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This meeting took place in 2008
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Structural Biology and Activation Mechanisms of Membrane Receptors (S1)
Organizer(s) Pierre De Meyts, Briony E. Forbes and Tom L. Blundell
September 16—21, 2008
St. John's College - Cambridge • University of Cambridge, Cambridge UK
Abstract Deadline: Jun 17, 2008
Late Abstract Deadline: Jul 17, 2008
Scholarship Deadline: May 15, 2008
Early Registration Deadline: Jul 17, 2008
Supported by the Directors' Fund
Summary of Meeting:
Considerable progress has been made in understanding the structure and function of membrane receptors and receptor signaling complexes since the first radioligand binding studies nearly four decades ago. The structures of the extracellular domains of many receptors in diverse classes are now available. However, the structural data have not always provided unambiguous information as to what the relevant physiological structure is or the precise nature of the binding and activation mechanism. To get the full picture, it is necessary to integrate structural information, biochemical and molecular biology approaches such as site-directed mutagenesis, photoaffinity crosslinking and bioluminescence resonance energy transfer, kinetics, and mathematical modeling. This symposium brings together experts in these various disciplines, both seasoned and fresh, for an open-minded debate on how to realize this integrative approach. A strong theme of the meeting is that there are more similarities than previously estimated between the mechanisms of activation of various classes of receptors. The study of the biological evolution of the ligand and receptor families and signal transduction mechanisms also provides key information on highly conserved modules. Finally, the promises and challenges in translating our knowledge of the structural biology of membrane receptor signaling to drug discovery will be discussed.
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Considerable progress has been made in understanding the structure and function of membrane receptors and receptor signaling complexes since the first radioligand binding studies nearly four decades ago. The structures of the extracellular domains of many receptors in diverse classes are now available. However, the structural data have not always provided unambiguous information as to what the relevant physiological structure is or the precise nature of the binding and activation mechanism. To get the full picture, it is necessary to integrate structural information, biochemical and molecular biology approaches such as site-directed mutagenesis, photoaffinity crosslinking and bioluminescence resonance energy transfer, kinetics, and mathematical modeling. This symposium brings together experts in these various disciplines, both seasoned and fresh, for an open-minded debate on how to realize this integrative approach. A strong theme of the meeting is that there are more similarities than previously estimated between the mechanisms of activation of various classes of receptors. The study of the biological evolution of the ligand and receptor families and signal transduction mechanisms also provides key information on highly conserved modules. Finally, the promises and challenges in translating our knowledge of the structural biology of membrane receptor signaling to drug discovery will be discussed.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, SEPTEMBER 16
WEDNESDAY, SEPTEMBER 17
THURSDAY, SEPTEMBER 18
FRIDAY, SEPTEMBER 19
SATURDAY, SEPTEMBER 20
SUNDAY, SEPTEMBER 21
Conference Program Print | View meeting in 12 hr (am/pm) time
TUESDAY, SEPTEMBER 16
15:00—19:30
Registration
Palmerston Foyer
18:30—19:30
Refreshments
Palmerston Foyer
19:30—21:30
Keynote Session
Palmerston
Michael C. Lawrence,
Walter and Eliza Hall Institute of Medical Research, Australia
Structural Insights into Ligand Binding in the Insulin Receptor Family
Structural Insights into Ligand Binding in the Insulin Receptor Family
Brian K. Kobilka,
Stanford University School of Medicine, USA
Structure and Dynamics of the Human beta 2 Adrenergic Receptor
Structure and Dynamics of the Human beta 2 Adrenergic Receptor
07:30—08:30
Breakfast
The Buttery
07:30—11:30
Poster Setup
Castlereigh/Foyer
08:30—11:30
Structural Biology of Ligands and Receptors of the Insulin/IGF Peptide Families
Ballroom 3
*
Tom L. Blundell,
University of Cambridge, UK
Michael A. Weiss,
Case Western Reserve University, USA
How Insulin Binds: Studies with Photoaffinity Crosslinking
How Insulin Binds: Studies with Photoaffinity Crosslinking
Jonathan Whittaker,
Case Western Reserve University, USA
Insights into Insulin and IGF-I Ligand-Receptor Interactions from Mutational Analysis
Insights into Insulin and IGF-I Ligand-Receptor Interactions from Mutational Analysis
Briony E. Forbes,
University of Adelaide, Australia
IGF Structural Determinants Involved in Receptor and Binding Protein Binding
IGF Structural Determinants Involved in Receptor and Binding Protein Binding
Yvonne Yvonne Jones,
University of Oxford, UK
Crystal Structure of the IGF-II/Mannose-6-Phosphate Receptor Complex
Crystal Structure of the IGF-II/Mannose-6-Phosphate Receptor Complex
09:40—10:00
Coffee Break
Palmerston Foyer
11:30—12:30
Lunch
The Hall
12:30—14:30
Poster Session 1
Castlereigh/Foyer
14:30—16:30
Workshop 1: New Structures or Structural Aspects
Ballroom 3
Brian M. Baker,
University of Notre Dame, USA
T Cell Receptor Cross-Reactivity via Cooperative Conformational Plasticity
T Cell Receptor Cross-Reactivity via Cooperative Conformational Plasticity
*
Tim R. Hercus,
University of South Australia and SA Pathology, Australia
The Structure of the GM-CSF Receptor Complex Reveals a New Mode of Cytokine Receptor Activation
The Structure of the GM-CSF Receptor Complex Reveals a New Mode of Cytokine Receptor Activation
Jonathan K. Tyzack†,
Trends in Biochemical Sciences, UK
Dragging (and Zooming and Rotating) Publication of 3D Molecular Structures into the 21st Century
Dragging (and Zooming and Rotating) Publication of 3D Molecular Structures into the 21st Century
Marie Parat,
University of Montreal, Canada
Molecular Analysis of Natriuretic Peptide Receptor: A Transmembrane Signal Transduction
Molecular Analysis of Natriuretic Peptide Receptor: A Transmembrane Signal Transduction
Lennart Zabeau,
Ghent University, Belgium
A Model for a Hexameric 2:4 Leptin:Leptin Receptor Complex
A Model for a Hexameric 2:4 Leptin:Leptin Receptor Complex
16:30—17:00
Coffee Available
Palmerston Foyer
17:00—19:00
Evolution of the Insulin/IGF Receptor Systems
Ballroom 3
*
Donald F. Steiner,
University Of Chicago, USA
Pierre De Meyts,
Hagedorn Research Institute, Novo Nordisk A/S, Denmark
Structure, Function and Evolution of Ligands and Receptors of the Insulin Peptide Family
Structure, Function and Evolution of Ligands and Receptors of the Insulin Peptide Family
Shu-Jin Chan,
University Of Chicago, USA
Where Insulin Binds: Mapping Contact Points in the Insulin:Insulin Receptor Complex
Where Insulin Binds: Mapping Contact Points in the Insulin:Insulin Receptor Complex
Robert S. Garofalo,
, USA
Insulin Receptors and Signaling in Drosophila
Insulin Receptors and Signaling in Drosophila
19:00
On Own for Dinner
07:30—08:30
Breakfast
The Buttery
08:30—11:30
From Receptor Structure to Activation Mechanism
Ballroom 3
*
Joseph Schlessinger,
Yale University School of Medicine, USA
Cell Signaling by Receptor Tyrosine Kinases: From Basic Principles to Cancer Therapy
Cell Signaling by Receptor Tyrosine Kinases: From Basic Principles to Cancer Therapy
Michael J. Waters,
University of Queensland, Australia
The Mechanism of Growth Hormone Receptor Activation Revisited
The Mechanism of Growth Hormone Receptor Activation Revisited
Krzysztof Palczewski,
Case Western Reserve University, USA
Oligomerization and Activation of GPCRs: Insights from Rhodopsin Structures
Oligomerization and Activation of GPCRs: Insights from Rhodopsin Structures
Wayne A. Hendrickson,
Columbia University, USA
Dimeric Associations in G-Protein Coupled Receptors
Dimeric Associations in G-Protein Coupled Receptors
09:40—10:00
Coffee Break
Palmerston Foyer
11:30
On Own for Lunch
16:30—17:00
Coffee & Snacks Available
Palmerston Foyer
17:00—19:00
The Proximal Steps of Receptor Activation and Signaling
Ballroom 3
*
Kenneth Siddle,
University of Cambridge, UK
Linda J. Pike,
Washington University School of Medicine, USA
Negative Cooperativity in EGF Receptor Signaling
Negative Cooperativity in EGF Receptor Signaling
Stevan R. Hubbard,
New York University School of Medicine, USA
Mechanisms of Protein Recruitment to the Insulin Receptor
Mechanisms of Protein Recruitment to the Insulin Receptor
Tarik Issad,
Institut Cochin-Institute de Recherches Biomédicales, France
Dynamics of Insulin and IGF-I Receptor Partnerships using BRET (Bioluminescence Resonance Energy Transfer)
Dynamics of Insulin and IGF-I Receptor Partnerships using BRET (Bioluminescence Resonance Energy Transfer)
19:00
On Own for Dinner
07:30—08:30
Breakfast
The Buttery
07:30—11:30
Poster Setup
Castlereigh/Foyer
08:30—11:30
Structure, Function and Crosstalk of G-Protein-Coupled Receptors (GPCRs)
Ballroom 3
Robert J. Lefkowitz,
HHMI/Duke University Medical Center, USA
beta-Arrestin Biased Agonism at Seven Transmembrane Receptors
beta-Arrestin Biased Agonism at Seven Transmembrane Receptors
Ross A.D. Bathgate,
University of Melbourne, Australia
Structural Relationships of the INSL/Relaxin Ligands and their G-Protein Coupled Receptors
Structural Relationships of the INSL/Relaxin Ligands and their G-Protein Coupled Receptors
Sabine Costagliola,
IRIBHM-Université libre de Bruxelles, Belgium
Functional Significance of Oligomerization and Negative Cooperativity in Glycoprotein Hormone Receptors
Functional Significance of Oligomerization and Negative Cooperativity in Glycoprotein Hormone Receptors
Ilpo Huhtaniemi,
Imperial College London, UK
In vivo Validation of LH Receptor Dimerization by Complementation in Knockout Mice
In vivo Validation of LH Receptor Dimerization by Complementation in Knockout Mice
09:40—10:00
Coffee Break
Palmerston Foyer
11:30—12:30
Lunch
The Hall
12:30—14:30
Poster Session 2
Castlereigh/Foyer
14:30—16:30
Workshop 2: New Methodological Approaches
Ballroom 3
*
Fariba M. Assadi-Porter,
University of Wisconsin-Madison, USA
Direct NMR Detection of the Binding of Functional Ligands to the Human Sweet Receptor, a Heterodimeric Family 3 GPCR
Direct NMR Detection of the Binding of Functional Ligands to the Human Sweet Receptor, a Heterodimeric Family 3 GPCR
Helen L. Attrill,
University of Oxford, UK
Characterising The Multimerization Of The Neurotensin Receptor Type I In Model Lipid Membrane Bilayers
Characterising The Multimerization Of The Neurotensin Receptor Type I In Model Lipid Membrane Bilayers
Nancy E. Caceres,
Ludgwig Institute for Cancer Research, Belgium
Investigating the Stoichiometry of the Active G-CSF Receptor (G-CSFR) Complex by Testing the Activity of coiled coil-G-CSFR Fusion Proteins
Investigating the Stoichiometry of the Active G-CSF Receptor (G-CSFR) Complex by Testing the Activity of coiled coil-G-CSFR Fusion Proteins
Anja Krippner-Heidenreich,
University of Newcastle, UK
Efficient Activation of the Tumour Necrosis Factor (TNF) Receptor is Highly Determined by the Stalk Region
Efficient Activation of the Tumour Necrosis Factor (TNF) Receptor is Highly Determined by the Stalk Region
Philippe Rondard,
Institut de Génomique Fonctionnelle, France
Molecular Functioning of the GABAB Receptor Revealed by Glycan Wedge Scanning
Molecular Functioning of the GABAB Receptor Revealed by Glycan Wedge Scanning
Johannes van Agthoven,
Biological NMR and Crystallography, France
The Stoichiometry and Stability of the Prolactin/Prolactin Receptor Complex is Influenced by its N-Terminus
The Stoichiometry and Stability of the Prolactin/Prolactin Receptor Complex is Influenced by its N-Terminus
16:30—17:00
Coffee Available
Palmerston Foyer
17:00—19:00
From Receptor Activation to Signal Transduction: Quantitative Approaches
Ballroom 3
*
Ralph A. Bradshaw,
, USA
Blagoy Blagoev,
University of Southern Denmark, Denmark
Quantitative Proteomics: Analysis of Signal Transduction Networks
Quantitative Proteomics: Analysis of Signal Transduction Networks
James Faeder,
University of Pittsburgh School of Medicine, USA
Structure-Based Modeling of EGF Receptor Signal Transduction
Structure-Based Modeling of EGF Receptor Signal Transduction
Yuko Saeki,
RIKEN, Genomic Sciences Center, Japan
Crosstalk between Signaling and Transcription Produces Switch-like Response in ErbB Receptor Network
Crosstalk between Signaling and Transcription Produces Switch-like Response in ErbB Receptor Network
19:00
On Own for Dinner
07:30—08:30
Breakfast
The Buttery
08:30—11:30
Challenges in Structural Biology of Membrane Receptors
Ballroom 3
*
Wayne A. Hendrickson,
Columbia University, USA
Gebhard F. X. Schertler,
Paul Scherrer Institut, Switzerland
Structure of a Conformationally Stabilized beta1 Adrenergic G Protein-Coupled Receptor
Structure of a Conformationally Stabilized beta1 Adrenergic G Protein-Coupled Receptor
Ulf Skoglund,
Karolinska Institutet, Sweden
Studies on Proteins, Membrane Proteins and Receptors using Molecular Electron Tomography
Studies on Proteins, Membrane Proteins and Receptors using Molecular Electron Tomography
Milka Vrecl,
Univerza v Ljubljani, Slovenia
The Use of Bioluminescence Resonance Energy Transfer 2 (BRET2) to Study G-Protein-Coupled Receptor (GPCR) Partner Interactions
The Use of Bioluminescence Resonance Energy Transfer 2 (BRET2) to Study G-Protein-Coupled Receptor (GPCR) Partner Interactions
Marisa Martin-Fernandez,
Daresbury Laboratory, UK
ErbB1 Inside-Out Signalling Regulates Global Ectodomain Orientation and Oligomer Topology
ErbB1 Inside-Out Signalling Regulates Global Ectodomain Orientation and Oligomer Topology
09:40—10:00
Coffee Break
Palmerston Foyer
11:30
On Own for Lunch
16:30—17:00
Coffee & Snacks Available
Palmerston Foyer
17:00—19:00
Receptor Structural Biology and Drug Discovery
Ballroom 3
Maja Jensen,
Plougmann and Vingtoft, Denmark
Allosteric and Biological Properties of Insulin Mimetic and Antagonist Peptides Targeting the Insulin Receptor Binding Sites
Allosteric and Biological Properties of Insulin Mimetic and Antagonist Peptides Targeting the Insulin Receptor Binding Sites
*
Alexander Levitzky,
Alexander Silberman Institute of Life Sciences, Israel
Developments in Signal Transduction Therapy of Cancer
Developments in Signal Transduction Therapy of Cancer
Tom L. Blundell,
University of Cambridge, UK
Targeting Membrane Receptors and Signalling Systems for Drug Discovery
Targeting Membrane Receptors and Signalling Systems for Drug Discovery
19:00—19:30
Social Hour
The Hall
19:30—20:30
Dinner
The Hall
20:00—23:00
Entertainment
The Hall
Departure
*Session Chair †Invited, not yet responded.
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