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This meeting took place in 2015
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Heart Disease and Regeneration: Insights from Development (X1)
Organizer(s) Vincent M. Christoffels, James F. Martin and Deborah L. Yelon
March 1—6, 2015
Copper Mountain Resort • Copper Mountain, CO USA
Discounted Abstract Deadline: Nov 4, 2014
Abstract Deadline: Dec 3, 2014
Scholarship Deadline: Nov 4, 2014
Discounted Registration Deadline: Jan 6, 2015
Sponsored by AstraZeneca and Bayer HealthCare Pharmaceuticals
Summary of Meeting:
Heart disease is the leading cause of death worldwide, affecting both children and adults. It is now clear that congenital heart defects result from disorders in developmental mechanisms of differentiation and morphogenesis and that these disorders are often the consequence of genetic variation. Moreover, there is increasing evidence that these same developmental mechanisms and genetic variations contribute to heart disease throughout life, and this understanding could be leveraged for regenerative therapies. This meeting will highlight new concepts in cardiovascular development, regeneration and repair and will emphasize common molecular mechanisms with therapeutic potential for cardiovascular regeneration. Sessions on the regulatory mechanisms of cardiac development, lineage specification, stem cell differentiation and proliferation will integrate current insights into the molecular mechanisms connecting patterning, morphogenesis, homeostasis and disease. Emerging technologies for genome editing and imaging will be discussed with the aim of facilitating new research directions and translational approaches. Overall, the goal of this meeting is to bring together researchers with expertise in cardiac development, molecular biology, stem cell biology, genetics and epigenetics to facilitate our understanding of heart development and homeostasis and to explore scientific directions and therapeutic approaches for the treatment of heart disease in children and adults.
View Scholarships/Awards
Heart disease is the leading cause of death worldwide, affecting both children and adults. It is now clear that congenital heart defects result from disorders in developmental mechanisms of differentiation and morphogenesis and that these disorders are often the consequence of genetic variation. Moreover, there is increasing evidence that these same developmental mechanisms and genetic variations contribute to heart disease throughout life, and this understanding could be leveraged for regenerative therapies. This meeting will highlight new concepts in cardiovascular development, regeneration and repair and will emphasize common molecular mechanisms with therapeutic potential for cardiovascular regeneration. Sessions on the regulatory mechanisms of cardiac development, lineage specification, stem cell differentiation and proliferation will integrate current insights into the molecular mechanisms connecting patterning, morphogenesis, homeostasis and disease. Emerging technologies for genome editing and imaging will be discussed with the aim of facilitating new research directions and translational approaches. Overall, the goal of this meeting is to bring together researchers with expertise in cardiac development, molecular biology, stem cell biology, genetics and epigenetics to facilitate our understanding of heart development and homeostasis and to explore scientific directions and therapeutic approaches for the treatment of heart disease in children and adults.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, MARCH 1
MONDAY, MARCH 2
TUESDAY, MARCH 3
WEDNESDAY, MARCH 4
THURSDAY, MARCH 5
FRIDAY, MARCH 6
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, MARCH 1
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Keynote Address (Joint)
*
Stefanie Dimmeler,
University of Frankfurt, Germany
*
Vincent M. Christoffels,
Academic Medical Center, Netherlands
Didier Stainier,
Max Planck Institute for Heart and Lung Research, Germany
Regulation of Cardiovascular Development
Regulation of Cardiovascular Development
09:00—11:15
Potential and Pitfalls of Cell Reprogramming (Joint)
Eric N. Olson,
University of Texas Southwestern Medical Center, USA
New Strategies for Heart Regeneration and Repair
New Strategies for Heart Regeneration and Repair
Sean M. Wu,
Stanford School of Medicine, USA
Molecular Basis of Cardiomyocyte Programming and Reprogramming
Molecular Basis of Cardiomyocyte Programming and Reprogramming
Deepak Srivastava,
Gladstone Institutes, USA
Reprogramming Approaches for Cardiovascular Disease
Reprogramming Approaches for Cardiovascular Disease
14:30—16:30
Workshop 1: Emerging Technologies: Genomics and Reprogramming
*
Benoit G. Bruneau,
Gladstone Institutes, USA
*
Laurie A. Boyer,
Massachusetts Institute of Technology, USA
Joseph A. Goldman,
Duke University, USA
Profiling of Dynamic Gene-Regulatory Programs during Zebrafish Heart Regeneration Using the Replacement Histone H3.3
Profiling of Dynamic Gene-Regulatory Programs during Zebrafish Heart Regeneration Using the Replacement Histone H3.3
Jonathon Hill,
University of Utah, USA
Self-Organized Map Analysis of Temporal RNA-Seq Datasets Reveals Gene Regulatory Interactions during Heart Looping and Atrio-Ventricular Canal Formation
Self-Organized Map Analysis of Temporal RNA-Seq Datasets Reveals Gene Regulatory Interactions during Heart Looping and Atrio-Ventricular Canal Formation
Kelvin See,
University of Pennsylvania, USA
Single Cardiomyocyte Nuclear RNA-Seq Reveals a De-Differentiation Stress Response in vivo
Single Cardiomyocyte Nuclear RNA-Seq Reveals a De-Differentiation Stress Response in vivo
Emily S. Noël,
Hubrecht Institute, Netherlands
Identification of Novel Regulators of Embryonic Laterality Using Tomo-Seq
Identification of Novel Regulators of Embryonic Laterality Using Tomo-Seq
Nikhil V. Munshi,
University of Texas Southwestern Medical Center, USA
Induction of Diverse Cardiac Cell Types by Reprogramming Fibroblasts with Cardiac Transcription Factors
Induction of Diverse Cardiac Cell Types by Reprogramming Fibroblasts with Cardiac Transcription Factors
Li Qian,
University of North Carolina at Chapel Hill, USA
Stoichiometry of Gata4, Mef2c and Tbx5 Influences the Efficiency and Quality of iCM Reprogramming
Stoichiometry of Gata4, Mef2c and Tbx5 Influences the Efficiency and Quality of iCM Reprogramming
14:30—16:30
Workshop 1: Myocyte / Non-Myocyte Interactions in Healthy and Diseased Myocardium
*
Milena Bastos Furtado,
The Jackson Lab, USA
*
Patrizia Camelliti,
University of Surrey, UK
Emily L. Ongstad,
MedImmune, USA
A Cx43 C-Terminal Mimetic Peptide Alters Myocyte-Fibroblast Interactions via Cx43 in the Injury Border Zone
A Cx43 C-Terminal Mimetic Peptide Alters Myocyte-Fibroblast Interactions via Cx43 in the Injury Border Zone
J. Travis Hinson,
The Jackson Laboratory, USA
Crosstalk between AMPK in Myocytes and Fibroblasts Regulates Cardiac Fibrosis
Crosstalk between AMPK in Myocytes and Fibroblasts Regulates Cardiac Fibrosis
Margaux A. Horn,
University of Manchester, UK
Remodelling of the Cardiac Extracellular Matrix following Induction and Recovery from Pacing-Induced Heart Failure in Sheep
Remodelling of the Cardiac Extracellular Matrix following Induction and Recovery from Pacing-Induced Heart Failure in Sheep
Inês J. Marques,
Centro Nacional de Investigaciones Cardiovasculres, Spain
The Lysyl Oxidase Gene Family in the Regeneration of the Cryoinjured Zebrafish Ventricle
The Lysyl Oxidase Gene Family in the Regeneration of the Cryoinjured Zebrafish Ventricle
Arjun Deb,
University of California, Los Angeles, USA
Mesenchymal-Endothelial-Transition Contributes to Neovascularization after Acute Cardiac Injury
Mesenchymal-Endothelial-Transition Contributes to Neovascularization after Acute Cardiac Injury
Celinda M. Kofron,
Rhode Island Hospital / Brown Medical School, USA
Modulation of Cardiomyocyte Electrical Activity by Cardiac Fibroblasts in a Novel 3D Platform
Modulation of Cardiomyocyte Electrical Activity by Cardiac Fibroblasts in a Novel 3D Platform
Marco Tarantola,
MPI for Dynamics and Self-Organization, Germany
Electromechanical Connectivity of Cardiomyocytes under Fibrotic Conditions
Electromechanical Connectivity of Cardiomyocytes under Fibrotic Conditions
17:00—19:00
Epigenetics of Cardiac Development
*
Brian L. Black,
University of California, San Francisco, USA
Hesham A. Sadek,
University of Texas Southwestern Medical Center, USA
Meis 1 in Heart Regeneration
Meis 1 in Heart Regeneration
Laurie A. Boyer,
Massachusetts Institute of Technology, USA
Transcriptional Regulation of Cardiac Cell Fate
Transcriptional Regulation of Cardiac Cell Fate
Dalit May,
Hebrew University of Jerusalem, Israel
Short Talk: Chromatin Dynamics in Myocardial Hibernation - The Role of Transcriptional Enhancers in Chronic Cardiac Ischemia
Short Talk: Chromatin Dynamics in Myocardial Hibernation - The Role of Transcriptional Enhancers in Chronic Cardiac Ischemia
17:00—19:00
Non-Myocytes in Cardiac Development
*
Roger R. Markwald,
Medical University of South Carolina, USA
Edward E. Morrisey,
University of Pennsylvania, USA
Mechanisms Promoting Cardiomyocyte Proliferation and Replenishment
Mechanisms Promoting Cardiomyocyte Proliferation and Replenishment
Russell Norris,
Medical University of South Carolina, USA
Daschous-Hippo: Novel Regulators of Myocyte – Non-Myocyte Interaction and Cardiac Growth
Daschous-Hippo: Novel Regulators of Myocyte – Non-Myocyte Interaction and Cardiac Growth
Rhonda Bassel-Duby,
University of Texas Southwestern Medical Center, USA
A Twist of Fate in Cardiac Regeneration
A Twist of Fate in Cardiac Regeneration
Milena Bastos Furtado,
The Jackson Lab, USA
Short Talk: Cardiogenic Transcriptional Network in Heart Fibroblast Biology and Disease
Short Talk: Cardiogenic Transcriptional Network in Heart Fibroblast Biology and Disease
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
19:30—22:00
Poster Session 1
Poster sessions provide exciting opportunities for engagement between all levels of investigators. Abstracts beginning with X1 or X2 and the number 1 are featured during this poster session.
08:00—11:15
Regulatory Networks for Cardiac Rhythm
*
Ivan P. Moskowitz,
University of Chicago, USA
Patrick T. Ellinor,
Massachusetts General Hospital, USA
Genetics of Atrial Fibrillation
Genetics of Atrial Fibrillation
Vincent M. Christoffels,
Academic Medical Center, Netherlands
Transcriptional Regulation of the Electrical Activity Pattern of the Heart
Transcriptional Regulation of the Electrical Activity Pattern of the Heart
Stacey L. Rentschler,
Washington University School of Medicine, USA
Canonical Wnt Signaling Regulates Myocardial Electrical Programming
Canonical Wnt Signaling Regulates Myocardial Electrical Programming
Sylvia M. Evans,
University of California, San Diego, USA
Role of Islet1 in Sinus Node Development
Role of Islet1 in Sinus Node Development
David S. Park,
New York University School of Medicine, USA
Short Talk: A Neuregulin-1/Er81/Nkx2-5 Signaling Cascade Confers Rapid Conduction in the Heart
Short Talk: A Neuregulin-1/Er81/Nkx2-5 Signaling Cascade Confers Rapid Conduction in the Heart
Stephanie Iris Protze,
University Health Network, Canada
Short Talk: Sinoatrial Node Pacemaker Cells Generated from Human Pluripotent Stem Cells Can Function as Biological Pacemaker
Short Talk: Sinoatrial Node Pacemaker Cells Generated from Human Pluripotent Stem Cells Can Function as Biological Pacemaker
08:00—11:00
Cardiac Non-Myocytes as Signaling Hubs: Biochemical Signals
*
Robert G. Gourdie,
Virginia Tech Carilion Research Institute, USA
Michelle D. Tallquist,
University of Hawaii, USA
Fibroblast Roles in Cardiac Function and Disease
Fibroblast Roles in Cardiac Function and Disease
Mark L. Entman,
Baylor College of Medicine, USA
Fibroblasts of Myeloid Origin and Immune-Inflammatory Dysregulation
Fibroblasts of Myeloid Origin and Immune-Inflammatory Dysregulation
Kenneth Walsh,
University of Virginia School of Medicine, USA
Non-Myocyte Contributions to Cardiokines: Deciphering the Cardiac Secretome
Non-Myocyte Contributions to Cardiokines: Deciphering the Cardiac Secretome
Katarzyna A. Cieslik,
Baylor College of Medicine, USA
Short Talk: Mesenchymal Fibroblasts Promote Myeloid Fibroblast Formation in the Aging Mouse Heart
Short Talk: Mesenchymal Fibroblasts Promote Myeloid Fibroblast Formation in the Aging Mouse Heart
17:00—19:00
Gene Regulatory Networks
*
James F. Martin,
Baylor College of Medicine, USA
Ivan P. Moskowitz,
University of Chicago, USA
Gene Regulatory Networks for Cardiac Form and Function
Gene Regulatory Networks for Cardiac Form and Function
Sophia Y. Tsai,
Baylor College of Medicine, USA
Role of COUP-TFII in Atrial Specification and Heart Failure
Role of COUP-TFII in Atrial Specification and Heart Failure
Brian L. Black,
University of California, San Francisco, USA
Transcriptional Pathways Controlling OFT Development
Transcriptional Pathways Controlling OFT Development
Alexandre R. Colas,
Sanford-Burnham Medical Research Institute, USA
Short Talk: Deciphering Cardiac Differentiation Using Whole Genome and "Whole Combinome" miRNA Screening: Implications for Stem Cell Differentiation, Somatic Reprogramming and Cardiac Regeneration
Short Talk: Deciphering Cardiac Differentiation Using Whole Genome and "Whole Combinome" miRNA Screening: Implications for Stem Cell Differentiation, Somatic Reprogramming and Cardiac Regeneration
17:00—19:00
Cardiac Non-Myocytes as Signaling Hubs: Biophysical Signals
*
Natalia Trayanova,
Johns Hopkins University, USA
Robert G. Gourdie,
Virginia Tech Carilion Research Institute, USA
Connexins as Regulators of Fibrosis and Clinical Targets for Scar Reduction Therapies
Connexins as Regulators of Fibrosis and Clinical Targets for Scar Reduction Therapies
Douglas W. Losordo,
Caladrius Biosciences, Inc., USA
The Microvasculature as a Therapeutic Target in Ischemic Tissue Repair
The Microvasculature as a Therapeutic Target in Ischemic Tissue Repair
Salim Seyfried,
University of Potsdam, Germany
Short Talk: Blood Flow and Bmp Signaling Control Endocardial Chamber Morphogenesis
Short Talk: Blood Flow and Bmp Signaling Control Endocardial Chamber Morphogenesis
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
19:30—22:00
Poster Session 2
Poster sessions provide exciting opportunities for engagement between all levels of investigators. Abstracts beginning with X1 or X2 and the number 2 are featured during this poster session.
08:00—11:15
Renewal and Plasticity
*
Kenneth D. Poss,
Duke University Medical Center, USA
Nadia Mercader,
Institut of Anatomy, University of Bern, Switzerland
Cellular and Molecular Mechanisms of Transient Cardiac Fibrosis followed by Heart Regeneration upon Cryoinjury in the Zebrafish
Cellular and Molecular Mechanisms of Transient Cardiac Fibrosis followed by Heart Regeneration upon Cryoinjury in the Zebrafish
Gordana V. Vunjak-Novakovic,
Columbia University, USA
Bioengineering Human Heart Tissue: Maturation and Utility for Drug Studies
Bioengineering Human Heart Tissue: Maturation and Utility for Drug Studies
Charles E. Murry,
University of Washington, USA
Chromatin Signatures Identify Regulators of Cardiac Development
Chromatin Signatures Identify Regulators of Cardiac Development
Sangita Choudhury,
Boston Children's Hospital, USA
Short Talk: Identification of Novel Regulators of Cardiomyocyte Proliferation as Regenerative Therapies for Heart Failure
Short Talk: Identification of Novel Regulators of Cardiomyocyte Proliferation as Regenerative Therapies for Heart Failure
Michaela Patterson,
University of Southern California, USA
Short Talk: Genetic Determinants of Adult Mammalian Heart Regeneration
Short Talk: Genetic Determinants of Adult Mammalian Heart Regeneration
08:00—11:00
Cardiac Non-Myocytes in Tissue Structure and Function in the Adult Heart
*
Merry L. Lindsey,
University of Nebraska Medical Center., USA
Doris A. Taylor,
Texas Heart Institute, USA
ECM Clues for Cardiac Re-Popularization: Lessons from the De-Cellularized Heart
ECM Clues for Cardiac Re-Popularization: Lessons from the De-Cellularized Heart
Nadia A. Rosenthal,
The Jackson Laboratory, USA
Immune Cell Regulation of Cardiac Regeneration
Immune Cell Regulation of Cardiac Regeneration
Shahin Rafii,
Weill Cornell Medical College, USA
Angiocrine Contribution of the Vascular Niche to Regeneration and Fibrosis
Angiocrine Contribution of the Vascular Niche to Regeneration and Fibrosis
Mario Delmar,
New York University, USA
Heterocellular Mechanical Junctions and Arrhythmogenesis: A Visual Proteomics Approach to the Study of Intercellular Communication in the Heart
Heterocellular Mechanical Junctions and Arrhythmogenesis: A Visual Proteomics Approach to the Study of Intercellular Communication in the Heart
Manuel Mayr,
King's College, University of London, UK
Short Talk: Glycoproteomics Analysis of the Human Cardiac Extracellular Matrix
Short Talk: Glycoproteomics Analysis of the Human Cardiac Extracellular Matrix
14:30—16:30
Workshop 2: Disease Models, Regeneration and Plasticity
*
Jeroen Bakkers,
Hubrecht Institute, Netherlands
*
Charles E. Murry,
University of Washington, USA
Mauro W. Costa,
, USA
A Novel Understanding of a Complex Disease: The Interplay of Congenital Heart Disease and Obesity
A Novel Understanding of a Complex Disease: The Interplay of Congenital Heart Disease and Obesity
Gaetano D'Amato,
Centro Nacional de Investigaciones Cardiovasculares CNIC, Spain
Sequential Notch Activation Underlies Ventricular Chamber Development
Sequential Notch Activation Underlies Ventricular Chamber Development
Diane Fatkin,
Victor Chang Cardiac Research Institute, Australia
Genetic Variants in the Left-Right Asymmetry Gene LEFTY2 May Contribute to AF Susceptibility
Genetic Variants in the Left-Right Asymmetry Gene LEFTY2 May Contribute to AF Susceptibility
C. Geoffrey Burns,
Harvard Medical School, Massachusetts General Hospital, USA
The AP-1 Transcription Factor Component Fosl2 Potentiates Myocardial Differentiation from the Zebrafish Second Heart Field
The AP-1 Transcription Factor Component Fosl2 Potentiates Myocardial Differentiation from the Zebrafish Second Heart Field
Ge Tao,
Baylor College of Medicine, USA
Paired-Like Homeodomain Transcription Factor 2 Promotes Mouse Myocardial Regeneration
Paired-Like Homeodomain Transcription Factor 2 Promotes Mouse Myocardial Regeneration
Christina V. Theodoris,
University of California, San Francisco, USA
iPSC-Based Modeling of Human NOTCH1 Mutations Reveals Novel Pathways Regulating Aortic Valve Disease
iPSC-Based Modeling of Human NOTCH1 Mutations Reveals Novel Pathways Regulating Aortic Valve Disease
14:30—16:30
Workshop 2: Epigenetic and RNA Regulation of the Hetero-Cellular Heart
*
Manuel Mayr,
King's College, University of London, UK
*
Katarzyna A. Cieslik,
Baylor College of Medicine, USA
Burcu Duygu,
Maastricht University, Netherlands
Regulation of Pathological cardiac Remodeling following Myocardial Infarction: The Role of miR-199b
Regulation of Pathological cardiac Remodeling following Myocardial Infarction: The Role of miR-199b
Jan Fiedler,
Hannover Medical School, Germany
Functional Relevance of Endothelial Hypoxia-Sensitive Long Non-Coding RNAs (lncRNAs)
Functional Relevance of Endothelial Hypoxia-Sensitive Long Non-Coding RNAs (lncRNAs)
Jörg Heineke,
Medizinische Hochschule Hannover, Germany
Impact of the Transcription Factor GATA2 in Endothelial Cells on Cardiac Failure through Regulation of Two Secreted Long Non-Coding RNAs
Impact of the Transcription Factor GATA2 in Endothelial Cells on Cardiac Failure through Regulation of Two Secreted Long Non-Coding RNAs
Peng Zhang,
Rhode Island Hospital and Alpert Medical School of Brown University, USA
A Novel Regulatory Role of MicroRNA-145 in Cardiac Fibroblasts
A Novel Regulatory Role of MicroRNA-145 in Cardiac Fibroblasts
Stephane Heymans,
Maastricht University Medical Centre, Netherlands
MicroRNA-146a Rewires Cardiac Metabolism and causes Cardiac Dysfunction in Hypertensive Heart Disease
MicroRNA-146a Rewires Cardiac Metabolism and causes Cardiac Dysfunction in Hypertensive Heart Disease
Hyun Kook,
Chonnam National University, South Korea
Posttranslational Modifications of Histone Deacetylase 2 in Cardiac Hypertrophy
Posttranslational Modifications of Histone Deacetylase 2 in Cardiac Hypertrophy
Jesung Moon,
University of Texas Southwestern Medical Center, USA
Improving Adult Muscle Tissue Regeneration Using Small Molecule Antagonists of Wnt-Mediated Signaling
Improving Adult Muscle Tissue Regeneration Using Small Molecule Antagonists of Wnt-Mediated Signaling
Emily K. Pugach,
University of Colorado, USA
Cre Expression Driven by the alpha-Myosin Heavy Chain Promoter Induces DNA Damage and Cardiotoxicity
Cre Expression Driven by the alpha-Myosin Heavy Chain Promoter Induces DNA Damage and Cardiotoxicity
17:00—19:00
Signaling Pathways: Integration and Crosstalk
*
Stacey L. Rentschler,
Washington University School of Medicine, USA
Steven J. Kattman,
, USA
Harnessing Cardiac Development for Cell Manufacturing
Harnessing Cardiac Development for Cell Manufacturing
Katherine E. Yutzey,
Cincinnati Children's Hospital Medical Center, USA
Regulation of Postnatal Cardiomyocyte Proliferation
Regulation of Postnatal Cardiomyocyte Proliferation
Jonathan A. Epstein,
University of Pennsylvania, USA
Cardiac Myocyte Lineage Commitment
Cardiac Myocyte Lineage Commitment
Gabriele D'Uva,
Weizmann Institute of Science, Israel
Short Talk: ERBB2 Triggers Mammalian Heart Regeneration by Promoting Cardiomyocyte Dedifferentiation and Proliferation
Short Talk: ERBB2 Triggers Mammalian Heart Regeneration by Promoting Cardiomyocyte Dedifferentiation and Proliferation
17:00—19:00
Cardiac Non-Myocytes as Targets of Interventions
*
Thomas Thum,
Medical School Hannover, Germany
Stefan Engelhardt,
Technical University of Munich, Germany
miRNAs as Modulators of Cardiac Fibrosis: Myocyte–Fibroblast Cross-Talk
miRNAs as Modulators of Cardiac Fibrosis: Myocyte–Fibroblast Cross-Talk
John A. Baugh,
University College Dublin, Ireland
Short Talk: Epigenetic Therapy for the Treatment of Cardiac Hypertrophy and Fibrosis
Short Talk: Epigenetic Therapy for the Treatment of Cardiac Hypertrophy and Fibrosis
Natalia Trayanova,
Johns Hopkins University, USA
Image-Based Computer Modeling of Cardiac Scar Effects and their Interventional Correction
Image-Based Computer Modeling of Cardiac Scar Effects and their Interventional Correction
Bernd K. Fleischmann,
Bonn University, Germany
Modulating the Myocardial Scar and Anti-Arrhythmogenesis
Modulating the Myocardial Scar and Anti-Arrhythmogenesis
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
19:30—22:00
Poster Session 3
Poster sessions provide exciting opportunities for engagement between all levels of investigators. Abstracts beginning with X1 and the number 3 are featured during this poster session.
08:00—11:15
Morphogenesis and Biomechanics
*
Katherine E. Yutzey,
Cincinnati Children's Hospital Medical Center, USA
Hiroshi Hamada,
Osaka University, Japan
Role of Cilia and Fluid Flow in Left-Right Symmetry Breaking
Role of Cilia and Fluid Flow in Left-Right Symmetry Breaking
Deborah L. Yelon,
University of California, San Diego, USA
Extracellular Interactions that Sculpt Cardiac Morphology
Extracellular Interactions that Sculpt Cardiac Morphology
Robert Fischer,
NHLBI, National Institutes of Health, USA
Shaping Endothelial Cells by Curvature Regulation
Shaping Endothelial Cells by Curvature Regulation
Jay W. Schneider,
University of Texas Southwestern Medical Center, USA
Short Talk: Cardiac Regeleration: Robust, Versatile and Tunable Myocardial Responses to Implanted Biomaterial Hydrogels
Short Talk: Cardiac Regeleration: Robust, Versatile and Tunable Myocardial Responses to Implanted Biomaterial Hydrogels
Alexia Vite,
Thomas Jefferson University, USA
Short Talk: Role of Cytoskeletal Tension in the Regulation of Yap Activity in the Heart
Short Talk: Role of Cytoskeletal Tension in the Regulation of Yap Activity in the Heart
08:00—11:00
Responses to Cardiac Injury: Who Does What?
*
Nadia A. Rosenthal,
The Jackson Laboratory, USA
Richard T. Lee,
Harvard University, USA
Nerve Dependence of Cardiac Regeneration
Nerve Dependence of Cardiac Regeneration
Merry L. Lindsey,
University of Nebraska Medical Center., USA
Proteomics of Post-Infarct Extracellular Matrix Remodeling
Proteomics of Post-Infarct Extracellular Matrix Remodeling
Joshua M. Hare,
University of Miami Miller School of Medicine, USA
Therapeutic Stem Cell Interactions for Heart Disease
Therapeutic Stem Cell Interactions for Heart Disease
Jeffrey W. Holmes,
University of Virginia, USA
Scar Structure and Mechanics: Therapeutic Implications of Fibroblast Mechanosensitivity
Scar Structure and Mechanics: Therapeutic Implications of Fibroblast Mechanosensitivity
Jennifer M. Davis,
Cincinnati Children's Hospital Medical Center, USA
Short Talk: MBNL1 Globally Regulates the Maturation of mRNAs that Promote Cellular Differentiation Programs
Short Talk: MBNL1 Globally Regulates the Maturation of mRNAs that Promote Cellular Differentiation Programs
17:00—18:45
Heart Repair: Make New Muscle or Better Scars? (Joint)
*
Peter Kohl,
University of Freiburg, Germany
*
Deborah L. Yelon,
University of California, San Diego, USA
Kenneth D. Poss,
Duke University Medical Center, USA
Natural Cardiac Repair Strategies
Natural Cardiac Repair Strategies
Paul R. Riley,
University of Oxford, UK
Epigenetic Reactivation of Adult Epicardium Underpins Endogenous Heart Repair
Epigenetic Reactivation of Adult Epicardium Underpins Endogenous Heart Repair
Roger R. Markwald,
Medical University of South Carolina, USA
The Living Scar: Engineering to Benefit Patient Health
The Living Scar: Engineering to Benefit Patient Health
18:45—19:30
Keynote Address (Joint)
Stefanie Dimmeler,
University of Frankfurt, Germany
Noncoding RNAs and Cardiac Repair
Noncoding RNAs and Cardiac Repair
19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:30—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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We gratefully acknowledge additional support for this conference from:
American Heart Association's Councils on Basic CV Sciences, and CV Disease in the Young |
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