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This meeting took place in 2011
Here are the related meetings in 2020:
Tuberculosis: Immunity and Immune Evasion (A2)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Tuberculosis: Immunology, Cell Biology and Novel Vaccination Strategies (J3)
Organizer(s) Stefan H.E. Kaufmann, Gerhard Walzl and Lalita Ramakrishnan
January 15—20, 2011
Fairmont Hotel Vancouver • Vancouver, BC Canada
Abstract Deadline: Sep 20, 2010
Late Abstract Deadline: Oct 18, 2010
Scholarship Deadline: Sep 20, 2010
Early Registration Deadline: Nov 15, 2010
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation. Sponsored by Novartis Institutes for BioMedical Research
Summary of Meeting:
The global epidemic of Tuberculosis (TB) stems from three main problems: 1) HIV/AIDS (TB is the number one cause of death for HIV-infected individuals); 2) the requirement for long-term multidrug therapy that in turn leads to noncompliance and relapse of transmissible infection; and 3) the only available vaccine BCG affords partial protection against disseminated TB in young children but not against adult pulmonary TB which is the main source of Mycobacterium tuberculosis (Mtb) transmission. Moreover, the outcomes of exposure to Mtb differ vastly even in seemingly immunocompetent individuals; differences in both innate and adaptive immunity appear to modulate outcomes. This meeting will primarily focus on immune responses underlying pathology of and protection against TB. This will pave the way towards a better understanding of basic mechanisms of host defense and also provide the basis for novel intervention strategies. Notably, it will provide information relevant for the design of novel vaccines and strategies to counteract Immune Reconstitution Inflammatory Syndrome (IRIS), which increasingly occurs in HIV/Mtb-infected individuals under antiretroviral therapy. This meeting will take place in parallel with the Keystone Symposia meeting on Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics, which emphasizes the pathogen. These meetings will share a keynote address and four plenary sessions, including a joint session on “Systems Biology”, an innovative and powerful approach that is just starting to be applied to TB research. Hence, these two Keystone Symposia meetings have a shared interest in TB but, at the same time, emphasize different aspects of this complex disease. We are convinced, therefore, that these meetings will attract all scientists and clinicians from the different areas of TB research and will therefore also facilitate the coming together of a wide variety of researchers: wet-lab researchers interested in molecular biology of the pathogen; immunologists and cell biologists focused on the host response; and clinicians developing novel intervention measures including diagnostics, vaccines and drugs.
View Scholarships/Awards
The global epidemic of Tuberculosis (TB) stems from three main problems: 1) HIV/AIDS (TB is the number one cause of death for HIV-infected individuals); 2) the requirement for long-term multidrug therapy that in turn leads to noncompliance and relapse of transmissible infection; and 3) the only available vaccine BCG affords partial protection against disseminated TB in young children but not against adult pulmonary TB which is the main source of Mycobacterium tuberculosis (Mtb) transmission. Moreover, the outcomes of exposure to Mtb differ vastly even in seemingly immunocompetent individuals; differences in both innate and adaptive immunity appear to modulate outcomes. This meeting will primarily focus on immune responses underlying pathology of and protection against TB. This will pave the way towards a better understanding of basic mechanisms of host defense and also provide the basis for novel intervention strategies. Notably, it will provide information relevant for the design of novel vaccines and strategies to counteract Immune Reconstitution Inflammatory Syndrome (IRIS), which increasingly occurs in HIV/Mtb-infected individuals under antiretroviral therapy. This meeting will take place in parallel with the Keystone Symposia meeting on Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics, which emphasizes the pathogen. These meetings will share a keynote address and four plenary sessions, including a joint session on “Systems Biology”, an innovative and powerful approach that is just starting to be applied to TB research. Hence, these two Keystone Symposia meetings have a shared interest in TB but, at the same time, emphasize different aspects of this complex disease. We are convinced, therefore, that these meetings will attract all scientists and clinicians from the different areas of TB research and will therefore also facilitate the coming together of a wide variety of researchers: wet-lab researchers interested in molecular biology of the pathogen; immunologists and cell biologists focused on the host response; and clinicians developing novel intervention measures including diagnostics, vaccines and drugs.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SATURDAY, JANUARY 15
SUNDAY, JANUARY 16
Following Session is for Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics (J4)
Following Session is for Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics (J4)
MONDAY, JANUARY 17
Following Session is for Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics (J4)
TUESDAY, JANUARY 18
Following Session is for Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics (J4)
WEDNESDAY, JANUARY 19
Following Session is for Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics (J4)
THURSDAY, JANUARY 20
Conference Program Print | View meeting in 12 hr (am/pm) time
SATURDAY, JANUARY 15
19:15—20:30
Welcome and Keynote Address (Joint)
*
David R. Sherman,
University of Washington, USA
Anthony S. Fauci,
NIAID, National Institutes of Health, USA
Tuberculosis in 2011: Major Challenges and Unprecedented Opportunities
Tuberculosis in 2011: Major Challenges and Unprecedented Opportunities
08:00—11:00
Tuberculosis Immunology: Bench to Clinic
Joyoti Basu,
Bose Institute, India
MicroRNA-mediated Immune Responses in Mycobacterium tuberculosis-infected Macrophages
MicroRNA-mediated Immune Responses in Mycobacterium tuberculosis-infected Macrophages
*
Andrea M. Cooper,
University of Leicester, UK
Cellular Responses to Mycobacterium tuberculosis in the Mouse Model
Cellular Responses to Mycobacterium tuberculosis in the Mouse Model
Federica Sallusto,
Università della Svizzera Italiana & ETH Zurich, Switzerland
Human T Cell Responses to Bacteria
Human T Cell Responses to Bacteria
Daniel L. Barber,
NIAID, National Institutes of Health, USA
PD-1 Expression by CD4 T Cells is Required for Host Resistance to Mycobacterium tuberculosis
PD-1 Expression by CD4 T Cells is Required for Host Resistance to Mycobacterium tuberculosis
Constance J. Martin,
Scholar Rock, USA
Short Talk: Death has its Consequences: Efferocytosis and Control of Tuberculosis
Short Talk: Death has its Consequences: Efferocytosis and Control of Tuberculosis
Following Session is for Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics (J4)
08:00—11:00
Environmental Sensing, Signaling and Stress Response
*
Sabine Ehrt,
Weill Cornell Medical College, USA
Sarah M. Fortune,
Harvard TH Chan School of Public Health, USA
A Time for Change: The Mutation Rate of Mycobacterium tuberculosis during Latent Infection
A Time for Change: The Mutation Rate of Mycobacterium tuberculosis during Latent Infection
Miriam Braunstein,
University of North Carolina at Chapel Hill, USA
The Accessory SecA2 Export System of Mycobacteria
The Accessory SecA2 Export System of Mycobacteria
Stewart H. Shuman,
Memorial Sloan-Kettering Institute, USA
Mechanisms of Mycobacterial dsDNA Break Repair
Mechanisms of Mycobacterial dsDNA Break Repair
Babak Javid,
Tsinghua University School of Medicine, China
Short Talk: Mistranslation is a Source of Adaptive Protein Diversity in Mycobacteria
Short Talk: Mistranslation is a Source of Adaptive Protein Diversity in Mycobacteria
Following Session is for Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics (J4)
14:30—16:30
Workshop: Tools for Tuberculosis Pathogenesis and Discovery of Novel Intervention Measures
*
David R. Sherman,
University of Washington, USA
Ekaterina Gelman,
École Polytechnique Fédérale de Lausanne, Switzerland
Real-Time Single-Cell Analysis of Isoniazid-Mediated Death and Persistence
Real-Time Single-Cell Analysis of Isoniazid-Mediated Death and Persistence
Heather L. Torrey,
Northeastern University, USA
Characterization of High-Persister Mutants of Mycobacterium tuberculosis
Characterization of High-Persister Mutants of Mycobacterium tuberculosis
Dany J. V. Beste,
University of Surrey, UK
13C Metabolic Flux Analysis Demonstrates that Mycobacterium tuberculosis is Able to Obtain Additional Carbon by C02 Fixation
13C Metabolic Flux Analysis Demonstrates that Mycobacterium tuberculosis is Able to Obtain Additional Carbon by C02 Fixation
Martin Gengenbacher,
Max-Planck-Institute for Infection Biology, Germany
Vitamin B6 Biosynthesis is Essential for Survival and Virulence of Mycobacterium tuberculosis
Vitamin B6 Biosynthesis is Essential for Survival and Virulence of Mycobacterium tuberculosis
Anthony David Baughn,
University of Minnesota, USA
Metabolomic Adaptations Underlying Anaerobic Persistence of Mycobacterium tuberculosis
Metabolomic Adaptations Underlying Anaerobic Persistence of Mycobacterium tuberculosis
Helene Botella,
Weill Cornell Medical College, USA
Pumping out Heavy Metals: A Strategy Evolved by Mycobacterium tuberculosis to Escape Novel Host Cell Microbicidal Mechanisms
Pumping out Heavy Metals: A Strategy Evolved by Mycobacterium tuberculosis to Escape Novel Host Cell Microbicidal Mechanisms
Christina L. Stallings,
Washington University School of Medicine, USA
Regulating rRNA Transcription during Mycobacterium tuberculosis Pathogenesis
Regulating rRNA Transcription during Mycobacterium tuberculosis Pathogenesis
17:00—19:00
Phagocyte Defense Mechanisms and Bacterial Evasion Strategies (Joint)
*
Lalita Ramakrishnan,
University of Cambridge, UK
Kenneth L. Rock,
University of Massachusetts Medical School, USA
Endosomal Fate of Particles and Inflammasome Activation
Endosomal Fate of Particles and Inflammasome Activation
Eric J. Brown,
Genentech, Inc, USA
The Role of EccA1 in Mycobacterium marinum Infection
The Role of EccA1 in Mycobacterium marinum Infection
Thierry Soldati,
University of Geneva, Switzerland
Interactions of Pathogenic Mycobacteria with Dictyostelium
Interactions of Pathogenic Mycobacteria with Dictyostelium
Pedro Moura-Alves,
Max Planck Institute for Infection Biology, Germany
Short Talk: Systematic Identification of NLR and CARD-Domain Containing Proteins Involved in IL-1b Response to Mycobacterium tuberculosis
Short Talk: Systematic Identification of NLR and CARD-Domain Containing Proteins Involved in IL-1b Response to Mycobacterium tuberculosis
08:00—11:00
Fundamentals of Persistence and Granuloma Formation
Anne O'Garra,
Francis Crick Institute, UK
Regulation of the Immune Response in Tuberculosis: Lessons Learned from Mouse Models and Human Disease
Regulation of the Immune Response in Tuberculosis: Lessons Learned from Mouse Models and Human Disease
John D. MacMicking,
Yale University, USA
Native Immunity to Tuberculosis: Host Genetics of the IFN-gamma Response
Native Immunity to Tuberculosis: Host Genetics of the IFN-gamma Response
Anca Dorhoi,
Friedrich-Loeffler-Institut, Germany
Orchestration of Innate Immunity of Tuberculosis
Orchestration of Innate Immunity of Tuberculosis
Peter J. Peters,
Netherlands Cancer Institute, Netherlands
Translocation to the Cytosol Determines Pathogenicity of Mycobacteria
Translocation to the Cytosol Determines Pathogenicity of Mycobacteria
Lee Kozakiewicz,
Albert Einstein College of Medicine, USA
Short Talk: The Role of B Cells in Shaping the Host Immune Response to Mycobacterium tuberculosis
Short Talk: The Role of B Cells in Shaping the Host Immune Response to Mycobacterium tuberculosis
Following Session is for Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics (J4)
08:00—11:00
Molecular and Evolutionary Determinants of Tuberculosis Pathogenicity
*
Sébastien Gagneux,
Swiss Tropical and Public Health Institute, Switzerland
Genetic Diversity in Mycobacterium tuberculosis: An Evolutionary Perspective
Genetic Diversity in Mycobacterium tuberculosis: An Evolutionary Perspective
Roland Brosch,
Institut Pasteur, France
Virulence Traits of Tubercle bacilli: Insights from a (Patho)genomic Perspective
Virulence Traits of Tubercle bacilli: Insights from a (Patho)genomic Perspective
Tim Stinear,
University of Melbourne, Australia
Evolution of Mycobacterial Pathogenicity
Evolution of Mycobacterial Pathogenicity
Olivier Neyrolles,
IPBS, CNRS-University of Toulouse, France
Mycobacteria Interactions with Host Cells
Mycobacteria Interactions with Host Cells
Rainer Kalscheuer,
Heinrich-Heine-University Duesseldorf, Germany
Short Talk: A Trehalose-Recycling ABC Transporter is Essential for Mycobacterium tuberculosis Virulence
Short Talk: A Trehalose-Recycling ABC Transporter is Essential for Mycobacterium tuberculosis Virulence
17:00—19:00
Capacity Building for Clinical Trials (Drugs, Vaccines and Diagnostics) and Raising Public Awareness (Joint)
*
Gerhard Walzl,
Stellenbosch University, South Africa
Ajit Lalvani,
Imperial College London, UK
Probing the Spectrum and Clinical Outcomes of Latent Tuberculosis through Immunology
Probing the Spectrum and Clinical Outcomes of Latent Tuberculosis through Immunology
David Alland,
Rutgers University, New Jersey Medical School, USA
The GeneXpert System for Point-of-Care Tuberculosis Diagnosis and Resistance Testing
The GeneXpert System for Point-of-Care Tuberculosis Diagnosis and Resistance Testing
William R. Bishai,
Johns Hopkins School of Medicine and K-RITH, USA
Short Talk: Tuberculosis Research Opportunities in KwaZulu Natal
Short Talk: Tuberculosis Research Opportunities in KwaZulu Natal
08:00—11:00
Diagnosis and Vaccines
Madhukar Pai,
McGill University, Canada
Tuberculosis Diagnosis in 2011: The Good, the Bad and the Ugly
Tuberculosis Diagnosis in 2011: The Good, the Bad and the Ugly
Gerhard Walzl,
Stellenbosch University, South Africa
Biomarkers for Different Forms of Tuberculosis
Biomarkers for Different Forms of Tuberculosis
Anneke C. Hesseling,
Desmond Tutu TB Centre, Faculty of Health Sciences, Stellenbosch University, South Africa
Childhood Tuberculosis, Pathogenesis, Diagnosis and Prevention
Childhood Tuberculosis, Pathogenesis, Diagnosis and Prevention
Helen McShane,
Jenner Institute, UK
Challenges in Tuberculosis Vaccine Development
Challenges in Tuberculosis Vaccine Development
H. Martin Vordermeier,
Animal Health & Veterinary Laboratories Agency, UK
Short Talk: Transcriptional Profiling of Disease Progression in Bovine Tuberculosis and the Identification of Diagnostic Biomarkers: Murine Microarray Studies can Predict Responses in Infected Cattle
Short Talk: Transcriptional Profiling of Disease Progression in Bovine Tuberculosis and the Identification of Diagnostic Biomarkers: Murine Microarray Studies can Predict Responses in Infected Cattle
Following Session is for Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics (J4)
08:00—11:00
Persistence Strategies
*
Christopher M. Sassetti,
University of Massachusetts Medical School, USA
Dynamic Regulation of Mycobacterial Cell Wall Synthesis via Ser/Thr Phosphosignalling
Dynamic Regulation of Mycobacterial Cell Wall Synthesis via Ser/Thr Phosphosignalling
Joeli Marrero,
Weill Cornell Medical College, USA
Carbon Metabolism in Mycobacterium tuberculosis during Infection
Carbon Metabolism in Mycobacterium tuberculosis during Infection
Kyu Y. Rhee,
Weill Cornell Medical College, USA
Metabolomic Adaptations of Central Carbon Metabolism in Mycobacterium tuberculosis and Implications for Pathogenesis
Metabolomic Adaptations of Central Carbon Metabolism in Mycobacterium tuberculosis and Implications for Pathogenesis
Galina V. Mukamolova,
University of Leicester, UK
Short Talk: Mycobacterial Death Prevented by Antibiotics
Short Talk: Mycobacterial Death Prevented by Antibiotics
Marcel A. Behr,
McGill University, Canada
Mechanisms of Mycobacterial Immunogenicity
Mechanisms of Mycobacterial Immunogenicity
14:30—16:30
Workshop: Bioinformatics and Systems Biology
Jeroen Maertzdorf,
Max Planck Institute for Infection Biology, Germany
Network and Expression Analyses Reveal Functional Clusters of Genes Correlating to Increased FCGR1 Expression in Tuberculosis
Network and Expression Analyses Reveal Functional Clusters of Genes Correlating to Increased FCGR1 Expression in Tuberculosis
Jenny Piercy,
University of Oxford, UK
Transcriptional Profiling to Predict Vaccine Success or Failure in Bovine Tuberculosis
Transcriptional Profiling to Predict Vaccine Success or Failure in Bovine Tuberculosis
Deepak Kaushal,
Tulane National Primate Research Center, USA
Transcriptomics of Primate Tuberculosis Granuloma Lesions: Markers of Latency, Reactivation and Immunity?
Transcriptomics of Primate Tuberculosis Granuloma Lesions: Markers of Latency, Reactivation and Immunity?
Poonam Rath,
Cornell Medical School, USA
Characterization of Immunomodulatory Genes of Mycobacterium tuberculosis
Characterization of Immunomodulatory Genes of Mycobacterium tuberculosis
Chuan Wang,
Fudan University, China
Comparative Gene Expression Profiles of microRNAs in Persons with Latent and Active Tuberculosis
Comparative Gene Expression Profiles of microRNAs in Persons with Latent and Active Tuberculosis
Kathryn Winglee,
Johns Hopkins University, USA
A Tool For Rapidly Identifying Strain Differences in Deep Sequencing Data
A Tool For Rapidly Identifying Strain Differences in Deep Sequencing Data
17:00—19:00
Systems Biology (Joint)
D. Branch Moody,
Brigham and Women's Hospital, USA
Scanning the Mycobacterium Tuberculosis Lipidome for New Virulence Pathways
Scanning the Mycobacterium Tuberculosis Lipidome for New Virulence Pathways
Luis Serrano,
Centre for Genomic Regulation, Spain
Systems Biology Analysis of a Small Prokaryote Reveals Unexpected Complexity in Prokaryotes
Systems Biology Analysis of a Small Prokaryote Reveals Unexpected Complexity in Prokaryotes
James Galagan,
Broad Institute of Massachusetts Institute of Technology and Harvard, USA
The Tuberculosis Systems Biology Consortium
The Tuberculosis Systems Biology Consortium
January Weiner,
Max Planck Institute of Infection Biology, Germany
Short Talk: Metabolic Network Analysis Helps to Unveil the Biology of Tuberculosis Infection
Short Talk: Metabolic Network Analysis Helps to Unveil the Biology of Tuberculosis Infection
08:00—11:30
Cellular and Genetic Mechanisms of Host Responses
*
Anne O'Garra,
Francis Crick Institute, UK
Philippe Gros,
McGill University, Canada
Forward Genetic Dissection of Early Innate Responses to Pathogens in Mice: IRF8 and Beyond
Forward Genetic Dissection of Early Innate Responses to Pathogens in Mice: IRF8 and Beyond
David M. Tobin,
Duke University School of Medicine, USA
Eicosanoid Balance Controls Susceptibility to Tuberculosis
Eicosanoid Balance Controls Susceptibility to Tuberculosis
Robert J. Wilkinson,
University of Cape Town, South Africa
Do Hypoxia-Inducible Mycobacterium tuberculosis Genes Encode Useful Antigens?
Do Hypoxia-Inducible Mycobacterium tuberculosis Genes Encode Useful Antigens?
David M. Lewinsohn,
Oregon Health & Science University, USA
Immune Recognition of Intracellular Infection with Mycobacterium tuberculosis
Immune Recognition of Intracellular Infection with Mycobacterium tuberculosis
Ronald N. Germain,
NIAID, National Institutes of Health, USA
Dynamic in situ Visualization of Immune System Interactions with Pathogens Using Intravital 2-Photon Microscopy
Dynamic in situ Visualization of Immune System Interactions with Pathogens Using Intravital 2-Photon Microscopy
Alissa C. Rothchild,
Seattle Children's Research Institute, USA
Short Talk: Antimicrobial Effector Functions of iNKT Cells Activated by Mycobacterium tuberculosis-Infected Macrophages
Short Talk: Antimicrobial Effector Functions of iNKT Cells Activated by Mycobacterium tuberculosis-Infected Macrophages
Following Session is for Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics (J4)
08:00—11:00
Physiology and Intervention
*
Stewart T. Cole,
Institut Pasteur, France
New Medicines for Tuberculosis (NM4TB): Benzothiazinones
New Medicines for Tuberculosis (NM4TB): Benzothiazinones
John S. Blanchard,
Albert Einstein College of Medicine, USA
Structure and Mechanism of Mtb Cyclodityrosine Synthetase
Structure and Mechanism of Mtb Cyclodityrosine Synthetase
Gyanu Lamichhane,
Johns Hopkins University, USA
Cross-Linking of the Peptidoglycan: Effect on Physiology of Mycobacterium Tuberculosis
Cross-Linking of the Peptidoglycan: Effect on Physiology of Mycobacterium Tuberculosis
Christine Cosma,
Cell Press, USA
Short Talk: A Zebrafish Larval Platform for Antitubercular Drug Discovery and Characterization in the Context of Dynamic Granulomatous Infection
Short Talk: A Zebrafish Larval Platform for Antitubercular Drug Discovery and Characterization in the Context of Dynamic Granulomatous Infection
15:30—18:00
The Host-Pathogen Interface (Joint)
John R. Chan,
Albert Einstein College of Medicine, USA
The Role of B Cells in Shaping the Immune Response to Mycobacterium tuberculosis
The Role of B Cells in Shaping the Immune Response to Mycobacterium tuberculosis
Joel D. Ernst,
University of California, San Francisco, USA
Limitations and Consequences of Adaptive Immunity in Tuberculosis
Limitations and Consequences of Adaptive Immunity in Tuberculosis
Kevin B. Urdahl,
Seattle Children's Research Institute, USA
Pathogen-Specific Regulatory T Cells and the Slow-Motion T Cell Response to Mycobacterium tuberculosis Infection
Pathogen-Specific Regulatory T Cells and the Slow-Motion T Cell Response to Mycobacterium tuberculosis Infection
Paolo Manzanillo,
University of California San Francisco, USA
Short Talk: Mycobacterial ESX-1 Secretion System Activates a Host Transcription Factor to Promote Pathogenesis
Short Talk: Mycobacterial ESX-1 Secretion System Activates a Host Transcription Factor to Promote Pathogenesis
*Session Chair †Invited, not yet responded.
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