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This meeting took place in 2006
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
HIV Pathogenesis (X5)
Organizer(s) Tristram G. Parslow, Julie M. Overbaugh and John M. Coffin
March 27—April 2, 2006
Keystone Resort • Keystone, CO USA
Abstract Deadline: Nov 29, 2005
Late Abstract Deadline: Dec 20, 2005
Scholarship Deadline: Nov 29, 2005
Early Registration Deadline: Jan 27, 2006
Part of the Global Health Series, Supported by the Bill & Melinda Gates Foundation
Joint Meeting:
HIV Vaccines (X6)
Summary of Meeting:
Our agenda for the Pathogenesis meeting is organized in 10 plenary sessions, each showcasing the latest insights gained from studying a particular aspect or model of HIV and HIV-related illness. Individual sessions will, for example, highlight recent studies of the HIV virion, its growth in infected cells and tissues, its resistance to antiviral drugs, and its transmission in human populations. Others will feature illuminating work on related viruses and viral diseases, including simian AIDS. Two sessions on HIV immune responses will be convened jointly with the Vaccines symposium, as will the keynote address. We also envision at least two afternoon workshops featuring speakers chosen from submitted abstracts, as these offer an opportunity to involve new and lesser-known investigators.
View Scholarships/Awards
Our agenda for the Pathogenesis meeting is organized in 10 plenary sessions, each showcasing the latest insights gained from studying a particular aspect or model of HIV and HIV-related illness. Individual sessions will, for example, highlight recent studies of the HIV virion, its growth in infected cells and tissues, its resistance to antiviral drugs, and its transmission in human populations. Others will feature illuminating work on related viruses and viral diseases, including simian AIDS. Two sessions on HIV immune responses will be convened jointly with the Vaccines symposium, as will the keynote address. We also envision at least two afternoon workshops featuring speakers chosen from submitted abstracts, as these offer an opportunity to involve new and lesser-known investigators.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
MONDAY, MARCH 27
TUESDAY, MARCH 28
WEDNESDAY, MARCH 29
THURSDAY, MARCH 30
FRIDAY, MARCH 31
SATURDAY, APRIL 1
SUNDAY, APRIL 2
Conference Program Print | View meeting in 12 hr (am/pm) time
MONDAY, MARCH 27
19:30—21:30
Keynote Session (Joint)
*
Tristram G. Parslow,
Emory University, USA
Introduction of HIV Pathogenesis Meeting
Introduction of HIV Pathogenesis Meeting
Joseph G. Sodroski,
Dana-Farber Cancer Institute, USA
Antiretroviral Activity of TRIM5 and Related TRIM Proteins
Antiretroviral Activity of TRIM5 and Related TRIM Proteins
*
Ruth M. Ruprecht,
Texas Biomedical Research Institute, USA
Introduction of HIV Vaccines Meeting
Introduction of HIV Vaccines Meeting
08:00—11:15
Lessons from the Virus
*
Tristram G. Parslow,
Emory University, USA
Michael F. Summers,
HHMI/University of Maryland, Baltimore County, USA
Structural Basis for Specific Membrane Targeting by the HIV-1 Gag Protein
Structural Basis for Specific Membrane Targeting by the HIV-1 Gag Protein
Hans-Georg Kräusslich,
Universitat Heidelberg, Germany
HIV Assembly and its Inhibition
HIV Assembly and its Inhibition
Peter E. Prevelige,
University of Alabama, Birmingham, USA
HIV Core Assembly and Its Inhibitors
HIV Core Assembly and Its Inhibitors
Wei-Shau Hu,
National Cancer Institute, National Institutes of Health, USA
Recombination and Complementation: Two Modes of Interactions among HIVs
Recombination and Complementation: Two Modes of Interactions among HIVs
Jacob Anglister,
Weizmann Institute of Science, Israel
Short Talk: Cross-Strand Electrostatic Interactions at the Base of the â-Hairpin of the HIV-1 V3 Region Create a Molecular Switch for Phenotype Conversion
Short Talk: Cross-Strand Electrostatic Interactions at the Base of the â-Hairpin of the HIV-1 V3 Region Create a Molecular Switch for Phenotype Conversion
Nathalie Arhel,
Institut Pasteur, France
Short Talk: Video Imaging of HIV-1 Intracellular Transport and Role of the Central DNA Flap in Active Nuclear Import
Short Talk: Video Imaging of HIV-1 Intracellular Transport and Role of the Central DNA Flap in Active Nuclear Import
08:00—11:00
Antigen Presentation and Dendritic Cells
*
Jacques F. Banchereau,
The Jackson Laboratory for Genomic Medicine, USA
Joana Loureieo,
Whitehead Institute for Biomedical Research, USA
Antigen Presentation via MHC Class II
Antigen Presentation via MHC Class II
Robert A. Seder,
NIAID, National Institutes of Health, USA
Toll-like Receptor Ligands Influence the Magnitude and Quality of HIV Specific Immune Responses in Non-human Primates
Toll-like Receptor Ligands Influence the Magnitude and Quality of HIV Specific Immune Responses in Non-human Primates
Mary A. Marovich,
NIAID, National Institutes of Health, USA
DC Vaccinations with HIV Antigens in Humans
DC Vaccinations with HIV Antigens in Humans
Donald I. Van Ryk,
NIAID, National Institutes of Health, USA
Short Talk: DC-SIGN Capture of HIV gp120 Relies on Avidity Effects, and is Altered by CD4 Ligation
Short Talk: DC-SIGN Capture of HIV gp120 Relies on Avidity Effects, and is Altered by CD4 Ligation
Paolo Monini,
Istituto Superiore di Sanità, Italy
Short Talk: Native Tat Enters Preferentially Dendritic Cells Inducing Tumor Necrosis Factor-alpha-Mediated Th1-Polarized Maturation and Immune Responses in Monkeys
Short Talk: Native Tat Enters Preferentially Dendritic Cells Inducing Tumor Necrosis Factor-alpha-Mediated Th1-Polarized Maturation and Immune Responses in Monkeys
Christine Trumpfheller,
Roche Glycart, Switzerland
Short Talk: Intensified and Protective CD4+ T Cell Immunity with Anti-Dendritic Cell HIV GAG Fusion Antibody Vaccine
Short Talk: Intensified and Protective CD4+ T Cell Immunity with Anti-Dendritic Cell HIV GAG Fusion Antibody Vaccine
14:30—16:30
Workshop 1: Boundary between Innate and Adaptive Immunity
*
Gene M. Shearer,
National Cancer Institute, National Institutes of Health, USA
Susanna C. Trapp,
University of Cologne, Germany
Co-Pathogens and HIV TLR3 Stimulation Dampens HIV Replication
Co-Pathogens and HIV TLR3 Stimulation Dampens HIV Replication
Sophie Chabot,
, USA
Mucosal Application of TLR2 Ligands Modulates the Gatekeeping Functions of the Follicle-Associated Epithelium to Promote Vaccine Uptake at Mucosal Surfaces
Mucosal Application of TLR2 Ligands Modulates the Gatekeeping Functions of the Follicle-Associated Epithelium to Promote Vaccine Uptake at Mucosal Surfaces
Daniel G. Kavanagh,
, USA
Transfection of Antigen-Loaded Dendritic Cells With mRNA Encoding IL-12 p70 Leads to Increased Expansion of HIV-Specific T Cells and Activation of Natural Killer Cells in vitro
Transfection of Antigen-Loaded Dendritic Cells With mRNA Encoding IL-12 p70 Leads to Increased Expansion of HIV-Specific T Cells and Activation of Natural Killer Cells in vitro
Thomas Lehner,
Guy's, King's & St. Thomas' Hospital Medical and Dental School, UK
Stimulation of Intracellular and Extracellular Innate Immune Responses to SIV and HIV-1
Stimulation of Intracellular and Extracellular Innate Immune Responses to SIV and HIV-1
*
Jay A. Berzofsky,
NCI, National Institutes of Health, USA
Circumventing CD4 Deficiency to Induce Long-Lived Memory CTL
Circumventing CD4 Deficiency to Induce Long-Lived Memory CTL
Marjorie Robert-Guroff,
NCI, National Institutes of Health, USA
Cellular Immunity following Systemic SIV DNA Priming/Mucosal Replication-Competent Ad-SIV Boosting of Rhesus Macaques is Enhanced by Cytokine DNAs and Includes Potent Mucosal CD8+T Cell Memory Responses
Cellular Immunity following Systemic SIV DNA Priming/Mucosal Replication-Competent Ad-SIV Boosting of Rhesus Macaques is Enhanced by Cytokine DNAs and Includes Potent Mucosal CD8+T Cell Memory Responses
17:00—19:00
Lessons from the Target Cell (I) -- Factors that Inhibit
*
Warner Craig Greene,
Gladstone Institute of Virology and Immunology, USA
New Perspectives on APOBEC3G Anti-retroviral Action and Regulation
New Perspectives on APOBEC3G Anti-retroviral Action and Regulation
Kevin C. Klein,
University of Washington, USA
Short Talk: Apobec3G Adopts Different Conformations in the Presence and Absence of RNA that may Correlate with Enzymatic Activity
Short Talk: Apobec3G Adopts Different Conformations in the Presence and Absence of RNA that may Correlate with Enzymatic Activity
Philippe Gallay,
The Scripps Research Institute, USA
Short Talk: Selective Destruction of the HIV-1 Capsid Shell by TRIM5alpha
Short Talk: Selective Destruction of the HIV-1 Capsid Shell by TRIM5alpha
Klaus Strebel,
NIAID, National Institutes of Health, USA
Short Talk: Degradation of APOBEC3G and Rescue of Viral Infectivity are Separable Activities of HIV-1 Vif
Short Talk: Degradation of APOBEC3G and Rescue of Viral Infectivity are Separable Activities of HIV-1 Vif
Kyeongeun Lee,
NCI, National Institutes of Health, USA
Short Talk: HIV-1 Cell Killing Blocked by Pre-mRNA Factor CPSF6
Short Talk: HIV-1 Cell Killing Blocked by Pre-mRNA Factor CPSF6
17:00—19:00
Harnessing Innate Immunity for Vaccines
*
Susan W. Barnett,
Bill & Melinda Gates Foundation, USA
Nina Bhardwaj,
Icahn School of Medicine at Mount Sinai, USA
Plasmacytoid DC: Linking Innate and Adaptive Immunity
Plasmacytoid DC: Linking Innate and Adaptive Immunity
Jay A. Levy,
University of California, San Francisco, USA
Importance of Innate Immunity in HIV Infection and Vaccine Development
Importance of Innate Immunity in HIV Infection and Vaccine Development
Galit Alter,
MIT and Harvard University, USA
Short Talk: NK Cells Respond Directly to HIV Derived Single-Stranded RNA via TLR in an APC Dependent Manner
Short Talk: NK Cells Respond Directly to HIV Derived Single-Stranded RNA via TLR in an APC Dependent Manner
Nada M. Melhem,
University of Pittsburgh, USA
Short Talk: Dendritic Cells Expressing Autologous Viral RNA Stimulate T-Cell Responses that Accurately Reflecting Virus Evolution during SIV Infection
Short Talk: Dendritic Cells Expressing Autologous Viral RNA Stimulate T-Cell Responses that Accurately Reflecting Virus Evolution during SIV Infection
Wei Jiang,
Case Western Reserve University, USA
Short Talk: TLR9 Ligation Induces Naïve B Cell Proliferation Independent of B Cell Receptor Activation
Short Talk: TLR9 Ligation Induces Naïve B Cell Proliferation Independent of B Cell Receptor Activation
08:00—11:30
B-Cell Development and Antibody Generation
*
Susan Zolla-Pazner,
Icahn School of Medicine at Mount Sinai, USA
*
John R. Mascola,
NIAID, National Institutes of Health, USA
Shane Crotty,
La Jolla Institute for Immunology, USA
Long Term Antibody Responses and B Cell Memory in Humans after Vaccination
Long Term Antibody Responses and B Cell Memory in Humans after Vaccination
Richard T. Wyatt,
IAVI Neutralizing Antibody Center, The Scripps Research Institute, USA
HIV-1 Envelope Glycoprotein Structural Analysis for Improved Immunogen Design
HIV-1 Envelope Glycoprotein Structural Analysis for Improved Immunogen Design
Ping Zhu,
Florida State University, USA
Short Talk: Distribution and Three-Dimensional Structure of AIDS Virus Envelope Spikes
Short Talk: Distribution and Three-Dimensional Structure of AIDS Virus Envelope Spikes
Herman F. Staats,
Duke University Medical Center, USA
Secretory IgA and HIV-1 Vaccines
Secretory IgA and HIV-1 Vaccines
Ruth M. Ruprecht,
Texas Biomedical Research Institute, USA
Vaccine Development Against HIV clade C in a Primate Model Involving SHIV clade C Mucosal Challenges
Vaccine Development Against HIV clade C in a Primate Model Involving SHIV clade C Mucosal Challenges
Frederic Bibollet-Ruche,
University of Pennsylvania, USA
Short Talk: Detection of Novel Neutralizing Antibody Responses to the Membrane Proximal External Region (MPER) of GP41 following Infection by HIV-1 Subtypes A, B, C, D, F, G, H, CRF01, CRF02, OR CRF11
Short Talk: Detection of Novel Neutralizing Antibody Responses to the Membrane Proximal External Region (MPER) of GP41 following Infection by HIV-1 Subtypes A, B, C, D, F, G, H, CRF01, CRF02, OR CRF11
Amandeep K. Gakhal,
Sutro Biopharma, USA
Short Talk: Dissecting the Neutralizing Antibody Specificities of Broadly Neutralizing Sera from HIV-1 Infected Donors
Short Talk: Dissecting the Neutralizing Antibody Specificities of Broadly Neutralizing Sera from HIV-1 Infected Donors
08:00—11:00
Lessons from the Target Cell (II) -- Factors that Enhance
*
Carol A. Carter,
State University of New York - Stony Brook, USA
Tsg101 and Other Cofactors of HIV Release
Tsg101 and Other Cofactors of HIV Release
John A. T. Young,
F.Hoffmann-La Roche Ltd, Switzerland
Cellular Cofactors in Early Steps of Retroviral Entry
Cellular Cofactors in Early Steps of Retroviral Entry
Angela Ciuffi,
Institute of Microbiology - CHUV/UNIL, Switzerland
Short Talk: HIV Integration Site Selection is Directed by Cellular LEDGF/p75
Short Talk: HIV Integration Site Selection is Directed by Cellular LEDGF/p75
Vicente Planelles,
University of Utah, USA
Short Talk: Vpr Induces Bax-Dependent Apoptosis Downstream of G2 Checkpoint Activation
Short Talk: Vpr Induces Bax-Dependent Apoptosis Downstream of G2 Checkpoint Activation
Serge Benichou,
Cochin Institute, France
Short Talk: Dynamic Interaction of HIV-1 Nef with Clathrin at the Plasma Membrane Revealed by Evanescent Wave Fluorescence Microscopy
Short Talk: Dynamic Interaction of HIV-1 Nef with Clathrin at the Plasma Membrane Revealed by Evanescent Wave Fluorescence Microscopy
René Daniel,
Thomas Jefferson University, USA
Short Talk: Nijmegen Breakage Syndrome Protein 1 Controls the ATM-Dependent DNA Damage Response to HIV-1 Integration
Short Talk: Nijmegen Breakage Syndrome Protein 1 Controls the ATM-Dependent DNA Damage Response to HIV-1 Integration
Erik S. Zimmerman,
University of Utah, USA
Short Talk: Mechanism of Induction of G2 Arrest by HIV-1 Vpr in vivo
Short Talk: Mechanism of Induction of G2 Arrest by HIV-1 Vpr in vivo
14:30—16:30
Workshop 1: Therapeutic Targets in the Virus and Host
*
Vinay K. Pathak,
National Cancer Institute, National Institutes of Health, USA
Identification of APOBEC3G Mutants that Exhibit a Defect in Virion Incorporation
Identification of APOBEC3G Mutants that Exhibit a Defect in Virion Incorporation
Krishan K. Pandey,
St. Louis University Health Sciences Center, USA
Human LEDGF/p75 Modulates Assembly and Disassembly of HIV-1 Synaptic Complexes in vitro
Human LEDGF/p75 Modulates Assembly and Disassembly of HIV-1 Synaptic Complexes in vitro
Rik Gijsbers,
Katholieke Universiteit Leuven, Belgium
Overexpression of the LEDGF/p75 Integrase Binding Domain abrogates HIV-1 Replication
Overexpression of the LEDGF/p75 Integrase Binding Domain abrogates HIV-1 Replication
Steven P. Edgcomb,
The Scripps Research Institute, USA
Attenuation of Rev Function by Modulation of the Oligomerization Domain
Attenuation of Rev Function by Modulation of the Oligomerization Domain
Richard E. Sutton,
Yale University School of Medicine, USA
Human Chromosome 2 Carries a Gene that Allows Infectious HIV Release from Mouse Cells
Human Chromosome 2 Carries a Gene that Allows Infectious HIV Release from Mouse Cells
Katrina Nolan,
University of Pennsylvania, USA
HIV-1 Variants Containing Partial Deletions within the V3 Loop: Effects on X4 vs. R5 Tropism and Sensitivity to Entry Inhibitors
HIV-1 Variants Containing Partial Deletions within the V3 Loop: Effects on X4 vs. R5 Tropism and Sensitivity to Entry Inhibitors
Elena Gustchina,
NIDDK, National Institutes of Health, USA
Fusion Inhibitors Targeting N- and C-Heptad Repeat Regions of Pre-hairpin Intermediate of gp41 Inhibit Fusion Synergistically
Fusion Inhibitors Targeting N- and C-Heptad Repeat Regions of Pre-hairpin Intermediate of gp41 Inhibit Fusion Synergistically
John J. Dwyer,
Trimeris Inc., USA
Design and Mechanism of Action of Fusion Inhibitor Peptides with Enhanced Activity Against ENF-Resistant Virus
Design and Mechanism of Action of Fusion Inhibitor Peptides with Enhanced Activity Against ENF-Resistant Virus
17:00—19:15
Lessons from the Immune Response I (Joint)
*
Ruth M. Ruprecht,
Texas Biomedical Research Institute, USA
Susan Zolla-Pazner,
Icahn School of Medicine at Mount Sinai, USA
Defining Shared Epitopes that Induce Broadly Neutralizing Antibodies
Defining Shared Epitopes that Induce Broadly Neutralizing Antibodies
Gary J. Nabel,
Sanofi, USA
New Antigen Designs for Env Responses
New Antigen Designs for Env Responses
Barton F. Haynes,
Duke University Medical Center, USA
Immunoregulation of Broadly Reactive Anti-HIV Antibody Responses
Immunoregulation of Broadly Reactive Anti-HIV Antibody Responses
Morgane Bomsel,
Institut Cochin, France
Short Talk: Characterization of HIV-1 Neutralizing Anti gp41-IgA by Screening a Phage-Display Fab IgA Library Derived from Mucosal Cells from HIV Highly Exposed but IgG sero Negative Individuals
Short Talk: Characterization of HIV-1 Neutralizing Anti gp41-IgA by Screening a Phage-Display Fab IgA Library Derived from Mucosal Cells from HIV Highly Exposed but IgG sero Negative Individuals
George M. Shaw,
University of Pennsylvania, USA
Short Talk: Characterization of HIV-1 Envelope in Acute HIV-1 Infection
Short Talk: Characterization of HIV-1 Envelope in Acute HIV-1 Infection
08:00—11:30
Lessons from the Immune Response II (Joint)
*
Jay A. Levy,
University of California, San Francisco, USA
Rafick Sekaly,
Emory University, USA
Memory T Cell Homeostasis in the Natural History of HIV Infection
Memory T Cell Homeostasis in the Natural History of HIV Infection
Sarah L. Rowland-Jones,
Oxford University, UK
Long-Term Non-Progression with HIV Infection: Lessons from HIV-2
Long-Term Non-Progression with HIV Infection: Lessons from HIV-2
Mark B. Feinberg,
IAVI International AIDS Vaccine Initiative, USA
Host-Virus Relationships in Nonpathogenic SIV Infections
Host-Virus Relationships in Nonpathogenic SIV Infections
David Price,
Cardiff University School of Medicine, UK
Short Talk: Functional Consequences of Peptide-Major Histocompatibility Complex Class I Antigen Presentation in the Context of Enhanced CD8 Coreceptor Binding: Implications for Vaccine Delivery
Short Talk: Functional Consequences of Peptide-Major Histocompatibility Complex Class I Antigen Presentation in the Context of Enhanced CD8 Coreceptor Binding: Implications for Vaccine Delivery
Arne Schneidewind,
Massachusetts General Hospital, USA
Short Talk: Impact of HLA-B27-Associated CTL Escape Mutations on HIV-1 Replicative Fitness
Short Talk: Impact of HLA-B27-Associated CTL Escape Mutations on HIV-1 Replicative Fitness
Photini Kiepiela,
University of KwaZulu Natal, South Africa
Short Talk: Epitope-Specific Differences in Control of HIV-1 Infection
Short Talk: Epitope-Specific Differences in Control of HIV-1 Infection
14:30—16:30
Workshop 2: HIV Pathogenesis in Host Cells and Tissues
*
Anna Aldovini,
Boston Children's Hospital and Harvard Medical School, USA
TRAIL-Mediated Apoptosis is Induced by HIV and SIV in Human and Macaque CD4+ T Cells but does Not Occur in Virus-Exposed CD4+ T cells from AIDS-Resistant Species
TRAIL-Mediated Apoptosis is Induced by HIV and SIV in Human and Macaque CD4+ T Cells but does Not Occur in Virus-Exposed CD4+ T cells from AIDS-Resistant Species
Elena Martinelli,
Population Council, USA
HIV-1 gp120 Inhibits TLR9 Mediated Activation and IFN-gamma Secretion in Plasmacytoid Dendritic Cells
HIV-1 gp120 Inhibits TLR9 Mediated Activation and IFN-gamma Secretion in Plasmacytoid Dendritic Cells
Ivona Pandrea,
University of Pittsburgh, USA
Dramatic CD4+ T Cell Depletion in the Intestine is a Hallmark of SIVagm.sab Infection in Caribbean AGMs
Dramatic CD4+ T Cell Depletion in the Intestine is a Hallmark of SIVagm.sab Infection in Caribbean AGMs
David E. Verhoeven,
Iowa State University, USA
Mechanistic and Phenotypic Analysis of Delayed Restoration of Intestinal CD4+ Lymphocytes during Antiviral Therapy of SIV Infected Rhesus Macaques
Mechanistic and Phenotypic Analysis of Delayed Restoration of Intestinal CD4+ Lymphocytes during Antiviral Therapy of SIV Infected Rhesus Macaques
Desiree Kunkel,
BCRT, Germany
Regulatory T Cells in the Gastrointestinal Mucosa in HIV/SIV Infection
Regulatory T Cells in the Gastrointestinal Mucosa in HIV/SIV Infection
Bin Li,
, USA
Rapid Reversion of Transmitted Sequence Polymorphisms Dominates Early HIV-1 Evolution
Rapid Reversion of Transmitted Sequence Polymorphisms Dominates Early HIV-1 Evolution
James P. Gregson,
Brigham Young University, USA
Distinct HIV Compartmentalization In and Among Secondary Lymphoid Tissues
Distinct HIV Compartmentalization In and Among Secondary Lymphoid Tissues
17:00—19:15
Lessons from Other Viruses
*
Stephen P. Goff,
Columbia University, USA
Host Restriction of Retrovirus Replication
Host Restriction of Retrovirus Replication
Hung Y. Fan,
University of California, Irvine, USA
Oncogenic Properties of the Envelope Protein of Jaagsiekte Sheep Retrovirus
Oncogenic Properties of the Envelope Protein of Jaagsiekte Sheep Retrovirus
James H. McLinden,
University Of Iowa, USA
Short Talk: Hepatitis C Virus and GB Viruses B and C NS5A Proteins Inhibit HIV Replication in Jurkat Cells
Short Talk: Hepatitis C Virus and GB Viruses B and C NS5A Proteins Inhibit HIV Replication in Jurkat Cells
Melody G. Duvall,
NIAID, National Institutes of Health, USA
Short Talk: Maintenance of HIV-Specific CD4+ T Cell Help Distinguishes HIV-2 from HIV-1 Infection
Short Talk: Maintenance of HIV-Specific CD4+ T Cell Help Distinguishes HIV-2 from HIV-1 Infection
17:00—19:15
T Cells: Effectors versus Suppressors
*
Richard A. Koup,
NIAID, National Institutes of Health, USA
Susan L. Swain,
University of Massachusetts Medical School, USA
Mechanisms of Influenza Protection by Primed CD4 T Cells
Mechanisms of Influenza Protection by Primed CD4 T Cells
*
Nina Bhardwaj,
Icahn School of Medicine at Mount Sinai, USA
Chungwon Chung,
VMRD, USA
Short Talk: Clonal Variation of CD8+ T Lymphocyte Efficacy in Suppression of SIV Replication
Short Talk: Clonal Variation of CD8+ T Lymphocyte Efficacy in Suppression of SIV Replication
Adriano Boasso,
Imperial College London, UK
Short Talk: Increased Regulatory T Cell Markers and Indoleamine 2,3 Dioxygenase in Spleen and Gut of SIV-Infected Macaques
Short Talk: Increased Regulatory T Cell Markers and Indoleamine 2,3 Dioxygenase in Spleen and Gut of SIV-Infected Macaques
Elizabeth Ramona Sharp,
University of California, San Francisco, USA
Short Talk: The Influence of CD4+CD25+ Regulatory T Cells on HLA-A2 Restricted HIV-Specific Immune Responses during Early and Chronic Infection
Short Talk: The Influence of CD4+CD25+ Regulatory T Cells on HLA-A2 Restricted HIV-Specific Immune Responses during Early and Chronic Infection
Jakob Nilsson,
Karolinska Institute, Sweden
Short Talk: A Direct Correlation between FOXP3 Expressing Regulatory T- Cells Present in Lymphoid Tissue and Viral Load of Untreated Chronically HIV-1 Infected Individuals
Short Talk: A Direct Correlation between FOXP3 Expressing Regulatory T- Cells Present in Lymphoid Tissue and Viral Load of Untreated Chronically HIV-1 Infected Individuals
08:00—11:15
Lessons from Therapy
*
John M. Coffin,
Tufts University, USA
Host-Virus Interactions
Host-Virus Interactions
François Clavel,
IUH, Université Paris Diderot, France
HIV Drug Resistance : Viral Strategies for Treatment Escape
HIV Drug Resistance : Viral Strategies for Treatment Escape
Roland Marquet,
IBMC du Centre National de la Recherche Scientifique, France
Short Talk: Targeting the Dimerization Initiation Site of HIV-1 Genomic RNA with Aminoglycosides: From Crystal to Cell
Short Talk: Targeting the Dimerization Initiation Site of HIV-1 Genomic RNA with Aminoglycosides: From Crystal to Cell
Andreas Schweizer,
University Hospital Zurich, Switzerland
Short Talk: CD4-Specific Designed Ankyrin Repeat Proteins Potently Inhibit HIV Entry
Short Talk: CD4-Specific Designed Ankyrin Repeat Proteins Potently Inhibit HIV Entry
Monica Macal,
Five Prime Therapeutics, Inc, USA
Short Talk: Restoration of the Gut Mucosal Immune System in HIV Infected Patients during HAART
Short Talk: Restoration of the Gut Mucosal Immune System in HIV Infected Patients during HAART
Ruy M. Ribeiro,
University of Lisbon, Portugal
Short Talk: Naïve and Memory Cell Turnover as Drivers of CCR5 to CXCR4-Tropism Switch in HIV-1: Implications for Therapy
Short Talk: Naïve and Memory Cell Turnover as Drivers of CCR5 to CXCR4-Tropism Switch in HIV-1: Implications for Therapy
08:00—11:30
Mucosal Immunity / Preclinical Studies
*
Satya Dandekar,
University of California, Davis, USA
*
Herman F. Staats,
Duke University Medical Center, USA
Barbara L. Shacklett,
University of California, Davis, USA
HIV-1 Specific T-Cell Responses in Mucosal Tissues
HIV-1 Specific T-Cell Responses in Mucosal Tissues
Susan W. Barnett,
Bill & Melinda Gates Foundation, USA
Trimeric HIV Env: Improved Adjuvants and Delivery
Trimeric HIV Env: Improved Adjuvants and Delivery
Leonidas Stamatatos,
Fred Hutchinson Cancer Research Center, USA
Distinct Immunogenic Properties of the SF162 Env on Infectious Virions and Soluble gp140 Protein
Distinct Immunogenic Properties of the SF162 Env on Infectious Virions and Soluble gp140 Protein
Julia L. Hurwitz,
St. Jude Children's Research Hospital, USA
Pre-Clinical and Clinical Development of a Multi-Envelope HIV-1 Vaccine
Pre-Clinical and Clinical Development of a Multi-Envelope HIV-1 Vaccine
Thorsten Demberg,
NCI, National Institutes of Health, USA
Short Talk: Immunogenicity and Protective Efficacy of Prime/Boost Vaccine Regimens based on Replication-Competent Ad Recombinants Encoding HIVtat, HIVenv, SIVgag, and SIVnef in a Rhesus Macaque SHIV89.6P Challenge Model
Short Talk: Immunogenicity and Protective Efficacy of Prime/Boost Vaccine Regimens based on Replication-Competent Ad Recombinants Encoding HIVtat, HIVenv, SIVgag, and SIVnef in a Rhesus Macaque SHIV89.6P Challenge Model
Andreas Mörner,
Public Health Agency of Sweden, Sweden
Short Talk: CD4 and CD8 IFN-gamma and IL-2 Responses and Control of SHIV Replication in Macaques Immunized with Multi-Gene Cocktail DNA or SFV followed by MVA
Short Talk: CD4 and CD8 IFN-gamma and IL-2 Responses and Control of SHIV Replication in Macaques Immunized with Multi-Gene Cocktail DNA or SFV followed by MVA
Siew Yen Chong,
Wyeth Pharmaceuticals, USA
Short Talk: Immunogenicity of Attenuated Recombinant Vesicular Stomatitis Virus Vectors Expressing HIV GAG in Rhesus Macaques
Short Talk: Immunogenicity of Attenuated Recombinant Vesicular Stomatitis Virus Vectors Expressing HIV GAG in Rhesus Macaques
14:30—16:30
Workshop 2: Neutralizing Antibodies
*
Richard T. Wyatt,
IAVI Neutralizing Antibody Center, The Scripps Research Institute, USA
Miroslaw K. Gorny,
New York University School of Medicine, USA
A Neutralizing Epitope is Present on Env Trimers but not Monomers Expressed on the Virions Pseudotyped with Env SF162
A Neutralizing Epitope is Present on Env Trimers but not Monomers Expressed on the Virions Pseudotyped with Env SF162
*
Harriet L. Robinson,
GeoVax Inc., USA
Correlation of the Avidity of anti-Env Ab with Neutralizing Activity for Incident Isolates
Correlation of the Avidity of anti-Env Ab with Neutralizing Activity for Incident Isolates
Yuxing Li,
University of Maryland, USA
Analysis of the Neutralizing Specificity in Complex Polyclonal Sera
Analysis of the Neutralizing Specificity in Complex Polyclonal Sera
Rogier W. Sanders,
University of Amsterdam and Weill Cornell Medical College, Netherlands
Functional Improvement of V1/V2-Deleted HIV-1 gp120 through Forced Virus Evolution
Functional Improvement of V1/V2-Deleted HIV-1 gp120 through Forced Virus Evolution
Hui Li,
University of Pennsylvania, USA
Conservation of the Neutralization Epitope for 4E10, but not 2F5, in Human and Simian Immunodeficiency Viruses of Diverse Evolutionary Origins
Conservation of the Neutralization Epitope for 4E10, but not 2F5, in Human and Simian Immunodeficiency Viruses of Diverse Evolutionary Origins
Madhumita Mahalanabis,
University of Washington, USA
Key Mutations in SIV Envelope of Macaques with Heterologous Neutralizing Antibody Responses
Key Mutations in SIV Envelope of Macaques with Heterologous Neutralizing Antibody Responses
Dan H. Barouch,
Beth Israel Deaconess Medical Center, USA
Hexon-Chimeric Adenovirus Serotype 5 Vectors Effectively Circumvent Pre-Existing Anti-Vector Immunity
Hexon-Chimeric Adenovirus Serotype 5 Vectors Effectively Circumvent Pre-Existing Anti-Vector Immunity
17:00—19:00
Lessons from the Tissues
*
James E.K. Hildreth,
UC Davis College of Biological Sciences, USA
Robert F. Siliciano,
Johns Hopkins University School of Medicine, USA
HIV Resevoirs, Latency, and Evolution
HIV Resevoirs, Latency, and Evolution
Thijs van Montfort,
Academic Medical Center, Netherlands
Short Talk: Transfer of Antibody Neutralized HIV-1 from Dendritic Cells and DC-SIGN Expressing Cells to CD4 Lymphocytes
Short Talk: Transfer of Antibody Neutralized HIV-1 from Dendritic Cells and DC-SIGN Expressing Cells to CD4 Lymphocytes
Jason M. Brenchley,
NIAID, National Institutes of Health, USA
Short Talk: Continued Infection of Mucosal CD4+ T Cells is Associated with Mucosal Depletion Despite Years of Antiretroviral Therapy
Short Talk: Continued Infection of Mucosal CD4+ T Cells is Associated with Mucosal Depletion Despite Years of Antiretroviral Therapy
Paul J. Peters,
University of Massachusetts, USA
Short Talk: Macrophage-Tropic R5 Envelopes are Infrequent in Blood, Lymph Nodes and Semen: Implications for Transmission and Pathogenesis
Short Talk: Macrophage-Tropic R5 Envelopes are Infrequent in Blood, Lymph Nodes and Semen: Implications for Transmission and Pathogenesis
Jacob D. Estes,
Oregon Health and Science University, USA
Short Talk: Rapid Secondary Lymphatic Tissue Fibrosis in Pathogenic SIV-Infected Rhesus Macaques Mediated by TGFbeta1+ Tregs
Short Talk: Rapid Secondary Lymphatic Tissue Fibrosis in Pathogenic SIV-Infected Rhesus Macaques Mediated by TGFbeta1+ Tregs
Jean-Charles J. B. Grivel,
Sidra Medical and Research Center, Qatar
Short Talk: HIV-1 Replication in Rectal Mucosa and Tonsillar Explant
Short Talk: HIV-1 Replication in Rectal Mucosa and Tonsillar Explant
17:00—19:30
Correlates of Protection Against Infection or Disease
*
Louis J. Picker,
Oregon Health & Science University, USA
Marta L. Marthas,
California National Primate Research Center, USA
Role for Innate Immunity in Protection of Vaccinated Infant Macaques Against Oral SIV: Has Terminology Limited How We Evaluate Vaccine Immunogenicity and Efficacy?
Role for Innate Immunity in Protection of Vaccinated Infant Macaques Against Oral SIV: Has Terminology Limited How We Evaluate Vaccine Immunogenicity and Efficacy?
*
Neil Almond,
National Institute Biology Standards, UK
The Characterisation of Protection Conferred by Live Attenuated SIV
The Characterisation of Protection Conferred by Live Attenuated SIV
Francisco Veas,
Institut de Recherche pour le Development, France
Short Talk: New Innate Immune Correlates in Caucasian HIV Exposed Uninfected Individuals
Short Talk: New Innate Immune Correlates in Caucasian HIV Exposed Uninfected Individuals
Genoveffa Franchini,
NCI, National Institutes of Health, USA
Importance of CD4+ T Cells in the Maintenance of SIV-Specific CD8+ T Memory Cells and their Role in Protection from SIVmac251
Importance of CD4+ T Cells in the Maintenance of SIV-Specific CD8+ T Memory Cells and their Role in Protection from SIVmac251
Melissa Precopio,
Ragon Institute of MGH, MIT, and Harvard, USA
Short Talk: Immunization with Vaccinia Virus Induces Polyfunctional T Cell Responses
Short Talk: Immunization with Vaccinia Virus Induces Polyfunctional T Cell Responses
Scott A. Brown,
St. Jude Children's Research Hospital, USA
Short Talk: HIV-1-Envelope-Specific CD4+ T-Cells Control Virus Challenge without CD8+ T-Cell or B-Cell Contributions in a Mouse Model System
Short Talk: HIV-1-Envelope-Specific CD4+ T-Cells Control Virus Challenge without CD8+ T-Cell or B-Cell Contributions in a Mouse Model System
08:00—11:15
Lessons from Animal Models
Ronald C. Desrosiers,
University of Miami Miller School of Medicine, USA
Replication-Competent and Replication-Incompetent SIV as Vaccines
Replication-Competent and Replication-Incompetent SIV as Vaccines
Jeffrey D. Lifson,
Leidos Biomedical Research, Inc., USA
Inactivated Vaccines
Inactivated Vaccines
Louis J. Picker,
Oregon Health & Science University, USA
New Insights in SIV Immunopathogenesis -- Connecting Viral Replication to Disease
New Insights in SIV Immunopathogenesis -- Connecting Viral Replication to Disease
*
Janice E. Clements,
Johns Hopkins University, USA
Innate Immune Responses Regulate SIV Replication in Macrophages In Vivo
Innate Immune Responses Regulate SIV Replication in Macrophages In Vivo
Miles P. Davenport,
University of New South Wales, Australia
Short Talk: Viral Load Predicts CD4+ T Cell Depletion in Acute SHIV Infection of Macaques
Short Talk: Viral Load Predicts CD4+ T Cell Depletion in Acute SHIV Infection of Macaques
Julie TerWee,
Colorado State University, USA
Short Talk: Cellular Signaling following Receptor Engagement: Correlates with Pathogenicity
Short Talk: Cellular Signaling following Receptor Engagement: Correlates with Pathogenicity
08:00—11:00
Clinical Trials: Prophylactic Vaccines
*
Gary J. Nabel,
Sanofi, USA
John A. Hural,
HIV Vaccine Trials Network, USA
Short Talk
Short Talk
Barbara Ensoli,
Istituto Superiore di Sanita, Italy
Tat-Based Vaccines: From Basic Science to Clinical Trials
Tat-Based Vaccines: From Basic Science to Clinical Trials
Nelson L. Michael,
Walter Reed Army Institute of Research, USA
U.S. Military HIV Research Program Preventive Vaccine Trials
U.S. Military HIV Research Program Preventive Vaccine Trials
Shan Lu,
University of Massachusetts Medical Center, USA
Short Talk: Update on the Immunogenicity and Safety of the Polyvalent DNA Prime-Protein Boost HIV-1 Vaccine Formulation DP6-001 in Healthy Volunteers
Short Talk: Update on the Immunogenicity and Safety of the Polyvalent DNA Prime-Protein Boost HIV-1 Vaccine Formulation DP6-001 in Healthy Volunteers
17:00—19:00
Lessons from the Real World
*
Julie M. Overbaugh,
Fred Hutchinson Cancer Research Center, USA
Grace John-Stewart,
University of Washington, USA
Maternal-Infant HIV-1 Transmission
Maternal-Infant HIV-1 Transmission
Eric Hunter,
Emory University, USA
Early Events in HIV Infection: Lessons from Transmission Pairs
Early Events in HIV Infection: Lessons from Transmission Pairs
Bruce D. Walker,
Ragon Institute of MGH, MIT and Harvard, USA
Elite Control of HIV Replication: Towards an Understanding of the Correlates of Immune Control
Elite Control of HIV Replication: Towards an Understanding of the Correlates of Immune Control
Anu Rebbapragada,
University of Toronto, Canada
Short Talk: HSV2 and HIV Interaction: Negative Synergy in the Female Genital Tract
Short Talk: HSV2 and HIV Interaction: Negative Synergy in the Female Genital Tract
17:00—19:00
Immune Therapy in HIV and Cancer
*
Genoveffa Franchini,
NCI, National Institutes of Health, USA
Jacques F. Banchereau,
The Jackson Laboratory for Genomic Medicine, USA
Interstitial Dendritic Cells and Langerhans Cells Prime Humoral and Cellular Immunity Respectively
Interstitial Dendritic Cells and Langerhans Cells Prime Humoral and Cellular Immunity Respectively
Montserrat Plana,
Hospital Clinic, Spain
Short Talk: Functional and Phenotypic Characterization of HIV-Specific CD8 T Cells after Autologous Dendritic Cells Based Therapeutic Vaccine
Short Talk: Functional and Phenotypic Characterization of HIV-Specific CD8 T Cells after Autologous Dendritic Cells Based Therapeutic Vaccine
Monica Vaccari,
NCI, National Institutes of Health, USA
Short Talk: CTLA4 Blockade In Antiretroviral Therapy-Treated SIVmac251-Infected Macaques Does Not Augment Global T Cell Activation And Viral Replication
Short Talk: CTLA4 Blockade In Antiretroviral Therapy-Treated SIVmac251-Infected Macaques Does Not Augment Global T Cell Activation And Viral Replication
Johan K. Sandberg,
Karolinska Institute, Sweden
Short Talk: Expansion of CD1d-Restricted NKT Cells in Patients with Primary HIV-1 Infection Treated with Interleukin-2
Short Talk: Expansion of CD1d-Restricted NKT Cells in Patients with Primary HIV-1 Infection Treated with Interleukin-2
*Session Chair †Invited, not yet responded.
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