Keystone Symposia

Herrenhausen Palace Floorplan

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This meeting took place in 2022


Here are the related meetings in 2023:
B Cell Biology in the Context of Infectious Diseases, Autoimmunity and B Cell Cancers (Z5)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

B Cell-T Cell Collaboration: Regulation and Dysregulation (T4)


Organizer(s) Victor L.J. Tybulewicz, Kai-Michael Toellner, Julie Zikherman and Pamela L. Schwartzberg
April 3—6, 2022
Herrenhausen Palace • Hannover, Germany
Abstract Deadline: Jan 11, 2022
Scholarship Deadline: Dec 7, 2021
Discounted Registration Deadline: Feb 2, 2022

Sponsored by BioLegend, Inc. and Takeda Pharmaceutical Company Limited In Collaboration with Volkswagen Foundation

Summary of Meeting:
B cell-T cell collaboration leads, via the germinal center reaction, to the generation of B cell memory and long-lived affinity-matured protective antibodies. This key immune response has been extensively studied, and, as a result, we have an increasingly refined understanding of the ligands, receptors, and intra-cellular pathways that are involved. However, many aspects of this remarkable process as it plays out in infections, vaccine responses, and chronic immunological diseases remain unknown. In particular, we still do not understand how B cells integrate complex antigenic and co-stimulatory inputs over time to make critical cell fate decisions, including the process of clonal selection in the germinal center as well as memory B cell and long-lived plasma cell differentiation. We do not fully appreciate the spectrum of ‘non-canonical’ B cell responses to various chronic and acute infections, especially those occurring in tissues rather than secondary lymphoid organs. And finally, many unanswered questions remain about normal and abnormal B cell responses to commensal flora, allergic antigens, and self-antigens that are essential to address if we hope to understand dysregulated B cell immune responses in inflammatory, allergic, and autoimmune disease. This meeting brings together scientists focused on both the B cell and the Tfh cell contributions to humoral immunity in order to share innovative research focused on addressing this broad set of questions. We aim to identify areas of future investigation, foster collaboration, and collectively generate the knowledge base required to design better vaccines and more precise strategies to treat diseases of immune dysregulation.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, April 3 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, April 6 with a closing plenary session from 15:30 to 18:30, followed by a social hour. We recommend return travel on Thursday, April 7 in order to fully experience the meeting.

SUNDAY, APRIL 3

16:00—20:00
Arrival and Registration

Grand Mussmann Hotel, Tivoli Room
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Central-Hotel Kaiserhof

MONDAY, APRIL 4

08:00—09:00
Breakfast (Individual Hotel)

Individual Hotel
09:00—10:30
Welcome and Keynote Session

Auditorium
* Pamela L. Schwartzberg, NIAID, National Institutes of Health, USA

* Julie Zikherman, University of California, San Francisco, USA

Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Immune Responses to Viruses and Vaccines

Garnett H. Kelsoe, Duke University and Medical Center, USA
Germinal Centers and Broadly Neutralizing Antibodies

Coffee Break

11:00—12:15
Immunity to Infection

Auditorium
* Victor L.J. Tybulewicz, Francis Crick Institute, UK

Kathrin de la Rosa, Max Delbruck Center, Germany
BIBAX: A Novel Structure-guided Approach to Improve Vaccine Safety and Efficacy

Nicole Baumgarth, University of California, Davis, USA
Short Talk: Two Sides of One Coin: Extrafollicular B Cell Responses to Infections

Susan Moir, NIAID, National Institutes of Health, USA
Signatures of B Cell Dysregulation in HIV Infection with Implications for SARS-CoV-2

12:15—13:30
Lunch

Ballroom
12:30—13:00
Poster Setup

Foyer/Seminar Room
13:00—20:00
Poster Viewing

Foyer/Seminar Room
13:30—15:00
Workshop 1: Germinal Centers: Generation and Function

Auditorium
* Kai-Michael Toellner, University of Birmingham, UK

Spencer Chen, Rockefeller University, USA
B Cell Receptor Signaling Prolongs Survival and Primes B cells for Germinal Center Selection

Clara Cousu, Institut Necker Enfants Malades, France
B Cells, What HELLS

J. Scott Hale, University of Utah, USA
De Novo Methylation Enforces Long-term Lineage-specific T Follicular Helper and T Helper-1 Memory Cell Programing

Ramin Herati, New York University, USA
PD-1 Directed Immunotherapy Alters Tfh and Humoral Immune Responses to Seasonal Influenza Vaccine

Kevin Ng, Francis Crick Institute, UK
Checkpoint Blockade Boosts Protective Germinal Centre Responses in Cancer

Michael Meyer-Hermann, Helmholtz Centre for Infection Research, Germany
A Molecular Theory of B cell Selection by T Follicular Helper Cells

Coraline Mlynarczyk, Weill Cornell Medicine, USA
A Faster Response to T Cell Help Selection Signals Yields “Super-competitor” B Cells Primed for Malignant Transformation

Sandra Nakandakari Higa, Rockefeller University, USA
Measuring T Cell Help to B Cells in Germinal Centers

Lingling Zhang, Francis Crick Institute, UK
Ca2+ signalling in IgG1+ Germinal Centre (GC) B Cells is Actively Regulated to Favour Positive Selection

15:00—15:30
Coffee Available

Foyer
15:30—18:00
Selection in the Germinal Center

Auditorium
* Roberta Pelanda, University of Colorado Denver, USA

Hai Qi, Tsinghua University, China
Remote Presentation: B Cell: T Cell Interactions in the Germinal Center

Victor L.J. Tybulewicz, Francis Crick Institute, UK
Critical Roles for Water Flux in T-dependent B Cell Responses

Michael Reth, Albert-Ludwigs University Freiburg, Germany
Short Talk: The Regulation of Different BCR Classes on Resting B Cells and their Function During Antigen Sensing

Gabriel D. Victora, Rockefeller University, USA
Affinity Maturation in the Germinal Center

Dessi Malinova, Queen's University Belfast, UK
Short Talk: Novel Players in B Cell Antigen Uptake and Trafficking

Anneli Peters, Ludwig Maximilians University, Germany
T:B Cell Communication in Ectopic Lymphoid Follicles in CNS Autoimmunity

18:00—19:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom
19:00—20:30
Poster Session 1

Foyer/Seminar Room

TUESDAY, APRIL 5

08:00—09:00
Breakfast (Individual Hotel)

Individual Hotel
09:00—12:00
Tfh Cells

Auditorium
* Nicole Baumgarth, University of California, Davis, USA

Carolyn King, University of Basel, Switzerland
Division of T cell labor in the lung

Andrea Reboldi, University of Massachusetts Medical School, USA
Short Talk: IgA B Cell Receptor Regulates Peyer's Patches Germinal Center Competition by Preventing Fas Counterselection

Pamela L. Schwartzberg, NIAID, National Institutes of Health, USA
Genetic Approaches to Understanding Tfh Cells during Viral Infections

Coffee Break

Michelle A. Linterman, Babraham Institute, UK
Rejuvenating the Germinal Centre Response

Michela Locci, University of Pennsylvania, USA
Short Talk: Regulation of Tfh Cells and Germinal Center Responses by mRNA-LNP Vaccines

Carola G. Vinuesa, Francis Crick Institute, UK
Regulation of Antibody Responses by Tfr Cells

12:00—13:30
Lunch

Ballroom
12:30—13:00
Poster Setup

Foyer/Seminar Room
13:00—20:00
Poster Viewing

Foyer/Seminar Room
13:30—15:00
Workshop 2: Immunological Memory

Auditorium
* Lars Nitschke, University of Erlangen, Germany

Pascal Chappert, Institut Necker Enfants Malades, France
Dynamic Interactions within Splenic Niche and Long-lasting GC Imprinting Defines Anti-vaccinia Long-lived Memory B Cells

David R. Fooksman, Albert Einstein College of Medicine, USA
Dynamics of Bone Marrow Plasma Cells

Liam Kealy, Monash University, Australia
The Role of DOT1L in the Regulation of Humoral Immunity

Jared Klarquist, University of Colorado, Anschutz, USA
B Cells Regulate CD8 T Cell Naïve, Effector, and Memory Programming

Casper Marsman, Sanquin Research, Netherlands
Termination of CD40L Co-stimulation Promotes Human B Cell Differentiation Into Antibody-Secreting Cells

Adam J. Fike, Pennsylvania State University College of Medicine, USA
B Cell Intrinsic STAT3 Controls Germinal Center Zone Organization, and Recycling and Plasma Cell Selection but not B cell Memory

Lauren B. Rodda, University of Washington, USA
SARS-CoV-2-specific Infection-imprinted Features of Hybrid Immunity are not Recapitulated by Repeated Vaccination

Annemiek B. van Spriel, Radboud University Medical Center, Netherlands
Humoral Immunity is Controlled by Tetraspanins through Protein organization in the Plasma Membrane

15:00—15:30
Coffee Available

Foyer
15:30—18:00
Memory

Auditorium
* Julie Zikherman†, University of California, San Francisco, USA

Jason G. Cyster, HHMI/University of California, San Francisco, USA
Generation of Memory B Cells

Taras Kreslavsky, Karolinska Institutet, Sweden
Short Talk: Regulation of Cell Fate Decisions in Early B Cell Activation

Thomas H. Winkler, FAU, Germany
Short Talk: Dynamic Selection Processes By-pass the Affinity Dead-end of Low Affinity Anti-NP Specific B Cells and Generate Low-affinity Memory B Cells

Kai-Michael Toellner, University of Birmingham, UK
Migration of Memory B Cells

Tri Giang Phan, Garvan Institute of Medical Research, Australia
Reactivation of Memory B Cells

Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Functions and Heterogeneity of Memory B Cells

18:00—19:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom
19:00—20:30
Poster Session 2

Foyer/Seminar Room

WEDNESDAY, APRIL 6

08:00—09:00
Breakfast (Individual Hotel)

Individual Hotel
09:00—12:00
Autoimmunity

Auditorium
* Carola G. Vinuesa, Francis Crick Institute, UK

Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Remote Presentation: Progression from Benign to Pathogenic Autoantibody by Somatic Mutation in a Rogue Clone

Andrew Getahun, University of Colorado School of Medicine, USA
Short Talk: Dysregulated PI3K Signaling can Make Autoreactive B Cells Receptive to Bystander T Cell Help

Julie Zikherman, University of California, San Francisco, USA
Balancing Tolerance and Humoral Immunity

Coffee Break

Roberta Pelanda, University of Colorado Denver, USA
Active PI3-Kinase Signaling and Downmodulation of CXCR4 Abrogate Central Tolerance in Autoreactive B Cells

Marvin van Luijn, Erasmus MC, University Medical Center, Netherlands
Short Talk: B Cells Infiltrating the Human Brain: From Peripheral Induction to Local Effector Function

Jennifer L. Gommerman, University of Toronto, Canada
Remote Presentation: B Cells and CNS inflammation

12:00—13:30
Lunch

Ballroom
12:30—13:00
Poster Setup

Foyer/Seminar Room
13:00—20:00
Poster Viewing

Foyer/Seminar Room
13:30—15:00
Workshop 3: Autoimmunity and Immune Dysregulation

Auditorium
* Thomas H. Winkler†, FAU, Germany

Kristen Bricker, Penn State University COM, USA
miR-21 Promotes B Cell Autoreactivity, Inflammatory Signaling, and Metabolism in TLR7-Driven Systemic Autoimmunity

Rasmus Iversen, University of Oslo, Norway
Circulating Autoreactive B Cells in Celiac Disease are Gut-homing Pre-plasma Cells Derived from Naïve B Cells

Niklas Krausse, Lund University, Sweden
Linking Early Life B Lymphopoiesis to B Cell Neoplasms Later in Life

Shannon McGettigan, Thomas Jefferson University, USA
Secreted IgM Modulates the Pool of IL-10 Producing B Cells

Mia J. Smith, University of Colorado Denver - Anschutz Medical Campus, USA
Activation of Extrafollicular Insulin-binding B Cells in Type 1 Diabetes Subjects

Eva Maria Stork, Leiden University Medical Center, Netherlands
T Helper Cell Subsets Differentially Modulate Human IgG Fc Glycosylation

Carla R. Nowosad, NYU, USA
Tunable Dynamics of B Cell Selection in Gut-draining Germinal Centers

15:00—15:30
Coffee Available

Foyer
15:30—18:15
Immune Dysregulation

Auditorium
* Pamela L. Schwartzberg, NIAID, National Institutes of Health, USA

Pavel Tolar, University College London, UK
B Cell Signal Wiring for Fate Decisions

Lars Nitschke, University of Erlangen, Germany
Short Talk: Siglec-G Controls the Severity of Chronic Lymphocytic Leukemia

Christopher D. C. Allen, University of California, San Francisco, USA
Generation and Function of IgE in Allergy

Andre Limnander, Regeneron, USA
Short Talk: A Therapeutic Strategy to Eliminate all Sources of IgE and Reset the Allergic Immune Response​

Stephanie C. Eisenbarth, Northwestern Univ Feinberg Sch Med, USA
The Antibody Response to Food

Jagan R. Muppidi, NCI, National Institutes of Health, USA
Short Talk: The Tumor Suppressor Ga13 Inhibits Germinal Center B Cell Proliferation by Limiting Cyclin D3 and Myc Protein Abundance

Ziv Shulman, Weizmann Institute, Israel
How Do Bacterial Infections Disrupt Germinal Center Reactions?

18:15—18:30
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Auditorium
18:30—19:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom
19:30—21:00
Poster Session 3

Foyer/Seminar Room

THURSDAY, APRIL 7

08:00—08:00
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks the Volkswagen Foundation for hosting this conference:

Volkswagen Stiftung
 

Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

BioLegend, Inc. Takeda Pharmaceutical Company Limited

We gratefully acknowledge additional support from these exhibitors at this conference:

BioLegend, Inc.
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI169927-01

Federal Funding was provided by the National Institutes of Health: Funding for this conference was made possible (in part) by 1R13AI169927-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

AdipoGen Life Sciences Science Immunology / AAAS

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: John Monson, Director of Corporate Relations, Email: johnm@keystonesymposia.org,
Phone:+1 970-262-2690

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Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179