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This meeting took place in 2012



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Mechanisms of Whole Organ Regeneration (Z4)


Organizer(s) Alejandro Sánchez Alvarado
April 1—6, 2012
Beaver Run Resort • Breckenridge, CO USA
Abstract Deadline: Dec 1, 2011
Late Abstract Deadline: Jan 6, 2012
Scholarship Deadline: Dec 1, 2011
Early Registration Deadline: Feb 1, 2012

Supported by the Directors' Fund


Summary of Meeting:
The regeneration of organs and organ systems after injury is widely, but unevenly, distributed among animals. Why organ regeneration is not shared by all animals, and whether mechanisms may or may not be conserved among those animals that can regenerate remain open questions. In recent years, the use of a wider range of model organisms and an increasing ability to use genetic tools to study regeneration has spurred significant progress in our understanding of animal regenerative biology. This meeting aims to delineate the molecular and cellular biological basis of regeneration by highlighting, comparing and contrasting the differences and similarities in regenerative capabilities and mechanisms among diverse animal species. How these biological findings may inform regenerative medicine and stem-cell biology and therapeutics will be considered and discussed. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Regenerative Tissue Engineering and Transplantation, which will share an opening and closing keynote address as well as two plenary sessions with this meeting.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, APRIL 1

15:00—19:30
Registration

Foyer
18:15—19:15
Refreshments

Foyer
19:15—20:30
Welcome and Keynote Address (Joint)

Peaks 1-5
* Rocky S. Tuan, University of Pittsburgh School of Medicine, USA

* Alejandro Sánchez Alvarado, Stowers Institute for Medical Research/HHMI, USA

Allan C. Spradling, HHMI/Carnegie Institute, USA
Lessons from Stem Cells on Regeneration and Tissue Engineering


MONDAY, APRIL 2

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Injury-Activated Regeneration

Peak 5
* Phillip A. Newmark, HHMI/University of Illinois at Urbana-Champaign, USA

Brigitte Galliot, University of Geneva, Sciences III - REGEN, Switzerland
Asymmetric Injury Responses Launch Two Different Types of Regenerative Programs in Hydra

Alejandro Sánchez Alvarado, Stowers Institute for Medical Research/HHMI, USA
Injury, Stem Cells and Regeneration of Body Parts in an Adult Organism

Elly M. Tanaka, IMP - Research Institute of Molecular Pathology, Austria
Injury-Associated Signaling Pathways that Initiate Spinal Cord Regeneration in Salamanders

Roeland Nusse, HHMI/Stanford University, USA
Wnt Signaling, Stem Cells and Tissue Repair

Matthew D. Keefe, University of Utah, USA
Short Talk: Molecular Mechanisms Controlling Exocrine Pancreas Growth and Regeneration

Juan A. Larraín, P. Universidad Catolica de Chile, Chile
Short Talk: Spinal Cord Regeneration in Xenopus

08:00—11:15
Clinical Applications and Challenges I

Peaks 1-4
* Ranieri Cancedda, University of Genova, Italy

* Kenneth R. Chien, Karolinska Institutet, Sweden

Anthony Atala, Wake Forest University, USA
Tissue Engineered Urologic Organs

Anthony P. Hollander, University of Bristol, UK
Tissue-Engineered Cartilage: From the Knee to the Airway

Maria Siemionow, Cleveland Clinic, USA
Composite Facial Allograft Transplantation: Application of Cell-Based Therapies

Mark E. Fleming, Walter Reed National Military Medical Center, USA
Short Talk: Regenerative Medicine Applications in Combat Casualty Care

Ugo Ripamonti, University of Wiwatersrand, South Africa
Short Talk: Grand Challenges for Craniomandibulofacial Reconstruction by Human Recombinant Transforming Growth Factor-beta3

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Breckenridge Ballroom
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Breckenridge Ballroom
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Physiological Regeneration

Peak 5
* Allan C. Spradling, HHMI/Carnegie Institute, USA

Jenny Hsieh, University of Texas Southwestern Medical Center, USA
Timing is Everything: Development of New Neurons in the Adult Brain

Linheng Li, Stowers Institute for Medical Research, USA
Using Surface Markers to Enrich Intestinal Stem Cells Under Homeostatic and Injured Conditions

Elaine V. Fuchs, Rockefeller University, USA
Stem Cells in the Skin: Natural Cycles of Regeneration

Valentina Greco, Yale School of Medicine, USA
Short Talk: Live Imaging Studies of the Stem Cell Niche of the Hair Follicle

17:00—19:00
Clinical Applications and Challenges II

Peaks 1-4
* Anthony P. Hollander, University of Bristol, UK

* Jeffrey M. Gimble, Tulane University School of Medicine, USA

Michelle Leroux Williams, Consultant, USA
Therapeutic Applications of Adult Mesenchymal Stem Cells

W. P. Andrew Lee, Johns Hopkins University School of Medicine, USA
Hand Transplantation Using a Cell-Based Protocol to Minimize Immunosuppression

Pedro M. Baptista, Wake Forest Institute for Regenerative Medicine, USA
Short Talk: Human Liver Bioengineering –Turning Science Fiction into Reality

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
19:30—22:00
Poster Session 1

Breckenridge Ballroom

TUESDAY, APRIL 3

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Organ Regeneration (Joint). Session Sponsored by Development

Peaks 1-5
* Bruno Péault, University of California, Los Angeles, USA

* Elly M. Tanaka, IMP - Research Institute of Molecular Pathology, Austria

Panagiotis Tsonis, University of Dayton, USA
Lens Regeneration in Newts

Kenneth D. Poss, Duke University Medical Center, USA
Regeneration in Zebrafish

Elke A. Ober, University of Copenhagen, Denmark
Liver Organogenesis in Zebrafish

Phillip A. Newmark, HHMI/University of Illinois at Urbana-Champaign, USA
Germ Cell Development and Regeneration in Planarians

Eric Lagasse, University of Pittsburgh, USA
Short Talk: The Lymph Node as an Ectopic Transplantation Site for Multiple Epithelial Tissues

Carolyn Adler, Cornell University, USA
Short Talk: A Novel Transmembrane Protein is Required for Organ Regeneration in Planaria

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Breckenridge Ballroom
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Breckenridge Ballroom
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Evolution and Regeneration

Peak 5
* Voot P. Yin, Mount Desert Island Biological Laboratories, USA

Wallace Marshall, University of California, San Francisco, USA
Regeneration and Pattern Formation in a Single Cell

Alexandra E. Bely, University of Maryland at College Park, USA
Evolution of Regeneration Ability: Insights from Annelids

Ashley W. Seifert, University of Kentucky, USA
Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys)

Juliette C. Azimzadeh, University of California San Francisco, USA
Short Talk: Centrosomes were Discarded in the Evolution of Planarians

17:00—19:00
Biomaterials, Matrices and Scaffolds I

Peaks 1-4
* Molly Stevens, Imperial College London, UK

Farshid Guilak, Duke University Medical Center, USA
Three-Dimensionally Woven Scaffold for Cell-Based Tissue Engineering

Christine E. Schmidt, University of Texas at Austin, USA
Electrically Conducting Polymers for Neural Tissue Engineering

Samuel I. Stupp, Northwestern University, USA
Ordered Filamentous Matrices and Cell-Like Objects for Regenerative Medicine

Dan McKinnon, University of Colorado, Boulder, USA
Short Talk: Dynamically Tunable Hydrogel Materials for Modeling Axon Guidance

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
19:30—22:00
Poster Session 2

Breckenridge Ballroom

WEDNESDAY, APRIL 4

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Aging, Development and Regeneration

Peak 5
* Alejandro Sánchez Alvarado, Stowers Institute for Medical Research/HHMI, USA

Anne Brunet, Stanford University, USA
Regeneration in Short-Lived Fish

Amy J. Wagers, Harvard University, USA
Aging and Rejuvenation of Tissue Stem Cells

Christoph Lepper, Carnegie Institution for Science, USA
Age-Dependent Genetic Regulation of Skeletal Muscle Stem Cells

Bernhard Kühn, Children's Hospital of Pittsburgh, USA
Short Talk: Cardiomyocyte Proliferation Contributes to Post-Natal Heart Growth in Humans

Sandra Rieger, University of Miami, USA
Short Talk: Reciprocal Interactions between Wounds and Peripheral Sensory Axons Promote Zebrafish Fin Regeneration

Ömer Hidir Yilmaz, Massachusetts Institute of Technology, USA
Short Talk: mTORC1 Signaling in the Paneth Cell Niche Regulates Intestinal Stem Cell Function in Response to Calorie Intake

Feng Chen, Stanford University, USA
Short Talk: The Existing Tracheal System Guides New Branch Growth by Scaffolding and Re-Expression of FGF during Drosophila Tracheal Remodeling

08:00—11:00
Biomaterials, Matrices and Scaffolds II

Peaks 1-4
* Anthony Atala, Wake Forest University, USA

* Christine E. Schmidt, University of Texas at Austin, USA

Molly Stevens, Imperial College London, UK
New Materials-Based Approaches for Tissue Regeneration

Xiao Hu, Tufts University, USA
Silk-Tropoelastin Biomaterial Alloys

Lisa A. Fortier, Cornell University College of Veterinary Medicine, USA
Equine Articular Cartilage Tissue Engineering

Teruo Okano, Tokyo Women’s Medical University, Japan
Cell Sheet Tissue Engineering for 3D Vascularized Tissues

Agneta Simionescu, Clemson University, USA
Short Talk: Diabetes-Related Alterations in Collagen Scaffolds used for Cardiovascular Tissue Engineering; Mitigation with Antioxidants

Chiara Villa, University of Milan, Italy
Short Talk: Thermoresponsive Material for Muscle Cell Sheet Engineering

09:20—09:40
Coffee Break

Foyer
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Regenerative Biology and Regenerative Medicine

Peak 5
* Anne Brunet, Stanford University, USA

András Simon, Karolinska Institutet, Sweden
Reversible Suppression of Neurogenesis in the Adult Vertebrate Brain

Michele De Luca, University of Modena and Reggio Emilia, Italy
Limbal Stem-Cell Therapy and Long-Term Corneal Regeneration

Olov Andersson, Karolinska Institutet, Sweden
Short Talk: A Chemical Screen in Zebrafish Identifies Adenosine Signaling as a Promoter of Pancreatic Beta-Cell Regeneration

17:00—19:30
Cells and Biological Mechanisms I

Peaks 1-4
* Farshid Guilak, Duke University Medical Center, USA

* Lisa A. Fortier, Cornell University College of Veterinary Medicine, USA

Rocky S. Tuan, University of Pittsburgh School of Medicine, USA
Adult Stem Cells and Nanomaterials in Skeletal Tissue Engineering and Regeneration

Helen M. Blau, Stanford University, USA
Bioengineered Niches to Control Stem Cell Fate and Function

Kevin C. Eggan, Harvard University, USA
Identification and Characterization of Small Reprogramming Molecules

Kelly R. Stevens, Massachusetts Institute of Technology and Harvard University, USA
Short Talk: Multi-Cellular Architecture Regulates Physiologic Function of 3D Engineered Liver Tissue in vitro and after Implantation

Tamir Rashid, University of Cambridge, UK
Reprogrammed Adult Cells for Liver Transplantation

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom

THURSDAY, APRIL 5

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Stem Cells and Regeneration

Peak 5
* Panagiotis Tsonis, University of Dayton, USA

Kenneth D. Birnbaum, New York University, USA
What is the Origin of Plant Cell Plasticity?

Jing-Wei Xiong, Peking University, China
Zebrafish Heart Regeneration

Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Stem Cell Self-Renewal in Regenerating Tissues

Voot P. Yin, Mount Desert Island Biological Laboratories, USA
miRNAs and Regeneration

Arnout G. Schepers, Hubrecht Institute, Netherlands
Short Talk: Direct Demonstration of Lgr5 Stem Cell Activity within Apc-Mutant Intestinal Adenomas

Gufa Lin, University of Minnesota, USA
Short Talk: Imparting Regenerative Capacity to Frog Limbs by Cell Transplantation

08:00—11:15
Cells and Biological Mechanisms II

Peaks 1-4
* Rocky S. Tuan, University of Pittsburgh School of Medicine, USA

* Helen M. Blau, Stanford University, USA

Bruno Péault, University of California, Los Angeles, USA
Prospective Identification of Multi-Lineage Stem Cells Present in Human Adult Organs and Tissues

Jeffrey M. Gimble, Tulane University School of Medicine, USA
Immunogenicity and Immunoregulatory Activities of Adipose Tissue-Derived Cells

Marc Penn, Summa Health System, USA
Mechanisms of Stem Cell-Based Repair of the Heart

Robert J. Deans, BlueRock Therapeutics, USA
Adult Stem Cells for Treatment of Graft Versus Host Disease

Taymour M. Hammoudi, Georgia Institute of Technology and Emory School of Medicine, USA
Short Talk: Novel 3D in vitro Co- and Tri-Culture Platform to Investigate Effects of Paracrine Signaling in Bone Marrow Niche Cells

Praveen R. Arany, Harvard University, USA
Short Talk: Laser Directs Stem Cells Differentiation via TGF-beta1 Activation

09:00—09:20
Coffee Break

Foyer
11:15
On Own for Lunch and Recreation

14:30—16:30
Panel: Crosscutting Topics in Regenerative Medicine: “Stone Soup” for Organ Regeneration (Joint)
A cross-disciplinary panel discussion to identify specific areas of biology and bioengineering that can best benefit from each other in advancing the science and clinical translation of regenerative medicine.

Breckenridge Ballroom
* Nadya L. Lumelsky, NIDCR, National Institutes of Health, USA

* Fei Wang, NIAMS, National Institutes of Health, USA

Farshid Guilak, Duke University Medical Center, USA

Christine E. Schmidt, University of Texas at Austin, USA

Samuel I. Stupp, Northwestern University, USA

Amy J. Wagers, Harvard University, USA

Rocky S. Tuan, University of Pittsburgh School of Medicine, USA

Jeffrey M. Gimble, Tulane University School of Medicine, USA

Sean J. Morrison, University of Texas Southwestern Medical Center, USA

Kenneth R. Chien, Karolinska Institutet, Sweden

Helen M. Blau, Stanford University, USA

16:30—17:00
Coffee Available

Foyer
17:00—18:15
New Vistas in Tissue Regeneration and Engineering (Joint)

Breckenridge Ballroom
* Kenneth D. Poss, Duke University Medical Center, USA

* Alejandro Sánchez Alvarado, Stowers Institute for Medical Research/HHMI, USA

Jeremy Brockes, University College London, UK
Tumor Suppressor Genes and Limb Regeneration

Kenneth R. Chien, Karolinska Institutet, Sweden
Driving Heart Progenitor Cell Fate and Regeneration in vivo via Chemically Modified mRNA

18:15—19:15
Keynote Address (Joint)

Breckenridge Ballroom
* Alejandro Sánchez Alvarado, Stowers Institute for Medical Research/HHMI, USA

* Rocky S. Tuan, University of Pittsburgh School of Medicine, USA

Susan J. Fisher, University of California, San Francisco, USA
Embryonic Stem Cells Related to Regenerative Medicine

19:15—20:15
Social Hour with Lite Bites

Breckenridge Ballroom
20:00—23:00
Entertainment

Breckenridge Ballroom

FRIDAY, APRIL 6

 
Departure


*Session Chair †Invited, not yet responded.


We gratefully acknowledge support for this conference from:


Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AG041553-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge additional support for this conference from:

Development, The Company of Biologists Ltd March of Dimes Foundation

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

S. Karger AG - Cells Tissues Organs

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-1179