkeley National Laboratory, USA
Summary of the Meeting: Looking to the Future
Summary of the Meeting: Looking to the Future
*Session Chair †Invited, not yet responded.
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