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This meeting took place in 2015



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Heart Disease and Regeneration: Insights from Development (X1)


Organizer(s) Vincent M. Christoffels, James F. Martin and Deborah L. Yelon
March 1—6, 2015
Copper Mountain Resort • Copper Mountain, Colorado USA
Discounted Abstract Deadline: Nov 4, 2014
Abstract Deadline: Dec 3, 2014
Scholarship Deadline: Nov 4, 2014
Discounted Registration Deadline: Jan 6, 2015

Sponsored by AstraZeneca and Bayer HealthCare Pharmaceuticals


Summary of Meeting:
Heart disease is the leading cause of death worldwide, affecting both children and adults. It is now clear that congenital heart defects result from disorders in developmental mechanisms of differentiation and morphogenesis and that these disorders are often the consequence of genetic variation. Moreover, there is increasing evidence that these same developmental mechanisms and genetic variations contribute to heart disease throughout life, and this understanding could be leveraged for regenerative therapies. This meeting will highlight new concepts in cardiovascular development, regeneration and repair and will emphasize common molecular mechanisms with therapeutic potential for cardiovascular regeneration. Sessions on the regulatory mechanisms of cardiac development, lineage specification, stem cell differentiation and proliferation will integrate current insights into the molecular mechanisms connecting patterning, morphogenesis, homeostasis and disease. Emerging technologies for genome editing and imaging will be discussed with the aim of facilitating new research directions and translational approaches. Overall, the goal of this meeting is to bring together researchers with expertise in cardiac development, molecular biology, stem cell biology, genetics and epigenetics to facilitate our understanding of heart development and homeostasis and to explore scientific directions and therapeutic approaches for the treatment of heart disease in children and adults.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 1

16:00—20:00
Arrival and Registration

Kokopelli's
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Kokopelli's

MONDAY, MARCH 2

07:00—08:00
Breakfast

Kokopelli's/Ptarmigan B-C
08:00—09:00
Keynote Address (Joint)

Big Horn Ballroom
* Stefanie Dimmeler, University of Frankfurt, Germany

* Vincent M. Christoffels, Academic Medical Center, Netherlands

Didier Stainier, Max Planck Institute for Heart and Lung Research, Germany
Regulation of Cardiovascular Development

09:00—11:15
Potential and Pitfalls of Cell Reprogramming (Joint)

Big Horn Ballroom
Eric N. Olson, University of Texas Southwestern Medical Center, USA
New Strategies for Heart Regeneration and Repair

Sean M. Wu, Stanford School of Medicine, USA
Molecular Basis of Cardiomyocyte Programming and Reprogramming

Deepak Srivastava, Gladstone Institutes, USA
Reprogramming Approaches for Cardiovascular Disease

09:40—10:00
Coffee Break

Kokopelli's
11:15—13:00
Poster Setup

Ptarmigan Ballroom
13:00—22:00
Poster Viewing

Ptarmigan Ballroom
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 1: Emerging Technologies: Genomics and Reprogramming

Big Horn B
* Benoit G. Bruneau, Gladstone Institutes, USA

* Laurie A. Boyer, Massachusetts Institute of Technology, USA

Joseph A. Goldman, Duke University, USA
Profiling of Dynamic Gene-Regulatory Programs during Zebrafish Heart Regeneration Using the Replacement Histone H3.3

Jonathon Hill, University of Utah, USA
Self-Organized Map Analysis of Temporal RNA-Seq Datasets Reveals Gene Regulatory Interactions during Heart Looping and Atrio-Ventricular Canal Formation

Kelvin See, University of Pennsylvania, USA
Single Cardiomyocyte Nuclear RNA-Seq Reveals a De-Differentiation Stress Response in vivo

Emily S. Noël, Hubrecht Institute, Netherlands
Identification of Novel Regulators of Embryonic Laterality Using Tomo-Seq

Nikhil V. Munshi, University of Texas Southwestern Medical Center, USA
Induction of Diverse Cardiac Cell Types by Reprogramming Fibroblasts with Cardiac Transcription Factors

Li Qian, University of North Carolina at Chapel Hill, USA
Stoichiometry of Gata4, Mef2c and Tbx5 Influences the Efficiency and Quality of iCM Reprogramming

14:30—16:30
Workshop 1: Myocyte / Non-Myocyte Interactions in Healthy and Diseased Myocardium

Big Horn C
* Milena Bastos Furtado, The Jackson Lab, USA

* Patrizia Camelliti, University of Surrey, UK

Emily L. Ongstad, MedImmune, USA
A Cx43 C-Terminal Mimetic Peptide Alters Myocyte-Fibroblast Interactions via Cx43 in the Injury Border Zone

J. Travis Hinson, The Jackson Laboratory, USA
Crosstalk between AMPK in Myocytes and Fibroblasts Regulates Cardiac Fibrosis

Margaux A. Horn, University of Manchester, UK
Remodelling of the Cardiac Extracellular Matrix following Induction and Recovery from Pacing-Induced Heart Failure in Sheep

Inês J. Marques, Centro Nacional de Investigaciones Cardiovasculres, Spain
The Lysyl Oxidase Gene Family in the Regeneration of the Cryoinjured Zebrafish Ventricle

Arjun Deb, University of California, Los Angeles, USA
Mesenchymal-Endothelial-Transition Contributes to Neovascularization after Acute Cardiac Injury

Celinda M. Kofron, Rhode Island Hospital / Brown Medical School, USA
Modulation of Cardiomyocyte Electrical Activity by Cardiac Fibroblasts in a Novel 3D Platform

Marco Tarantola, MPI for Dynamics and Self-Organization, Germany
Electromechanical Connectivity of Cardiomyocytes under Fibrotic Conditions

16:30—17:00
Coffee Available

Kokopelli's
17:00—19:00
Epigenetics of Cardiac Development

Big Horn B
* Brian L. Black, University of California, San Francisco, USA

Benoit G. Bruneau, Gladstone Institutes, USA
Transcriptional Regulation of Heart Development

Hesham A. Sadek, University of Texas Southwestern Medical Center, USA
Meis 1 in Heart Regeneration

Laurie A. Boyer, Massachusetts Institute of Technology, USA
Transcriptional Regulation of Cardiac Cell Fate

Dalit May, Hebrew University of Jerusalem, Israel
Short Talk: Chromatin Dynamics in Myocardial Hibernation - The Role of Transcriptional Enhancers in Chronic Cardiac Ischemia

17:00—19:00
Non-Myocytes in Cardiac Development

Big Horn C
* Roger R. Markwald, Medical University of South Carolina, USA

Edward E. Morrisey, University of Pennsylvania, USA
Mechanisms Promoting Cardiomyocyte Proliferation and Replenishment

Russell Norris, Medical University of South Carolina, USA
Daschous-Hippo: Novel Regulators of Myocyte – Non-Myocyte Interaction and Cardiac Growth

Rhonda Bassel-Duby, University of Texas Southwestern Medical Center, USA
A Twist of Fate in Cardiac Regeneration

Milena Bastos Furtado, The Jackson Lab, USA
Short Talk: Cardiogenic Transcriptional Network in Heart Fibroblast Biology and Disease

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ptarmigan Ballroom
19:30—22:00
Poster Session 1
Poster sessions provide exciting opportunities for engagement between all levels of investigators. Abstracts beginning with X1 or X2 and the number 1 are featured during this poster session.

Ptarmigan Ballroom

TUESDAY, MARCH 3

07:00—08:00
Breakfast

Kokopelli's/Ptarmigan B-C
08:00—11:15
Regulatory Networks for Cardiac Rhythm

Big Horn B
* Ivan P. Moskowitz, University of Chicago, USA

Patrick T. Ellinor, Massachusetts General Hospital, USA
Genetics of Atrial Fibrillation

Vincent M. Christoffels, Academic Medical Center, Netherlands
Transcriptional Regulation of the Electrical Activity Pattern of the Heart

Stacey L. Rentschler, Washington University School of Medicine, USA
Canonical Wnt Signaling Regulates Myocardial Electrical Programming

Sylvia M. Evans, University of California, San Diego, USA
Role of Islet1 in Sinus Node Development

David S. Park, New York University School of Medicine, USA
Short Talk: A Neuregulin-1/Er81/Nkx2-5 Signaling Cascade Confers Rapid Conduction in the Heart

Stephanie Iris Protze, University Health Network, Canada
Short Talk: Sinoatrial Node Pacemaker Cells Generated from Human Pluripotent Stem Cells Can Function as Biological Pacemaker

08:00—11:00
Cardiac Non-Myocytes as Signaling Hubs: Biochemical Signals

Big Horn C
* Robert G. Gourdie, Virginia Tech Carilion Research Institute, USA

Michelle D. Tallquist, University of Hawaii, USA
Fibroblast Roles in Cardiac Function and Disease

Mark L. Entman, Baylor College of Medicine, USA
Fibroblasts of Myeloid Origin and Immune-Inflammatory Dysregulation

Kenneth Walsh, University of Virginia School of Medicine, USA
Non-Myocyte Contributions to Cardiokines: Deciphering the Cardiac Secretome

Thomas Thum, Medical School Hannover, Germany
Noncoding RNAs in Cardiac Cell-Cell Communication

Katarzyna A. Cieslik, Baylor College of Medicine, USA
Short Talk: Mesenchymal Fibroblasts Promote Myeloid Fibroblast Formation in the Aging Mouse Heart

09:20—09:40
Coffee Break

Kokopelli's
11:15—13:00
Poster Setup

Ptarmigan Ballroom
13:00—22:00
Poster Viewing

Ptarmigan Ballroom
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Kokopelli's
17:00—19:00
Gene Regulatory Networks

Big Horn B
* James F. Martin, Baylor College of Medicine, USA

Ivan P. Moskowitz, University of Chicago, USA
Gene Regulatory Networks for Cardiac Form and Function

Sophia Y. Tsai, Baylor College of Medicine, USA
Role of COUP-TFII in Atrial Specification and Heart Failure

Brian L. Black, University of California, San Francisco, USA
Transcriptional Pathways Controlling OFT Development

Alexandre R. Colas, Sanford-Burnham Medical Research Institute, USA
Short Talk: Deciphering Cardiac Differentiation Using Whole Genome and "Whole Combinome" miRNA Screening: Implications for Stem Cell Differentiation, Somatic Reprogramming and Cardiac Regeneration

17:00—19:00
Cardiac Non-Myocytes as Signaling Hubs: Biophysical Signals

Big Horn C
* Natalia Trayanova, Johns Hopkins University, USA

Peter Kohl, University of Freiburg, Germany
Myocyte-Nonmyocyte Electro-Mechanical Cross-Talk

Robert G. Gourdie, Virginia Tech Carilion Research Institute, USA
Connexins as Regulators of Fibrosis and Clinical Targets for Scar Reduction Therapies

Douglas W. Losordo, Caladrius Biosciences, Inc., USA
The Microvasculature as a Therapeutic Target in Ischemic Tissue Repair

Salim Seyfried, University of Potsdam, Germany
Short Talk: Blood Flow and Bmp Signaling Control Endocardial Chamber Morphogenesis

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ptarmigan Ballroom
19:30—22:00
Poster Session 2
Poster sessions provide exciting opportunities for engagement between all levels of investigators. Abstracts beginning with X1 or X2 and the number 2 are featured during this poster session.

Ptarmigan Ballroom

WEDNESDAY, MARCH 4

07:00—08:00
Breakfast

Kokopelli's/Ptarmigan B-C
08:00—11:15
Renewal and Plasticity

Big Horn B
* Kenneth D. Poss, Duke University Medical Center, USA

Nadia Mercader, Institut of Anatomy, University of Bern, Switzerland
Cellular and Molecular Mechanisms of Transient Cardiac Fibrosis followed by Heart Regeneration upon Cryoinjury in the Zebrafish

James F. Martin, Baylor College of Medicine, USA
Hippo-Signaling in Heart Regeneration

Gordana V. Vunjak-Novakovic, Columbia University, USA
Bioengineering Human Heart Tissue: Maturation and Utility for Drug Studies

Charles E. Murry, University of Washington, USA
Chromatin Signatures Identify Regulators of Cardiac Development

Sangita Choudhury, Boston Children's Hospital, USA
Short Talk: Identification of Novel Regulators of Cardiomyocyte Proliferation as Regenerative Therapies for Heart Failure

Michaela Patterson, University of Southern California, USA
Short Talk: Genetic Determinants of Adult Mammalian Heart Regeneration

08:00—11:00
Cardiac Non-Myocytes in Tissue Structure and Function in the Adult Heart

Big Horn C
* Merry L. Lindsey, University of Mississippi Medical Center, USA

Doris A. Taylor, Texas Heart Institute, USA
ECM Clues for Cardiac Re-Popularization: Lessons from the De-Cellularized Heart

Nadia A. Rosenthal, The Jackson Laboratory, USA
Immune Cell Regulation of Cardiac Regeneration

Shahin Rafii, Weill Cornell Medical College, USA
Angiocrine Contribution of the Vascular Niche to Regeneration and Fibrosis

Mario Delmar, New York University, USA
Heterocellular Mechanical Junctions and Arrhythmogenesis: A Visual Proteomics Approach to the Study of Intercellular Communication in the Heart

Manuel Mayr, King's College, University of London, UK
Short Talk: Glycoproteomics Analysis of the Human Cardiac Extracellular Matrix

09:20—09:40
Coffee Break

Kokopelli's
11:15—13:00
Poster Setup

Ptarmigan Ballroom
13:00—22:00
Poster Viewing

Ptarmigan Ballroom
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 2: Disease Models, Regeneration and Plasticity

Big Horn B
* Jeroen Bakkers, Hubrecht Institute, Netherlands

* Charles E. Murry, University of Washington, USA

Mauro W. Costa, The Jackson Laboratory, USA
A Novel Understanding of a Complex Disease: The Interplay of Congenital Heart Disease and Obesity

Gaetano D'Amato, Centro Nacional de Investigaciones Cardiovasculares CNIC, Spain
Sequential Notch Activation Underlies Ventricular Chamber Development

Diane Fatkin, Victor Chang Cardiac Research Institute, Australia
Genetic Variants in the Left-Right Asymmetry Gene LEFTY2 May Contribute to AF Susceptibility

C. Geoffrey Burns, Harvard Medical School, Massachusetts General Hospital, USA
The AP-1 Transcription Factor Component Fosl2 Potentiates Myocardial Differentiation from the Zebrafish Second Heart Field

Ge Tao, Baylor College of Medicine, USA
Paired-Like Homeodomain Transcription Factor 2 Promotes Mouse Myocardial Regeneration

Christina V. Theodoris, University of California, San Francisco, USA
iPSC-Based Modeling of Human NOTCH1 Mutations Reveals Novel Pathways Regulating Aortic Valve Disease

Chi-Chung Wu, Ulm University, Germany
BMP Signaling Is Essential for Zebrafish Heart Regeneration

14:30—16:30
Workshop 2: Epigenetic and RNA Regulation of the Hetero-Cellular Heart

Big Horn C
* Manuel Mayr, King's College, University of London, UK

* Katarzyna A. Cieslik, Baylor College of Medicine, USA

Burcu Duygu, Maastricht University, Netherlands
Regulation of Pathological cardiac Remodeling following Myocardial Infarction: The Role of miR-199b

Jan Fiedler, Hannover Medical School, Germany
Functional Relevance of Endothelial Hypoxia-Sensitive Long Non-Coding RNAs (lncRNAs)

Jörg Heineke, Medizinische Hochschule Hannover, Germany
Impact of the Transcription Factor GATA2 in Endothelial Cells on Cardiac Failure through Regulation of Two Secreted Long Non-Coding RNAs

Peng Zhang, Rhode Island Hospital and Alpert Medical School of Brown University, USA
A Novel Regulatory Role of MicroRNA-145 in Cardiac Fibroblasts

Stephane Heymans, Maastricht University Medical Centre, Netherlands
MicroRNA-146a Rewires Cardiac Metabolism and causes Cardiac Dysfunction in Hypertensive Heart Disease

Hyun Kook, Chonnam National University, South Korea
Posttranslational Modifications of Histone Deacetylase 2 in Cardiac Hypertrophy

Jesung Moon, University of Texas Southwestern Medical Center, USA
Improving Adult Muscle Tissue Regeneration Using Small Molecule Antagonists of Wnt-Mediated Signaling

Emily K. Pugach, University of Colorado, USA
Cre Expression Driven by the alpha-Myosin Heavy Chain Promoter Induces DNA Damage and Cardiotoxicity

16:30—17:00
Coffee Available

Kokopelli's
17:00—19:00
Signaling Pathways: Integration and Crosstalk

Big Horn B
* Stacey L. Rentschler, Washington University School of Medicine, USA

Steven J. Kattman, , USA
Harnessing Cardiac Development for Cell Manufacturing

Katherine E. Yutzey, Cincinnati Children's Hospital Medical Center, USA
Regulation of Postnatal Cardiomyocyte Proliferation

Jonathan A. Epstein, University of Pennsylvania, USA
Cardiac Myocyte Lineage Commitment

Gabriele D'Uva, Weizmann Institute of Science, Israel
Short Talk: ERBB2 Triggers Mammalian Heart Regeneration by Promoting Cardiomyocyte Dedifferentiation and Proliferation

17:00—19:00
Cardiac Non-Myocytes as Targets of Interventions

Big Horn C
* Thomas Thum, Medical School Hannover, Germany

Stefan Engelhardt, Technical University of Munich, Germany
miRNAs as Modulators of Cardiac Fibrosis: Myocyte–Fibroblast Cross-Talk

John A. Baugh, University College Dublin, Ireland
Short Talk: Epigenetic Therapy for the Treatment of Cardiac Hypertrophy and Fibrosis

Natalia Trayanova, Johns Hopkins University, USA
Image-Based Computer Modeling of Cardiac Scar Effects and their Interventional Correction

Bernd K. Fleischmann, Bonn University, Germany
Modulating the Myocardial Scar and Anti-Arrhythmogenesis

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ptarmigan Ballroom
19:30—22:00
Poster Session 3
Poster sessions provide exciting opportunities for engagement between all levels of investigators. Abstracts beginning with X1 and the number 3 are featured during this poster session.

Ptarmigan Ballroom

THURSDAY, MARCH 5

07:00—08:00
Breakfast

Kokopelli's/Ptarmigan B-C
08:00—11:15
Morphogenesis and Biomechanics

Big Horn B
* Katherine E. Yutzey, Cincinnati Children's Hospital Medical Center, USA

Hiroshi Hamada, Osaka University, Japan
Role of Cilia and Fluid Flow in Left-Right Symmetry Breaking

Deborah L. Yelon, University of California, San Diego, USA
Extracellular Interactions that Sculpt Cardiac Morphology

Jeroen Bakkers, Hubrecht Institute, Netherlands
Mechanisms Driving Cardiac Left-Right Asymmetry

Robert Fischer, NHLBI, National Institutes of Health, USA
Shaping Endothelial Cells by Curvature Regulation

Jay W. Schneider, University of Texas Southwestern Medical Center, USA
Short Talk: Cardiac Regeleration: Robust, Versatile and Tunable Myocardial Responses to Implanted Biomaterial Hydrogels

Alexia Vite, Thomas Jefferson University, USA
Short Talk: Role of Cytoskeletal Tension in the Regulation of Yap Activity in the Heart

08:00—11:00
Responses to Cardiac Injury: Who Does What?

Big Horn C
* Nadia A. Rosenthal, The Jackson Laboratory, USA

Richard T. Lee, Harvard University, USA
Nerve Dependence of Cardiac Regeneration

Merry L. Lindsey, University of Mississippi Medical Center, USA
Proteomics of Post-Infarct Extracellular Matrix Remodeling

Joshua M. Hare, University of Miami Miller School of Medicine, USA
Therapeutic Stem Cell Interactions for Heart Disease

Jeffrey W. Holmes, University of Virginia, USA
Scar Structure and Mechanics: Therapeutic Implications of Fibroblast Mechanosensitivity

Jennifer M. Davis, Cincinnati Children's Hospital Medical Center, USA
Short Talk: MBNL1 Globally Regulates the Maturation of mRNAs that Promote Cellular Differentiation Programs

09:20—09:40
Coffee Break

Kokopelli's
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Kokopelli's
17:00—18:45
Heart Repair: Make New Muscle or Better Scars? (Joint)

Big Horn B
* Peter Kohl, University of Freiburg, Germany

* Deborah L. Yelon, University of California, San Diego, USA

Kenneth D. Poss, Duke University Medical Center, USA
Natural Cardiac Repair Strategies

Paul R. Riley, University of Oxford, UK
Epigenetic Reactivation of Adult Epicardium Underpins Endogenous Heart Repair

Roger R. Markwald, Medical University of South Carolina, USA
The Living Scar: Engineering to Benefit Patient Health

18:45—19:30
Keynote Address (Joint)

Big Horn B
Stefanie Dimmeler, University of Frankfurt, Germany
Noncoding RNAs and Cardiac Repair

19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Big Horn C
20:30—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Big Horn C

FRIDAY, MARCH 6

 
Departure


*Session Chair †Invited, not yet responded.


We gratefully acknowledge support for this conference from:


Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

AstraZeneca Bayer HealthCare Pharmaceuticals

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL126262-01

Funding for this conference was made possible (in part) by 1R13HL126262-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge additional support for this conference from:


American Heart Association's Councils on Basic CV Sciences, and CV Disease in the Young

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Cellular Dynamics International

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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