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This meeting took place in 2014
Here are the related meetings in 2021:
Cancer Stem Cells: Advances in Biology and Clinical Translation (EK46)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Stem Cells and Cancer (J8)
Organizer(s) Tannishtha Reya, Craig T. Jordan and Philip A. Beachy
February 2—7, 2014
Fairmont Banff Springs • Banff, AB Canada
Discounted Abstract Deadline: Oct 11, 2013
Abstract Deadline: Nov 6, 2013
Scholarship Deadline: Oct 11, 2013
Discounted Registration Deadline: Dec 3, 2013
Supported by the Directors' Fund
Summary of Meeting:
This meeting will bring together leaders in cancer research with the overall goal of defining new pathways and mechanisms that drive oncogenesis and that may be targeted in therapy. In particular, the meeting will examine the links between stem cell development and cancer initiation and progression: how signals active during stem cell development may be reactivated in cancer growth and relapse, the importance of the cell of origin for cancer initiation and the role of cancer stem cells in cancer propagation. The conference will also address how cancers grow and invade the surrounding microenvironment by highlighting work on in vivo imaging and metastasis. A major objective of the meeting will be to consider these issues in context of translation; key panels will discuss development of better preclinical models of cancer and designing more effective approaches to move basic discoveries to the clinic.
View Scholarships/Awards
This meeting will bring together leaders in cancer research with the overall goal of defining new pathways and mechanisms that drive oncogenesis and that may be targeted in therapy. In particular, the meeting will examine the links between stem cell development and cancer initiation and progression: how signals active during stem cell development may be reactivated in cancer growth and relapse, the importance of the cell of origin for cancer initiation and the role of cancer stem cells in cancer propagation. The conference will also address how cancers grow and invade the surrounding microenvironment by highlighting work on in vivo imaging and metastasis. A major objective of the meeting will be to consider these issues in context of translation; key panels will discuss development of better preclinical models of cancer and designing more effective approaches to move basic discoveries to the clinic.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, FEBRUARY 2
MONDAY, FEBRUARY 3
TUESDAY, FEBRUARY 4
WEDNESDAY, FEBRUARY 5
THURSDAY, FEBRUARY 6
FRIDAY, FEBRUARY 7
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, FEBRUARY 2
08:00—11:15
Signaling Pathways in Stem Cells
*
Elaine V. Fuchs,
Rockefeller University, USA
Jürgen A. Knoblich,
Institute of Molecular Biotechnology, Austria
Using Drosophila as a Model System for Tumorigenesis and Cancer Stem Cells
Using Drosophila as a Model System for Tumorigenesis and Cancer Stem Cells
Nick Barker,
Institute of Medical Biology, Singapore
Short Talk: Lgr5+ve Gastric Stem Cells Divide Symmetrically to Effect Epithelial Homeostasis in the Pylorus
Short Talk: Lgr5+ve Gastric Stem Cells Divide Symmetrically to Effect Epithelial Homeostasis in the Pylorus
Pantelis Rompolas,
Yale University School of Medicine, USA
Short Talk: Spatial Organization within a Niche as a Determinant of Stem Cell Fate
Short Talk: Spatial Organization within a Niche as a Determinant of Stem Cell Fate
Thea D. Tlsty,
University of California, San Francisco, USA
Stochastic Cellular States Associated with Malignancy
Stochastic Cellular States Associated with Malignancy
Geoffrey M. Wahl,
The Salk Institute, USA
Investigating Human Breast Cancer through the Lens of Development
Investigating Human Breast Cancer through the Lens of Development
E. Alejandro Sweet-Cordero,
Stanford University, USA
Identification and Characterization of Tumor Propagating Cells in a Mouse Model of NSCLC
Identification and Characterization of Tumor Propagating Cells in a Mouse Model of NSCLC
08:00—11:15
Signaling Mechanisms at the Cell Surface
Stefano Piccolo,
University of Padua, Italy
Wnt Signaling through YAP and TAZ
Wnt Signaling through YAP and TAZ
William I. Weis,
Stanford University, USA
Short Talk: Structural Basis of GSK-3 Regulation by Autoinhibition and by the Wnt Receptor LRP6
Short Talk: Structural Basis of GSK-3 Regulation by Autoinhibition and by the Wnt Receptor LRP6
*
Stephen C. Blacklow,
Harvard Medical School, USA
A Tail of Two Sites: Structural Basis for Recognition of Notch Ligands by Mind Bomb Proteins
A Tail of Two Sites: Structural Basis for Recognition of Notch Ligands by Mind Bomb Proteins
Jeremy F. Reiter,
University of California, San Francisco, USA
Restricted Access: The Transition Zone Controls Ciliary Composition and Vertebrate Hh Signaling
Restricted Access: The Transition Zone Controls Ciliary Composition and Vertebrate Hh Signaling
Yulu Cherry Liu,
University of Toronto, Canada
Short Talk: The PPFIA1-PP2A Protein Complex Regulates Kif7 Ciliary Trafficking and Hedgehog Signaling
Short Talk: The PPFIA1-PP2A Protein Complex Regulates Kif7 Ciliary Trafficking and Hedgehog Signaling
17:00—19:00
Shared Signals in Stem Cells and Cancer
*
Thea D. Tlsty,
University of California, San Francisco, USA
Philip A. Beachy,
HHMI/Stanford University, USA
The Jekyll and Hyde Nature of Hedgehog Signaling in Cancer: Insights from the Urinary Bladder
The Jekyll and Hyde Nature of Hedgehog Signaling in Cancer: Insights from the Urinary Bladder
Carman Man Chung Li,
Massachusetts Institute of Technology, USA
Short Talk: The Roles of Pulmonary and Gastrointestinal Developmental Programs in Regulating Lung Cancer Metastasis
Short Talk: The Roles of Pulmonary and Gastrointestinal Developmental Programs in Regulating Lung Cancer Metastasis
Tannishtha Reya,
University of California, San Diego, USA
Developmental Pathways in Stem Cells and Cancer
Developmental Pathways in Stem Cells and Cancer
17:00—19:00
Signaling Mechanisms and Cancer
Adolfo Ferrando,
Columbia University, USA
An Oncogenic Metabolic Switch Mediates Resistance to NOTCH1 Inhibition in T-ALL
An Oncogenic Metabolic Switch Mediates Resistance to NOTCH1 Inhibition in T-ALL
Holger Gerhardt,
Max Delbrück Center for Molecular Medicine, Germany
Dll4/Notch Dynamics in Vascular Branching
Dll4/Notch Dynamics in Vascular Branching
*
Warren S. Pear,
University of Pennsylvania, USA
Targeting the Notch:Myc Axis in Cancer
Targeting the Notch:Myc Axis in Cancer
Madelon M. Maurice,
University Medical Center Utrecht, Netherlands
Short Talk: Cancer Mutations Derail Wnt Signalling via Conformational Conversion of the Scaffold Protein Axin
Short Talk: Cancer Mutations Derail Wnt Signalling via Conformational Conversion of the Scaffold Protein Axin
08:00—11:15
Cancer Cell of Origin
*
John E. Dick,
Princess Margaret Cancer Centre, Canada
Robert J. Wechsler-Reya,
Sanford-Burnham Medical Research Institute, USA
Stem Cells and the Origins of Medulloblastoma
Stem Cells and the Origins of Medulloblastoma
Luis F. Parada,
Memorial Sloan Kettering Cancer Center, USA
Genetic Mouse Models of Neural Cancer: Unique Insights and Translational Tools for Therapeutic Development
Genetic Mouse Models of Neural Cancer: Unique Insights and Translational Tools for Therapeutic Development
Laetitia J. Seguin,
University of California, San Diego, USA
Short Talk: beta3 Integrin/KRAS/RalB Complex Drives Tumor Stemness and Resistance to EGFR Inhibition
Short Talk: beta3 Integrin/KRAS/RalB Complex Drives Tumor Stemness and Resistance to EGFR Inhibition
Menno J. Oudhoff,
Biomedical Research Centre, Canada
Short Talk: Set7 at the Intersection between Hippo/Yap and Wnt/beta-Catenin Signalling in Intestinal Homeostasis, Regeneration and Cancer
Short Talk: Set7 at the Intersection between Hippo/Yap and Wnt/beta-Catenin Signalling in Intestinal Homeostasis, Regeneration and Cancer
Leonard I. Zon,
HHMI/Boston Children's Hospital, USA
A Stem Cell Program Triggered at the Onset on Cancer
A Stem Cell Program Triggered at the Onset on Cancer
08:00—11:15
Nuclear Responses and Tumorigenesis
*
Jon C. Aster,
Brigham and Women's Hospital, USA
Determinants of Notch Target Gene Activation and Notch-“Addiction” in Cancer
Determinants of Notch Target Gene Activation and Notch-“Addiction” in Cancer
Raphael Kopan,
University of Cincinnati College of Medicine, USA
Can We Record the Nuclear Footprints of Notch Signaling in Single Cells?
Can We Record the Nuclear Footprints of Notch Signaling in Single Cells?
Mariann Bienz,
MRC Laboratory of Molecular Biology, UK
Nuclear Wnt Signaling
Nuclear Wnt Signaling
Marian Waterman,
University of California, Irvine, USA
A New Link Between Wnt, Warburg Metabolism, Stem Cells and Cancer
A New Link Between Wnt, Warburg Metabolism, Stem Cells and Cancer
Henner F. Farin,
Hubrecht Institute, Netherlands
Short Talk: Wnt3 Gradient in Intestinal Epithelial Crypts Is Formed by Proliferative Dilution of Membrane-Associated Growth Factor
Short Talk: Wnt3 Gradient in Intestinal Epithelial Crypts Is Formed by Proliferative Dilution of Membrane-Associated Growth Factor
Joseph Rosenbluh,
Broad Institute, USA
Short Talk: Global Detailed Characterization of WNT Dependencies
Short Talk: Global Detailed Characterization of WNT Dependencies
11:15—12:30
Roundtable: Preclinical Models and Early Translation
*
Craig T. Jordan,
University of Colorado, Anschutz Medical Campus, USA
*
Tannishtha Reya,
University of California, San Diego, USA
Robert S. Kerbel,
Sunnybrook Research Institute, Canada
Recapitulating Postsurgical Adjuvant or Metastatic Therapy in Mice as a Strategy to Improve Predicting Clinical Outcomes
Recapitulating Postsurgical Adjuvant or Metastatic Therapy in Mice as a Strategy to Improve Predicting Clinical Outcomes
Zena Werb,
University of California, San Francisco, USA
Luis F. Parada,
Memorial Sloan Kettering Cancer Center, USA
David A. Cheresh,
University of California, San Diego, USA
17:00—19:00
Cancer Stem Cells
Sean J. Morrison,
University of Texas Southwestern Medical Center, USA
Hematopoietic Stem Cells Require a Highly Regulated Rate of Protein Synthesis
Hematopoietic Stem Cells Require a Highly Regulated Rate of Protein Synthesis
*
John E. Dick,
Princess Margaret Cancer Centre, Canada
Complex Mechanisms Underlie Intra-Tumoral Heterogeneity
Complex Mechanisms Underlie Intra-Tumoral Heterogeneity
Robert J. Vanner,
Hospital for Sick Children, Canada
Short Talk: Quiescent Therapy Resistant Sox2+ Cells Drive Hierarchical Growth and Relapse in Shh-Subgroup Medulloblastoma
Short Talk: Quiescent Therapy Resistant Sox2+ Cells Drive Hierarchical Growth and Relapse in Shh-Subgroup Medulloblastoma
Jeffrey M. Rosen,
Baylor College of Medicine, USA
Wnt and Fgf Signaling in Mammary Stem Cells and Breast Cancer
Wnt and Fgf Signaling in Mammary Stem Cells and Breast Cancer
17:00—19:15
Developmental Pathways and Tumor Initiation
*
Freddy Radtke,
EPFL SV ISREC UPRAD, Switzerland
Tumor Suppressive Roles of Notch in Epithelial Cells
Tumor Suppressive Roles of Notch in Epithelial Cells
Owen J. Sansom,
Beatson Institute of Cancer Research, UK
mTORC1 Is Required Following Apc Loss
mTORC1 Is Required Following Apc Loss
Rune C.M. Toftgard,
Karolinska Institutet, Sweden
Hedgehog Signal Transduction and Cancer Initiation
Hedgehog Signal Transduction and Cancer Initiation
Philip H. Jones,
Wellcome Trust Sanger Institute / University of Cambridge, UK
Short Talk: Inhibition of Notch Signaling Confers Clonal Dominance In Esophageal Epithelium
Short Talk: Inhibition of Notch Signaling Confers Clonal Dominance In Esophageal Epithelium
08:00—11:00
Stem Cells, Development and Cancer (Joint)
*
Tannishtha Reya,
University of California, San Diego, USA
*
Frederic J. de Sauvage,
Genentech, Inc., USA
Cédric Blanpain,
Universite Libre de Bruxelles, Belgium
Keynote Address: Developmental Pathways Regulating Stemness in Skin Cancers
Keynote Address: Developmental Pathways Regulating Stemness in Skin Cancers
Ciara Metcalfe,
Genentech, USA
Short Talk: Lgr5+ Stem Cells are Indispensible for Radiation-Induced Intestinal Regeneration
Short Talk: Lgr5+ Stem Cells are Indispensible for Radiation-Induced Intestinal Regeneration
Catriona H.M. Jamieson,
University of California, San Diego, USA
The Niche Specific Role of RNA Editing in Leukemia Stem Cell Generation
The Niche Specific Role of RNA Editing in Leukemia Stem Cell Generation
David A. Cheresh,
University of California, San Diego, USA
Reversing Cancer Stemness and Drug Resistance
Reversing Cancer Stemness and Drug Resistance
14:30—16:30
Workshop
*
Lauren I. R. Ehrlich,
University of Texas at Austin, USA
Ho-Chou Tu,
Children's Hospital Boston, USA
The Pluripotency Factor LIN28 Promotes Colorectal Tumorigenesis and Progression
The Pluripotency Factor LIN28 Promotes Colorectal Tumorigenesis and Progression
Andrew C. White,
Cornell University, USA
Stem Cell Quiescence Acts as a Tumor Suppressor Mechanism in Hair Follicle Initiated Squamous Tumors
Stem Cell Quiescence Acts as a Tumor Suppressor Mechanism in Hair Follicle Initiated Squamous Tumors
Ching-Cheng Chen,
City of Hope National Medical Center, USA
Acute Myeloid Leukemia-Derived Exosomes Transform Bone Marrow Niche into Leukemic Niche
Acute Myeloid Leukemia-Derived Exosomes Transform Bone Marrow Niche into Leukemic Niche
Borhane Guezguez,
McMaster Stem Cell and Cancer Research Institute, Canada
Modeling the Human Bone Marrow HSC Niche in vivo
Modeling the Human Bone Marrow HSC Niche in vivo
Martin Lackmann,
Monash University, Australia
Therapeutic Targeting of EphA3 in the Tumor Microenvironment Inhibits Cancer Growth
Therapeutic Targeting of EphA3 in the Tumor Microenvironment Inhibits Cancer Growth
Gerald Schwank,
ETH Zurich, Switzerland
Genome Editing by CRISPR/Cas9 in Intestinal Stem Cell Organoids
Genome Editing by CRISPR/Cas9 in Intestinal Stem Cell Organoids
17:00—19:15
Cancer in Context: The Microenvironment and Metastasis
*
Jeffrey M. Rosen,
Baylor College of Medicine, USA
Zena Werb,
University of California, San Francisco, USA
Imaging the Immune Microenvironment in Mammary Development and Cancer
Imaging the Immune Microenvironment in Mammary Development and Cancer
Lauren I. R. Ehrlich,
University of Texas at Austin, USA
Short Talk: The Tumor Microenvironment Promotes Tumorigenesis in T-ALL
Short Talk: The Tumor Microenvironment Promotes Tumorigenesis in T-ALL
Jing Yang,
University of California, San Diego, USA
Epithelial-Mesenchymal Plasticity in Carcinoma Metastasis
Epithelial-Mesenchymal Plasticity in Carcinoma Metastasis
Manuel Valiente,
Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Serpins Promote Cancer Cell Survival and Vascular Cooption in Brain Metastasis
Short Talk: Serpins Promote Cancer Cell Survival and Vascular Cooption in Brain Metastasis
Carla F. Kim,
Boston Children's Hospital, USA
Microenvironmental Regulation of Lung Stem Cell Differentiation
Microenvironmental Regulation of Lung Stem Cell Differentiation
17:00—19:00
Developmental Pathways in Cancer and Metastasis
*
Michael D. Taylor,
Hospital for Sick Children, Canada
Heterogeneity and Therapeutic Resistance Amongst the Shh Medulloblastomas
Heterogeneity and Therapeutic Resistance Amongst the Shh Medulloblastomas
Kimberly Stegmaier,
Dana-Farber Cancer Institute, USA
Targeting Mutated NOTCH1 in Cancer
Targeting Mutated NOTCH1 in Cancer
Joerg Huelsken,
Ecole Polytechnique Fédérale de Lausanne, Switzerland
Targeting Tumor/Stroma Interactions to Overcome Metastasis
Targeting Tumor/Stroma Interactions to Overcome Metastasis
Taran S. Gujral,
Harvard Medical School, USA
Short Talk: Wnt5-Fzd2 Signaling Drives Epithelial-Mesenchymal Transition, Tumor Progression, and Metastasis
Short Talk: Wnt5-Fzd2 Signaling Drives Epithelial-Mesenchymal Transition, Tumor Progression, and Metastasis
08:00—11:15
New Regulatory Pathways in Cancer
*
Zena Werb,
University of California, San Francisco, USA
Andreas Trumpp,
German Cancer Research Center, Germany
Mesenchymal and MDS Stem Cells Shape an Interactive Disease Unit in the Bone Marrow
Mesenchymal and MDS Stem Cells Shape an Interactive Disease Unit in the Bone Marrow
Lewis A. Chodosh,
University of Pennsylvania School of Medicine, USA
Mechanisms Controlling Tumor Dormancy and Recurrence
Mechanisms Controlling Tumor Dormancy and Recurrence
Robert MacLeod,
Ionis Pharmaceuticals, Inc., USA
Short Talk: Preclinical and Early Clinical Evaluation of the Next Generation STAT3 Antisense Oligonucleotide STAT3rx/AZD9150
Short Talk: Preclinical and Early Clinical Evaluation of the Next Generation STAT3 Antisense Oligonucleotide STAT3rx/AZD9150
Daniel S. Pereira,
Agensys, Inc, USA
Short Talk: AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody (MMAE) Drug Conjugate as a Potential Therapeutic for Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia and Acute Myeloid Leukemia
Short Talk: AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody (MMAE) Drug Conjugate as a Potential Therapeutic for Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia and Acute Myeloid Leukemia
08:00—11:15
Emerging Cancer Drug Targets in Development Pathways
*
Weilan Ye,
Genentech, Inc., USA
The Norrin-Mediated Canonical Wnt Signaling Pathway Regulates Vascular Integrity
The Norrin-Mediated Canonical Wnt Signaling Pathway Regulates Vascular Integrity
Feng Cong,
Novartis Institutes for BioMedical Research, USA
Control of Wnt Signaling by Ubiquitin and Tankyrase
Control of Wnt Signaling by Ubiquitin and Tankyrase
Babita Madan,
DUKE-NUS Graduate Medical School, Singapore
Short Talk: Novel Porcn Inhibitors Are Safe and Effective in the Treatment of Wnt-Dependent Cancers
Short Talk: Novel Porcn Inhibitors Are Safe and Effective in the Treatment of Wnt-Dependent Cancers
Bradley E. Bernstein,
Massachusetts General Hospital, USA
Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-Like Cells
Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-Like Cells
Austin Gurney,
Napa Biotechnology Consulting, USA
Targeting Stem Cell Pathways in Cancer
Targeting Stem Cell Pathways in Cancer
Raoul C.D.S. Coombes,
Imperial College London, UK
Short Talk: Antibodies to Nicastrin inhibit Invasion and Metastasis in Models of Breast Cancer
Short Talk: Antibodies to Nicastrin inhibit Invasion and Metastasis in Models of Breast Cancer
11:15—12:15
Special Lecture: Keynote Address (Joint)
Irving L. Weissman,
Stanford University, USA
Reversing Cancer Stemness and Drug Resistance
Reversing Cancer Stemness and Drug Resistance
17:00—19:15
Targeting Cancer Stem Cells: Trials and Translation
*
Vishva M. Dixit,
Genentech, Inc., USA
Craig T. Jordan,
University of Colorado, Anschutz Medical Campus, USA
Targeting Metabolic Properties to More Effectively Eradicate Leukemia Stem Cells
Targeting Metabolic Properties to More Effectively Eradicate Leukemia Stem Cells
Annette Friebe,
Nexigen GmbH, Germany
Short Talk: Drugging the Undruggables - Cell-Permeable Peptide Antagonists Targeting the Wnt Signaling Pathway
Short Talk: Drugging the Undruggables - Cell-Permeable Peptide Antagonists Targeting the Wnt Signaling Pathway
Peter Chu,
Eclipse BioInnovations, USA
Short Talk: Therapeutic Targeting of Cancer Stem Cells with BNC101, a Functional Anti-LGR5 Monoclonal Antibody
Short Talk: Therapeutic Targeting of Cancer Stem Cells with BNC101, a Functional Anti-LGR5 Monoclonal Antibody
Jeremy Naftali Rich,
Cleveland Clinic, USA
Partners in Crime: Tumor Stem Cells and the Tumor Microenvironment
Partners in Crime: Tumor Stem Cells and the Tumor Microenvironment
Michael F. Clarke,
Stanford University, USA
Regulation of Normal and Cancer Stem Cell Self Renewal and Senescence by USP16
Regulation of Normal and Cancer Stem Cell Self Renewal and Senescence by USP16
17:00—19:00
Targeting Developmental Pathways: Clinical Experience
Gavin O. Thurston,
Regeneron Pharmaceuticals Inc., USA
Blockade of Dll4-Notch Signaling in Tumor Angiogenesis
Blockade of Dll4-Notch Signaling in Tumor Angiogenesis
Jean Y. Tang,
Stanford University School of Medicine, USA
Hedgehog Pathway Inhibitor Clinical Trials
Hedgehog Pathway Inhibitor Clinical Trials
*
Frederic J. de Sauvage,
Genentech, Inc., USA
Innate and Acquired Resistance to Hedgehog Pathways Inhibitors
Innate and Acquired Resistance to Hedgehog Pathways Inhibitors
Lawrence Lum,
University of Texas, Southwestern Medical Center, USA
Short Talk: Extra-Mitochondrial Bcl-2 Anti-Apoptotic Proteins Regulate Gli Transcriptional Activity
Short Talk: Extra-Mitochondrial Bcl-2 Anti-Apoptotic Proteins Regulate Gli Transcriptional Activity
*Session Chair †Invited, not yet responded.
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