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This meeting took place in 2012
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Mechanisms of Whole Organ Regeneration (Z4)
Organizer(s) Alejandro Sánchez Alvarado
April 1—6, 2012
Beaver Run Resort • Breckenridge, CO USA
Abstract Deadline: Dec 1, 2011
Late Abstract Deadline: Jan 6, 2012
Scholarship Deadline: Dec 1, 2011
Early Registration Deadline: Feb 1, 2012
Supported by the Directors' Fund
Joint Meeting:
Regenerative Tissue Engineering and Transplantation (Z3)
Summary of Meeting:
The regeneration of organs and organ systems after injury is widely, but unevenly, distributed among animals. Why organ regeneration is not shared by all animals, and whether mechanisms may or may not be conserved among those animals that can regenerate remain open questions. In recent years, the use of a wider range of model organisms and an increasing ability to use genetic tools to study regeneration has spurred significant progress in our understanding of animal regenerative biology. This meeting aims to delineate the molecular and cellular biological basis of regeneration by highlighting, comparing and contrasting the differences and similarities in regenerative capabilities and mechanisms among diverse animal species. How these biological findings may inform regenerative medicine and stem-cell biology and therapeutics will be considered and discussed. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Regenerative Tissue Engineering and Transplantation, which will share an opening and closing keynote address as well as two plenary sessions with this meeting.
View Scholarships/Awards
The regeneration of organs and organ systems after injury is widely, but unevenly, distributed among animals. Why organ regeneration is not shared by all animals, and whether mechanisms may or may not be conserved among those animals that can regenerate remain open questions. In recent years, the use of a wider range of model organisms and an increasing ability to use genetic tools to study regeneration has spurred significant progress in our understanding of animal regenerative biology. This meeting aims to delineate the molecular and cellular biological basis of regeneration by highlighting, comparing and contrasting the differences and similarities in regenerative capabilities and mechanisms among diverse animal species. How these biological findings may inform regenerative medicine and stem-cell biology and therapeutics will be considered and discussed. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Regenerative Tissue Engineering and Transplantation, which will share an opening and closing keynote address as well as two plenary sessions with this meeting.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, APRIL 1
MONDAY, APRIL 2
TUESDAY, APRIL 3
WEDNESDAY, APRIL 4
THURSDAY, APRIL 5
FRIDAY, APRIL 6
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, APRIL 1
19:15—20:30
Welcome and Keynote Address (Joint)
Allan C. Spradling,
HHMI/Carnegie Institute, USA
Lessons from Stem Cells on Regeneration and Tissue Engineering
Lessons from Stem Cells on Regeneration and Tissue Engineering
08:00—11:15
Injury-Activated Regeneration
Brigitte Galliot,
University of Geneva, Sciences III - REGEN, Switzerland
Asymmetric Injury Responses Launch Two Different Types of Regenerative Programs in Hydra
Asymmetric Injury Responses Launch Two Different Types of Regenerative Programs in Hydra
Alejandro Sánchez Alvarado,
Stowers Institute for Medical Research/HHMI, USA
Injury, Stem Cells and Regeneration of Body Parts in an Adult Organism
Injury, Stem Cells and Regeneration of Body Parts in an Adult Organism
Elly M. Tanaka,
IMP - Research Institute of Molecular Pathology, Austria
Injury-Associated Signaling Pathways that Initiate Spinal Cord Regeneration in Salamanders
Injury-Associated Signaling Pathways that Initiate Spinal Cord Regeneration in Salamanders
Matthew D. Keefe,
University of Utah, USA
Short Talk: Molecular Mechanisms Controlling Exocrine Pancreas Growth and Regeneration
Short Talk: Molecular Mechanisms Controlling Exocrine Pancreas Growth and Regeneration
Juan A. Larraín,
P. Universidad Catolica de Chile, Chile
Short Talk: Spinal Cord Regeneration in Xenopus
Short Talk: Spinal Cord Regeneration in Xenopus
08:00—11:15
Clinical Applications and Challenges I
*
Ranieri Cancedda,
Università degli Studi di Genova, Genoa (UNIGE), Italy
*
Kenneth R. Chien,
Karolinska Institutet, Sweden
Anthony P. Hollander,
University of Bristol, UK
Tissue-Engineered Cartilage: From the Knee to the Airway
Tissue-Engineered Cartilage: From the Knee to the Airway
Maria Siemionow,
Cleveland Clinic, USA
Composite Facial Allograft Transplantation: Application of Cell-Based Therapies
Composite Facial Allograft Transplantation: Application of Cell-Based Therapies
Mark E. Fleming,
Walter Reed National Military Medical Center, USA
Short Talk: Regenerative Medicine Applications in Combat Casualty Care
Short Talk: Regenerative Medicine Applications in Combat Casualty Care
Ugo Ripamonti,
University of Wiwatersrand, South Africa
Short Talk: Grand Challenges for Craniomandibulofacial Reconstruction by Human Recombinant Transforming Growth Factor-beta3
Short Talk: Grand Challenges for Craniomandibulofacial Reconstruction by Human Recombinant Transforming Growth Factor-beta3
17:00—19:00
Physiological Regeneration
*
Allan C. Spradling,
HHMI/Carnegie Institute, USA
Jenny Hsieh,
University of Texas Southwestern Medical Center, USA
Timing is Everything: Development of New Neurons in the Adult Brain
Timing is Everything: Development of New Neurons in the Adult Brain
Linheng Li,
Stowers Institute for Medical Research, USA
Using Surface Markers to Enrich Intestinal Stem Cells Under Homeostatic and Injured Conditions
Using Surface Markers to Enrich Intestinal Stem Cells Under Homeostatic and Injured Conditions
Valentina Greco,
Yale School of Medicine, USA
Short Talk: Live Imaging Studies of the Stem Cell Niche of the Hair Follicle
Short Talk: Live Imaging Studies of the Stem Cell Niche of the Hair Follicle
17:00—19:00
Clinical Applications and Challenges II
*
Jeffrey M. Gimble,
Tulane University School of Medicine, USA
Michelle Leroux Williams,
Consultant, USA
Therapeutic Applications of Adult Mesenchymal Stem Cells
Therapeutic Applications of Adult Mesenchymal Stem Cells
W. P. Andrew Lee,
Johns Hopkins University School of Medicine, USA
Hand Transplantation Using a Cell-Based Protocol to Minimize Immunosuppression
Hand Transplantation Using a Cell-Based Protocol to Minimize Immunosuppression
Pedro M. Baptista,
Wake Forest Institute for Regenerative Medicine, USA
Short Talk: Human Liver Bioengineering –Turning Science Fiction into Reality
Short Talk: Human Liver Bioengineering –Turning Science Fiction into Reality
08:00—11:15
Organ Regeneration (Joint). Session Sponsored by Development
*
Bruno Péault,
University of California, Los Angeles, USA
Panagiotis Tsonis,
University of Dayton, USA
Lens Regeneration in Newts
Lens Regeneration in Newts
Elke A. Ober,
University of Copenhagen, Denmark
Liver Organogenesis in Zebrafish
Liver Organogenesis in Zebrafish
Phillip A. Newmark,
HHMI/University of Illinois at Urbana-Champaign, USA
Germ Cell Development and Regeneration in Planarians
Germ Cell Development and Regeneration in Planarians
Eric Lagasse,
University of Pittsburgh, USA
Short Talk: The Lymph Node as an Ectopic Transplantation Site for Multiple Epithelial Tissues
Short Talk: The Lymph Node as an Ectopic Transplantation Site for Multiple Epithelial Tissues
Carolyn Adler,
Cornell University, USA
Short Talk: A Novel Transmembrane Protein is Required for Organ Regeneration in Planaria
Short Talk: A Novel Transmembrane Protein is Required for Organ Regeneration in Planaria
17:00—19:00
Evolution and Regeneration
Wallace Marshall,
University of California, San Francisco, USA
Regeneration and Pattern Formation in a Single Cell
Regeneration and Pattern Formation in a Single Cell
Alexandra E. Bely,
University of Maryland at College Park, USA
Evolution of Regeneration Ability: Insights from Annelids
Evolution of Regeneration Ability: Insights from Annelids
Ashley W. Seifert,
University of Kentucky, USA
Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys)
Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys)
Juliette C. Azimzadeh,
University of California San Francisco, USA
Short Talk: Centrosomes were Discarded in the Evolution of Planarians
Short Talk: Centrosomes were Discarded in the Evolution of Planarians
17:00—19:00
Biomaterials, Matrices and Scaffolds I
Farshid Guilak,
Duke University Medical Center, USA
Three-Dimensionally Woven Scaffold for Cell-Based Tissue Engineering
Three-Dimensionally Woven Scaffold for Cell-Based Tissue Engineering
Christine E. Schmidt,
University of Texas at Austin, USA
Electrically Conducting Polymers for Neural Tissue Engineering
Electrically Conducting Polymers for Neural Tissue Engineering
Samuel I. Stupp,
Northwestern University, USA
Ordered Filamentous Matrices and Cell-Like Objects for Regenerative Medicine
Ordered Filamentous Matrices and Cell-Like Objects for Regenerative Medicine
Dan McKinnon,
University of Colorado, Boulder, USA
Short Talk: Dynamically Tunable Hydrogel Materials for Modeling Axon Guidance
Short Talk: Dynamically Tunable Hydrogel Materials for Modeling Axon Guidance
08:00—11:15
Aging, Development and Regeneration
Christoph Lepper,
Carnegie Institution for Science, USA
Age-Dependent Genetic Regulation of Skeletal Muscle Stem Cells
Age-Dependent Genetic Regulation of Skeletal Muscle Stem Cells
Bernhard Kühn,
Children's Hospital of Pittsburgh, USA
Short Talk: Cardiomyocyte Proliferation Contributes to Post-Natal Heart Growth in Humans
Short Talk: Cardiomyocyte Proliferation Contributes to Post-Natal Heart Growth in Humans
Sandra Rieger,
University of Miami, USA
Short Talk: Reciprocal Interactions between Wounds and Peripheral Sensory Axons Promote Zebrafish Fin Regeneration
Short Talk: Reciprocal Interactions between Wounds and Peripheral Sensory Axons Promote Zebrafish Fin Regeneration
Ömer Hidir Yilmaz,
Massachusetts Institute of Technology, USA
Short Talk: mTORC1 Signaling in the Paneth Cell Niche Regulates Intestinal Stem Cell Function in Response to Calorie Intake
Short Talk: mTORC1 Signaling in the Paneth Cell Niche Regulates Intestinal Stem Cell Function in Response to Calorie Intake
Feng Chen,
Stanford University, USA
Short Talk: The Existing Tracheal System Guides New Branch Growth by Scaffolding and Re-Expression of FGF during Drosophila Tracheal Remodeling
Short Talk: The Existing Tracheal System Guides New Branch Growth by Scaffolding and Re-Expression of FGF during Drosophila Tracheal Remodeling
08:00—11:00
Biomaterials, Matrices and Scaffolds II
Lisa A. Fortier,
Cornell University College of Veterinary Medicine, USA
Equine Articular Cartilage Tissue Engineering
Equine Articular Cartilage Tissue Engineering
Teruo Okano,
Tokyo Women’s Medical University, Japan
Cell Sheet Tissue Engineering for 3D Vascularized Tissues
Cell Sheet Tissue Engineering for 3D Vascularized Tissues
Agneta Simionescu,
Clemson University, USA
Short Talk: Diabetes-Related Alterations in Collagen Scaffolds used for Cardiovascular Tissue Engineering; Mitigation with Antioxidants
Short Talk: Diabetes-Related Alterations in Collagen Scaffolds used for Cardiovascular Tissue Engineering; Mitigation with Antioxidants
Chiara Villa,
University of Milan, Italy
Short Talk: Thermoresponsive Material for Muscle Cell Sheet Engineering
Short Talk: Thermoresponsive Material for Muscle Cell Sheet Engineering
17:00—19:00
Regenerative Biology and Regenerative Medicine
András Simon,
Karolinska Institutet, Sweden
Reversible Suppression of Neurogenesis in the Adult Vertebrate Brain
Reversible Suppression of Neurogenesis in the Adult Vertebrate Brain
Michele De Luca,
University of Modena and Reggio Emilia, Italy
Limbal Stem-Cell Therapy and Long-Term Corneal Regeneration
Limbal Stem-Cell Therapy and Long-Term Corneal Regeneration
Olov Andersson,
Karolinska Institutet, Sweden
Short Talk: A Chemical Screen in Zebrafish Identifies Adenosine Signaling as a Promoter of Pancreatic Beta-Cell Regeneration
Short Talk: A Chemical Screen in Zebrafish Identifies Adenosine Signaling as a Promoter of Pancreatic Beta-Cell Regeneration
17:00—19:30
Cells and Biological Mechanisms I
*
Lisa A. Fortier,
Cornell University College of Veterinary Medicine, USA
Rocky S. Tuan,
University of Pittsburgh School of Medicine, USA
Adult Stem Cells and Nanomaterials in Skeletal Tissue Engineering and Regeneration
Adult Stem Cells and Nanomaterials in Skeletal Tissue Engineering and Regeneration
Kevin C. Eggan,
Harvard University, USA
Identification and Characterization of Small Reprogramming Molecules
Identification and Characterization of Small Reprogramming Molecules
Kelly R. Stevens,
Massachusetts Institute of Technology and Harvard University, USA
Short Talk: Multi-Cellular Architecture Regulates Physiologic Function of 3D Engineered Liver Tissue in vitro and after Implantation
Short Talk: Multi-Cellular Architecture Regulates Physiologic Function of 3D Engineered Liver Tissue in vitro and after Implantation
Tamir Rashid,
University of Cambridge, UK
Reprogrammed Adult Cells for Liver Transplantation
Reprogrammed Adult Cells for Liver Transplantation
08:00—11:15
Stem Cells and Regeneration
*
Panagiotis Tsonis,
University of Dayton, USA
Kenneth D. Birnbaum,
New York University, USA
What is the Origin of Plant Cell Plasticity?
What is the Origin of Plant Cell Plasticity?
Sean J. Morrison,
University of Texas Southwestern Medical Center, USA
Stem Cell Self-Renewal in Regenerating Tissues
Stem Cell Self-Renewal in Regenerating Tissues
Arnout G. Schepers,
Hubrecht Institute, Netherlands
Short Talk: Direct Demonstration of Lgr5 Stem Cell Activity within Apc-Mutant Intestinal Adenomas
Short Talk: Direct Demonstration of Lgr5 Stem Cell Activity within Apc-Mutant Intestinal Adenomas
Gufa Lin,
University of Minnesota, USA
Short Talk: Imparting Regenerative Capacity to Frog Limbs by Cell Transplantation
Short Talk: Imparting Regenerative Capacity to Frog Limbs by Cell Transplantation
08:00—11:15
Cells and Biological Mechanisms II
Bruno Péault,
University of California, Los Angeles, USA
Prospective Identification of Multi-Lineage Stem Cells Present in Human Adult Organs and Tissues
Prospective Identification of Multi-Lineage Stem Cells Present in Human Adult Organs and Tissues
Jeffrey M. Gimble,
Tulane University School of Medicine, USA
Immunogenicity and Immunoregulatory Activities of Adipose Tissue-Derived Cells
Immunogenicity and Immunoregulatory Activities of Adipose Tissue-Derived Cells
Marc Penn,
Summa Health System, USA
Mechanisms of Stem Cell-Based Repair of the Heart
Mechanisms of Stem Cell-Based Repair of the Heart
Robert J. Deans,
Synthego Corporation, USA
Adult Stem Cells for Treatment of Graft Versus Host Disease
Adult Stem Cells for Treatment of Graft Versus Host Disease
Taymour M. Hammoudi,
Georgia Institute of Technology and Emory School of Medicine, USA
Short Talk: Novel 3D in vitro Co- and Tri-Culture Platform to Investigate Effects of Paracrine Signaling in Bone Marrow Niche Cells
Short Talk: Novel 3D in vitro Co- and Tri-Culture Platform to Investigate Effects of Paracrine Signaling in Bone Marrow Niche Cells
Praveen R. Arany,
Harvard University, USA
Short Talk: Laser Directs Stem Cells Differentiation via TGF-beta1 Activation
Short Talk: Laser Directs Stem Cells Differentiation via TGF-beta1 Activation
14:30—16:30
Panel: Crosscutting Topics in Regenerative Medicine: 'Stone Soup' for Organ Regeneration (Joint)
A cross-disciplinary panel discussion to identify specific areas of biology and bioengineering that can best benefit from each other in advancing the science and clinical translation of regenerative medicine.
Jeffrey M. Gimble,
Tulane University School of Medicine, USA
Kenneth R. Chien,
Karolinska Institutet, Sweden
17:00—18:15
New Vistas in Tissue Regeneration and Engineering (Joint)
Jeremy Brockes,
University College London, UK
Tumor Suppressor Genes and Limb Regeneration
Tumor Suppressor Genes and Limb Regeneration
Kenneth R. Chien,
Karolinska Institutet, Sweden
Driving Heart Progenitor Cell Fate and Regeneration in vivo via Chemically Modified mRNA
Driving Heart Progenitor Cell Fate and Regeneration in vivo via Chemically Modified mRNA
18:15—19:15
Keynote Address (Joint)
Susan J. Fisher,
University of California, San Francisco, USA
Embryonic Stem Cells Related to Regenerative Medicine
Embryonic Stem Cells Related to Regenerative Medicine
*Session Chair †Invited, not yet responded.
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