Keystone Symposia

Fairmont Banff Springs Floorplan

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This meeting took place in 2014


Here are the related meetings in 2020:
CANCELLED - Cancer Stem Cells: Advances in Biology and Clinical Translation (T2)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Stem Cells and Cancer (J8)


Organizer(s) Tannishtha Reya, Craig T. Jordan and Philip A. Beachy
February 2—7, 2014
Fairmont Banff Springs • Banff, AB Canada
Discounted Abstract Deadline: Oct 11, 2013
Abstract Deadline: Nov 6, 2013
Scholarship Deadline: Oct 11, 2013
Discounted Registration Deadline: Dec 3, 2013

Supported by the Directors' Fund


Summary of Meeting:
This meeting will bring together leaders in cancer research with the overall goal of defining new pathways and mechanisms that drive oncogenesis and that may be targeted in therapy. In particular, the meeting will examine the links between stem cell development and cancer initiation and progression: how signals active during stem cell development may be reactivated in cancer growth and relapse, the importance of the cell of origin for cancer initiation and the role of cancer stem cells in cancer propagation. The conference will also address how cancers grow and invade the surrounding microenvironment by highlighting work on in vivo imaging and metastasis. A major objective of the meeting will be to consider these issues in context of translation; key panels will discuss development of better preclinical models of cancer and designing more effective approaches to move basic discoveries to the clinic.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 2

16:00—20:00
Arrival and Registration

Van Horne Foyer

MONDAY, FEBRUARY 3

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:15
Signaling Pathways in Stem Cells

Van Horne Ballroom A/B
* Elaine V. Fuchs, Rockefeller University, USA

Jürgen A. Knoblich, Institute of Molecular Biotechnology, Austria
Using Drosophila as a Model System for Tumorigenesis and Cancer Stem Cells

Nick Barker, Institute of Medical Biology, Singapore
Short Talk: Lgr5+ve Gastric Stem Cells Divide Symmetrically to Effect Epithelial Homeostasis in the Pylorus

Pantelis Rompolas, Yale University School of Medicine, USA
Short Talk: Spatial Organization within a Niche as a Determinant of Stem Cell Fate

Thea D. Tlsty, University of California, San Francisco, USA
Stochastic Cellular States Associated with Malignancy

Geoffrey M. Wahl, The Salk Institute, USA
Investigating Human Breast Cancer through the Lens of Development

E. Alejandro Sweet-Cordero, Stanford University, USA
Identification and Characterization of Tumor Propagating Cells in a Mouse Model of NSCLC

08:00—11:15
Signaling Mechanisms at the Cell Surface

Van Horne Ballroom C
Stefano Piccolo, University of Padua, Italy
Wnt Signaling through YAP and TAZ

Xi He, Harvard Medical School, USA
Understanding the Mechanism of Wnt/beta-Catenin Signaling

William I. Weis, Stanford University, USA
Short Talk: Structural Basis of GSK-3 Regulation by Autoinhibition and by the Wnt Receptor LRP6

* Stephen C. Blacklow, Harvard Medical School, USA
A Tail of Two Sites: Structural Basis for Recognition of Notch Ligands by Mind Bomb Proteins

Jeremy F. Reiter, University of California, San Francisco, USA
Restricted Access: The Transition Zone Controls Ciliary Composition and Vertebrate Hh Signaling

Yulu Cherry Liu, University of Toronto, Canada
Short Talk: The PPFIA1-PP2A Protein Complex Regulates Kif7 Ciliary Trafficking and Hedgehog Signaling

09:20—09:40
Coffee Break

Van Horne Foyer
11:15—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
11:15—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Shared Signals in Stem Cells and Cancer

Van Horne Ballroom A/B
* Thea D. Tlsty, University of California, San Francisco, USA

Philip A. Beachy, HHMI/Stanford University, USA
The Jekyll and Hyde Nature of Hedgehog Signaling in Cancer: Insights from the Urinary Bladder

Carman Man Chung Li, Massachusetts Institute of Technology, USA
Short Talk: The Roles of Pulmonary and Gastrointestinal Developmental Programs in Regulating Lung Cancer Metastasis

Tannishtha Reya, University of California, San Diego, USA
Developmental Pathways in Stem Cells and Cancer

Elaine V. Fuchs, Rockefeller University, USA
Signaling of Skin Stem Cells in Homeostasis and Cancer

17:00—19:00
Signaling Mechanisms and Cancer

Van Horne Ballroom C
Adolfo Ferrando, Columbia University, USA
An Oncogenic Metabolic Switch Mediates Resistance to NOTCH1 Inhibition in T-ALL

Holger Gerhardt, Max Delbrück Center for Molecular Medicine, Germany
Dll4/Notch Dynamics in Vascular Branching

* Warren S. Pear, University of Pennsylvania, USA
Targeting the Notch:Myc Axis in Cancer

Madelon M. Maurice, University Medical Center Utrecht, Netherlands
Short Talk: Cancer Mutations Derail Wnt Signalling via Conformational Conversion of the Scaffold Protein Axin

19:00—20:00
Social Hour with Lite Bites

Mezzanine 2
19:30—22:00
Poster Session 1

Mezzanine 2

TUESDAY, FEBRUARY 4

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:15
Cancer Cell of Origin

Van Horne Ballroom A/B
* John E. Dick, Princess Margaret Cancer Centre, Canada

Robert J. Wechsler-Reya, Sanford-Burnham Medical Research Institute, USA
Stem Cells and the Origins of Medulloblastoma

Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA
Genetic Mouse Models of Neural Cancer: Unique Insights and Translational Tools for Therapeutic Development

Laetitia J. Seguin, University of California, San Diego, USA
Short Talk: beta3 Integrin/KRAS/RalB Complex Drives Tumor Stemness and Resistance to EGFR Inhibition

Menno J. Oudhoff, Biomedical Research Centre, Canada
Short Talk: Set7 at the Intersection between Hippo/Yap and Wnt/beta-Catenin Signalling in Intestinal Homeostasis, Regeneration and Cancer

Leonard I. Zon, HHMI/Boston Children's Hospital, USA
A Stem Cell Program Triggered at the Onset on Cancer

08:00—11:15
Nuclear Responses and Tumorigenesis

Van Horne Ballroom C
* Jon C. Aster, Brigham and Women's Hospital, USA
Determinants of Notch Target Gene Activation and Notch-“Addiction” in Cancer

Raphael Kopan, University of Cincinnati College of Medicine, USA
Can We Record the Nuclear Footprints of Notch Signaling in Single Cells?

Mariann Bienz, MRC Laboratory of Molecular Biology, UK
Nuclear Wnt Signaling

Marian Waterman, University of California, Irvine, USA
A New Link Between Wnt, Warburg Metabolism, Stem Cells and Cancer

Henner F. Farin, Hubrecht Institute, Netherlands
Short Talk: Wnt3 Gradient in Intestinal Epithelial Crypts Is Formed by Proliferative Dilution of Membrane-Associated Growth Factor

Joseph Rosenbluh, Broad Institute, USA
Short Talk: Global Detailed Characterization of WNT Dependencies

09:20—09:40
Coffee Break

Van Horne Foyer
11:15—12:30
Roundtable: Preclinical Models and Early Translation

Van Horne Ballroom A/B
* Craig T. Jordan, University of Colorado, Anschutz Medical Campus, USA

* Tannishtha Reya, University of California, San Diego, USA

Robert S. Kerbel, Sunnybrook Research Institute, Canada
Recapitulating Postsurgical Adjuvant or Metastatic Therapy in Mice as a Strategy to Improve Predicting Clinical Outcomes

Zena Werb, University of California, San Francisco, USA

Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA

David A. Cheresh, University of California, San Diego, USA

11:00—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
12:30—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Cancer Stem Cells

Van Horne Ballroom A/B
Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Hematopoietic Stem Cells Require a Highly Regulated Rate of Protein Synthesis

* John E. Dick, Princess Margaret Cancer Centre, Canada
Complex Mechanisms Underlie Intra-Tumoral Heterogeneity

Robert J. Vanner, Hospital for Sick Children, Canada
Short Talk: Quiescent Therapy Resistant Sox2+ Cells Drive Hierarchical Growth and Relapse in Shh-Subgroup Medulloblastoma

Jeffrey M. Rosen, Baylor College of Medicine, USA
Wnt and Fgf Signaling in Mammary Stem Cells and Breast Cancer

17:00—19:15
Developmental Pathways and Tumor Initiation

Van Horne Ballroom C
* Freddy Radtke, EPFL SV ISREC UPRAD, Switzerland
Tumor Suppressive Roles of Notch in Epithelial Cells

Owen J. Sansom, Beatson Institute of Cancer Research, UK
mTORC1 Is Required Following Apc Loss

Rune C.M. Toftgard, Karolinska Institutet, Sweden
Hedgehog Signal Transduction and Cancer Initiation

Philip H. Jones, Wellcome Trust Sanger Institute / University of Cambridge, UK
Short Talk: Inhibition of Notch Signaling Confers Clonal Dominance In Esophageal Epithelium

19:15—20:15
Social Hour with Lite Bites

Mezzanine 2
19:30—22:00
Poster Session 2

Mezzanine 2

WEDNESDAY, FEBRUARY 5

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:00
Stem Cells, Development and Cancer (Joint)

Van Horne Ballroom A/B
* Tannishtha Reya, University of California, San Diego, USA

* Frederic J. de Sauvage, Genentech, Inc., USA

Cédric Blanpain, Universite Libre de Bruxelles, Belgium
Keynote Address: Developmental Pathways Regulating Stemness in Skin Cancers

Roeland Nusse, HHMI/Stanford University, USA
Wnt Signaling and Stem Cell Control

Ciara Metcalfe, Genentech, USA
Short Talk: Lgr5+ Stem Cells are Indispensible for Radiation-Induced Intestinal Regeneration

Catriona H.M. Jamieson, University of California, San Diego, USA
The Niche Specific Role of RNA Editing in Leukemia Stem Cell Generation

David A. Cheresh, University of California, San Diego, USA
Reversing Cancer Stemness and Drug Resistance

09:30—09:50
Coffee Break

Van Horne Foyer
11:30—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
11:00—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop

Van Horne Ballroom A/B
* Lauren I. R. Ehrlich, University of Texas at Austin, USA

Ho-Chou Tu, Children's Hospital Boston, USA
The Pluripotency Factor LIN28 Promotes Colorectal Tumorigenesis and Progression

Andrew C. White, Cornell University, USA
Stem Cell Quiescence Acts as a Tumor Suppressor Mechanism in Hair Follicle Initiated Squamous Tumors

Ching-Cheng Chen, City of Hope National Medical Center, USA
Acute Myeloid Leukemia-Derived Exosomes Transform Bone Marrow Niche into Leukemic Niche

Borhane Guezguez, McMaster Stem Cell and Cancer Research Institute, Canada
Modeling the Human Bone Marrow HSC Niche in vivo

Martin Lackmann, Monash University, Australia
Therapeutic Targeting of EphA3 in the Tumor Microenvironment Inhibits Cancer Growth

Gerald Schwank, ETH Zurich, Switzerland
Genome Editing by CRISPR/Cas9 in Intestinal Stem Cell Organoids

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:15
Cancer in Context: The Microenvironment and Metastasis

Van Horne Ballroom A/B
* Jeffrey M. Rosen, Baylor College of Medicine, USA

Zena Werb, University of California, San Francisco, USA
Imaging the Immune Microenvironment in Mammary Development and Cancer

Lauren I. R. Ehrlich, University of Texas at Austin, USA
Short Talk: The Tumor Microenvironment Promotes Tumorigenesis in T-ALL

Jing Yang, University of California, San Diego, USA
Epithelial-Mesenchymal Plasticity in Carcinoma Metastasis

Manuel Valiente, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Serpins Promote Cancer Cell Survival and Vascular Cooption in Brain Metastasis

Carla F. Kim, Boston Children's Hospital, USA
Microenvironmental Regulation of Lung Stem Cell Differentiation

17:00—19:00
Developmental Pathways in Cancer and Metastasis

Van Horne Ballroom C
* Michael D. Taylor, Hospital for Sick Children, Canada
Heterogeneity and Therapeutic Resistance Amongst the Shh Medulloblastomas

Kimberly Stegmaier, Dana-Farber Cancer Institute, USA
Targeting Mutated NOTCH1 in Cancer

Joerg Huelsken, Ecole Polytechnique Fédérale de Lausanne, Switzerland
Targeting Tumor/Stroma Interactions to Overcome Metastasis

Taran S. Gujral, Harvard Medical School, USA
Short Talk: Wnt5-Fzd2 Signaling Drives Epithelial-Mesenchymal Transition, Tumor Progression, and Metastasis

19:15—20:15
Social Hour with Lite Bites

Mezzanine 2
19:30—22:00
Poster Session 3

Mezzanine 2

THURSDAY, FEBRUARY 6

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:15
New Regulatory Pathways in Cancer

Van Horne Ballroom A/B
* Zena Werb, University of California, San Francisco, USA

Andreas Trumpp, German Cancer Research Center, Germany
Mesenchymal and MDS Stem Cells Shape an Interactive Disease Unit in the Bone Marrow

Lewis A. Chodosh, University of Pennsylvania School of Medicine, USA
Mechanisms Controlling Tumor Dormancy and Recurrence

Vishva M. Dixit, Genentech, Inc., USA
Apoptosis and Cancer

Robert MacLeod, Ionis Pharmaceuticals, Inc., USA
Short Talk: Preclinical and Early Clinical Evaluation of the Next Generation STAT3 Antisense Oligonucleotide STAT3rx/AZD9150

Daniel S. Pereira, Agensys, Inc, USA
Short Talk: AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody (MMAE) Drug Conjugate as a Potential Therapeutic for Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia and Acute Myeloid Leukemia

08:00—11:15
Emerging Cancer Drug Targets in Development Pathways

Van Horne Ballroom C
* Weilan Ye, Genentech, Inc., USA
The Norrin-Mediated Canonical Wnt Signaling Pathway Regulates Vascular Integrity

Feng Cong, Novartis Institutes for BioMedical Research, USA
Control of Wnt Signaling by Ubiquitin and Tankyrase

Babita Madan, DUKE-NUS Graduate Medical School, Singapore
Short Talk: Novel Porcn Inhibitors Are Safe and Effective in the Treatment of Wnt-Dependent Cancers

Bradley E. Bernstein, Massachusetts General Hospital, USA
Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-Like Cells

Austin Gurney, OncoMed Pharmaceuticals, Inc., USA
Targeting Stem Cell Pathways in Cancer

Raoul C.D.S. Coombes, Imperial College London, UK
Short Talk: Antibodies to Nicastrin inhibit Invasion and Metastasis in Models of Breast Cancer

09:20—09:40
Coffee Break

Van Horne Foyer
11:15—12:15
Special Lecture: Keynote Address (Joint)

Van Horne Ballroom A/B
Irving L. Weissman, Stanford University, USA
Reversing Cancer Stemness and Drug Resistance

12:15—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:15
Targeting Cancer Stem Cells: Trials and Translation

Van Horne Ballroom A/B
* Vishva M. Dixit, Genentech, Inc., USA

Craig T. Jordan, University of Colorado, Anschutz Medical Campus, USA
Targeting Metabolic Properties to More Effectively Eradicate Leukemia Stem Cells

Annette Friebe, Nexigen GmbH, Germany
Short Talk: Drugging the Undruggables - Cell-Permeable Peptide Antagonists Targeting the Wnt Signaling Pathway

Peter Chu, Eclipse BioInnovations, USA
Short Talk: Therapeutic Targeting of Cancer Stem Cells with BNC101, a Functional Anti-LGR5 Monoclonal Antibody

Jeremy Naftali Rich, Cleveland Clinic, USA
Partners in Crime: Tumor Stem Cells and the Tumor Microenvironment

Michael F. Clarke, Stanford University, USA
Regulation of Normal and Cancer Stem Cell Self Renewal and Senescence by USP16

17:00—19:00
Targeting Developmental Pathways: Clinical Experience

Van Horne Ballroom C
Gavin O. Thurston, Regeneron Pharmaceuticals Inc., USA
Blockade of Dll4-Notch Signaling in Tumor Angiogenesis

Jean Y. Tang, Stanford University School of Medicine, USA
Hedgehog Pathway Inhibitor Clinical Trials

* Frederic J. de Sauvage, Genentech, Inc., USA
Innate and Acquired Resistance to Hedgehog Pathways Inhibitors

Lawrence Lum, University of Texas, Southwestern Medical Center, USA
Short Talk: Extra-Mitochondrial Bcl-2 Anti-Apoptotic Proteins Regulate Gli Transcriptional Activity

19:15—20:15
Social Hour with Lite Bites

Mezzanine 2
20:00—23:00
Entertainment

Mezzanine 2

FRIDAY, FEBRUARY 7

 
Departure


*Session Chair †Invited, not yet responded.


We gratefully acknowledge support for this conference from:


Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA183072-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge additional support for this conference from:

AdipoGen International Cell Signaling Technology, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-1179