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This meeting took place in 2022

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Exosomes, Microvesicles and Other Extracellular Vesicles - RESCHEDULED (RB3)

Organizer(s) Clotilde Thery, Andrew Hill and Susmita Sahoo
October 30—November 2, 2022
Eldorado Hotel & Spa • Santa Fe, NM USA
Abstract Deadline: Jul 28, 2022
Scholarship Deadline: Nov 9, 2021
Discounted Registration Deadline: Aug 30, 2022

Sponsored by Cell Research, Chinese Society for Cell Biology, (Cell Research), Ionis Pharmaceuticals, Inc., Moderna, Takeda Pharmaceutical Company Limited and Ultragenyx Pharmaceutical Inc.

Summary of Meeting:
Extracellular vesicles (EVs), including exosomes, microvesicles and others are membranous nanovesicles, contain bioactive molecules such as lipids, proteins, RNA and metabolites derived from the cell of their origin. EVs carry these important cargo molecules throughout the body, signaling to distant tissues and orchestrating systemic responses. The profile of cargo they carry provides a cell-specific signature, which can reveal important insights about the cell of origin, and pathophysiological mechanisms. As such, there is growing excitement about their potential use as disease biomarkers, and/or therapeutic entities. The goal of this meeting is to disseminate the latest discoveries regarding both basic biology and clinical utility of EVs. In particular, the program will explore the role of EVs in human disease pathogenesis, novel therapeutic approaches with EVs, and biomarker developments. In addition to scientific insights, the meeting will cover new methodologies, tools and technologies for studying EVs, to enable further advancements in characterization of EV processes and facilitate translational impact into diagnostic and therapeutic applications. By integrating research in basic science with the clinical perspectives, this meeting will foster cross-disciplinary discussions and collaborations to drive the field forward towards medical impacts. In addition, the program format features panel discussions and workshops to spur insightful discussions and encourage interactions between young investigators and distinguished international experts for training, mentorship and networking opportunities.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time

The meeting will begin on Sunday, October 30 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, November 2 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, November 3 in order to fully experience the meeting.


Arrival and Registration

Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Eldorado B



Eldorado B
EV Isolation, Characterization and Normalization (8:00-11:00 AM)

Eldorado A
* Andrew Hill, Victoria University, Australia

Kenneth W. Witwer, Johns Hopkins Medical Institutions, USA
Remote Presentation: Guidelines (MISEV2018), Rigor and Standardization Initiatives for EV Studies

Robert J. Coffey, Jr., Vanderbilt University Medical Center, USA
Update on Isolation and Characterization of Extracellular Vesicles and Nanoparticles

Coffee Break

Aleksandar Milosavljevic, Baylor College of Medicine, USA
A Map of Extracellular RNA-Binding Proteins (exRBPs) and their exRNA Cargo in Human Biofluids

Cláudio Pinheiro, Gent University, Belgium
Short Talk: Evaluation of Disparate Methods to Separate Extracellular Vesicles from Multiple Biofluids in the Extracellular Vesicle Quality Control (EVQC) Study

Ariana K. von Lersner, Vanderbilt University, USA
Short Talk: "EV Fingerprinting": Resolving the Heterogeneity of Extracellular Vesicle Populations using Dimensional Reduction of Multi-Parametric Flow Cytometry Data

Lizandra Jimenez, Vanderbilt University, USA
Short Talk: Evaluation of Culture Conditions on the Presence of Ago2 and miRNAs in Small Extracellular Vesicles

Ferdinando Pucci, Oregon Health & Science University, USA
Short Talk: “EV Painting” Uncovers Hidden Surface Interactions Between Tumor EVs and Immune Cells in vivo

On Own for Lunch

Poster Setup

Eldorado B
Poster Viewing

Eldorado B
Hands On Workshop: Tools for Analysis of RNA Sequencing Data in Extracellular RNA and EVs (2:30-4:30 PM)

Eldorado A
* Roger P. Alexander, Extracellular RNA Communication Consortium, USA
Using the exceRpt Small-exRNA-seq Processing Pipeline: A Case Study on the Impact of Exercise

Antonin Morillon, Institut Curie, France
Characterization of the Long Noncoding Transcriptome from Urinary Extracellular Vesicles of Prostate Cancer Patients

Robert Fullem, Baylor College of Medicine, USA
exRNA Data Slicer: Find your Regions of Interest in the exRNA Atlas

Navneet Dogra, Icahn School of Medicine at Mount Sinai, USA
Characterizing the Neurosecretome: Extracellular Particles of the Brain and their Lineage in Blood

Coffee Available

Biogenesis and Transfer of EVs (5:00-7:15 PM)

Eldorado A
* Rania Ghossoub, INSERM U1068, France

Pascale Zimmermann, Centre de Recherche en Cancerologie de Marseille and KU Leuven, France
Syntenin-Dependent Exosome Formation and Induced Molecular Signaling in Cell-to-Cell Communication

Maureen M. Barr, Rutgers University, USA
Cilia-Derived Vesicle Biogenesis and Signaling in Animal Communication

Niek Dekker, AstraZeneca, Sweden
Engineered Extracellular Vesicles for Drug Delivery for Regenerative Therapy

Bahnisikha Barman, Vanderbilt University, USA
Short Talk: VAP-A-CERT Linkages at ER-Membrane Contact Sites Regulate Biogenesis of RNA Containing Extracellular Vesicles

Daniel Humphrys, University of Washington, USA
Short Talk: Functionalizing the Membrane of Enveloped Protein Nanocages

Justin Williams, UC Berkeley, USA
Short Talk: Annexin A6 Mediates Calcium-dependent Exosome Secretion

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Eldorado B
Poster Session 1

Eldorado B



Eldorado B
EVs and Cancer (8:00-10:15 AM)

Eldorado A
* Robert J. Coffey, Jr., Vanderbilt University Medical Center, USA

Michele De Palma, École Polytechnique Fédérale de Lausanne, Switzerland
Remote Presentation: Harnessing Tumor-Derived Extracellular Vesicles for Cancer Therapy

Clotilde Théry, Institut Curie, France
Exosomes and Other EVs in Tumor-Immune System Cross-Talk

Coffee Break

Wei Guo, University of Pennsylvania, USA
Exosomes in Immune Suppression and Tumor Progression

Nuno Bastos, i3S - Institute for Research and Innovation in Health, Porto, Portugal
Short Talk: Loss of Rab27a in Pancreatic Cancer Steers an Inflammatory Microenvironment that Promotes Disease Progression

EVs in Aging-Nervous System (10:15-11:45 AM)

Eldorado A
* Christian Neri, IBPS, Sorbonne University, France

Andrew Hill, Victoria University, Australia
EVs in Neurodegenerative Diseases

Efrat Levy, NYU Langone Health, USA
Mitovesicles are Central to Neuronal Integrity in Aging and in Neurodegenerative Diseases

Michael Hantak, University of Utah, USA
Short Talk: Arc EVs are Virus-like Intercellular Communicators

Natayme Rocha Tartaglia, Sorbonne University, France
Short Talk: Extracellular Vesicle Remodeling in Response to Mutant Huntingtin

On Own for Lunch

Poster Setup

Eldorado B
Poster Viewing

Eldorado B
Career Roundtable (3:30-4:30 PM)

Zia A
Elena Aikawa, Harvard Medical School, Brigham and Women’s Hospital, USA

Niek Dekker, AstraZeneca, Sweden

Navneet Dogra, Icahn School of Medicine at Mount Sinai, USA

Coffee Available

EVs and Cardio-Metabolic Physio/pathology (5:00-7:00 PM)

Eldorado A
Clair Crewe, Washington University School of Medicine in St. Louis, USA
Adipocyte Energetic Stress Induces Mitochondrial-Derived Extracellular Vesicle Production to Regulate Systemic Metabolism

Elena Aikawa, Harvard Medical School, Brigham and Women’s Hospital, USA
The Role of Extracellular Vesicles in Cardiovascular Calcification

* Susmita Sahoo, Icahn School of Medicine at Mount Sinai, USA
EVs in Myocardial Gene Delivery

Alan M. Adamczyk, University Of Buenos Aires, Argentina
Short Talk: Plasma Extracellular Vesicles Dampen Macrophage-driven Inflammation

Tamires Marques Zanotto, State University of Campinas, Brazil
Short Talk: Designing a New Therapeutic Approach using Exosomal miRNAs to Target Metabolic Disease: PCSK9 Inhibition Effects in Reducing Atherosclerosis Risk

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Eldorado B
Poster Session 2

Eldorado B



Eldorado B
Non Mammalian EVs and Viruses (8:00-11:00 AM)

Eldorado A
* Clotilde Théry, Institut Curie, France

Matias Ostrowski, University of Buenos Aires, Argentina
Remote Presentation: HIV Pathogenesis and Extracellular Vesicles-Mediated Inflammation

Esther Nolte-'t Hoen, Utrecht University, Netherlands
Viral and Host Mechanisms Driving the Release of EV-Enclosed Picornaviruses

Coffee Break

Tanina Arab, Johns Hopkins University, USA
Short Talk: EV Packaging of U6 Small Nuclear RNA in SIV Infection

Daniel C. Rabe, Massachusetts General Hospital, USA
Short Talk: Microfluidic Detection of SARS-CoV-2 and Virus-Related Extracellular Vesicles to Predict Outcome in COVID-19 Patients

Aadil Sheikh, Baylor University, USA
Short Talk: Bacteria-Derived Outer Membrane Vesicles Contain Unique Small RNA Species and Interact with Host Cells

Danilo Rodrigues da Silva, University of Florida, USA
Short Talk: Mammalian Cell Internalization of Lactobacillus Johnsonii N6.2 Derived Nanovesicles Induce Upregulation of Cellular Immune Response

On Own for Lunch

Coffee Available

Novel Technological Developments (5:00-6:45 PM)

Eldorado A
* Alissa M. Weaver, Vanderbilt University School of Medicine, USA

Jennifer C. Jones, NCI, National Institutes of Health, USA
Remote Presentation: New Approaches to Individual EV Assays and EV Repertoire Studies

Chioma Okeoma, Stony Brook University, USA
Novel Technology for Nano-particle Isolation

Thomas Gaborrski, Rochester Institute of Technology, USA
Short Talk: Development of Nanopocket Membranes for the Purification and Fractionation of Extracellular Vesicle Subpopulations

Qin Zhang, Vanderbilt University Medical Center, USA
Short Talk: Supermeres are Functional Extracellular Nanoparticles Replete with Disease Biomarkers and Therapeutic Targets

Olesia Gololobova, Johns Hopkins University, USA
Short Talk: Asymmetric Flow Field-Flow Fractionation for Separation and Characterization of exRNA Carriers: Blood Plasma Lipoproteins and Extracellular Vesicles

Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Eldorado A
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Eldorado B



*Session Chair †Invited, not yet responded.

Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

Chinese Society for Cell Biology, (Cell Research) Ionis Pharmaceuticals, Inc.
Moderna Takeda Pharmaceutical Company Limited
Ultragenyx Pharmaceutical Inc.

We gratefully acknowledge additional support from these exhibitors at this conference:

BioLegend, Inc. Izon Science
Please stop by to meet these exhibitors during the conference.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1 R13 CA257245-01

Funding for this conference was made possible (in part) by 1R13CA257245-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge additional support for this conference from:

AdipoGen Life Sciences NanoFCM Co., Ltd
Science Signaling / AAAS

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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