INEC Killarney Convention Centre Floorplan
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This meeting took place in 2011
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Lipid Biology and Lipotoxicity (E2)
Organizer(s) Scott A. Summers and Rudolf Zechner
May 15—20, 2011
INEC Killarney Convention Centre • Killarney, Co. Kerry Ireland
Abstract Deadline: Jan 13, 2011
Late Abstract Deadline: Feb 15, 2011
Scholarship Deadline: Jan 13, 2011
Early Registration Deadline: Mar 15, 2011
Organized in Collaboration with Science Foundation Ireland
Summary of Meeting:
The accumulation of fat in tissues not suited for lipid storage has deleterious consequences on organ function, leading to cellular damage that underlies diabetes, heart disease, and hypertension. Illustrating the relationship is the fact that numerous effective therapeutics ameliorate metabolic disease symptoms by limiting the inappropriate deposition of fat in peripheral tissues (e.g. thiazolidinediones, metformin, or statins). Recent advances in genomics and lipidomics offer researchers an opportunity to make a substantial leap in the understanding and treatment of pathogenic conditions resulting from the excessive production and/or underutilization of fat. This meeting reviews these areas, placing specific emphasis on the following: (a) relationships between ectopic lipid deposition and metabolic disease; (b) mechanisms through which lipid excess alter tissue function; (c) regulatory processes that control lipid storage and metabolism; and (d) technological advances in the area of lipid analysis (i.e. lipidomics).
View Scholarships/Awards
The accumulation of fat in tissues not suited for lipid storage has deleterious consequences on organ function, leading to cellular damage that underlies diabetes, heart disease, and hypertension. Illustrating the relationship is the fact that numerous effective therapeutics ameliorate metabolic disease symptoms by limiting the inappropriate deposition of fat in peripheral tissues (e.g. thiazolidinediones, metformin, or statins). Recent advances in genomics and lipidomics offer researchers an opportunity to make a substantial leap in the understanding and treatment of pathogenic conditions resulting from the excessive production and/or underutilization of fat. This meeting reviews these areas, placing specific emphasis on the following: (a) relationships between ectopic lipid deposition and metabolic disease; (b) mechanisms through which lipid excess alter tissue function; (c) regulatory processes that control lipid storage and metabolism; and (d) technological advances in the area of lipid analysis (i.e. lipidomics).
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, MAY 15
MONDAY, MAY 16
TUESDAY, MAY 17
WEDNESDAY, MAY 18
THURSDAY, MAY 19
FRIDAY, MAY 20
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, MAY 15
15:00—19:30
Registration
INEC Conference Centre Foyer
18:15—19:15
Refreshments
INEC Conference Centre Foyer
19:15—20:30
Welcome and Keynote Address
INEC Main Auditorium
Roger H. Unger,
University of Texas Southwestern Medical Center, USA
Origins of the Lipotoxicity Hypothesis: Implications for Human Disease
Origins of the Lipotoxicity Hypothesis: Implications for Human Disease
08:00—09:00
Breakfast
INEC Conference Centre Foyer
09:00—12:00
Ectopic Lipid Accumulation and Disease
INEC Main Auditorium
*
Gregory J. Cooney,
University of Sydney, Australia
Antonio J. Vidal-Puig,
University of Cambridge, UK
Adipose tissue expandability, lipotoxicity and the Metabolic syndrome
Adipose tissue expandability, lipotoxicity and the Metabolic syndrome
Rosalind A. Coleman,
University of North Carolina at Chapel Hill, USA
Tissue-Specific Deficiencies of Acyl-CoA Synthetase-1 in Mice
Tissue-Specific Deficiencies of Acyl-CoA Synthetase-1 in Mice
Jens C. Brüning,
Max Planck Institute for Metabolism Research, Germany
Role of FTO in Obesity
Role of FTO in Obesity
Gos Micklem,
University of Cambridge, UK
Short Talk: metabolicMine: An Integrated Web Resource of Data & Tools to Support the Common Metabolic Disease Research Community
Short Talk: metabolicMine: An Integrated Web Resource of Data & Tools to Support the Common Metabolic Disease Research Community
10:20—10:40
Coffee Break
INEC Confenece Centre Foyer
12:00—13:00
Poster Setup
INEC Conference Centre Foyer
13:00—22:00
Poster Viewing
INEC Conference Centre Foyer
12:00
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
INEC Conference Centre Foyer
17:00—19:15
Fatty Liver/NASH
INEC Main Auditorium
*
Michael Trauner,
Medical University of Vienna, Austria
Philipp E. Scherer,
University of Texas Southwestern Medical Center, USA
Adipokines, Mitochondrial Function and Fatty Liver
Adipokines, Mitochondrial Function and Fatty Liver
Catherine Postic,
INSERM, Institut Cochin, France
The Transcription Factor ChREBP and Hepatic Steatosis
The Transcription Factor ChREBP and Hepatic Steatosis
Anil K. Agarwal,
University of Texas Southwestern Medical Center, USA
Lipodystrophy and Hepatic Steatosis Due to Agpat2 Deficiency
Lipodystrophy and Hepatic Steatosis Due to Agpat2 Deficiency
Patricia C. Chui,
Beth Israel Deaconess Medical Center, USA
Short Talk: Fibroblast Growth Factor 21 Plays a Critical and Protective Role in the Development of Steatohepatitis
Short Talk: Fibroblast Growth Factor 21 Plays a Critical and Protective Role in the Development of Steatohepatitis
19:15—20:15
Social Hour with Lite Bites
INEC Conference Centre Foyer
19:30—22:00
Poster Session 1
INEC Conference Centre Foyer
08:00—09:00
Breakfast
INEC Conference Centre Foyer
09:00—12:00
Lipid-Induced Insulin Resistance
INEC Main Auditorium
Deborah M. Muoio,
Duke University Medical Center, USA
Incomplete Lipid Oxidation and Insulin Resistance in Skeletal Muscle
Incomplete Lipid Oxidation and Insulin Resistance in Skeletal Muscle
Mark A. Febbraio,
Monash Institute of Pharmaceutical Sciences, Australia
Regulation of Lipid-Induced Inflammation in Macrophages: Role in Obesity-Induced Insulin Resistance
Regulation of Lipid-Induced Inflammation in Macrophages: Role in Obesity-Induced Insulin Resistance
Karen Reue,
University of California, Los Angeles, USA
Lipin-1 and Protection from Muscle Lipotoxicity
Lipin-1 and Protection from Muscle Lipotoxicity
Scott A. Summers,
University of Utah, USA
A Role for Ceramides at the Nexus of Inflammation and Metabolic Diseases
A Role for Ceramides at the Nexus of Inflammation and Metabolic Diseases
Caleb Lord,
University of Texas Southwestern Medical Center, USA
Short Talk: CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action
Short Talk: CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action
10:20—10:40
Coffee Break
INEC Confenece Centre Foyer
12:00—13:00
Poster Setup
INEC Conference Centre Foyer
13:00—22:00
Poster Viewing
INEC Conference Centre Foyer
12:00
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
INEC Conference Centre Foyer
17:00—19:15
Lipid Hydrolysis and Oxidation
INEC Main Auditorium
*
Richard Lehner,
University of Alberta, Canada
Rudolf Zechner,
University of Graz, Austria
ATGL (PNPLA2) and Adiponutrin (PNPLA3): Closely Related Enzymes with Different Functions
ATGL (PNPLA2) and Adiponutrin (PNPLA3): Closely Related Enzymes with Different Functions
Richard Roy,
McGill University, Canada
Genes that Affect Lipid Storage and Hydrolysis in Response to Energy/Environmental Stress
Genes that Affect Lipid Storage and Hydrolysis in Response to Energy/Environmental Stress
Thomas Scherer,
Mount Sinai School of Medicine, USA
Short Talk: Short–Term Overfeeding Disrupts Brain Insulin Control of Liver and Adipose Tissue Function
Short Talk: Short–Term Overfeeding Disrupts Brain Insulin Control of Liver and Adipose Tissue Function
Takashi Osumi,
University of Hyogo, Japan
Short Talk: Physiological Significance of Micro-Lipid Droplets and Intracellular Traffic of Lipid Droplet-Associated Proteins in Adipocyte Lipolysis
Short Talk: Physiological Significance of Micro-Lipid Droplets and Intracellular Traffic of Lipid Droplet-Associated Proteins in Adipocyte Lipolysis
19:15—20:15
Social Hour with Lite Bites
INEC Conference Centre Foyer
19:30—22:00
Poster Session 2
INEC Conference Centre Foyer
08:00—09:00
Breakfast
INEC Conference Centre Foyer
09:00—12:00
Physiology of Lipid Droplet Formation
INEC Main Auditorium
*
David B. Savage,
University of Cambridge, UK
Robert G. Parton,
University of Queensland, Australia
Cav-/- Mice are Resistant to Diet-induced Obesity
Cav-/- Mice are Resistant to Diet-induced Obesity
Michael P. Czech,
University of Massachusetts Medical School, USA
Lipid Droplet Proteins in the Control of Peripheral Insulin Sensitivity
Lipid Droplet Proteins in the Control of Peripheral Insulin Sensitivity
Ronald P. Kühnlein,
Max-Planck-Institut für Biophysikalische Chemie, Germany
Lipid Droplet Proteins and Fat Storage in Flies
Lipid Droplet Proteins and Fat Storage in Flies
Sheetal Gandotra,
University of Cambridge, UK
Short Talk: Human Perilipin Deficiency is Associated with Partial Lipodystrophy, Hypertriglyceridaemia and Insulin Resistant Diabetes
Short Talk: Human Perilipin Deficiency is Associated with Partial Lipodystrophy, Hypertriglyceridaemia and Insulin Resistant Diabetes
10:20—10:40
Coffee Break
INEC Confenece Centre Foyer
12:00—13:00
Poster Setup
INEC Conference Centre Foyer
13:00—22:00
Poster Viewing
INEC Conference Centre Foyer
12:00
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
INEC Conference Centre Foyer
17:00—19:30
Lipid Synthesis and Storage
INEC Main Auditorium
*
Jacqueline M. Stephens,
Louisiana State University, USA
Ira J. Goldberg,
New York University, USA
Introduction to the Journal of Lipid Research Lectureship
Introduction to the Journal of Lipid Research Lectureship
Robert V. Farese Jr.,
Harvard School of Public Health, USA
Journal of Lipid Research Lecture: How Cells Fatten Up: Fat Synthesis and Lipid Droplets
Journal of Lipid Research Lecture: How Cells Fatten Up: Fat Synthesis and Lipid Droplets
Juleen R. Zierath,
Karolinska Institutet, Sweden
Role of Diacylglycerol Kinase delta in Insulin Sensitivity and Energy
Role of Diacylglycerol Kinase delta in Insulin Sensitivity and Energy
Ajay Chawla,
Merck and University of California, San Francisco, USA
Short Talk: Macrophages and Brown Fat Metabolism
Short Talk: Macrophages and Brown Fat Metabolism
Joerg Heeren,
University Medical Center Hamburg-Eppendorf, Germany
Short Talk: Activation of Brown Adipose Tissue is a Master Regulator of Systemic Triglyceride Metabolism
Short Talk: Activation of Brown Adipose Tissue is a Master Regulator of Systemic Triglyceride Metabolism
19:30—20:30
Social Hour with Lite Bites
INEC Conference Centre Foyer
19:30—22:00
Poster Session 3
INEC Conference Centre Foyer
08:00—09:00
Breakfast
INEC Conference Centre Foyer
09:00—12:00
Cardiovascular Complications of Lipotoxicity
INEC Main Auditorium
*
Sander Kersten,
Wageningen University, Netherlands
E. Dale Abel,
University of Iowa, Carver College of Medicine, USA
Lipid-Induced Mitochondrial Dysfunction in the Heart
Lipid-Induced Mitochondrial Dysfunction in the Heart
Ira J. Goldberg,
New York University, USA
Lipotoxicity in the Heart
Lipotoxicity in the Heart
Jean E. Schaffer,
Harvard University, USA
Unexpected Regulators of Metabolic Stress
Unexpected Regulators of Metabolic Stress
Gary D. Lopaschuk,
University of Alberta, Canada
Contribution of Fatty Acid Oxidation to Lipotoxicity in the Heart
Contribution of Fatty Acid Oxidation to Lipotoxicity in the Heart
Ebru Erbay,
Bilkent University, Turkey
Short Talk: Nutritional Modification of Lipotoxic Endoplasmic Reticulum Stress and Inflammation by a Bioactive Lipokine Prevents Atherosclerosis
Short Talk: Nutritional Modification of Lipotoxic Endoplasmic Reticulum Stress and Inflammation by a Bioactive Lipokine Prevents Atherosclerosis
10:20—10:40
Coffee Break
INEC Confenece Centre Foyer
12:00
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
INEC Conference Centre Foyer
17:00—19:00
Lipid Handling of Beta Cells
INEC Main Auditorium
*
Kyle Hoehn,
University of New South Wales, Australia
Marc Prentki,
Montreal Diabetes Research Center, Canada
Glycerolipid/Fatty Acid Cycling and beta-Cell Signal Transduction in Health and Diabetes
Glycerolipid/Fatty Acid Cycling and beta-Cell Signal Transduction in Health and Diabetes
Vincent Poitout,
Montreal Diabetes Research Center, Canada
Glucolipodysfunction of the Pancreatic Beta Cell
Glucolipodysfunction of the Pancreatic Beta Cell
Ernesto Bernal-Mizrachi,
University of Miami Miller School of Medicine, USA
Nutrient Regulation of beta-Cell Mass
Nutrient Regulation of beta-Cell Mass
Trevor J. Biden,
Garvan Institute of Medical Research, Australia
Short Talk: A Lipidomic Screen Links Ceramide with ER Stress in Pancreatic beta-Cell Lipotoxicity
Short Talk: A Lipidomic Screen Links Ceramide with ER Stress in Pancreatic beta-Cell Lipotoxicity
19:00—20:00
Social Hour with Lite Bites
INEC Conference Centre Foyer
20:00—23:00
Entertainment
INEC Conference Centre Foyer
Departure
*Session Chair †Invited, not yet responded.
We gratefully acknowledge the generous grant for this conference provided by:
We gratefully acknowledge additional support for this conference from:
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Journal of Lipid Research |
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