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This meeting took place in 2015
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The Human Proteome (D7)
Organizer(s) Matthias Mann, Mathias Uhlén, Catherine E. Costello and Albert J.R. Heck
April 24—29, 2015
Clarion Hotel Sign • Stockholm, Sweden
Discounted Abstract Deadline: Dec 22, 2014
Abstract Deadline: Jan 27, 2015
Scholarship Deadline: Dec 22, 2014
Discounted Registration Deadline: Feb 24, 2015
Organized in collaboration with Knut and Alice Wallenberg Foundation and Science for Life Laboratory - Stockholm. Sponsored by Thermo Fisher Scientific Inc.
Summary of Meeting:
The 2015 Symposium on The Human Proteome follows the very successful 2012 Keystone meeting in the same location in Sweden. As before, we have made every effort to present proteomics research of outstanding excellence and current scientific interest. Unlike the previous meeting, this one has a defining and topical theme: The completion of the human proteome. In fact, the date and venue are chosen, in part, because they coincides with the completion of the Human Protein Atlas, a very large undertaking to generate antibodies and localization information for all human protein coding regions. This event also coincides with the expected completion of complete proteome measurements of mammalian cells by mass spectrometry-based proteomics, which will be a major highlight of the conference and attract not only scientific but also media interest. Two sessions will be dedicated to covering the completion of human proteome, encompassing the leading researchers engaged with this important topic. Further sessions are dedicated to the rapid advances in mass spectrometric technology in proteomics. Complementing these advances, one session will deal with the analysis of intact proteins. Further topics represented are interaction proteomics and post-translational modifications. Related topics such as network analysis, crosslinking and of course conceptually novel applications of proteomics in cell biology and biomedicine will round off the program. Given the quality of the invited speakers and the breakthrough presentations, we expect the 2015 Keystone Symposium on The Human Proteome to be the scientifically most exciting event in this field.
View Scholarships/Awards
The 2015 Symposium on The Human Proteome follows the very successful 2012 Keystone meeting in the same location in Sweden. As before, we have made every effort to present proteomics research of outstanding excellence and current scientific interest. Unlike the previous meeting, this one has a defining and topical theme: The completion of the human proteome. In fact, the date and venue are chosen, in part, because they coincides with the completion of the Human Protein Atlas, a very large undertaking to generate antibodies and localization information for all human protein coding regions. This event also coincides with the expected completion of complete proteome measurements of mammalian cells by mass spectrometry-based proteomics, which will be a major highlight of the conference and attract not only scientific but also media interest. Two sessions will be dedicated to covering the completion of human proteome, encompassing the leading researchers engaged with this important topic. Further sessions are dedicated to the rapid advances in mass spectrometric technology in proteomics. Complementing these advances, one session will deal with the analysis of intact proteins. Further topics represented are interaction proteomics and post-translational modifications. Related topics such as network analysis, crosslinking and of course conceptually novel applications of proteomics in cell biology and biomedicine will round off the program. Given the quality of the invited speakers and the breakthrough presentations, we expect the 2015 Keystone Symposium on The Human Proteome to be the scientifically most exciting event in this field.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
FRIDAY, APRIL 24
SATURDAY, APRIL 25
SUNDAY, APRIL 26
MONDAY, APRIL 27
TUESDAY, APRIL 28
WEDNESDAY, APRIL 29
Conference Program Print | View meeting in 12 hr (am/pm) time
FRIDAY, APRIL 24
08:30—09:30
Welcome and Keynote Address
*
Mathias Uhlen,
KTH Royal Inst of Technology, Sweden
Opening of the Meeting
Opening of the Meeting
*
Matthias Mann,
Max Planck Institute of Biochemistry, Germany
Introduction of the Keynote Address
Introduction of the Keynote Address
Vishva M. Dixit,
Genentech, Inc., USA
Proteomics in Drug Target Identification, Oncology and Immunology
Proteomics in Drug Target Identification, Oncology and Immunology
09:30—12:00
Completion of the Human Proteome I
*
Albert J.R. Heck,
Utrecht University, Netherlands
Mathias Uhlen,
KTH Royal Inst of Technology, Sweden
Completing the Human Protein Atlas
Completing the Human Protein Atlas
Rudolf H. Aebersold,
Institute of Molecular Systems Biology, ETH Zürich, Switzerland
Quantifying Proteotypes
Quantifying Proteotypes
Matthias Mann,
Max Planck Institute of Biochemistry, Germany
Large-Scale Proteomics Moves to the Clinic
Large-Scale Proteomics Moves to the Clinic
Anthony W. Purcell,
Monash University, Australia
Short Talk: An Immune-Centric View of the Human Proteome
Short Talk: An Immune-Centric View of the Human Proteome
Jens S. Andersen,
University of Southern Denmark, Denmark
Short Talk: Centrosomes and Centriolar Satellites Associate with Negative Regulators of Innate Immune Signaling
Short Talk: Centrosomes and Centriolar Satellites Associate with Negative Regulators of Innate Immune Signaling
17:00—19:00
Advances in the Technology of Mass Spectrometry-Based Proteomics
*
Ralph A. Bradshaw,
University of California, Irvine, USA
Alexander Makarov,
Thermo Fisher, Germany
Orbitrap Mass Spectrometry for Proteomics
Orbitrap Mass Spectrometry for Proteomics
Juergen Cox,
Max Planck Institute for Biochemistry, Germany
Controlling False Discovery Rates (FDRs) in Genome-Wide Proteomics Datasets
Controlling False Discovery Rates (FDRs) in Genome-Wide Proteomics Datasets
Joshua J. Coon,
University of Wisconsin, USA
One-Hour Proteomes and Deep Sequencing
One-Hour Proteomes and Deep Sequencing
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:45
Signaling and Post-Translational Modification
*
Maxey C.M. Chung,
National University of Singapore, Singapore
Catherine E. Costello,
Boston University School of Medicine, USA
Applications of Glycomic Strategies for the Analysis of Biologically Significant Glycoproteins
Applications of Glycomic Strategies for the Analysis of Biologically Significant Glycoproteins
Emma K. Lundberg,
SciLifeLab Stockholm and School of Biotechnology, KTH, Sweden
Subcellular Localization of the Human Proteome
Subcellular Localization of the Human Proteome
Misha Savitski,
Cellzome GmbH, Germany
Tracking Cancer Drugs in Living Cells by Thermal Profiling of the Proteome
Tracking Cancer Drugs in Living Cells by Thermal Profiling of the Proteome
Neil G. Rumachik,
Stanford University, USA
Short Talk: Protein O-GlcNAcylation Oscillates and Acts as a Nutrient Sensor during Neural Differentiation of Human Embryonic Stem Cells
Short Talk: Protein O-GlcNAcylation Oscillates and Acts as a Nutrient Sensor during Neural Differentiation of Human Embryonic Stem Cells
Alfred Vertegaal,
Leiden University Medical Center, Netherlands
Short Talk: Uncovering Dynamic Small Ubiquitin-Like Modifier Signaling Networks in a Site-Specific Manner
Short Talk: Uncovering Dynamic Small Ubiquitin-Like Modifier Signaling Networks in a Site-Specific Manner
17:00—19:15
Clinical and Drug-Related Proteomics
*
Ileana M. Cristea,
Princeton University, USA
Philipp Mertins,
Broad Institute of MIT and Harvard, USA
Proteogenomic and Phosphoproteomic Analysis of Breast Cancer
Proteogenomic and Phosphoproteomic Analysis of Breast Cancer
Christie L. Hunter,
AB SCIEX, USA
Large-Scale Targeted Quantitative Proteomics for Biomarker Research
Large-Scale Targeted Quantitative Proteomics for Biomarker Research
Tamar Geiger,
Tel Aviv University, Israel
Genome-Scale Proteomic Profiling of Breast Cancer Progression
Genome-Scale Proteomic Profiling of Breast Cancer Progression
Wendy Sandoval,
Genentech, Inc., USA
Short Talk: High-Resolution Mass Spectrometric Characterization of Chain Pairing Variants in Co-Expressed Bispecific Antibody Production under Native and Acidic Conditions
Short Talk: High-Resolution Mass Spectrometric Characterization of Chain Pairing Variants in Co-Expressed Bispecific Antibody Production under Native and Acidic Conditions
Simone Lemeer,
Utrecht University, Netherlands
Short Talk: Elucidating Small Molecule Inhibitor Resistance in Lung Cancer
Short Talk: Elucidating Small Molecule Inhibitor Resistance in Lung Cancer
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:45
Interaction Proteomics
*
Catherine E. Costello,
Boston University School of Medicine, USA
Jun Qin,
Baylor College of Medicine, USA
Towards Comprehensive Analysis of Endogenous Protein Interactions
Towards Comprehensive Analysis of Endogenous Protein Interactions
Christine Vogel,
New York University, USA
Protein Expression Dynamics in Mammalian Cells Responding to Environmental Stress
Protein Expression Dynamics in Mammalian Cells Responding to Environmental Stress
Ileana M. Cristea,
Princeton University, USA
The Impact of Protein Interaction Studies on Discovering Host Defense Factors during Viral Infections
The Impact of Protein Interaction Studies on Discovering Host Defense Factors during Viral Infections
Evangelia Petsalaki,
Lunenfeld-Tanenbaum Research Institute, Canada
Short Talk: Barcode-Fusion Genetics Yeast-Two Yybrid (BFG-Y2H): Toward a Multidimensional Protein Interaction Map
Short Talk: Barcode-Fusion Genetics Yeast-Two Yybrid (BFG-Y2H): Toward a Multidimensional Protein Interaction Map
Georg Kustatscher,
University of Edinburgh, UK
Short Talk: Chromatin Factors Mapped by Co-Regulation Patterns in Proteomic Experiments
Short Talk: Chromatin Factors Mapped by Co-Regulation Patterns in Proteomic Experiments
17:00—19:15
Networks and Cross-Linking
*
Tamar Geiger,
Tel Aviv University, Israel
Lars Juhl Jensen,
University of Copenhagen, Denmark
In silico and Text-Based Analysis of Cellular Networks
In silico and Text-Based Analysis of Cellular Networks
Yasushi Ishihama,
Kyoto University, Japan
Chromatographic Challenges Facing Complete Human Proteome and Phosphoproteome Analysis
Chromatographic Challenges Facing Complete Human Proteome and Phosphoproteome Analysis
Juri Rappsilber,
Wellcome Trust Centre, University of Edinburgh, UK
Protein Structure Determination in Biological Matrices by Mass Spectrometry and Computational Biology
Protein Structure Determination in Biological Matrices by Mass Spectrometry and Computational Biology
Franz Herzog,
Gene Center Munich, Germany
Short Talk: Insights into Chromatin Assembled Protein Complexes by Cross-Link Driven Hybrid Structural Biology
Short Talk: Insights into Chromatin Assembled Protein Complexes by Cross-Link Driven Hybrid Structural Biology
Jeroen Krijgsveld,
EMBL, Germany
Short Talk: Novel Approaches to Investigate Global and Locus-Specific Chromatin Composition
Short Talk: Novel Approaches to Investigate Global and Locus-Specific Chromatin Composition
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:45
Completion of the Human Proteome II
*
Ronald Hendrickson,
Memorial Sloan Kettering Cancer Center, USA
Alexander Fields,
University of California, San Francisco, USA
Quantitative and Global Monitoring of Protein Translation with Ribosome Profiling
Quantitative and Global Monitoring of Protein Translation with Ribosome Profiling
Bernhard Küster,
Technische Universität München, Germany
Human Proteomes: From Basic Science to Understanding Drug Action
Human Proteomes: From Basic Science to Understanding Drug Action
Jun Wang,
iCarbonX, China
Million Genomes Ahead
Million Genomes Ahead
Karsten Krug,
University of Tuebingen, Germany
Short Talk: Assessing the Influence of Modified Non-Synonymous Single Nucleotide Variants on Signal Transduction Networks in Human Proteome
Short Talk: Assessing the Influence of Modified Non-Synonymous Single Nucleotide Variants on Signal Transduction Networks in Human Proteome
Petra Van Damme,
Ghent University, Belgium
Short Talk: Study of N-Terminal Proteoform Diversity by N-Terminomics and Ribosome Profiling
Short Talk: Study of N-Terminal Proteoform Diversity by N-Terminomics and Ribosome Profiling
17:00—18:45
Mass Spectometry-Based Proteomics of Intact Proteins
*
Anne-Claude Gingras,
Lunenfeld-Tanenbaum Research Institute, Canada
Neil L. Kelleher,
Northwestern University, USA
A Top Down Approach to the Human Proteome Project: Has the Time Now Come?
A Top Down Approach to the Human Proteome Project: Has the Time Now Come?
Albert J.R. Heck,
Utrecht University, Netherlands
Protein-Protein Reaction Monitoring by Native Mass Spectrometry
Protein-Protein Reaction Monitoring by Native Mass Spectrometry
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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