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This meeting took place in 2012
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Complications of Diabetes: Mechanisms of Injury and Failure of Repair (C5)
Organizer(s) Rama Natarajan, Matthias Kretzler and E. Dale Abel
March 11—16, 2012
Boston Park Plaza • Boston, Massachusetts USA
Abstract Deadline: Nov 10, 2011
Late Abstract Deadline: Dec 14, 2011
Scholarship Deadline: Nov 10, 2011
Early Registration Deadline: Jan 12, 2012
Sponsored by Merck & Co., Inc.
Summary of Meeting:
Diabetes is associated with significantly accelerated rates of several microvascular and macrovascular complications including nephropathy, neuropathy, retinopathy and atherosclerosis. Furthermore, results from both clinical trials and animal studies indicate that these complications might progress despite glycemic control, a phenomenon termed metabolic memory. Ongoing studies have identified biochemical and nuclear mechanisms, genetic determinants, epigenetic factors and non-coding RNAs in the pathogenesis of diabetic complications. Thus, the study of the key mechanisms leading to injury in target organs and failure of adaptive processes holds great promise for the identification of mechanism-targeted therapeutic approaches. These experimental approaches have been aided by tremendous advances in high-throughput genomic and epigenomic technologies, integrated systems biology and bioinformatics. Advances in the fields of stem cell therapies, induced pluripotency and regenerative medicine have provided new hope for the treatment of complications. The goal of this interdisciplinary meeting is to integrate these evolving concepts with current knowledge to facilitate a systems-level understanding of diabetic complications.
View Scholarships/Awards
Diabetes is associated with significantly accelerated rates of several microvascular and macrovascular complications including nephropathy, neuropathy, retinopathy and atherosclerosis. Furthermore, results from both clinical trials and animal studies indicate that these complications might progress despite glycemic control, a phenomenon termed metabolic memory. Ongoing studies have identified biochemical and nuclear mechanisms, genetic determinants, epigenetic factors and non-coding RNAs in the pathogenesis of diabetic complications. Thus, the study of the key mechanisms leading to injury in target organs and failure of adaptive processes holds great promise for the identification of mechanism-targeted therapeutic approaches. These experimental approaches have been aided by tremendous advances in high-throughput genomic and epigenomic technologies, integrated systems biology and bioinformatics. Advances in the fields of stem cell therapies, induced pluripotency and regenerative medicine have provided new hope for the treatment of complications. The goal of this interdisciplinary meeting is to integrate these evolving concepts with current knowledge to facilitate a systems-level understanding of diabetic complications.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, MARCH 11
MONDAY, MARCH 12
TUESDAY, MARCH 13
WEDNESDAY, MARCH 14
THURSDAY, MARCH 15
FRIDAY, MARCH 16
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, MARCH 11
19:15—20:30
Welcome and Keynote Address
*
Rama Natarajan,
Beckman Research Institute of City of Hope, USA
Kenneth R. Chien,
Karolinska Institutet, Sweden
Driving Heart Progenitor Cell Fate and Regeneration in vivo via Chemically Modified mRNA
Driving Heart Progenitor Cell Fate and Regeneration in vivo via Chemically Modified mRNA
08:30—11:45
Mechanisms for Glucotoxicity and Lipotoxicity
George L. King,
Joslin Diabetes Center, USA
Characterization of Protective Factors for Diabetic Retinopathy and Nephropathy
Characterization of Protective Factors for Diabetic Retinopathy and Nephropathy
Karin E. Bornfeldt,
University of Washington School of Medicine, USA
Monocyte/Macrophage Fatty Acid Metabolism is More Important than Glucose Metabolism in Mediating an Inflammatory Phenotype and Atherosclerosis
Monocyte/Macrophage Fatty Acid Metabolism is More Important than Glucose Metabolism in Mediating an Inflammatory Phenotype and Atherosclerosis
Ann Marie Schmidt,
New York University Langone Medical Center, USA
RAGE, Signal Transduction and the Vascular Complications of Diabetes
RAGE, Signal Transduction and the Vascular Complications of Diabetes
Günaj Rakipovski,
Novo Nordisk, Denmark
Short Talk: Fluctuating hyperglycemia induces higer levels of oxidative stress relative to sustained hyperglycemia in obese rats – possible role for lack of metabolic adaptation
Short Talk: Fluctuating hyperglycemia induces higer levels of oxidative stress relative to sustained hyperglycemia in obese rats – possible role for lack of metabolic adaptation
Adam R. Wende,
University of Alabama at Birmingham, USA
Short Talk: Glucose-Mediated Control of Mitochondrial Gene Expression and Oxidative Phosphorylation Protein Function in the Heart
Short Talk: Glucose-Mediated Control of Mitochondrial Gene Expression and Oxidative Phosphorylation Protein Function in the Heart
14:30—16:30
Workshop 1: Techniques and Translational Approaches
Thomas M. Coffman,
NUS Duke Singapore, Singapore
Animal Models and Update on AMDCC
Animal Models and Update on AMDCC
Hans-Joachim Anders,
University of Munich, Germany
Chemokine Related Targets in Diabetic Nephropathy
Chemokine Related Targets in Diabetic Nephropathy
Karin Agnes Maria Jandeleit-Dahm,
Monash University, Australia
Drug Targets and Drugs for Diabetic Complications
Drug Targets and Drugs for Diabetic Complications
Matthew D. Breyer,
Janssen Pharmaceutical Company, USA
Hurdles to the Development of Therapies for Diabetic Nephropathy: Making the Leap from Bench to Bedside
Hurdles to the Development of Therapies for Diabetic Nephropathy: Making the Leap from Bench to Bedside
17:00—19:00
Micro- and Macrovascular Damage Mechanisms
*
George L. King,
Joslin Diabetes Center, USA
Moshe Levi,
Georgetown University, USA
Role of LXR in Diabetic Complications
Role of LXR in Diabetic Complications
Masaomi Nangaku,
University of Tokyo School of Medicine, Japan
Abnormal Oxygen Metabolism and Epigenetic Changes in Diabetic Kidney Disease
Abnormal Oxygen Metabolism and Epigenetic Changes in Diabetic Kidney Disease
Nhat-Tu Le,
University of Rochester, USA
Short Talk: A Crucial Role of p90RSK-Mediated Reduction of Endothelial ERK5 Transcriptional Activity in Endothelial Inflammation, Dysfunction, and Atherosclerosis Formation
Short Talk: A Crucial Role of p90RSK-Mediated Reduction of Endothelial ERK5 Transcriptional Activity in Endothelial Inflammation, Dysfunction, and Atherosclerosis Formation
08:30—11:45
Molecular Mechanisms of Injury and Novel Approaches to Cellular Repair
Paola Romagnani,
University of Florence, Italy
Renal Progenitors for Kidney Regeneration: A 'Renopoietic' System?
Renal Progenitors for Kidney Regeneration: A 'Renopoietic' System?
Jan Kajstura,
Brigham and Women's Hospital, Harvard Medical School, USA
Stem Cell and Diabetic Cardiomyopathy
Stem Cell and Diabetic Cardiomyopathy
Maria B. Grant,
University of Florida, USA
Activation of the ACE2/Angiotensin-(1-7)/Mas Receptor Axis Enhances the Reparative Function of Dysfunctional Diabetic Endothelial Progenitors
Activation of the ACE2/Angiotensin-(1-7)/Mas Receptor Axis Enhances the Reparative Function of Dysfunctional Diabetic Endothelial Progenitors
Sarah X. Zhang,
University of Oklahoma Health Sciences Center, USA
ER Stress, Angiogenesis and Inflammation in Diabetic Retinopathy
ER Stress, Angiogenesis and Inflammation in Diabetic Retinopathy
Josephine M. Forbes,
Mater Medical Research Institute, Australia
Short Talk: Deletion of the Mitochondrial Flavoprotein Apoptosis Inducing Factor (AIF) Accelerates the Progression of Diabetic Nephropathy
Short Talk: Deletion of the Mitochondrial Flavoprotein Apoptosis Inducing Factor (AIF) Accelerates the Progression of Diabetic Nephropathy
Zongwei Wang,
Massachusetts General Hospital, USA
Short Talk: Inhibition of inflammatory mediators reverses the bladder dysfunction associated with Type 2 Diabetes
Short Talk: Inhibition of inflammatory mediators reverses the bladder dysfunction associated with Type 2 Diabetes
14:30—16:30
Workshop 2: Extramural Funding Opportunities for Diabetes Complications Research
*
Ann Marie Schmidt,
New York University Langone Medical Center, USA
Tamara Darsow,
American Diabetes Association, USA
Teresa Jones,
NIDDK, National Institutes of Health, USA
Tracy Rankin,
NIDDK, National Institutes of Health, USA
17:00—19:00
Oxidative Stress and Mitochondrial Dysfunction
Subramaniam Pennathur,
University of Michigan, USA
Role of Lipoporotein Oxidation in Atherosclerosis
Role of Lipoporotein Oxidation in Atherosclerosis
Irina G. Obrosova,
Pennington Biomedical Research Center, Louisiana State University System, USA
Oxidative-Nitrosative Stress in Diabetic Neuropathy
Oxidative-Nitrosative Stress in Diabetic Neuropathy
Hanna E. Abboud,
University of Texas, USA
Noxes, NADPH Oxidase and Diabetic Complications
Noxes, NADPH Oxidase and Diabetic Complications
Xianwen Yi,
University of North Carolina, USA
Short Talk: Antioxidants, Mitochondria and Diabetic Nephropathy
Short Talk: Antioxidants, Mitochondria and Diabetic Nephropathy
08:30—11:45
Lessons Learned from Animal and Human Models of Diabetic Complications
*
Katalin Susztak,
University of Pennsylvania, USA
Frank Chip Brosius III,
University of Michigan, USA
How a Systems Approach Using Humans and Mice Can Bring New Insight to Understanding Diabetic Complications
How a Systems Approach Using Humans and Mice Can Bring New Insight to Understanding Diabetic Complications
E. Dale Abel,
University of Iowa, Carver College of Medicine, USA
Novel Molecular Mechanisms for Diabetic Cardiomyopathy
Novel Molecular Mechanisms for Diabetic Cardiomyopathy
Mark Yore,
Beth Israel Deaconess Medical Center & Harvard Medical School, USA
Vascular and Neural Dysfunction in Diabetic Models
Vascular and Neural Dysfunction in Diabetic Models
Charles E. Alpers,
University of Washington, USA
Short Talk: The BTBR ob/ob Mouse is a Good Model of Diabetic Complications
Short Talk: The BTBR ob/ob Mouse is a Good Model of Diabetic Complications
Richard C. Davis,
University of California, Los Angeles, USA
Short Talk: Genetic Mapping of Genes Contributing to Diabetic Complications
Short Talk: Genetic Mapping of Genes Contributing to Diabetic Complications
15:00—17:00
Genetics
Andrzej S. Krolewski,
Joslin Diabetes Center, USA
Genetics of Nephropathy in Type 1 Diabetes: Search for Genes Contributing to Rapid Progression to End Stage Renal Disease (ESRD)
Genetics of Nephropathy in Type 1 Diabetes: Search for Genes Contributing to Rapid Progression to End Stage Renal Disease (ESRD)
Barry I. Freedman,
Wake Forest University Baptist Medical Center, USA
Genetic Factors in Diabetic and Non-Diabetic Nephropathy
Genetic Factors in Diabetic and Non-Diabetic Nephropathy
Eoin P. Brennan,
Conway Institute, Ireland
Short Talk: New Genetic loci Associated with Kidney Disease in Type 1 Diabetes
Short Talk: New Genetic loci Associated with Kidney Disease in Type 1 Diabetes
08:30—11:45
Role of Epigenetics and MicroRNAs in Diabetic End-Organ Damage
*
Hanna E. Abboud,
University of Texas, USA
Katalin Susztak,
University of Pennsylvania, USA
Epigenetics in Human Diabetic Kidney Disease
Epigenetics in Human Diabetic Kidney Disease
Rama Natarajan,
Beckman Research Institute of City of Hope, USA
Role of Epigenetic Mechanisms and microRNAs Underlying Inflammation in Diabetic Vascular Complications and Metabolic Memory
Role of Epigenetic Mechanisms and microRNAs Underlying Inflammation in Diabetic Vascular Complications and Metabolic Memory
Farhad Danesh,
University of Texas MD Anderson Cancer Center, USA
The Emerging Role of MicroRNAs in Diabetic Nephropathy
The Emerging Role of MicroRNAs in Diabetic Nephropathy
Assam El-Osta,
Monash University, Australia
Epigenetic Changes in Hyperglycemic Memory of Endothelial Dysfunction in Diabetes
Epigenetic Changes in Hyperglycemic Memory of Endothelial Dysfunction in Diabetes
Mary R. Loeken,
Joslin Diabetes Center, USA
Short Talk: Inhibition of Differentiation-Induced DNA Methylation Patterns Explains Disturbed Embryo Gene Expression during Diabetic Embryopathy
Short Talk: Inhibition of Differentiation-Induced DNA Methylation Patterns Explains Disturbed Embryo Gene Expression during Diabetic Embryopathy
Nancy E. Castro,
City of Hope, USA
Short Talk: miR-30 and miR-130 Family Inhibition by Transforming Growth Factor beta1 Leads to Enhanced Pro-Fibrotic Genes in Mouse Kidney Mesangial Cells
Short Talk: miR-30 and miR-130 Family Inhibition by Transforming Growth Factor beta1 Leads to Enhanced Pro-Fibrotic Genes in Mouse Kidney Mesangial Cells
17:00—19:00
Integrative Biology Approaches to Diabetic Complications
Aldons J. Lusis,
University of California, Los Angeles, USA
Systems-Based Approaches to Cardiovascular and Metabolic Diseases
Systems-Based Approaches to Cardiovascular and Metabolic Diseases
Matthias Kretzler,
University of Michigan, USA
Integration of Large-Scale Data Sets in Diabetic Nephropathy: Defining Networks of Repair, Progression and Response to Therapy
Integration of Large-Scale Data Sets in Diabetic Nephropathy: Defining Networks of Repair, Progression and Response to Therapy
Edward P. Feener,
KalVista Pharmaceuticals, USA
Proteomic Networks in Diabetic Complications
Proteomic Networks in Diabetic Complications
Wenjun Ju,
University of Michigan, USA
Short Talk: A Novel Approach for Discovering Chronic Kidney Disease Associated Human Podocyte-Specific Genes
Short Talk: A Novel Approach for Discovering Chronic Kidney Disease Associated Human Podocyte-Specific Genes
*Session Chair †Invited, not yet responded.
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