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This meeting took place in 2010
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New Insights into Healthspan and Diseases of Aging: From Molecular to Functional Senescence (B2)
Organizer(s) Sean M. Oldham, David A. Sinclair, Jan Vijg and Heidi Scrable
January 31—February 5, 2010
Granlibakken Tahoe • Tahoe City, CA USA
Abstract Deadline: Sep 24, 2009
Late Abstract Deadline: Oct 30, 2009
Scholarship Deadline: Sep 24, 2009
Early Registration Deadline: Nov 30, 2009
Supported by The Directors' Fund
Summary of Meeting:
Aging can be defined as the gradual loss of the ability of the organism to maintain homeostasis. Our aim will be to focus on the molecular and cellular mechanisms by which tissue and organ function deteriorate and homeostasis fails rather than on longevity itself, which has been the theme of previous Keystone Symposia meetings on aging. Work from a variety of models is recognizing that organisms, especially humans, are complicated systems in which interventions that extend lifespan might not necessarily block the aging and loss of function in specific organs or tissues and vice versa. Continuing this approach will help us gain an understanding and appreciation of the complexity that underlies aging in humans. The aim of this meeting is to reveal the integration and communication between pathways and systems during functional aging and their relationship with longevity. This meeting will highlight important questions to address in future research. Most importantly, what are the common and disparate causes underlying the cellular and physiological mechanisms responsible for human senescent phenotypes?
View Scholarships/Awards
Aging can be defined as the gradual loss of the ability of the organism to maintain homeostasis. Our aim will be to focus on the molecular and cellular mechanisms by which tissue and organ function deteriorate and homeostasis fails rather than on longevity itself, which has been the theme of previous Keystone Symposia meetings on aging. Work from a variety of models is recognizing that organisms, especially humans, are complicated systems in which interventions that extend lifespan might not necessarily block the aging and loss of function in specific organs or tissues and vice versa. Continuing this approach will help us gain an understanding and appreciation of the complexity that underlies aging in humans. The aim of this meeting is to reveal the integration and communication between pathways and systems during functional aging and their relationship with longevity. This meeting will highlight important questions to address in future research. Most importantly, what are the common and disparate causes underlying the cellular and physiological mechanisms responsible for human senescent phenotypes?
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, JANUARY 31
MONDAY, FEBRUARY 1
TUESDAY, FEBRUARY 2
WEDNESDAY, FEBRUARY 3
THURSDAY, FEBRUARY 4
FRIDAY, FEBRUARY 5
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, JANUARY 31
19:30—20:30
Keynote Address
Andrzej Bartke,
Southern Illinois University School of Medicine, USA
Growth Hormone: Elixir of Youth or Dangerous Snake Oil?
Growth Hormone: Elixir of Youth or Dangerous Snake Oil?
08:00—11:15
Aging Pathways I
*
Marc Tatar,
Brown University, USA
Cynthia Kenyon,
Calico, USA
Insulin and Aging
Insulin and Aging
Leonard P. Guarente,
Massachusetts Institute of Technology, USA
Sirtuins Aging and Disease
Sirtuins Aging and Disease
Anne Brunet,
Stanford University, USA
The Plasticity of Aging Describing the Role of FoxO3 in Maintaining Neuronal Stem Cell Pool
The Plasticity of Aging Describing the Role of FoxO3 in Maintaining Neuronal Stem Cell Pool
William B. Mair,
Harvard School of Public Health, USA
Short Talk: AMPK and Calcineurin extend lifespan via the CREB Regulated Transcription Co-activator (CRTC-1)
Short Talk: AMPK and Calcineurin extend lifespan via the CREB Regulated Transcription Co-activator (CRTC-1)
Maaike van den Berg,
University of Bristol, UK
Short Talk: Regulation of FOXO4 through ROS Regulated Ral-JIP1-JNK Complex Assembly
Short Talk: Regulation of FOXO4 through ROS Regulated Ral-JIP1-JNK Complex Assembly
17:00—19:00
Aging Pathways II
*
Rolf Bodmer,
Sanford-Burnham Medical Research Institute, USA
Jennifer Cermak,
Sirtris, a GSK Company, USA
Targeting Sirtuins: Drug Development for Diseases of Aging
Targeting Sirtuins: Drug Development for Diseases of Aging
Robert S. Garofalo,
, USA
Insulin Resistane: Insights from high resolution transcriptional profiling
Insulin Resistane: Insights from high resolution transcriptional profiling
Sean M. Oldham,
Takeda Pharmaceuticals International Co., USA
Role of Nutrient Sensing TOR Pathway in Obesity and Aging
Role of Nutrient Sensing TOR Pathway in Obesity and Aging
Matthew D. McGee,
Buck Institute for Research on Aging, USA
Short Talk: 3D Digital Atlas of Aging in C. elegans
Short Talk: 3D Digital Atlas of Aging in C. elegans
08:00—11:15
Molecules and Aging I
Jan Vijg,
Albert Einstein College of Medicine, USA
Genomic Instability, Transcriptional Deregulation and Aging
Genomic Instability, Transcriptional Deregulation and Aging
Judith Campisi,
Buck Institute for Research on Aging, USA
The Double Edged Sword of Cellular Senescence
The Double Edged Sword of Cellular Senescence
George M. Martin,
University of Washington, USA
Human diseases of Ageing and their evolutionary substrates
Human diseases of Ageing and their evolutionary substrates
Raul Mostoslavsky,
Harvard Medical School, USA
Short Talk: The Histone Deacetylase SIRT6 Functions as a Master Regulator of Glucose Homeostasis
Short Talk: The Histone Deacetylase SIRT6 Functions as a Master Regulator of Glucose Homeostasis
Eduardo Nunes Chini,
Mayo Clinic, USA
Short Talk: CD38 and DBC1: regulators of the non-oxidative functions of NAD; role of inhibitors of the longevity related enzyme SIRT1
Short Talk: CD38 and DBC1: regulators of the non-oxidative functions of NAD; role of inhibitors of the longevity related enzyme SIRT1
17:00—19:00
Molecules and Aging II
Rafael de Cabo,
NIA, National Institutes of Health, USA
From Molecules to Nutritional Interventions for Healthy Aging
From Molecules to Nutritional Interventions for Healthy Aging
*
Philipp Oberdoerffer,
NCI, National Institutes of Health, USA
Short Talk: A Mechanistic Link between DNA Damage, Chromatin and Aging
Short Talk: A Mechanistic Link between DNA Damage, Chromatin and Aging
08:00—11:15
Cells and Organelles Aging
Thomas A. Rando,
Stanford University School of Medicine, USA
Stem cell aging, DNA damage and asymmetric cell division
Stem cell aging, DNA damage and asymmetric cell division
Leanne Jones,
University of California, Los Angeles, USA
Stem Cell-Niche Cell Interactions during Aging
Stem Cell-Niche Cell Interactions during Aging
*
Sean J. Morrison,
University of Texas Southwestern Medical Center, USA
Stem Cell Renewal and changes in stem cell function during aging
Stem Cell Renewal and changes in stem cell function during aging
Pier Lorenzo Puri,
Sanford-Burnham Medical Research Institute, USA
Short Talk: DNA Damage Signaling to MyoD and the Control of the Genomic Stability of Skeletal Muscles during Development and Aging
Short Talk: DNA Damage Signaling to MyoD and the Control of the Genomic Stability of Skeletal Muscles during Development and Aging
Giana Angelo,
Fred Hutchinson Cancer Research Center, USA
Short Talk: Adult Worms Protect Germline Stem Cells and Extend their Reproductive Span in Response to Starvation
Short Talk: Adult Worms Protect Germline Stem Cells and Extend their Reproductive Span in Response to Starvation
14:30—16:30
Workshop: Stress, Mitochondria, and Aging
Nicholas Day,
Buck Institute for Research on Aging, USA
A Novel Inducible Mouse Model of Endogenous Mitochondrial Oxidative Stress Causes Heart Disease
A Novel Inducible Mouse Model of Endogenous Mitochondrial Oxidative Stress Causes Heart Disease
Hadise Kabil,
University of Michigan, USA
Activity of the Transsulfuration Pathway Determines Lifespan Extension in Response to Dietary Restriction in Drosophila
Activity of the Transsulfuration Pathway Determines Lifespan Extension in Response to Dietary Restriction in Drosophila
*
Pankaj Kapahi,
Buck Institute for Research on Aging, USA
4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila
4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila
David B. Lombard,
University of Michigan, USA
Mitochondrial Protein Acetylation in Calorie Restriction and Aging
Mitochondrial Protein Acetylation in Calorie Restriction and Aging
Iain Scott,
University of Pittsburgh, USA
The Functional Characterization of SIRT3 Modulation of Complex V of the Electron Transfer Chain
The Functional Characterization of SIRT3 Modulation of Complex V of the Electron Transfer Chain
Cristiano Simone,
Consorzio Mario Negri Sud, Italy
FoxO3A Localizes to Mitochondria and Regulates the Expression of the Mitochondrial Genome in Response to Nutrient Deprivation
FoxO3A Localizes to Mitochondria and Regulates the Expression of the Mitochondrial Genome in Response to Nutrient Deprivation
Michael C. Velarde,
Institute of Biology, Philippines
Superoxide Dismutase 2 Deficiency Promotes Cellular Senescence and Excessive Differentiation in Mouse Epidermis
Superoxide Dismutase 2 Deficiency Promotes Cellular Senescence and Excessive Differentiation in Mouse Epidermis
17:00—19:00
Cells and Organelles Aging II
Michael S. Grotewiel,
Virginia Commonwealth University, USA
Age-Related Locomotor Impairment in Drosophila
Age-Related Locomotor Impairment in Drosophila
Theodore W. Peters,
Buck Institute for Research on Aging, USA
Short Talk: Age-Dependent Accumulation of Insoluble Proteins is Conserved Across Taxa
Short Talk: Age-Dependent Accumulation of Insoluble Proteins is Conserved Across Taxa
08:00—11:15
Physiological Systems, Aging and Disease I
Session is Sponsored by The Ellison Medical Foundation
Paul Joseph Shaw,
Washington University, USA
Sleep Aging
Sleep Aging
Michael O. Thorner,
University of Virginia, USA
Potential Role of Ghrelin Mimetics in Preventing Frailty and Partially Reversing Sarcopenia of Aging
Potential Role of Ghrelin Mimetics in Preventing Frailty and Partially Reversing Sarcopenia of Aging
Marc Tatar,
Brown University, USA
Drosophila as a Model for Analysis of Innate Immune Aging
Drosophila as a Model for Analysis of Innate Immune Aging
Rolf Bodmer,
Sanford-Burnham Medical Research Institute, USA
Cardiac Aging
Cardiac Aging
Matthew Gill,
Buck Institute for Research on Aging, USA
Short Talk: Endocannabinoid signaling and aging in C. elegans
Short Talk: Endocannabinoid signaling and aging in C. elegans
Richard A. Kerber,
University of Louisville, USA
Short Talk: Association of Gene Expression Patterns in Lymphoblastoid Cell Lines with Familial Longevity and Survival
Short Talk: Association of Gene Expression Patterns in Lymphoblastoid Cell Lines with Familial Longevity and Survival
17:00—19:00
Physiological Systems, Aging and Disease II
Session is Sponsored by The Ellison Medical Foundation
Monica Driscoll,
Rutgers University, USA
Genetic and Pharmacological Extension of Healthspan in a Simple Animal Model
Genetic and Pharmacological Extension of Healthspan in a Simple Animal Model
Bradley J. Willcox,
Pacific Health Research Institute, USA
Pathophysiological and Sociopsychological Evidence for Active and Resilient Centenarian
Pathophysiological and Sociopsychological Evidence for Active and Resilient Centenarian
Floyd (Ski) Chilton,
University of Arizona, USA
Short Talk: Impact of the Varying Frequencies at Common Genetic Variants in the FADS Gene Cluster on Circulating Levels of Inflammatory Fatty Acids in African Americans and Caucasians
Short Talk: Impact of the Varying Frequencies at Common Genetic Variants in the FADS Gene Cluster on Circulating Levels of Inflammatory Fatty Acids in African Americans and Caucasians
*Session Chair †Invited, not yet responded.
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