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This meeting took place in 2010
Here are the related meetings in 2020:
Obesity and NAFLD: Mechanisms and Therapeutics (B3)
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Adipose Tissue Biology (J3)
Organizer(s) Sheila Collins, Karsten Kristiansen and Silvia Corvera
January 24—29, 2010
Keystone Resort • Keystone, CO USA
Abstract Deadline: Sep 23, 2009
Late Abstract Deadline: Oct 23, 2009
Scholarship Deadline: Sep 23, 2009
Early Registration Deadline: Nov 24, 2009
Supported by The Directors' Fund
Joint Meeting:
Neuronal Control of Appetite, Metabolism and Weight (J4)
Summary of Meeting:
The study of adipose tissue has evolved over the years from merely being a passing note in most physiology texts to now playing center stage in the etiology of most metabolic diseases. This shift was assisted by early studies exploring the molecular signals and gene expression changes that dictate the differentiated state of a cell, for which the adipocyte was a model. Such studies led to the discovery of PPARgamma as one of those key regulators of adipogenesis, and later the realization that it was the pharmacologic target of the glitazone class of anti-diabetic agents. Further seminal studies from The Jackson Laboratories on mouse genetics of obesity paved the way for the discovery of adipocyte-derived regulatory hormones (“adipokines”) such as leptin and its receptor. These in turn ushered in the current state of vigorous investigation dissecting the molecular pathways of satiety and other aspects of signaling cross-talk between adipose tissue and other organs. The updated view of adipose tissue as a bona fide endocrine organ has been further extended to include it as a potential reservoir of stem cells for tissue engineering and an integral player in inflammatory status and insulin resistance. This meeting will cover these and other topics of the adipose biology field, including the role of angiogenesis in adipose tissue expansion; the white fat-brown fat debate; the contribution of the circadian clock to the hormonal and neural signals that coordinate food intake and activity for metabolic balance; and the connections between central and peripheral signals involved in the unanticipated lipodystrophic disorders resulting from such therapeutic regimens as antipsychotics and anti-retrovirals. A series of hot-topic sessions and short talks from submitted abstracts are also planned.
View Scholarships/Awards
The study of adipose tissue has evolved over the years from merely being a passing note in most physiology texts to now playing center stage in the etiology of most metabolic diseases. This shift was assisted by early studies exploring the molecular signals and gene expression changes that dictate the differentiated state of a cell, for which the adipocyte was a model. Such studies led to the discovery of PPARgamma as one of those key regulators of adipogenesis, and later the realization that it was the pharmacologic target of the glitazone class of anti-diabetic agents. Further seminal studies from The Jackson Laboratories on mouse genetics of obesity paved the way for the discovery of adipocyte-derived regulatory hormones (“adipokines”) such as leptin and its receptor. These in turn ushered in the current state of vigorous investigation dissecting the molecular pathways of satiety and other aspects of signaling cross-talk between adipose tissue and other organs. The updated view of adipose tissue as a bona fide endocrine organ has been further extended to include it as a potential reservoir of stem cells for tissue engineering and an integral player in inflammatory status and insulin resistance. This meeting will cover these and other topics of the adipose biology field, including the role of angiogenesis in adipose tissue expansion; the white fat-brown fat debate; the contribution of the circadian clock to the hormonal and neural signals that coordinate food intake and activity for metabolic balance; and the connections between central and peripheral signals involved in the unanticipated lipodystrophic disorders resulting from such therapeutic regimens as antipsychotics and anti-retrovirals. A series of hot-topic sessions and short talks from submitted abstracts are also planned.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, JANUARY 24
MONDAY, JANUARY 25
TUESDAY, JANUARY 26
WEDNESDAY, JANUARY 27
THURSDAY, JANUARY 28
FRIDAY, JANUARY 29
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, JANUARY 24
19:30—20:30
Keynote Address (Joint)
Jeffrey M. Friedman,
Rockefeller University, USA
Leptin’s Loop: Dissecting the Physiologic Systems Regulating Food Intake and Metabolism
Leptin’s Loop: Dissecting the Physiologic Systems Regulating Food Intake and Metabolism
08:00—11:15
Circadian Control of Adiposity and Metabolism (Joint)
*
Martin G. Myers, Jr.,
University of Michigan, USA
Joseph T. Bass,
Northwestern University, USA
Clock and Per: Gene Network Controls on Metabolism/Adiposity
Clock and Per: Gene Network Controls on Metabolism/Adiposity
Julian Mercer,
Rowett Research Institute, UK
Effect of Rhythms, Diet and Feeding Patterns on Hypothalamic Gene Expression
Effect of Rhythms, Diet and Feeding Patterns on Hypothalamic Gene Expression
Georgios Paschos,
University of Pennsylvania, USA
Short Talk: Obesity in Mice with Adipose Tissue-Specific Deletion of Bmal1
Short Talk: Obesity in Mice with Adipose Tissue-Specific Deletion of Bmal1
Clifford J. Rosen,
Maine Medical Center, USA
Short Talk: Nocturnin, a Circadian Clock Gene, Stimulates Adipogenesis by Promoting Nuclear Transport of PPARgamma
Short Talk: Nocturnin, a Circadian Clock Gene, Stimulates Adipogenesis by Promoting Nuclear Transport of PPARgamma
11:15—11:30
NIDDK Discussion of Funding Issues
Philip F. Smith,
NIDDK, National Institutes of Health, USA
17:00—19:15
Angiogenesis and Adipose Mass: Factors and Regulation
*
Anna Krook,
Karolinska Institutet, Sweden
Silvia Corvera,
University of Massachusetts Medical School, USA
Adipose Tissue Angiogenesis and the Development of Insulin Resistant in Human
Adipose Tissue Angiogenesis and the Development of Insulin Resistant in Human
H. Roger Lijnen,
University of Leuven, Belgium
Roles of MMPs in Development of Adipose Tissue
Roles of MMPs in Development of Adipose Tissue
Zofia Zukowska,
University of Minnesota, USA
Neurogenic Regulation of Angiogenesis and adipogenesis – Role of Neuropeptid Y
Neurogenic Regulation of Angiogenesis and adipogenesis – Role of Neuropeptid Y
Dong-Hoon Kim,
University of Cincinnati, USA
Short Talk: Differential Adipose Tissue Remodeling Related to Angiogenesis and Inflammation in Young Obesity-Prone C57Bl/6 Mice and Obesity-Resistant FVB/N Mice
Short Talk: Differential Adipose Tissue Remodeling Related to Angiogenesis and Inflammation in Young Obesity-Prone C57Bl/6 Mice and Obesity-Resistant FVB/N Mice
James E. Minchin,
Duke University, USA
Short Talk: Real-Time Imaging of Adipose Depot Morphogenesis in Zebrafish
Short Talk: Real-Time Imaging of Adipose Depot Morphogenesis in Zebrafish
17:00—19:00
Molecular Programming of Hypothalamic Circuitry
Joel K. Elmquist,
University of Texas Southwestern Medical Center, USA
Cellular and Molecular Mechanisms Regulating Energy Balance and Glucose Homeostasis
Cellular and Molecular Mechanisms Regulating Energy Balance and Glucose Homeostasis
Richard B. Simerly,
Vanderbilt University, USA
Hormonal Specification of Hypothalamic Connectivity
Hormonal Specification of Hypothalamic Connectivity
Yi-Chun Loraine Tung,
University of Cambridge Metabolic Research Laboratories, UK
Short Talk: Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats
Short Talk: Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats
08:00—11:15
Fat (R)evolution - The Brown vs. White Fat Debate
Bruce M. Spiegelman,
Harvard Medical School, USA
Obesity-Linked Phosphorylation of PPARgamma by cdk5 Causes Fat Cell Gene Dysregulation and Is a Direct Target of the Anti-Diabetic PPARgamma Ligand
Obesity-Linked Phosphorylation of PPARgamma by cdk5 Causes Fat Cell Gene Dysregulation and Is a Direct Target of the Anti-Diabetic PPARgamma Ligand
Karsten Kristiansen,
University of Copenhagen, Denmark
Single Gene Mutations that Promote Brown Adipocyte Differentiation
Single Gene Mutations that Promote Brown Adipocyte Differentiation
Marika Charalambous,
Queen Mary University of London, UK
Short Talk: Impaired Thermogenesis and Persistent Hypothyroidism caused by Altered Dosage of Imprinted Genes
Short Talk: Impaired Thermogenesis and Persistent Hypothyroidism caused by Altered Dosage of Imprinted Genes
Yu-Hua Tseng,
Joslin Diabetes Center/Harvard Medical School, USA
Short Talk: Identification of Brown Fat Progenitors in Mouse Skeletal Muscle
Short Talk: Identification of Brown Fat Progenitors in Mouse Skeletal Muscle
08:00—11:15
Nutrient Sensing in the Brain
*
Roger D. Cone,
University of Michigan, USA
Martin G. Myers, Jr.,
University of Michigan, USA
Neuromodulators of Leptin Action
Neuromodulators of Leptin Action
Michael Rosenbaum,
Columbia University Medical College, USA
Leptin and Energy Homeostasis in Humans
Leptin and Energy Homeostasis in Humans
Tamas L. Horvath,
Yale School of Medicine, USA
Fuel Utilization by Neurons: A Determinant of “Nutrient Sensing"
Fuel Utilization by Neurons: A Determinant of “Nutrient Sensing"
Dong Kong,
Tufts University School of Medicine, USA
Short Talk: Glucose Sensing by MCH Neurons Regulates Glucose Homeostasis and is Inhibited by UCP2
Short Talk: Glucose Sensing by MCH Neurons Regulates Glucose Homeostasis and is Inhibited by UCP2
Hong Wang,
University of Colorado Health Science Center, USA
Short Talk: Neuron-Specific Lipoprotein Lipase Deficiency Perturbs the Regulation of Energy Balance and Leads to Obesity by Modifying the Expression of the Orexigenic Neuropeptides AgRP and NPY
Short Talk: Neuron-Specific Lipoprotein Lipase Deficiency Perturbs the Regulation of Energy Balance and Leads to Obesity by Modifying the Expression of the Orexigenic Neuropeptides AgRP and NPY
14:30—16:30
Workshop 1: New Aspects of Adipogenesis, Lipid Droplets and Triglyceride Metabolism
Cristina M. Rondinone,
Cellarity Inc., USA
Introductory 'In Memoriam' for Dean Londos
Introductory 'In Memoriam' for Dean Londos
Chris E. Lowe,
Horizon Discovery Ltd, UK
The ATF6alpha Pathway of the Unfolded Protein Response is Required for Adipogenesis
The ATF6alpha Pathway of the Unfolded Protein Response is Required for Adipogenesis
Ana G. Cristancho,
University of Pennsylvania School of Medicine, USA
Transcription Factor 7-like 1 (TCF7L1) is required for PPARgamma2 Expression during Adipogenesis
Transcription Factor 7-like 1 (TCF7L1) is required for PPARgamma2 Expression during Adipogenesis
Susanne Mandrup,
University of Southern Denmark, Denmark
MED14 Tethers the Mediator to the N-Terminal Domain of PPARgamma and is Required for Full Transcriptional Activity and Adipogenesis
MED14 Tethers the Mediator to the N-Terminal Domain of PPARgamma and is Required for Full Transcriptional Activity and Adipogenesis
Charles Harris,
Gladstone Institute for Cardiovascular Disease, USA
DGAT Enzymes Are Required for Triglyceride Synthesis and Lipid Droplet Formation But Not for Other Aspects of Adipogenesis
DGAT Enzymes Are Required for Triglyceride Synthesis and Lipid Droplet Formation But Not for Other Aspects of Adipogenesis
Cynthia Smas,
University of Toledo, USA
Functional Analysis of FSP27 Protein Regions for Lipid Droplet Localization, Caspase-Dependent Apoptosis and Dimerization with CIDEA
Functional Analysis of FSP27 Protein Regions for Lipid Droplet Localization, Caspase-Dependent Apoptosis and Dimerization with CIDEA
Lise Madsen†,
University of Copenhagen, Denmark
Transdifferentiation of White into Brown Adipose Tissue Requires Cyclooxygenases
Transdifferentiation of White into Brown Adipose Tissue Requires Cyclooxygenases
17:00—19:15
Insights from Model Organisms (Joint)
*
Karsten Kristiansen,
University of Copenhagen, Denmark
Roger D. Cone,
University of Michigan, USA
Biological Functions of AgRP and AgRP2 in Zebrafish
Biological Functions of AgRP and AgRP2 in Zebrafish
Sri Devi Narasimhan,
Cell Press, USA
Identifying Phosphatases that Modulate the Insulin/IGF-1 Signaling Pathway
Identifying Phosphatases that Modulate the Insulin/IGF-1 Signaling Pathway
Sean M. Oldham,
Takeda Pharmaceuticals International Co., USA
Role of Nutrient Sensing TOR Pathway in High Fat Diet-induced Signaling Pathway and aging
Role of Nutrient Sensing TOR Pathway in High Fat Diet-induced Signaling Pathway and aging
Biao Wang,
The Salk Institute, USA
Short Talk: Drosophila Salt Inducible Kinase (SIK) in Fat Metabolism
Short Talk: Drosophila Salt Inducible Kinase (SIK) in Fat Metabolism
Christine Hausen,
Institute for Genetics, University of Cologne, Germany
Short Talk: Conserved Role for Insulin Receptor Signaling in Catecholaminergic Cells in Control of Energy Homeostasis
Short Talk: Conserved Role for Insulin Receptor Signaling in Catecholaminergic Cells in Control of Energy Homeostasis
08:00—11:15
Immune Signals and Energy Homeostasis/Body Composition (Joint)
*
Randy J. Seeley,
University of Michigan, USA
Steven E. Shoelson,
Harvard Medical School, Joslin Diabetes Center, USA
Obesity, Inflammation and Insulin Resistance (Basic and Clinical Issues)
Obesity, Inflammation and Insulin Resistance (Basic and Clinical Issues)
Ajay Chawla,
Merck and University of California, San Francisco, USA
Immune Regulation of Nutrient Metabolism and Aging
Immune Regulation of Nutrient Metabolism and Aging
Carey N. Lumeng,
University of Michigan, USA
Short Talk: MGL1 Promotes Adipose Tissue Inflammation and Insulin Resistance by Regulating 7/4hi Monocytes in Obesity
Short Talk: MGL1 Promotes Adipose Tissue Inflammation and Insulin Resistance by Regulating 7/4hi Monocytes in Obesity
Umut Ozcan,
Harvard Medical School, USA
The ER Stress and Leptin Resistance
The ER Stress and Leptin Resistance
Daniel L. Marks,
Oregon Health & Science University, USA
The Role of Central Melanocortin’s in Cachexia
The Role of Central Melanocortin’s in Cachexia
Jose M. Garcia,
Baylor College of Medicine, USA
Short Talk: The Effects of Peripheral Ghrelin Administration on the Lipid Metabolism are Primarily Mediated through Changes in Food Intake in a Model of Cachexia
Short Talk: The Effects of Peripheral Ghrelin Administration on the Lipid Metabolism are Primarily Mediated through Changes in Food Intake in a Model of Cachexia
17:00—19:00
Bariatric Surgery and the Treatment of Metabolic Disease
John W. Newcomer,
Washington University School of Medicine, USA
Francesco Rubino,
Weill Cornell Medical College, USA
Resolution of Diabetes and Bariatric Surgery
Resolution of Diabetes and Bariatric Surgery
Paul O'Brien,
Monash University, Australia
Appetite Control and Bariatric Surgery
Appetite Control and Bariatric Surgery
Randy J. Seeley,
University of Michigan, USA
Bariatric Surgery: Beyond Restriction and Malabsorption
Bariatric Surgery: Beyond Restriction and Malabsorption
Thomas Alexander Lutz,
University of Zürich, Switzerland
Short Talk: Roux-en-Y Gastric Bypass Increases Energy Expenditure Affects Taste Preference and Impairs Bone Structure Rats
Short Talk: Roux-en-Y Gastric Bypass Increases Energy Expenditure Affects Taste Preference and Impairs Bone Structure Rats
Jocelyne Magré,
INSERM, France
Genetics of Congenital Generalized Lipodystrophy
Genetics of Congenital Generalized Lipodystrophy
08:00—11:15
Adipose Stem Cells: Biology and Application (Bone Marrow vs. Adipose Tissue; Characteristics/Signaling that Promote their Differentiation; Plastics/Reconstructive, Tissue Engineering Aspects)
Hei Sook Sul,
University of California, Berkeley, USA
Pref-1: Role in Adipogenesis and Mesenchymal Cell Fate
Pref-1: Role in Adipogenesis and Mesenchymal Cell Fate
Rei Ogawa,
Nippon Medical School, Japan
Application of Adipose Stem Cells for Plastic Surgery - In Particular about Cartilage Regeneration
Application of Adipose Stem Cells for Plastic Surgery - In Particular about Cartilage Regeneration
Ormond A. MacDougald,
University of Michigan, USA
Role of Wnt Signaling in the Regulation of Adipocyte Differentiation
Role of Wnt Signaling in the Regulation of Adipocyte Differentiation
Zoubir E. Amri,
INSERM U470, France
Short Talk: Human Multipotent Adipose-Derived Stem Cells Differentiate into Functional Brown Adipocytes
Short Talk: Human Multipotent Adipose-Derived Stem Cells Differentiate into Functional Brown Adipocytes
Daniel R. Zeve,
University of Texas Southwestern Medical Center at Dallas, USA
Short Talk: Defining Developmentally Important Genes within the White Adipose Progenitor Cells
Short Talk: Defining Developmentally Important Genes within the White Adipose Progenitor Cells
Maryam Ahmadian,
The Salk Institute, USA
Short Talk: Adipose-Specific Phospholipase A2 (AdPLA) Ablation Prevents Diet-Induced and Genetic Obesity: A Novel Lipodystrophy Model
Short Talk: Adipose-Specific Phospholipase A2 (AdPLA) Ablation Prevents Diet-Induced and Genetic Obesity: A Novel Lipodystrophy Model
08:00—11:15
Thinking Outside of the Hypothalamus
*
Daniel L. Marks,
Oregon Health & Science University, USA
Marta Korbonits,
Barts and The London, Queen Mary's School of Medicine and Dentistry, UK
Cross-Talk of Endocannabinoids and Ghrelin
Cross-Talk of Endocannabinoids and Ghrelin
Darren Opland,
University of Michigan, USA
Short Talk: VTA Leptin Receptor Neurons Specifically Project to and Regulate CART Neurons of the Extended Central Amygdala
Short Talk: VTA Leptin Receptor Neurons Specifically Project to and Regulate CART Neurons of the Extended Central Amygdala
Alastair V. Ferguson,
Queen's University, Canada
Sensory Circumventricular Organs: Integrative Control Centers Regulating Energy Balance?
Sensory Circumventricular Organs: Integrative Control Centers Regulating Energy Balance?
Hans Rudolf Berthoud,
Pennington Biomedical Research Center, USA
Hedonic, Emotional, Cognitive, and Metabolic Controls of Appetite and Energy Balance: Who is The Boss?
Hedonic, Emotional, Cognitive, and Metabolic Controls of Appetite and Energy Balance: Who is The Boss?
Lora K. Heisler,
Rowett Institute, University of Aberdeen, UK
Serotonin Influences Melanocortin Pathways to Affect Energy Balance
Serotonin Influences Melanocortin Pathways to Affect Energy Balance
Matthew R. Hayes,
University of Pennsylvania, USA
Short Talk: Endogenous Leptin Signaling in the NTS is Required for Energy Balance Regulation
Short Talk: Endogenous Leptin Signaling in the NTS is Required for Energy Balance Regulation
17:00—19:15
Drug Development: Treating the Brain and Beyond (Joint)
Eduardo Dunayevich,
Amgen, USA
The Combination of Bupropion and Naltrexone in the Treatment of Obesity: From Bench to Pivotal Trials
The Combination of Bupropion and Naltrexone in the Treatment of Obesity: From Bench to Pivotal Trials
Donald J. Marsh,
Merck Research Laboratories, USA
New Neuropeptide Target Systems: Neuromedin U
New Neuropeptide Target Systems: Neuromedin U
Michael Culler,
Ipsen/Biomeasure, USA
Novel Peptide Ligands of the Melanocortin Type 4 Receptor for the Treatment of Obesity and Metabolic Disease
Novel Peptide Ligands of the Melanocortin Type 4 Receptor for the Treatment of Obesity and Metabolic Disease
Lee M. Kaplan,
Massachusetts General Hospital, USA
Short Talk: Roux-en-Y Bypass Stimulates BAT Activity and Central Control Thermogenesis in Mice
Short Talk: Roux-en-Y Bypass Stimulates BAT Activity and Central Control Thermogenesis in Mice
Alan Koncarevic,
Acceleron Pharma, USA
Short Talk: Induction of a Thermogenic Program in White Adipose Tissue of HFD-Fed Mice Treated with a Soluble ActRIIB
Short Talk: Induction of a Thermogenic Program in White Adipose Tissue of HFD-Fed Mice Treated with a Soluble ActRIIB
*Session Chair †Invited, not yet responded.
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