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This meeting took place in 2005



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Cancer and Development (J6)


Organizer(s) Matthew Scott and Roeland Nusse
February 5—10, 2005
Fairmont Banff Springs • Banff, AB Canada
Abstract Deadline: Oct 5, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 6, 2004

Supported by The Director's Fund


Summary of Meeting:
Genes critical for development have been implicated in cancer processes in rapidly increasing numbers. This meeting will bring together leading researchers in both cancer and development to facilitate mutual learning. Scientific areas to be included will be cancer progression steps, telomeres and telomerase, signal transduction pathways, chromatin machines, mouse models of human cancer, transcriptional regulators, extracellular matrix, cell cycle and DNA repair, stem cells, and cell cycle.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, FEBRUARY 5

15:00—19:30
Registration

Van Horne Foyer
18:30—19:30
Refreshments

Van Horne Foyer
19:30—21:30
Keynote Session: Development, Cancer, and the Microenvironment (Joint)

Van Horne Ballroom A/B
Zena Werb, University of California, San Francisco, USA
Historical Perspective and What Development Tells Us about Cancer

Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
Metastasis as a Developmental Problem

19:30—21:30
Keynote Session: Development, Cancer, and the Microenvironment (Joint)

Van Horne Ballroom A/B
Zena Werb, University of California, San Francisco, USA
Historical Perspective and What Development Tells Us about Cancer

Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
Metastasis as a Developmental Problem


SUNDAY, FEBRUARY 6

07:00—08:00
Breakfast

Alberta/New Brunswick/Cascade
08:00—11:00
Signal Transduction Pathways in Development and Cancer

Van Horne Ballroom B
* Mariann Bienz, MRC Laboratory of Molecular Biology, UK
Wnt Signaling and Dishevelled Function

Roeland Nusse, HHMI/Stanford University, USA
Wnt Signaling and Growth Control

Matthew P. Scott, Stanford University, USA
Development and Cancer of the Cerebellum

Matthias Hebrok, University of California, San Francisco, USA
Embryonic Signaling Pathways in Pancreatic Cancer

JoMichelle D. Corrales, Impact Communications, USA
Short Talk: Gli2 Mediates the Mitogenic Function of Sonic Hedgehog in the Developing Mouse Cerebellum

08:00—11:00
Angiogenesis and the Microenvironment

Van Horne Ballroom A
* Luisa Iruela-Arispe, University of California, Los Angeles, USA
Microenvironmental Regulation of Vascular Patterning

Nancy J. Boudreau, NCI, National Institutes of Health, USA
Co-Ordinate Loss of Hox D10 in Breast Tumor Progression and Angiogenesis; Bi-Directional Communication between Breast Tumor Epithelium and Angiogenic Stroma

Randall S. Johnson, University of Cambridge, UK
The Role of Endothelial Cell Hypoxic Response in Tumor Formation

Mary J.C. Hendrix, Children's Memorial Research Center at Northwestern University, USA
The Epigenetic Effect of the Metastatic Microenvironment on Tumor Cell Plasticity

Gavin O. Thurston, Regeneron Pharmaceuticals Inc., USA
Short Talk

09:20—09:40
Coffee Break

Van Horne Foyer
11:00—13:00
Poster Setup

Alberta/New Brunswick/Riverview
13:00—22:00
Poster Viewing

Alberta/New Brunswick/Riverview
16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:00
Cell Cycle

Van Horne Ballroom B
* Iswar K. Hariharan, University of California, Berkeley, USA
Pathways that Regulate Growth and Cell Proliferation in Drosophila and Humans

Tian Xu, Yale University School of Medicine, USA
Deciphering Genetic Basis of Tumor Growth and Metastasis in Drosophila

Michael A. Dyer, HHMI/St. Jude Children's Research Hospital, USA
The Role of the Rb Family in Retinal Development and Retinoblastoma

Erica L. Jackson, University of California, San Francisco, USA
Short Talk: PDGF Signaling in Neural Stem Cells and Glioma Formation

17:00—19:00
Microenvironmental Influence on Metastasis

Van Horne Ballroom A
Jeffrey W. Pollard, Queen's Medical Research Institute, UK
Macrophages Promote Mammary Tumor Progression and Metastasis.

Kenneth J. Pienta, Cue Biopharma, Inc., USA
Metastatic Cancer is a Heterogeneous Group of Diseases

* Richard O. Hynes, Massachusetts Institute of Technology, USA
ECM Receptors and Metastasis

Pepper Jo Schedin, Oregon Health & Science University, USA
Short Talk: Remodeling of the Mammary Tumor Microenvironment Following Pregnancy Promotes Tumor Cell Metastasis; a Plausible Mechanism for Poor Prognosis of Pregnancy-Associated Breast Cancer

19:00—20:00
Social Hour

Alberta/New Brunswick/Riverview
19:30—22:00
Poster Session 1

Alberta/New Brunswick/Riverview

MONDAY, FEBRUARY 7

07:00—08:00
Breakfast

Alberta/New Brunswick/Cascade
08:00—11:00
Cancer Gene Functions

Van Horne Ballroom B
Dean Walton Felsher, Stanford University, USA
Conditional Transgenic Mouse Models of Oncogenesis in a Developmental Context

Charles J. Sherr, St. Jude Children's Research Hospital, USA
The Ink4a/Arf Tumor Suppressor Network

* Owen N. Witte, HHMI/University of California, Los Angeles, USA
Prostate Stem Cells and Prostate Cancer Development

Thomas Curran, Children's Hospital of Philadelphia, USA
Mouse Models and Molecular Targeted Therapies: Sonic Hedgehog Pathway Antagonist in Medulloblastoma

Robert B. Clarke, University of Manchester, UK
Short Talk: Isolation and Characterization of Human Mammary Stem Cells

08:00—11:00
Stromal-Epithelial and Heterotypic Interactions

Van Horne Ballroom A
* Harold L. Moses, Vanderbilt University, USA
Stromal and Epithelial TGF-ß Signaling in Carcinoma Initiation and Progression

Mary Helen Barcellos-Hoff, New York School of Medicine, USA
Modulation of Mammary Stromal-Epithelial Interactions During Radiation Carcinogenesis

Terry A. Van Dyke, National Cancer Institute, National Institutes of Health, USA
Selective Inactivation of P53 in Prostate Stroma in Response to Epithelial Tumorigenesis; Coevolution of Both Compartments During Tumor Progression

Leland W.K. Chung, Emory University School of Medicine, USA
Stromal-Epithelial Interaction in Prostate Cancer Bone Metastasis

Olivier De Wever, University of Ghent, Belgium
Short Talk: Implication of Stromal Myofibroblasts in Cancer Invasion

09:20—09:40
Coffee Break

Van Horne Foyer
11:00—13:00
Poster Setup

Alberta/New Brunswick/Riverview
13:00—22:00
Poster Viewing

Alberta/New Brunswick/Riverview
16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:00
Cancer Origins

Van Horne Ballroom B
* Elizabeth H. Blackburn, University of California, San Francisco, USA
Distinct growth responses of human cancer cells to perturbing telomeres and telomerase

Robert J. Coffey, Jr., Vanderbilt University Medical Center, USA
Identification of Developmentally Regulated Genes in Human Colorectal Cancer (CRC)

Ling-Jie Kong, Merck Research Laboratories, USA
Short Talk: The Role of the Rb Family Protein p130 in Telomere Length Control

Sumana Datta, Texas A & M University, USA
Short Talk: Brain Development and Prostate Cancer: From Flies to Humans

Ellen E. McCarthy, Columbia University, USA
Short Talk: Bard1 and Mammary Tumorigenesis

17:00—19:00
Recent Advances in Signaling in 3D Microenvironments

Van Horne Ballroom A
* Joan S. Brugge, Harvard Medical School, USA
Signaling Pathways in Morphogenesis and Apoptosis

Valerie M. Weaver, University of California, San Francisco, USA
Tissue Polarity and the Mechanism of Epithelial Resistance to Chemotherapy

Edna Cukierman, Fox Chase Cancer Center, USA
Primed Stroma 3D-Adhesions; Inciters of Tumor Permissiveness

John L. Muschler, California Pacific Medical Center, USA
Short Talk: Loss of dystroglycan function alters responses to laminin-1 in carcinoma cells

19:00—20:00
Social Hour

Alberta/New Brunswick/Riverview
19:30—22:00
Poster Session 2

Alberta/New Brunswick/Riverview

TUESDAY, FEBRUARY 8

07:00—08:00
Breakfast

Alberta/New Brunswick/Cascade
08:00—11:00
Cancer Models (Joint)

Van Horne Ballroom A/B
* Ronald A. DePinho, University of Texas MD Anderson Cancer Center, USA
Genetics and Biology of Pancreas Cancer

Elaine V. Fuchs, Rockefeller University, USA
Stem Cells and their Lineages in Skin

Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA
Epigenetic Changes in Cancer and the Reversibility of the Malignant Phenotype

Derek Radisky, Mayo Clinic, USA
Short Talk: MMP-3-Induced Malignancy in Mammary Epithelial Cells

James F. Amatruda, University of Texas Southwestern Medical Center, USA
Short Talk: A Genetic Model of Testicular Cancer in the Zebrafish

09:20—09:40
Coffee Break

Van Horne Foyer
11:00—13:00
Poster Setup

Alberta/New Brunswick/Riverview
13:00—22:00
Poster Viewing

Alberta/New Brunswick/Riverview
14:30—16:30
Workshop: Cancer, Aging and the Microenvironment

Van Horne Ballroom A
* Judith Campisi, Buck Institute for Research on Aging, USA
Cancer and Aging: Role of the Senescent Microenvironment

Irmgard Irminger-Finger, University of Geneva, Switzerland
Short Talk: Function of BARD1 in Tumor Suppression and Aging

S. Ruby Chan, Washington University, USA
Short Talk: Characterization of Mammary Adenocarcinomas that Spontaneously Develop in Aged STAT1-Deficient Female Mice

Babett Bartling, Martin Luther University, Germany
Short Talk: RAGE Diminishes the Proliferative Effect of Fibroblasts on Human Lung Cancer Cells

Thea D. Tlsty, University of California, San Francisco, USA
Epigenetic and Genetic Changes Control Tumorigenic Phenotypes and Occur in vivo in Human Mammary Epithelia

16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:15
Signaling Pathways and Cancer

Van Horne Ballroom B
Philip A. Beachy, HHMI/Stanford University, USA
Hedgehog Signal Transduction

* Hans C. Clevers, Hubrecht Institute, Netherlands
Beta-Catenin-TCF in Development and Cancer

Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Oncogenesis and Developmental Control

Lee L. Rubin, Harvard University, USA
The Hedgehog Signaling Pathway and Cancer: Therapeutic Use of Small Molecule Antagonists

Robert J. Wechsler-Reya, Sanford-Burnham Medical Research Institute, USA
Short Talk: Molecular and Cellular Origins of Medulloblastoma

17:00—19:00
The Extracellular Matrix and its Degrading Enzymes in Tumor Progression and Metastasis

Van Horne Ballroom A
* Lynn M. Matrisian, Vanderbilt University School of Medicine, USA
MMPs in Cancer

Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA
Extracellular Matrix Degradome Contributes to a Novel Class of Tumor Suppressors

Seth L. Schor, University of Dundee, UK
Migration Stimulating Factor (MSF): A Potent Bi-Directional Mediator of Tumor-Stromal Interactions

James P. Quigley, The Scripps Research Institute, USA
Short Talk: Janus Nature of Tumor Microenvironment: MMPs from the Stromal Face and the Tumor Face

19:15—20:15
Social Hour

Alberta/New Brunswick/Riverview
19:30—22:00
Poster Session 3

Alberta/New Brunswick/Riverview

WEDNESDAY, FEBRUARY 9

07:00—08:00
Breakfast

Alberta/New Brunswick/Cascade
08:00—11:00
Growth Control

Van Horne Ballroom B
Max S. Wicha, University of Michigan, USA
Stem Cells in Human Human Breast Development and Cancer

Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA
Growth Control in C. elegans

* Anton J. M. Berns, Netherlands Cancer Institute, Netherlands
Mouse Models for Cancer

A. Thomas Look, Dana-Farber Cancer Institute, USA
Genetics of T-Cell Acute Lymphoblastic Leukemia: The Role of Notch

Johannes L. Bos, University Medical Center Utrecht, Netherlands
Short Talk: Genetic Mapping of Notch1 Activity in vivo

08:00—11:00
Role of Inflammatory Cells and Cytokines in the Tissue and Tumor Microenvironment

Van Horne Ballroom A
* Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA
Mast Cells and Tumor Induction Models

Douglas Hanahan, ISREC, Switzerland
Immune Enhancement and Therapy of Cancer

Lisa M. Coussens, Oregon Health & Science University, USA
Innate and Adaptive Immune Interactions Regulate Cancer Development

Kornelia Polyak, Dana-Farber Cancer Institute, Harvard Medical School, USA
Molecular Profile of the Tumor Microenvironment in Breast Cancer

Julia L. Wilson, , UK
Short Talk: Expression of the Chemokine Receptor CXCR4 Alters the Behavior of Ovarian Cancer Cells in vitro and in vivo

09:20—09:40
Coffee Break

Van Horne Foyer
16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:00
Checkpoints and Signal Transduction

Van Horne Ballroom B
Anindya Dutta, University of Virginia, USA
Checkpoint Pathways Monitor Levels of Replication Initiators in Cancer Cells

* Garry P. Nolan, Stanford University, USA
Single Cell Proteomics of Cancer: Remodeling of Networks on a Patient by Patient Basis

Esther M. Verheyen, Simon Fraser University, Canada
Short Talk: Control of Wnt and BMP Signaling by the Nemo-like Kinase during Drosophila Development

Johannes L. Bos, University Medical Center Utrecht, Netherlands
Short Talk: The Small GTPase Rap1, the cAMP Target Epac and Integrin- and Cadherin-Mediated Cell Adhesion

17:00—19:00
Concluding Session

Van Horne Ballroom A
M. Judah Folkman, Children's Hospital Boston, USA
How Early Can Cancer be Treated?

Mina J. Bissell, Lawrence Berkeley National Laboratory, USA
Summary of the Meeting: Looking to the Future

19:00—20:00
Social Hour

Cascade/Conservatory/Riverview
20:00—23:00
Entertainment

Cascade/Conservatory/Riverview

THURSDAY, FEBRUARY 10

 
Departure


*Session Chair †Invited, not yet responded.


We gratefully acknowledge support for this conference from:


Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13-CA112977-01



We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Curis, Inc.

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