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This meeting took place in 2014
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The Brain: Adaptation and Maladaptation in Chronic Pain (E3)
Organizer(s) Frank Porreca, David Borsook and David W. Dodick
June 15—20, 2014
Keystone Resort • Keystone, CO USA
Discounted Abstract Deadline: Feb 13, 2014
Abstract Deadline: Mar 13, 2014
Scholarship Deadline: Feb 13, 2014
Discounted Registration Deadline: Apr 30, 2014
Sponsored by Regeneron Pharmaceuticals, Inc.
Summary of Meeting:
SIGNIFICANCE: The Institutes of Medicine indicate that pain affects more than 100 million Americans and costs more than an estimated $540-630 billion, a number predicted to only increase as our population ages and is influenced by lifestyle. We have few effective treatments for migraine or chronic pain. GOALS: Understanding the complexities of brain circuits involved in pain and migraine headache has been a major challenge in neurobiology that has limited the discovery of new therapies. For decades, the pain and headache communities have separately focused on peripheral mechanisms. INNOVATION: This conference brings together the world’s leading experts in brain systems neuroscience to highlight the advances in understanding brain systems relevant to the neurobiology of migraine and chronic pain. We wish to explore neurobiology of pain and headache together with contributions and attendance from both communities. APPROACH: A conversation of a number of new technologies has opened new opportunities to better understand the neural networks involved in the emotional, cognitive and sensory components of pain and consequent suffering. New technologies have opened doors to revolutionize our concepts of the impact of pain on the brain. OPPORTUNITY: Bringing together scientists from different disciplines related to, but not exclusively connected to pain and headache as a key to integration and bridging of disciplines and advancement of knowledge in these areas of clinical need. Accumulating functional and imaging data implicate headache and chronic pains as diseases of the brain – either primarily or secondarily as a consequence of peripheral damage. OUTCOME: We are at an exciting moment in the neurosciences where new understanding of brain function promises to change paradigms for drug discovery for neurological disorders. The promise is great, and the next decade of brain sciences research will redefine disease states, including predictive and personalized medicine, allow imaging the brain during pain and its relief by treatments in the individual patients suffering from pain.
View Scholarships/Awards
SIGNIFICANCE: The Institutes of Medicine indicate that pain affects more than 100 million Americans and costs more than an estimated $540-630 billion, a number predicted to only increase as our population ages and is influenced by lifestyle. We have few effective treatments for migraine or chronic pain. GOALS: Understanding the complexities of brain circuits involved in pain and migraine headache has been a major challenge in neurobiology that has limited the discovery of new therapies. For decades, the pain and headache communities have separately focused on peripheral mechanisms. INNOVATION: This conference brings together the world’s leading experts in brain systems neuroscience to highlight the advances in understanding brain systems relevant to the neurobiology of migraine and chronic pain. We wish to explore neurobiology of pain and headache together with contributions and attendance from both communities. APPROACH: A conversation of a number of new technologies has opened new opportunities to better understand the neural networks involved in the emotional, cognitive and sensory components of pain and consequent suffering. New technologies have opened doors to revolutionize our concepts of the impact of pain on the brain. OPPORTUNITY: Bringing together scientists from different disciplines related to, but not exclusively connected to pain and headache as a key to integration and bridging of disciplines and advancement of knowledge in these areas of clinical need. Accumulating functional and imaging data implicate headache and chronic pains as diseases of the brain – either primarily or secondarily as a consequence of peripheral damage. OUTCOME: We are at an exciting moment in the neurosciences where new understanding of brain function promises to change paradigms for drug discovery for neurological disorders. The promise is great, and the next decade of brain sciences research will redefine disease states, including predictive and personalized medicine, allow imaging the brain during pain and its relief by treatments in the individual patients suffering from pain.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, JUNE 15
MONDAY, JUNE 16
TUESDAY, JUNE 17
WEDNESDAY, JUNE 18
THURSDAY, JUNE 19
FRIDAY, JUNE 20
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, JUNE 15
08:30—08:45
Opening Remarks
David W. Dodick,
Mayo Clinic, USA
David Borsook,
Children's Hospital, USA
Frank Porreca,
University of Arizona, USA
08:45—09:45
Keynote Address
*
Frank Porreca,
University of Arizona, USA
Michael W. Salter,
Hospital for Sick Children and University of Toronto, Canada
Neuron-Glia Signaling in Pain Neuroplasticity
Neuron-Glia Signaling in Pain Neuroplasticity
09:45—12:15
Plasticity of Brain Neurons, Glia and Other Processes
*
Stephen B. McMahon,
King's College London, UK
Ru-Rong Ji,
Duke University, USA
Microglial and Astroglial Signaling in Persistent Pain
Microglial and Astroglial Signaling in Persistent Pain
Magdalena Luciuk,
University of Sydney, Australia
Short Talk: Microglial Phenotype in the Medullary Reticular Region in Chronic Pain
Short Talk: Microglial Phenotype in the Medullary Reticular Region in Chronic Pain
Amanda L. Ellis,
University of Colorado, USA
Short Talk: Administering Morphine following Spinal Cord Injury Amplifies Central Neuropathic Pain
Short Talk: Administering Morphine following Spinal Cord Injury Amplifies Central Neuropathic Pain
Giorgio A. Ascoli,
George Mason University, USA
Neuronal Morphology Goes Digital: A Research Hub for Cellular and System Neuroscience
Neuronal Morphology Goes Digital: A Research Hub for Cellular and System Neuroscience
14:00—15:30
Workshop: New Technologies to Understand the Brain in Pain
*
David Borsook,
Children's Hospital, USA
Yves De Koninck,
Université Laval, Quebec Mental Health Institute, Canada
Towards an All-Optical Functional Dissection of Pain Pathways
Towards an All-Optical Functional Dissection of Pain Pathways
Katja Wiech,
University of Oxford, UK
Jon-Kar Zubieta,
University of Michigan, USA
Effects of tDCS on Endogenous Opioid Mechanisms
Effects of tDCS on Endogenous Opioid Mechanisms
Tor D. Wager,
University of Colorado at Boulder, USA
Towards fMRI-Based Biomarkers for Pain and Emotion
Towards fMRI-Based Biomarkers for Pain and Emotion
16:00—18:00
New Technologies to Image the Human Brain Structure and Function
*
Robert C. Coghill,
Cincinnati Children's Hopsital, USA
Yves De Koninck,
Université Laval, Quebec Mental Health Institute, Canada
Probing the Brain with Light
Probing the Brain with Light
Jing Wang,
New York University School of Medicine, USA
Short Talk: Optogenetic Activation of Corticostriatal Circuitry Regulates Chronic Neuropathic Pain
Short Talk: Optogenetic Activation of Corticostriatal Circuitry Regulates Chronic Neuropathic Pain
Katja Wiech,
University of Oxford, UK
Imaging Pain
Imaging Pain
Richard Hargreaves,
Celgene, USA
Imaging to Optimize Analgesic Drug Discovery and Development
Imaging to Optimize Analgesic Drug Discovery and Development
08:30—09:30
Keynote Address
*
Frank Porreca,
University of Arizona, USA
Howard L. Fields,
University of California, San Francisco, USA
Mesolimbic Circuits: Where Pain and Pleasure Interact
Mesolimbic Circuits: Where Pain and Pleasure Interact
09:30—11:45
Dissecting Basic Brain Circuits Involved in Pain Behaviors
*
A. Vania Apkarian,
Northwestern University, USA
Mark Tommerdahl,
University of North Carolina, USA
Role of the Primary Somatosensory Cortex in Pain
Role of the Primary Somatosensory Cortex in Pain
Robert C. Coghill,
Cincinnati Children's Hopsital, USA
The Role of the Posterior Parietal Cortex in Pain
The Role of the Posterior Parietal Cortex in Pain
Karen Davis,
University of Toronto/Toronto Western Research Institute, Canada
Pain-Attention Brain Circuitry Phenotypes: Potential for Personalized Therapeutics?
Pain-Attention Brain Circuitry Phenotypes: Potential for Personalized Therapeutics?
Neil Schwartz,
Stanford University, USA
Short Talk: Decreased Motivation during Chronic Pain Requires Depression of the Nucleus Accumbens Indirect Pathway
Short Talk: Decreased Motivation during Chronic Pain Requires Depression of the Nucleus Accumbens Indirect Pathway
16:00—18:15
Preclinical to Clinical Evaluation of Pain - Garnering a Better Approximation to the Human Condition
*
Maria Fitzgerald,
University College London, UK
Frank Porreca,
University of Arizona, USA
Reward Circuits and Pain
Reward Circuits and Pain
Andrew Charles,
University of California, Los Angeles, USA
Translational Models of the Migraine Brain State
Translational Models of the Migraine Brain State
Mirko Santello,
University of Bern, Switzerland
Short Talk: Dysfunction of Dendritic Properties of Cortical Pyramidal Neurons in a Chronic Pain Model
Short Talk: Dysfunction of Dendritic Properties of Cortical Pyramidal Neurons in a Chronic Pain Model
Gary R. Strichartz,
Harvard Medical School, Brigham and Women's Hospital, USA
Short Talk: Critical Role of the RVM in Chronic Pain after Thoracotomy
Short Talk: Critical Role of the RVM in Chronic Pain after Thoracotomy
Chas Bountra,
University of Oxford, UK
Working Together Pre-Competitively, Exploring Novel Epigenetic Proteins and Using Human Cells to Increase the Probability of Discovering New Analgesics
Working Together Pre-Competitively, Exploring Novel Epigenetic Proteins and Using Human Cells to Increase the Probability of Discovering New Analgesics
19:30—21:00
Local Community Panel Discussion on Pain
Drs. David Dodick and Frank Porreca, along with a local physician, Dr. Ross Dickstein, will present a community panel discussion on 'Pain' at the Silverthorne Community Center in Silverthorne CO. The discussion, which is targeted at a lay audience, is part of a Keystone Symposia outreach program to bring interesting science to our local community in Summit County. Bus transportation will be available for a limited number of conference participants who would like to attend the panel discussion.
08:30—09:30
Keynote Address
*
David W. Dodick,
Mayo Clinic, USA
David Borsook,
Children's Hospital, USA
Pain in Neurological Disease
Pain in Neurological Disease
09:30—12:00
Pain in Neurological Disease States
*
Giandomenico Iannetti,
University College London, UK
Emeran Mayer,
University of California, Los Angeles, USA
Brain Networks in Chronic Visceral Pain
Brain Networks in Chronic Visceral Pain
Todd J. Schwedt,
Mayo Clinic, USA
The Interictal Migraine Brain: Hypersensitive, Hypervigilant and Hyperactive
The Interictal Migraine Brain: Hypersensitive, Hypervigilant and Hyperactive
A. Vania Apkarian,
Northwestern University, USA
The Neurological basis of Chronic Pain: Causes and Consequences
The Neurological basis of Chronic Pain: Causes and Consequences
Vasco Galhardo,
Faculdade de Medicina - Universidade do Porto, Portugal
Short Talk: Dopaminergic Reversal of Pain-Related Working Memory Deficits
Short Talk: Dopaminergic Reversal of Pain-Related Working Memory Deficits
Catherine D. Chong,
Mayo Clinic Arizona, USA
Short Talk: Atypical Age-Related Cortical Thinning in Episodic Migraine
Short Talk: Atypical Age-Related Cortical Thinning in Episodic Migraine
16:00—18:00
Altered Processing of Pain
*
Rami Burstein,
Harvard Medical School, USA
Herta Flor,
Medical Faculty Mannheim, Heidelberg University, Germany
Brain Circuits Involved in Phantom Limb Pain
Brain Circuits Involved in Phantom Limb Pain
Rami Burstein,
Harvard Medical School, USA
Neurochemical Pathways that Modulate Thalamic Trigeminovascular Neurons
Neurochemical Pathways that Modulate Thalamic Trigeminovascular Neurons
Jon Levine,
University of California, San Francisco, USA
Mirror Mirror on the Wall, Who Is the Sexiest of Them All
Mirror Mirror on the Wall, Who Is the Sexiest of Them All
Dustin Green,
University of Texas Health Science Center at San Antonio, USA
Short Talk: Role of Endogenous TRPV1 Agonists in a Post-Burn Pain Model of Partial-Thickness Injury
Short Talk: Role of Endogenous TRPV1 Agonists in a Post-Burn Pain Model of Partial-Thickness Injury
08:30—09:30
Keynote Address
*
David Borsook,
Children's Hospital, USA
09:30—11:15
The Brain and Self-Trickery in Pain and Analgesia
*
Karen Davis,
University of Toronto/Toronto Western Research Institute, Canada
Jon-Kar Zubieta,
University of Michigan, USA
Opioid Mechanisms, Pain Regulation and Placebo Analgesia
Opioid Mechanisms, Pain Regulation and Placebo Analgesia
Giandomenico Iannetti,
University College London, UK
Pain and Perception
Pain and Perception
Tor D. Wager,
University of Colorado at Boulder, USA
Neuroimaging of the Generation and Regulation of Pain
Neuroimaging of the Generation and Regulation of Pain
Richard D. Lane,
University of Arizona, USA
Short Talk: Neural Correlates of Deficits in Pain-Related Affective Meaning Construction in Patients with Chronic Pain Disorder
Short Talk: Neural Correlates of Deficits in Pain-Related Affective Meaning Construction in Patients with Chronic Pain Disorder
16:00—18:15
The Brain in Development
*
Tor D. Wager,
University of Colorado at Boulder, USA
Maria Fitzgerald,
University College London, UK
Pain in the Young Brain Becomes Pain in the Older Brain
Pain in the Young Brain Becomes Pain in the Older Brain
Stephen B. McMahon,
King's College London, UK
Pain Genetics and Epigenetics
Pain Genetics and Epigenetics
P. Ellen Grant,
Boston Children's Hospital, USA
Human Brain Measures in Development
Human Brain Measures in Development
Lorenzo Fabrizi,
University College London, UK
Short Talk: How Does Nociceptive Processing in the Human Infant Brain Compare with That in Adults?
Short Talk: How Does Nociceptive Processing in the Human Infant Brain Compare with That in Adults?
Dusica Bajic,
Boston Children's Hospital, USA
Short Talk: Rat Periaqueductal Gray Neurotransmitter Gene Expression with Development and Chronic Morphine
Short Talk: Rat Periaqueductal Gray Neurotransmitter Gene Expression with Development and Chronic Morphine
*Session Chair †Invited, not yet responded.
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Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
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