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This meeting took place in 2014
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Omics Meets Cell Biology: Applications to Human Health and Disease (B3)
Organizer(s) Anne-Claude Gingras, Igor Stagljar and A.J. Marian Walhout
February 18—23, 2014
Sagebrush Inn & Suites • Taos, NM USA
Discounted Abstract Deadline: Oct 17, 2013
Abstract Deadline: Nov 20, 2013
Scholarship Deadline: Oct 17, 2013
Discounted Registration Deadline: Dec 16, 2013
Sponsored by Biogen Idec and Novo Nordisk A/S. Supported by an educational donation provided by Amgen.
Summary of Meeting:
This conference brings together researchers who are applying and developing novel “Omics” approaches to interrogate system-level networks with an ultimate goal of understanding the functions of proteins of therapeutic importance. The conference will place a special emphasis on the interface between “Omics”-level sciences as applied to and integrated with classical molecular- and cell-biological studies. Because these large-scale projects involve multidisciplinary teams from both academic and biotech/pharma labs that are situated in different institutions all over the world, this meeting will provide a unique opportunity for diverse research groups to get together and discuss new ideas, approaches and novel results. More specifically, this conference explores how classical approaches to study biological processes, such as those used in cell biology, biochemistry and genetics, intersect with the new “Omics” technologies to advance our understanding of biological pathways associated with various human diseases. Extensive research in the past decade has shown that data sets generated by various “Omics” technologies represent a unique resource for biologists. However, a number of challenging technical and conceptual issues have been identified. These issues and resulting solutions will ultimately determine their impact on biology and medicine. Some of the issues include completeness and reproducibility of large-scale data sets, and how different data types obtained from the same and different systems can be integrated. Perhaps most importantly, a key objective of the meeting will be to explore the development of simple and robust methods for understanding the meaning of “Omics” data. This in turn will further facilitate the integration and dissemination of the data.
View Scholarships/Awards
This conference brings together researchers who are applying and developing novel “Omics” approaches to interrogate system-level networks with an ultimate goal of understanding the functions of proteins of therapeutic importance. The conference will place a special emphasis on the interface between “Omics”-level sciences as applied to and integrated with classical molecular- and cell-biological studies. Because these large-scale projects involve multidisciplinary teams from both academic and biotech/pharma labs that are situated in different institutions all over the world, this meeting will provide a unique opportunity for diverse research groups to get together and discuss new ideas, approaches and novel results. More specifically, this conference explores how classical approaches to study biological processes, such as those used in cell biology, biochemistry and genetics, intersect with the new “Omics” technologies to advance our understanding of biological pathways associated with various human diseases. Extensive research in the past decade has shown that data sets generated by various “Omics” technologies represent a unique resource for biologists. However, a number of challenging technical and conceptual issues have been identified. These issues and resulting solutions will ultimately determine their impact on biology and medicine. Some of the issues include completeness and reproducibility of large-scale data sets, and how different data types obtained from the same and different systems can be integrated. Perhaps most importantly, a key objective of the meeting will be to explore the development of simple and robust methods for understanding the meaning of “Omics” data. This in turn will further facilitate the integration and dissemination of the data.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, FEBRUARY 18
WEDNESDAY, FEBRUARY 19
THURSDAY, FEBRUARY 20
FRIDAY, FEBRUARY 21
SATURDAY, FEBRUARY 22
SUNDAY, FEBRUARY 23
Conference Program Print | View meeting in 12 hr (am/pm) time
TUESDAY, FEBRUARY 18
08:00—09:00
Keynote Address
*
Igor Stagljar,
University of Toronto, Canada
Brenda J. Andrews,
University of Toronto, Canada
Exploring Biological Pathways and Networks Using Yeast Functional Genomics
Exploring Biological Pathways and Networks Using Yeast Functional Genomics
09:00—11:15
Proteomics Technologies: Applications to Disease
*
Igor Stagljar,
University of Toronto, Canada
Anne-Claude Gingras,
Lunenfeld-Tanenbaum Research Institute, Canada
Signaling Interactome Dynamics in Health and Disease
Signaling Interactome Dynamics in Health and Disease
Ileana M. Cristea,
Princeton University, USA
Proteomics Meets Virology
Proteomics Meets Virology
Mikko Taipale,
University of Toronto, Canada
Short Talk: A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways
Short Talk: A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways
Martin Beck,
European Molecular Biology Laboratory, Germany
Short Talk: Cell-Type Specific Nuclear Pores: How the Nuclear Transport System Is Fine-Tuned toward Context-Specific Needs
Short Talk: Cell-Type Specific Nuclear Pores: How the Nuclear Transport System Is Fine-Tuned toward Context-Specific Needs
11:15—12:15
Panel: Industry Options in "Omics": From Technology Development to Applications
The goal of this workshop is to present young researchers with the evidence for why Industry is a good option for doing OMICs-based sciences after they complete their PhD and/or postdoctoral training.
*
Igor Stagljar,
University of Toronto, Canada
Giulio Superti-Furga,
Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Domagoj Vucic,
Genentech, Inc., USA
Sabine Bahn,
University of Cambridge, UK
17:00—19:00
Omics Meets Genetics and Gene Expression
*
A.J. Marian Walhout,
University of Massachusetts Medical School, USA
Heng Zhu,
Johns Hopkins University School of Medicine, USA
DNA Methylation Presents Distinct Binding Sites for Human Transcription Factors
DNA Methylation Presents Distinct Binding Sites for Human Transcription Factors
Michael P. Snyder,
Stanford University School of Medicine, USA
Personalized Medicine: Personal Omics Profiling of Healthy and Disease States
Personalized Medicine: Personal Omics Profiling of Healthy and Disease States
Marko Jovanovic,
Max Planck Institute of Brain Research, Germany
Short Talk: Quantitating the Mammalian Transcriptome and Proteome Relationship in a Dynamic Response to Pathogen Signal
Short Talk: Quantitating the Mammalian Transcriptome and Proteome Relationship in a Dynamic Response to Pathogen Signal
Michael J. Lee,
University of Massachusetts Medical School, USA
Dynamic Rewiring of Apoptotic Signaling: A Network-Centric Study of Combination Therapies for Triple-Negative Breast Cancer
Dynamic Rewiring of Apoptotic Signaling: A Network-Centric Study of Combination Therapies for Triple-Negative Breast Cancer
08:00—11:00
From Genotype and Phenotype
*
Markus Ralser,
Francis Crick Institute, UK
Charlie M. Boone,
University of Toronto, Canada
The Genetic Landscape of a Cell
The Genetic Landscape of a Cell
Andrew Fraser,
University of Toronto, Canada
A Whole Can of Worms: The Effect of Genome Evolution on Loss-of-Function Phenotypes in Different Nematodes
A Whole Can of Worms: The Effect of Genome Evolution on Loss-of-Function Phenotypes in Different Nematodes
Yoshikazu Ohya,
University of Tokyo, Japan
High-Resolution Phenotyping to Elucidate Essential Complex Cellular Processes
High-Resolution Phenotyping to Elucidate Essential Complex Cellular Processes
Louise Evans,
Institute of Cancer Research, UK
Short Talk: High-Content Combinatorial RNAi Screens Reveal Large-Scale Signaling Networks Regulating Cytokinesis
Short Talk: High-Content Combinatorial RNAi Screens Reveal Large-Scale Signaling Networks Regulating Cytokinesis
Giulio Superti-Furga,
Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Molecular Networks: Drug Action and Genome-Informed Medicine
Molecular Networks: Drug Action and Genome-Informed Medicine
11:00—12:00
Panel: Academic Careers in "Omics": Starting Up a Successful Research Program
*
Anne-Claude Gingras,
Lunenfeld-Tanenbaum Research Institute, Canada
17:00—19:00
Omics Meets Drug Discovery
*
Giulio Superti-Furga,
Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Stefan Knapp,
University of Oxford, UK
Using Structural (Chemo)-Proteomics as a Tool for Target Discovery
Using Structural (Chemo)-Proteomics as a Tool for Target Discovery
Domagoj Vucic,
Genentech, Inc., USA
Targeting Ubiquitin Ligases in Cancer and Inflammation
Targeting Ubiquitin Ligases in Cancer and Inflammation
Gerard Drewes,
GlaxoSmithKline, Germany
Charting Drug Target Complexes with Small Molecules
Charting Drug Target Complexes with Small Molecules
Irma Lemmens,
Ghent University/VIB, Belgium
Short Talk: MAPPIT and KISS, Two Complementary Methods to Detect Protein-Protein and Protein-Small Molecule Interactions in Living Mammalian Cells
Short Talk: MAPPIT and KISS, Two Complementary Methods to Detect Protein-Protein and Protein-Small Molecule Interactions in Living Mammalian Cells
08:00—11:15
Computational Analysis of Systems Biology
*
Anne-Claude Gavin,
European Molecular Biology Laboratory, Germany
Trey Ideker,
University of California, San Diego, USA
Mapping the Genetic Networks of Cancer
Mapping the Genetic Networks of Cancer
Nuno Bandeira,
University of California, San Diego, USA
The Transformative Role of Data Repositories in High Throughput Proteomics
The Transformative Role of Data Repositories in High Throughput Proteomics
Olga G. Troyanskaya,
Princeton University, USA
From Functional Genomics Studies to the Cell-Lineage Specific View of Human Disease
From Functional Genomics Studies to the Cell-Lineage Specific View of Human Disease
Jonathan H. Young,
Texas Tech University Health Sciences Center, USA
Short Talk: Novel Drug Targets for Non-Small Cell Lung Cancer from Computational Analysis of a Whole Genome RNAi Screen
Short Talk: Novel Drug Targets for Non-Small Cell Lung Cancer from Computational Analysis of a Whole Genome RNAi Screen
Murat Tasan,
University of Toronto, Canada
Short Talk: Causal Networks in Genome-Wide Association Studies
Short Talk: Causal Networks in Genome-Wide Association Studies
A.J. Marian Walhout,
University of Massachusetts Medical School, USA
Nutritional Regulatory Networks
Nutritional Regulatory Networks
11:15—12:15
Panel: Publishing High Impact "Omics" Papers
*
A.J. Marian Walhout,
University of Massachusetts Medical School, USA
17:00—19:00
An Integrated View of Cellular Signaling
*
Ileana M. Cristea,
Princeton University, USA
Shohei Koide,
New York University Langone Health, USA
Controlling Signaling Networks by Protein Design
Controlling Signaling Networks by Protein Design
Walter Kolch,
University College Dublin, Ireland
Signalling Networks Regulated by Compartmentalised Ras Signalling
Signalling Networks Regulated by Compartmentalised Ras Signalling
Anne E. White,
Harvard Medical School, USA
Short Talk: Quantitative Analysis of the Hippo Pathway in Low and High-Density Cells
Short Talk: Quantitative Analysis of the Hippo Pathway in Low and High-Density Cells
Igor Stagljar,
University of Toronto, Canada
Dynamic Interactomes of “Druggable” Membrane Proteins: Roles in Human Health and Disease
Dynamic Interactomes of “Druggable” Membrane Proteins: Roles in Human Health and Disease
08:00—11:00
Global Analysis of Metabolic and Lipidomics Networks
Markus Ralser,
Francis Crick Institute, UK
EMBO Young Investigator Lecture: Genetic Basis of Stability and Flexibility of Metabolic Networks
EMBO Young Investigator Lecture: Genetic Basis of Stability and Flexibility of Metabolic Networks
Anne-Claude Gavin,
European Molecular Biology Laboratory, Germany
Expending the Interaction Space: Protein-Lipid Networks
Expending the Interaction Space: Protein-Lipid Networks
Peer Bork,
European Molecular Biology Laboratory, Germany
Metagenomic Analysis of the Human Gut Microbiome: Variation, Stratification and Associations to Disease
Metagenomic Analysis of the Human Gut Microbiome: Variation, Stratification and Associations to Disease
17:00—18:45
Omics and Neurodegenerative Disorders
*
Bernd Wollscheid,
ETH Zürich, Switzerland
Sabine Bahn,
University of Cambridge, UK
Serum Biomarkers for Psychiatric Disorders
Serum Biomarkers for Psychiatric Disorders
Erich E. Wanker,
Max Delbrueck Center for Molecular Medicine, Germany
From Protein Interaction Networks to Neurodegenerative Disease Mechanisms
From Protein Interaction Networks to Neurodegenerative Disease Mechanisms
Eric J. Bennett,
University of California, San Diego, USA
Using the Ubiquitin-Modified Proteome to Evaluate Protein Homeostasis Function
Using the Ubiquitin-Modified Proteome to Evaluate Protein Homeostasis Function
18:45—19:30
Closing Address
*
Anne-Claude Gingras,
Lunenfeld-Tanenbaum Research Institute, Canada
Rudolf H. Aebersold,
Institute of Molecular Systems Biology, ETH Zürich, Switzerland
Network Driven Protein Biomarker Discovery and Validation
Network Driven Protein Biomarker Discovery and Validation
*Session Chair †Invited, not yet responded.
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