Keystone Symposia

Fairmont Hotel Vancouver Floorplan

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This meeting took place in 2011


Here are the related meetings in 2021:
Tuberculosis: Science Aimed at Ending the Epidemic (EK10)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Tuberculosis: Immunology, Cell Biology and Novel Vaccination Strategies (J3)


Organizer(s) Stefan H.E. Kaufmann, Gerhard Walzl and Lalita Ramakrishnan
January 15—20, 2011
Fairmont Hotel Vancouver • Vancouver, BC Canada
Abstract Deadline: Sep 20, 2010
Late Abstract Deadline: Oct 18, 2010
Scholarship Deadline: Sep 20, 2010
Early Registration Deadline: Nov 15, 2010

Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation. Sponsored by Novartis Institutes for BioMedical Research


Summary of Meeting:
The global epidemic of Tuberculosis (TB) stems from three main problems: 1) HIV/AIDS (TB is the number one cause of death for HIV-infected individuals); 2) the requirement for long-term multidrug therapy that in turn leads to noncompliance and relapse of transmissible infection; and 3) the only available vaccine BCG affords partial protection against disseminated TB in young children but not against adult pulmonary TB which is the main source of Mycobacterium tuberculosis (Mtb) transmission. Moreover, the outcomes of exposure to Mtb differ vastly even in seemingly immunocompetent individuals; differences in both innate and adaptive immunity appear to modulate outcomes. This meeting will primarily focus on immune responses underlying pathology of and protection against TB. This will pave the way towards a better understanding of basic mechanisms of host defense and also provide the basis for novel intervention strategies. Notably, it will provide information relevant for the design of novel vaccines and strategies to counteract Immune Reconstitution Inflammatory Syndrome (IRIS), which increasingly occurs in HIV/Mtb-infected individuals under antiretroviral therapy. This meeting will take place in parallel with the Keystone Symposia meeting on Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics, which emphasizes the pathogen. These meetings will share a keynote address and four plenary sessions, including a joint session on “Systems Biology”, an innovative and powerful approach that is just starting to be applied to TB research. Hence, these two Keystone Symposia meetings have a shared interest in TB but, at the same time, emphasize different aspects of this complex disease. We are convinced, therefore, that these meetings will attract all scientists and clinicians from the different areas of TB research and will therefore also facilitate the coming together of a wide variety of researchers: wet-lab researchers interested in molecular biology of the pathogen; immunologists and cell biologists focused on the host response; and clinicians developing novel intervention measures including diagnostics, vaccines and drugs.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, JANUARY 15

15:00—19:30
Registration

BC Foyer
18:15—19:15
Refreshments

BC Foyer
19:15—20:30
Welcome and Keynote Address (Joint)

British Columbia Ballroom
* Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany

* David R. Sherman, University of Washington, USA

Anthony S. Fauci, NIAID, National Institutes of Health, USA
Tuberculosis in 2011: Major Challenges and Unprecedented Opportunities


SUNDAY, JANUARY 16

07:00—08:00
Breakfast

Pacific Ballroom, Vancouver Island Room
08:00—11:00
Tuberculosis Immunology: Bench to Clinic

British Ballroom
Joyoti Basu, Bose Institute, India
MicroRNA-mediated Immune Responses in Mycobacterium tuberculosis-infected Macrophages

* Andrea M. Cooper, University of Leicester, UK
Cellular Responses to Mycobacterium tuberculosis in the Mouse Model

Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
Human T Cell Responses to Bacteria

Daniel L. Barber, NIAID, National Institutes of Health, USA
PD-1 Expression by CD4 T Cells is Required for Host Resistance to Mycobacterium tuberculosis

Constance J. Martin, Scholar Rock, USA
Short Talk: Death has its Consequences: Efferocytosis and Control of Tuberculosis

08:00—11:00
Environmental Sensing, Signaling and Stress Response

Columbia Ballroom
* Sabine Ehrt, Weill Cornell Medical College, USA

Sarah M. Fortune, Harvard TH Chan School of Public Health, USA
A Time for Change: The Mutation Rate of Mycobacterium tuberculosis during Latent Infection

Miriam Braunstein, University of North Carolina at Chapel Hill, USA
The Accessory SecA2 Export System of Mycobacteria

Sandhya S. Visweswariah, Indian Institute of Science, India
Cyclic AMP in Mycobacteria

Stewart H. Shuman, Memorial Sloan-Kettering Institute, USA
Mechanisms of Mycobacterial dsDNA Break Repair

Babak Javid, University of California San Francisco, USA
Short Talk: Mistranslation is a Source of Adaptive Protein Diversity in Mycobacteria

09:20—09:40
Coffee Break

BC Foyer
11:00—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
11:00
On Own for Lunch and Recreation

14:30—16:30
Workshop: Tools for Tuberculosis Pathogenesis and Discovery of Novel Intervention Measures

British/Columbia Ballroom
* David R. Sherman, University of Washington, USA

Ekaterina Gelman, École Polytechnique Fédérale de Lausanne, Switzerland
Real-Time Single-Cell Analysis of Isoniazid-Mediated Death and Persistence

Heather L. Torrey, Northeastern University, USA
Characterization of High-Persister Mutants of Mycobacterium tuberculosis

Dany J. V. Beste, University of Surrey, UK
13C Metabolic Flux Analysis Demonstrates that Mycobacterium tuberculosis is Able to Obtain Additional Carbon by C02 Fixation

Martin Gengenbacher, Max-Planck-Institute for Infection Biology, Germany
Vitamin B6 Biosynthesis is Essential for Survival and Virulence of Mycobacterium tuberculosis

Anthony David Baughn, University of Minnesota, USA
Metabolomic Adaptations Underlying Anaerobic Persistence of Mycobacterium tuberculosis

Helene Botella, Weill Cornell Medical College, USA
Pumping out Heavy Metals: A Strategy Evolved by Mycobacterium tuberculosis to Escape Novel Host Cell Microbicidal Mechanisms

Christina L. Stallings, Washington University School of Medicine, USA
Regulating rRNA Transcription during Mycobacterium tuberculosis Pathogenesis

16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Phagocyte Defense Mechanisms and Bacterial Evasion Strategies (Joint)

British/Columbia Ballroom
* Lalita Ramakrishnan, University of Cambridge, UK

Kenneth L. Rock, University of Massachusetts Medical School, USA
Endosomal Fate of Particles and Inflammasome Activation

Eric J. Brown, Genentech, Inc, USA
The Role of EccA1 in Mycobacterium marinum Infection

Thierry Soldati, University of Geneva, Switzerland
Interactions of Pathogenic Mycobacteria with Dictyostelium

Pedro Moura-Alves, Max Planck Institute for Infection Biology, Germany
Short Talk: Systematic Identification of NLR and CARD-Domain Containing Proteins Involved in IL-1b Response to Mycobacterium tuberculosis

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
19:30—22:00
Poster Session 1

Pacific Ballroom

MONDAY, JANUARY 17

07:00—08:00
Breakfast

Pacific Ballroom, Vancouver Island Room
08:00—11:00
Fundamentals of Persistence and Granuloma Formation

British Ballroom
* Joel D. Ernst, University of California, San Francisco, USA

Anne O'Garra, Francis Crick Institute, UK
Regulation of the Immune Response in Tuberculosis: Lessons Learned from Mouse Models and Human Disease

John D. MacMicking, Yale University, USA
Native Immunity to Tuberculosis: Host Genetics of the IFN-gamma Response

Anca Dorhoi, Friedrich-Loeffler-Institut, Germany
Orchestration of Innate Immunity of Tuberculosis

Peter J. Peters, Netherlands Cancer Institute, Netherlands
Translocation to the Cytosol Determines Pathogenicity of Mycobacteria

Lee Kozakiewicz, Albert Einstein College of Medicine, USA
Short Talk: The Role of B Cells in Shaping the Host Immune Response to Mycobacterium tuberculosis

08:00—11:00
Molecular and Evolutionary Determinants of Tuberculosis Pathogenicity

Columbia Ballroom
* Sébastien Gagneux, Swiss Tropical and Public Health Institute, Switzerland
Genetic Diversity in Mycobacterium tuberculosis: An Evolutionary Perspective

Roland Brosch, Institut Pasteur, France
Virulence Traits of Tubercle bacilli: Insights from a (Patho)genomic Perspective

Tim Stinear, University of Melbourne, Australia
Evolution of Mycobacterial Pathogenicity

Olivier Neyrolles, IPBS, CNRS-University of Toulouse, France
Mycobacteria Interactions with Host Cells

Rainer Kalscheuer, Heinrich-Heine-University Duesseldorf, Germany
Short Talk: A Trehalose-Recycling ABC Transporter is Essential for Mycobacterium tuberculosis Virulence

09:20—09:40
Coffee Break

BC Foyer
11:00—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Capacity Building for Clinical Trials (Drugs, Vaccines and Diagnostics) and Raising Public Awareness (Joint)

British/Columbia Ballroom
* Gerhard Walzl, Stellenbosch University, South Africa

Ajit Lalvani, Imperial College London, UK
Probing the Spectrum and Clinical Outcomes of Latent Tuberculosis through Immunology

David Alland, Rutgers University, New Jersey Medical School, USA
The GeneXpert System for Point-of-Care Tuberculosis Diagnosis and Resistance Testing

William R. Bishai, Johns Hopkins School of Medicine and K-RITH, USA
Short Talk: Tuberculosis Research Opportunities in KwaZulu Natal

Mark Harrington, Treatment Action Group, USA
Global TB R&D Investments: Trends and Needs, 2005-2015

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
19:30—22:00
Poster Session 2

Pacific Ballroom

TUESDAY, JANUARY 18

07:00—08:00
Breakfast

Pacific Ballroom, Vancouver Island Room
07:30—08:00
Poster Setup

Pacific Ballroom
08:00—17:00
Poster Viewing

Pacific Ballroom
08:00—11:00
Diagnosis and Vaccines

British Ballroom
* Ajit Lalvani, Imperial College London, UK

Madhukar Pai, McGill University, Canada
Tuberculosis Diagnosis in 2011: The Good, the Bad and the Ugly

Gerhard Walzl, Stellenbosch University, South Africa
Biomarkers for Different Forms of Tuberculosis

Anneke C. Hesseling, Desmond Tutu TB Centre, Faculty of Health Sciences, Stellenbosch University, South Africa
Childhood Tuberculosis, Pathogenesis, Diagnosis and Prevention

Helen McShane, Jenner Institute, UK
Challenges in Tuberculosis Vaccine Development

H. Martin Vordermeier, Animal Health & Veterinary Laboratories Agency, UK
Short Talk: Transcriptional Profiling of Disease Progression in Bovine Tuberculosis and the Identification of Diagnostic Biomarkers: Murine Microarray Studies can Predict Responses in Infected Cattle

08:00—11:00
Persistence Strategies

Columbia Ballroom
* Christopher M. Sassetti, University of Massachusetts Medical School, USA
Dynamic Regulation of Mycobacterial Cell Wall Synthesis via Ser/Thr Phosphosignalling

Joeli Marrero, Weill Cornell Medical College, USA
Carbon Metabolism in Mycobacterium tuberculosis during Infection

Kyu Y. Rhee, Weill Cornell Medical College, USA
Metabolomic Adaptations of Central Carbon Metabolism in Mycobacterium tuberculosis and Implications for Pathogenesis

Galina V. Mukamolova, University of Leicester, UK
Short Talk: Mycobacterial Death Prevented by Antibiotics

Marcel A. Behr, McGill University, Canada
Mechanisms of Mycobacterial Immunogenicity

09:20—09:40
Coffee Break

BC Foyer
11:00—12:00
Lunch

Pacific Ballroom
11:30—14:30
Poster Session 3

Pacific Ballroom
14:30—16:30
Workshop: Bioinformatics and Systems Biology

British/Columbia Ballroom
* Johnjoe McFadden, University of Surrey, UK
Introduction

Jeroen Maertzdorf, Max Planck Institute for Infection Biology, Germany
Network and Expression Analyses Reveal Functional Clusters of Genes Correlating to Increased FCGR1 Expression in Tuberculosis

Jenny Piercy, University of Oxford, UK
Transcriptional Profiling to Predict Vaccine Success or Failure in Bovine Tuberculosis

Deepak Kaushal, Texas Biomedical Research Institute, USA
Transcriptomics of Primate Tuberculosis Granuloma Lesions: Markers of Latency, Reactivation and Immunity?

Poonam Rath, Cornell Medical School, USA
Characterization of Immunomodulatory Genes of Mycobacterium tuberculosis

Chuan Wang, Fudan University, China
Comparative Gene Expression Profiles of microRNAs in Persons with Latent and Active Tuberculosis

Kathryn Winglee, Johns Hopkins University, USA
A Tool For Rapidly Identifying Strain Differences in Deep Sequencing Data

16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Systems Biology (Joint)

British/Columbia Ballroom
* Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany

D. Branch Moody, Brigham and Women's Hospital, USA
Scanning the Mycobacterium Tuberculosis Lipidome for New Virulence Pathways

Luis Serrano, Centre for Genomic Regulation, Spain
Systems Biology Analysis of a Small Prokaryote Reveals Unexpected Complexity in Prokaryotes

James Galagan, Broad Institute of Massachusetts Institute of Technology and Harvard, USA
The Tuberculosis Systems Biology Consortium

January Weiner, Max Planck Institute of Infection Biology, Germany
Short Talk: Metabolic Network Analysis Helps to Unveil the Biology of Tuberculosis Infection

19:00
On Own for Dinner


WEDNESDAY, JANUARY 19

07:00—08:00
Breakfast

Pacific Ballroom, Vancouver Island Room
07:30—08:00
Poster Setup

Pacific Ballroom
08:00—17:00
Poster Viewing

Pacific Ballroom
08:00—11:30
Cellular and Genetic Mechanisms of Host Responses

British Ballroom
* Anne O'Garra, Francis Crick Institute, UK

Philippe Gros, McGill University, Canada
Forward Genetic Dissection of Early Innate Responses to Pathogens in Mice: IRF8 and Beyond

David M. Tobin, Duke University School of Medicine, USA
Eicosanoid Balance Controls Susceptibility to Tuberculosis

Robert J. Wilkinson, University of Cape Town, South Africa
Do Hypoxia-Inducible Mycobacterium tuberculosis Genes Encode Useful Antigens?

David M. Lewinsohn, Oregon Health & Science University, USA
Immune Recognition of Intracellular Infection with Mycobacterium tuberculosis

Ronald N. Germain, NIAID, National Institutes of Health, USA
Dynamic in situ Visualization of Immune System Interactions with Pathogens Using Intravital 2-Photon Microscopy

Alissa C. Rothchild, University of Massachusetts Amherst, USA
Short Talk: Antimicrobial Effector Functions of iNKT Cells Activated by Mycobacterium tuberculosis-Infected Macrophages

08:00—11:00
Physiology and Intervention

Columbia Ballroom
David L. Pompliano, Lodo Therapeutics, USA
The Challenges of Antibacterial Discovery

* Stewart T. Cole, Institut Pasteur, France
New Medicines for Tuberculosis (NM4TB): Benzothiazinones

John S. Blanchard, Albert Einstein College of Medicine, USA
Structure and Mechanism of Mtb Cyclodityrosine Synthetase

Gyanu Lamichhane, Johns Hopkins University, USA
Cross-Linking of the Peptidoglycan: Effect on Physiology of Mycobacterium Tuberculosis

Christine Cosma, Cell Press, USA
Short Talk: A Zebrafish Larval Platform for Antitubercular Drug Discovery and Characterization in the Context of Dynamic Granulomatous Infection

09:50—10:10
Coffee Break

BC Foyer
11:00—12:30
Lunch

Pacific Ballroom
11:30—15:00
Poster Session 4

Pacific Ballroom
15:00—15:30
Coffee Available

BC Foyer
15:30—18:00
The Host-Pathogen Interface (Joint)

British/Columbia Ballroom
* John D. MacMicking, Yale University, USA

John R. Chan, Albert Einstein College of Medicine, USA
The Role of B Cells in Shaping the Immune Response to Mycobacterium tuberculosis

Joel D. Ernst, University of California, San Francisco, USA
Limitations and Consequences of Adaptive Immunity in Tuberculosis

Kevin B. Urdahl, Seattle Children's Research Institute, USA
Pathogen-Specific Regulatory T Cells and the Slow-Motion T Cell Response to Mycobacterium tuberculosis Infection

Marc K. Jenkins, University of Minnesota Medical School, USA
How CD4+ T Cells Remember Infections

Paolo Manzanillo, University of California San Francisco, USA
Short Talk: Mycobacterial ESX-1 Secretion System Activates a Host Transcription Factor to Promote Pathogenesis

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
20:00—23:00
Entertainment

Pacific Ballroom

THURSDAY, JANUARY 20

 
Departure


*Session Chair †Invited, not yet responded.


We gratefully acknowledge support for this conference from:


Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI092856-01



We gratefully acknowledge additional support for this conference from:

Bill & Melinda Gates Foundation Burroughs Wellcome Fund
Novartis Institutes for BioMedical Research
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


Genentech, Inc.

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