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This meeting took place in 2011
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Pathogenesis of Influenza: Virus-Host Interactions (E3)
Organizer(s) Siamon Gordon, Malik Peiris and Kanta Subbarao
May 23—28, 2011
Sheraton Hong Kong Hotel & Towers • Kowloon, Hong Kong China
Abstract Deadline: Jan 21, 2011
Late Abstract Deadline: Feb 22, 2011
Scholarship Deadline: Jan 21, 2011
Early Registration Deadline: Mar 22, 2011
Organized in Collaboration with The University of Hong Kong as part of its Centenary Celebrations;
also made possible by an Area of Excellence in Influenza grant
funded by the University Grants Committee of Hong Kong
also made possible by an Area of Excellence in Influenza grant
funded by the University Grants Committee of Hong Kong
Summary of Meeting:
The mechanisms underlying the pathogenesis of influenza remain controversial. The direct cytopathic effects of viral replication, tissue tropism of the virus, viral-bacterial synergy, as well as innate host responses are inextricably linked and play roles to varying degrees in “seasonal,” zoonotic and pandemic influenza, examples being the pandemics of 1918 and 2009 and H5N1 avian influenza. Animal models, though indispensible, have significant limitations with regard to physiological relevance to human disease. The current symposium brings together researchers working on the virus, viral receptors and tissue tropism, innate and adaptive immunity, systems biology and clinical aspects of lung injury and host defense, to address questions on the pathogenesis of influenza. The aim will be to integrate data from animal and ex vivo / in vitro human experimental models as well as human disease to understand pathogenesis of influenza and how this may lead to effective interventions. As this symposium will take place in the aftermath of the first pandemic in 40 years, there will be a wealth of new knowledge as well as intense scientific interest in the subject. In view of the particular interest in influenza and other viral respiratory diseases generated in the Asia-Pacific region arising from the avian flu H5N1 and SARS experience, situating the meeting in Hong Kong would be particularly appropriate.
View Scholarships/Awards
The mechanisms underlying the pathogenesis of influenza remain controversial. The direct cytopathic effects of viral replication, tissue tropism of the virus, viral-bacterial synergy, as well as innate host responses are inextricably linked and play roles to varying degrees in “seasonal,” zoonotic and pandemic influenza, examples being the pandemics of 1918 and 2009 and H5N1 avian influenza. Animal models, though indispensible, have significant limitations with regard to physiological relevance to human disease. The current symposium brings together researchers working on the virus, viral receptors and tissue tropism, innate and adaptive immunity, systems biology and clinical aspects of lung injury and host defense, to address questions on the pathogenesis of influenza. The aim will be to integrate data from animal and ex vivo / in vitro human experimental models as well as human disease to understand pathogenesis of influenza and how this may lead to effective interventions. As this symposium will take place in the aftermath of the first pandemic in 40 years, there will be a wealth of new knowledge as well as intense scientific interest in the subject. In view of the particular interest in influenza and other viral respiratory diseases generated in the Asia-Pacific region arising from the avian flu H5N1 and SARS experience, situating the meeting in Hong Kong would be particularly appropriate.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
MONDAY, MAY 23
TUESDAY, MAY 24
WEDNESDAY, MAY 25
THURSDAY, MAY 26
FRIDAY, MAY 27
SATURDAY, MAY 28
Conference Program Print | View meeting in 12 hr (am/pm) time
MONDAY, MAY 23
15:00—19:30
Registration
Ballroom A, Foyer
18:15—19:15
Refreshments
Ballroom A, Foyer
19:15—22:00
Keynote Session
Ballroom B,C
*
Malik Peiris,
University of Hong Kong, Hong Kong
Introduction
Introduction
Sir John J. Skehel,
MRC National Institute of Medical Research, UK
Structure Function of HA
Structure Function of HA
Robert G. Webster,
St. Jude Children's Research Hospital, USA
The Ecology of Influenza Viruses
The Ecology of Influenza Viruses
Peter C. Doherty,
University of Melbourne, Australia
T Cells
T Cells
08:00—09:00
Breakfast
Celestial Court
08:00—09:00
Poster Setup
Ballroom A
09:00—12:00
Virology
Ballroom B-C
Yi Guan,
University of Hong Kong, Hong Kong
The Emergence of the H1N1/2009 Pandemic Influenza virus
The Emergence of the H1N1/2009 Pandemic Influenza virus
Nadia Naffakh,
Institut Pasteur, France
Influenza Ribonucleoproteins - Host Cell Interactions
Influenza Ribonucleoproteins - Host Cell Interactions
Jim-Tong Horng,
Chang Gung University, Taiwan
Short Talk: Identification of BPR3P0128 as an Inhibitor against Cap Snatching Activity of Influenza Virus
Short Talk: Identification of BPR3P0128 as an Inhibitor against Cap Snatching Activity of Influenza Virus
10:20—10:40
Coffee Break
Ballroom A, Foyer
12:00—13:00
Lunch
Ballroom A, Tang Rooms
12:00—17:00
Poster Viewing
Ballroom A
12:00—14:30
Poster Session 1
Ballroom A
14:00—14:30
Coffee Available
Ballroom A, Foyer
14:30—17:00
Virus Receptors/Glycans/Structure
Ballroom B-C
*
Sir John J. Skehel,
MRC National Institute of Medical Research, UK
John Nicholls,
University of Hong Kong, China
Receptors in the Human Respiratory Tract - Making and Breaking the links
Receptors in the Human Respiratory Tract - Making and Breaking the links
Ram Sasisekharan,
Massachusetts Institute of Technology, USA
Glycans and HA
Glycans and HA
Ian A. Wilson,
The Scripps Research Institute, USA
New Insights into Broad Neutralization of Influenza Virus and Implications for a Universal Flu Vaccine
New Insights into Broad Neutralization of Influenza Virus and Implications for a Universal Flu Vaccine
Patrick C. Reading,
University of Melbourne, Australia
Short Talk: Specific Sites of N-linked Glycosylation on the Hemagglutinin of H1N1 Subtype Influenza A Virus Determine Sensitivity to C-Type Lectins of the Innate Immune System
Short Talk: Specific Sites of N-linked Glycosylation on the Hemagglutinin of H1N1 Subtype Influenza A Virus Determine Sensitivity to C-Type Lectins of the Innate Immune System
Gillian M. Air,
University of Oklahoma Health Sciences Center, USA
Binding and Cleavage of Sialylated Glycans by H3N2 and H1N1 Influenza Viruses
Binding and Cleavage of Sialylated Glycans by H3N2 and H1N1 Influenza Viruses
08:00—09:00
Breakfast
Celestial Court
09:00—12:00
Human Disease, Lung Injury and Human-Cell Experimental Models
Ballroom B-C
Sherif R. Zaki,
Centers for Disease Control and Prevention, USA
Influenza Pathogenesis in Humans: Revisited
Influenza Pathogenesis in Humans: Revisited
Arthur Slutsky,
University of Toronto, Canada
Lung Injury and ARDS
Lung Injury and ARDS
Paul G. Thomas,
St. Jude Children's Research Hospital, USA
Short Talk: Elucidating Early Site-of-Infection Immune Responses to Influenza A in Young Children
Short Talk: Elucidating Early Site-of-Infection Immune Responses to Influenza A in Young Children
Sagi Shapira,
Broad Institute, USA
Host-Influenza Interactions
Host-Influenza Interactions
Malik Peiris,
University of Hong Kong, Hong Kong
Human ex-vivo and in-vitro Experimental Models for Studying Influenza Pathogenesis
Human ex-vivo and in-vitro Experimental Models for Studying Influenza Pathogenesis
10:20—10:40
Coffee Break
Ballroom A, Foyer
12:00—13:00
Lunch
Ballroom A, Tang Rooms
13:00—14:30
Workshop 1: Pathogen-Host Interaction
Ballroom B-C
*
Nadia Naffakh,
Institut Pasteur, France
Marciela DeGrace,
Harvard University, USA
Dissecting the Role of Trafficking Machinery in the Influenza a Life Cycle Reveals Novel Restriction Factors
Dissecting the Role of Trafficking Machinery in the Influenza a Life Cycle Reveals Novel Restriction Factors
Gregory A. Boivin,
McGill University, Canada
Combining Clinical and Expression QTLs in the Context of Infection: New Insights into Susceptibility to Influenza
Combining Clinical and Expression QTLs in the Context of Infection: New Insights into Susceptibility to Influenza
Michael C.W. Chan,
University of Hong Kong, Hong Kong
Impaired Alveolar Edema Fluid Clearance in Human Alveolar Epithelial Cells Injured by Severe Influenza A Virus Infection
Impaired Alveolar Edema Fluid Clearance in Human Alveolar Epithelial Cells Injured by Severe Influenza A Virus Infection
Rafael A. Medina,
Pontificia Universidad Catolica de Chile, Chile
Effects of Glycosylations in the Globular Head of the 2009 H1N1 Influenza Virus Hemagglutinin: Modulation of Virulence and Antigenicity
Effects of Glycosylations in the Globular Head of the 2009 H1N1 Influenza Virus Hemagglutinin: Modulation of Virulence and Antigenicity
Iris K. Pang,
Chinese University of Hong Kong, Hong Kong
Mechanism of IL-1- Dependent Protective Immunity Against Influenza Virus
Mechanism of IL-1- Dependent Protective Immunity Against Influenza Virus
14:00—14:30
Coffee Available
Ballroom A, Foyer
14:30—16:45
Experimental Models
Ballroom B-C
Andrew S. Pekosz,
Johns Hopkins University, USA
Influenza A Virus Infection of Primary, Differentiated Respiratory Epithelial Cell Cultures
Influenza A Virus Infection of Primary, Differentiated Respiratory Epithelial Cell Cultures
Jacqueline M. Katz,
Centers for Disease Control and Prevention, USA
Small Animal Models for the Study of Influenza Virus Pathogenesis
Small Animal Models for the Study of Influenza Virus Pathogenesis
Kanta Subbarao,
WHO Collaborating Centre for Reference and Research on Influenza, Australia
Replication of Influenza Viruses in Non-Human Primates
Replication of Influenza Viruses in Non-Human Primates
16:45—17:00
European Research Activities on Influenza
Ballroom B-C
Christian Desaintes,
European Commission, Belgium
Short Talk: Research Activities Supported by the European Commission on Influenza
Short Talk: Research Activities Supported by the European Commission on Influenza
08:00—09:00
Breakfast
Celestial Court
08:00—09:00
Poster Setup
Ballroom A
09:00—12:00
Immunity
Ballroom B-C
*
Jacqueline M. Katz,
Centers for Disease Control and Prevention, USA
Gunther Hartmann,
Universitätsklinikum Bonn, Germany
Mechanisms of RNA Recognition through RIG-I and TLR7
Mechanisms of RNA Recognition through RIG-I and TLR7
Hui-Ling Yen,
University of Hong Kong, Hong Kong
Short Talk: Gene Constellation Determines the Transmissibility of the 2009 Pandemic H1N1 Influenza Viruses in a Ferret Model
Short Talk: Gene Constellation Determines the Transmissibility of the 2009 Pandemic H1N1 Influenza Viruses in a Ferret Model
Jenny P.Y. Ting,
University of North Carolina at Chapel Hill, USA
NLRs and Viral Infection
NLRs and Viral Infection
Seema Lakdawala,
University of Pittsburgh School of Medicine, USA
Short Talk: Aerosol Transmission of the Pandemic H1N1 Influenza Virus
Short Talk: Aerosol Transmission of the Pandemic H1N1 Influenza Virus
Toshihiro Ito,
Okayama University, Japan
Short Talk: The Critical Role of Notch Ligand Delta-like 1 in Influenza A Virus Infection
Short Talk: The Critical Role of Notch Ligand Delta-like 1 in Influenza A Virus Infection
Ken J. Ishii,
National Institute of Biomedical Innovation, Health and Nutrition, Japan
Endo- and Exogenous Adjuvant for Influenza Vaccination
Endo- and Exogenous Adjuvant for Influenza Vaccination
10:20—10:40
Coffee Break
Ballroom A, Foyer
12:00—13:00
Lunch
Ballroom A, Tang Rooms
12:00—17:00
Poster Viewing
Ballroom A
12:00—14:30
Poster Session 2
Ballroom A
14:00—14:30
Coffee Available
Ballroom A, Foyer
14:30—17:00
Immunity, Systems Biology, Gender and Susceptibility
Ballroom B-C
*
Peter C. Doherty,
University of Melbourne, Australia
Tao Dong,
University of Oxford, UK
Antigen Specific T Cells in Human Influenza A Virus Infection
Antigen Specific T Cells in Human Influenza A Virus Infection
Jack R. Bennink,
NIAID, National Institutes of Health, USA
Antigenic Drift: Mechanisms of Influenza A Virus Hemagglutinin Immune Escape
Antigenic Drift: Mechanisms of Influenza A Virus Hemagglutinin Immune Escape
Thomas C. Friedrich,
University of Wisconsin, USA
Short Talk: Cross-Reactive T Cells are Involved in Rapid Clearance of 2009 Pandemic H1N1 Influenza Virus Infection by Nonhuman Primates
Short Talk: Cross-Reactive T Cells are Involved in Rapid Clearance of 2009 Pandemic H1N1 Influenza Virus Infection by Nonhuman Primates
Ronald N. Germain,
NIAID, National Institutes of Health, USA
A Systems Approach to Influenza Infection and Vaccine Responses
A Systems Approach to Influenza Infection and Vaccine Responses
Sabra L. Klein,
Johns Hopkins University, USA
Sex Differences in Response to Influenza Virus Infection and Vaccination
Sex Differences in Response to Influenza Virus Infection and Vaccination
08:00—09:00
Breakfast
Celestial Court
09:00—12:00
Pathogenesis and Transmission
Ballroom B-C
Adolfo García-Sastre,
Mount Sinai School of Medicine, USA
In vivo Dynamics of Influenza Virus Infection
In vivo Dynamics of Influenza Virus Infection
Connie Y.H. Leung,
University of Hong Kong, Hong Kong
Short Talk: Toll-like Receptor (TLR)3 Signaling Contributes to Enhanced Disease Severity in H5N1 but not Pandemic H1N1 Infection in Mice
Short Talk: Toll-like Receptor (TLR)3 Signaling Contributes to Enhanced Disease Severity in H5N1 but not Pandemic H1N1 Infection in Mice
Christopher J. O'Donnell,
NHLBI, National Institutes of Health, USA
Short Talk: Antibody Pressure by a Human Monoclonal Antibody (hMAb) Targeting the Sa Region of 2009 Pandemic H1N1 Virus Hemagglutinin can Drive the Development of a More Virulent Virus
Short Talk: Antibody Pressure by a Human Monoclonal Antibody (hMAb) Targeting the Sa Region of 2009 Pandemic H1N1 Virus Hemagglutinin can Drive the Development of a More Virulent Virus
Alexandra Godlee,
Imperial College London, UK
Influenza-Induced Immunological Alterations in the Respiratory Tract
Influenza-Induced Immunological Alterations in the Respiratory Tract
10:20—10:40
Coffee Break
Ballroom A, Foyer
12:00—13:00
Lunch
Ballroom A, Tang Rooms
13:00—14:30
Workshop 2: Modulation of Infection
Ballroom B-C
Kobporn Boonnak,
Mahidol University, Thailand
Treatment of Influenza Virus Infection with Viral Peptides Linked to Dendritic Cells
Treatment of Influenza Virus Infection with Viral Peptides Linked to Dendritic Cells
Huailiang Ma,
Emory University, USA
Human Annexin A6 Interacts with the Influenza A Virus M2 Protein and Negatively Modulates Infection
Human Annexin A6 Interacts with the Influenza A Virus M2 Protein and Negatively Modulates Infection
Wenwei Tu,
University of Hong Kong, China
Pamidronate Boosts gammadelta-T-Cell Immunity and Controls Influenza A Infection: A Novel Therapeutic Option for Influenza
Pamidronate Boosts gammadelta-T-Cell Immunity and Controls Influenza A Infection: A Novel Therapeutic Option for Influenza
Susanne Herold,
University of Giessen Lung Center, Germany
Alveolar Epithelial Cells Shape Pulmonary Dendritic Cell Antiviral Responses in Severe Influenza Virus Pneumonia by Expression of GM-CSF
Alveolar Epithelial Cells Shape Pulmonary Dendritic Cell Antiviral Responses in Severe Influenza Virus Pneumonia by Expression of GM-CSF
Michael Schotsaert,
Icahn School of Medicine at Mount Sinai, USA
M2e-Based Universal Vaccine Protects against Influenza A Virus Challenge and Enhances Heterosubtypic Immunity during Subsequent Infections
M2e-Based Universal Vaccine Protects against Influenza A Virus Challenge and Enhances Heterosubtypic Immunity during Subsequent Infections
14:00—14:30
Coffee Available
Ballroom A, Foyer
14:30—17:00
Interventions
Ballroom B-C
*
Kanta Subbarao,
WHO Collaborating Centre for Reference and Research on Influenza, Australia
Philip Dormitzer,
Pfizer Vaccine Research and Development, USA
Advances in Vaccines Against Seasonal and Pandemic Influenza
Advances in Vaccines Against Seasonal and Pandemic Influenza
YanChun Peng,
University of Oxford, UK
Short Talk: Influenza Specific T Cell Responses after Influenza Virus Challenge in Individuals Vaccinated with NP and M1 Containing MVA Vaccine
Short Talk: Influenza Specific T Cell Responses after Influenza Virus Challenge in Individuals Vaccinated with NP and M1 Containing MVA Vaccine
Chi-Huey Wong,
Academia Sinica, Taiwan
Toward the Design of Universal Glycoprotein Vaccines against Influenza and other Viral Diseases
Toward the Design of Universal Glycoprotein Vaccines against Influenza and other Viral Diseases
Stephan Ludwig,
University of Münster, Germany
Intracellular Signal Transduction and Influenza Virus Infection – Identifying Novel Targets for Antiviral Therapy
Intracellular Signal Transduction and Influenza Virus Infection – Identifying Novel Targets for Antiviral Therapy
17:30—17:35
Depart hotel lobby and transfer to cruise
20:00—21:15
Dragon Pearl Cruise with dinner
21:00—21:15
Disembark Dragon Pearl Cruise and transfer back to hotel
Departure
*Session Chair †Invited, not yet responded.
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