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This meeting took place in 2014
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Cell Death Signaling in Cancer and the Immune System (S2)
Organizer(s) Gustavo Amarante-Mendes, Douglas R. Green and Kim Newton
October 28—November 2, 2014
Casa Grande Hotel • Guarujá, São Paulo Brazil
Discounted Abstract Deadline: Jun 26, 2014
Abstract Deadline: Jul 29, 2014
Scholarship Deadline: Jun 26, 2014
Discounted Registration Deadline: Aug 28, 2014
Organized in collaboration with the São Paulo Research Foundation (FAPESP) and the National Council for Scientific and Technological Development (CNPq) - Brazil. Sponsored by AbbVie Inc., Genentech, Inc. H3 Biomedicine Inc. and TESARO, Inc.
Summary of Meeting:
Cellular decisions to live or die are fundamental to development and adult homeostasis, playing roles in a wide variety of physiological and pathological processes. These include cancer, degenerative disease, innate and adaptive immunity, ischemia-reperfusion injury and infectious disease. Over the past decades, the fundamental molecular mechanisms underlying one form of cell death, apoptosis, have been largely defined. Other forms of cell death, such as programmed necrosis or autophagic cell death, are not as well understood. In this meeting, the pathways that impact on a cell’s decision to live or die will be presented in the context of physiology and disease, and ways to influence that decision therapeutically will be explored. The consequence of cell death for the body is also of great interest, as the clearance of dying cells impacts on other physiological processes. The successful elucidation of the molecular pathways controlling and mediating apoptosis has come to fruition as agents for cancer and other therapies are entering the clinic. Similar promise exists for other forms of cell death as our knowledge of these advances. In addition, we are beginning to understand how processes relating to cell death and survival play roles in other biological processes, such as the secretion of cytokines and the response to infection. This meeting brings together researchers in the fields of cell death and survival from around the world. As the study of cell death moves beyond the central mechanisms of apoptosis to wider issues of regulation and other forms of cell death, this vibrant area of research widens its influence and importance for human health and disease.
View Scholarships/Awards
Cellular decisions to live or die are fundamental to development and adult homeostasis, playing roles in a wide variety of physiological and pathological processes. These include cancer, degenerative disease, innate and adaptive immunity, ischemia-reperfusion injury and infectious disease. Over the past decades, the fundamental molecular mechanisms underlying one form of cell death, apoptosis, have been largely defined. Other forms of cell death, such as programmed necrosis or autophagic cell death, are not as well understood. In this meeting, the pathways that impact on a cell’s decision to live or die will be presented in the context of physiology and disease, and ways to influence that decision therapeutically will be explored. The consequence of cell death for the body is also of great interest, as the clearance of dying cells impacts on other physiological processes. The successful elucidation of the molecular pathways controlling and mediating apoptosis has come to fruition as agents for cancer and other therapies are entering the clinic. Similar promise exists for other forms of cell death as our knowledge of these advances. In addition, we are beginning to understand how processes relating to cell death and survival play roles in other biological processes, such as the secretion of cytokines and the response to infection. This meeting brings together researchers in the fields of cell death and survival from around the world. As the study of cell death moves beyond the central mechanisms of apoptosis to wider issues of regulation and other forms of cell death, this vibrant area of research widens its influence and importance for human health and disease.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, OCTOBER 28
WEDNESDAY, OCTOBER 29
THURSDAY, OCTOBER 30
FRIDAY, OCTOBER 31
SATURDAY, NOVEMBER 1
SUNDAY, NOVEMBER 2
Conference Program Print | View meeting in 12 hr (am/pm) time
TUESDAY, OCTOBER 28
08:30—09:30
Keynote Address
*
Douglas R. Green,
St. Jude Children's Research Hospital, USA
09:30—12:00
Cell Death Signaling I
*
Seamus J. Martin,
Trinity College Dublin, Ireland
Guy S. Salvesen,
Sanford-Burnham Medical Research Institute, USA
A Toolbox of Highly Selective Caspase Chemical Reagents
A Toolbox of Highly Selective Caspase Chemical Reagents
Mohanish Deshmukh,
University of North Carolina at Chapel Hill, USA
How Cells Evade Apoptosis: From Neurons to Cancer
How Cells Evade Apoptosis: From Neurons to Cancer
Stefan J. Riedl,
Sanford-Burnham Medical Research Institute, USA
Short Talk: Structure and Mechanism: Death Domains in the Regulation of Immunity and Cancer
Short Talk: Structure and Mechanism: Death Domains in the Regulation of Immunity and Cancer
Douglas R. Green,
St. Jude Children's Research Hospital, USA
How Cells Survive: Single Cell Analysis Reveals Properties of Non-Genetic Apoptosis Resistance
How Cells Survive: Single Cell Analysis Reveals Properties of Non-Genetic Apoptosis Resistance
14:30—16:30
Workshop 1: Cancer
*
David W. Andrews,
Sunnybrook Research Institute, Canada
Peter Huebener,
University Hospital Hamburg-Eppendorf, Germany
HMGB1 Links Chronic Injury and Cancer in the Liver
HMGB1 Links Chronic Injury and Cancer in the Liver
Keehoon Jung,
Harvard Medical School, Massachusetts General Hospital, USA
Targeting the Immune Microenvironment to Improve Colorectal Cancer Treatment
Targeting the Immune Microenvironment to Improve Colorectal Cancer Treatment
Nga Lam,
Walter and Eliza Hall Institute, Australia
Understanding the Role of Bcl-G in Cell Death Signaling And Colorectal Cancer
Understanding the Role of Bcl-G in Cell Death Signaling And Colorectal Cancer
Yannick Böge,
University Hospital Zürich, Switzerland
An Apoptosis-Driven Pathway to Hepatocarcinogenesis
An Apoptosis-Driven Pathway to Hepatocarcinogenesis
Hetal Brahmbhatt,
McMaster University, Canada
Identification and Characterization of Small Molecules that Enhance the Pro-Apoptotic Activity of Bax
Identification and Characterization of Small Molecules that Enhance the Pro-Apoptotic Activity of Bax
Stephen E. Girardin,
University of Toronto, Canada
The Mitochondrial Protein NLRX1 Controls the Balance between Extrinsic and Intrinsic Apoptosis
The Mitochondrial Protein NLRX1 Controls the Balance between Extrinsic and Intrinsic Apoptosis
Gabriel Ichim,
, UK
Limited Mitochondrial Permeabilisation Causes DNA-Damage and Genomic Instability in the Absence of Cell Death
Limited Mitochondrial Permeabilisation Causes DNA-Damage and Genomic Instability in the Absence of Cell Death
Fabien Llambi,
St. Jude Children's Research Hospital, USA
BOK is a Pro-Apoptotic Effector Protein Regulated by the Ubiquitin-Proteasome System
BOK is a Pro-Apoptotic Effector Protein Regulated by the Ubiquitin-Proteasome System
17:00—19:00
Cell Death Signaling II
*
Shigekazu Nagata,
IFReC, Osaka University, Japan
Marion MacFarlane,
MRC Toxicology Unit, UK
c-FLIP-Mediated Regulation of Caspase-8 DED Chain Assembly Determines Cell Fate
c-FLIP-Mediated Regulation of Caspase-8 DED Chain Assembly Determines Cell Fate
Peter Vandenabeele,
VIB, Ghent University, Belgium
Necroptosis versus Apoptosis
Necroptosis versus Apoptosis
Francis Ka-Ming Chan,
Duke University, USA
Playing with Fire: Necroptosis-Dependent and Independent Roles of RIPK3 in Inflammation
Playing with Fire: Necroptosis-Dependent and Independent Roles of RIPK3 in Inflammation
Silvia Alvarez-Diaz,
Walter and Eliza Hall Institute, Australia
Short Talk: MLKL Plays a Critical Role Inducing Necroptosis within a Physiological Context
Short Talk: MLKL Plays a Critical Role Inducing Necroptosis within a Physiological Context
08:30—11:45
Cell Death and Cancer I
*
Karen H. Vousden,
Francis Crick Institute, UK
Andreas E. Strasser,
Walter and Eliza Hall Institute of Medical Research, Australia
How Does p53 Prevent Cancer?
How Does p53 Prevent Cancer?
David W. Andrews,
Sunnybrook Research Institute, Canada
Regulation of Mitochondrial Membrane Permeabilization by Bcl-2 Family Proteins
Regulation of Mitochondrial Membrane Permeabilization by Bcl-2 Family Proteins
Axel Witt,
University Hospital Cologne, Germany
Short Talk: IAP Antagonization Induces Inflammatory Destruction of Vasculature Endothelium and Inhibits Tumor Growth
Short Talk: IAP Antagonization Induces Inflammatory Destruction of Vasculature Endothelium and Inhibits Tumor Growth
Gerry Melino,
University of Rome ‘Tor Vergata’, Italy
Control of Cell Fate by miRNA
Control of Cell Fate by miRNA
Ruslan Medzhitov,
HHMI/Yale University School of Medicine, USA
Cellular Cooperation in Normal Tissues and Tumors
Cellular Cooperation in Normal Tissues and Tumors
Stephen W. Fesik,
Vanderbilt University School of Medicine, USA
Short Talk: Mcl-1 Inhibitors for the Treatment of TNBC and Other Cancers
Short Talk: Mcl-1 Inhibitors for the Treatment of TNBC and Other Cancers
14:30—16:30
Workshop 2: Host Defense
*
Petr Broz,
University of Lausanne, Switzerland
*
Thirumala-Devi Kanneganti,
St. Jude Children's Research Hospital, USA
Goutam Gupta,
Los Alamos National Laboratory, USA
Preventing Host Cell Death by Engineering of Novel Innate Immune Defense
Preventing Host Cell Death by Engineering of Novel Innate Immune Defense
Luciana Paroneto Medina,
Institute of Biomedical Sciences, University of São Paulo, Brazil
PGE2 as a Regulator of Experimental Autoimmune Encephalomyelitis (EAE)
PGE2 as a Regulator of Experimental Autoimmune Encephalomyelitis (EAE)
Maria Andree,
University of Cologne, Germany
BID-Dependent Release of Mitochondrial SMAC Dampens XIAP-Mediated Immunity Against Shigella
BID-Dependent Release of Mitochondrial SMAC Dampens XIAP-Mediated Immunity Against Shigella
Dmitry M. Shayakhmetov,
Emory University, USA
The Identification of the Novel Physiologically-Regulated Necrotic Cell Death Pathway Mediated by the Interferon-Regulatory Factor 3 (IRF3)
The Identification of the Novel Physiologically-Regulated Necrotic Cell Death Pathway Mediated by the Interferon-Regulatory Factor 3 (IRF3)
Eugenio D. Hottz,
Oswaldo Cruz Foundation, Brazil
Activation of Inflammasome and Cell Death Pathways in Platelets Modulate Inflammatory Responses in Dengue
Activation of Inflammasome and Cell Death Pathways in Platelets Modulate Inflammatory Responses in Dengue
Jennifer Martinez,
NIEHS, National Institutes of Health, USA
LC3-Associated Phagocytosis as a Critical Regulator of Inflammation
LC3-Associated Phagocytosis as a Critical Regulator of Inflammation
17:00—19:00
Cell Death and Cancer II
*
Simone Fulda,
University Hospital Frankfurt, Germany
Gerard I. Evan,
University of Cambridge, UK
Killing Cancers without Killing Normal Tissues
Killing Cancers without Killing Normal Tissues
Andreas Bergmann,
University of Massachusetts Medical School, USA
Short Talk: Autophagy Regulates Tissue Overgrowth in a Context-Dependent Manner
Short Talk: Autophagy Regulates Tissue Overgrowth in a Context-Dependent Manner
08:30—11:30
Cell Death and Host Defense I
*
Ruslan Medzhitov,
HHMI/Yale University School of Medicine, USA
Petr Broz,
University of Lausanne, Switzerland
Caspase-11 Activation Requires Lysis of Pathogen-Containing Vacuoles by IFN-Induced GTPases
Caspase-11 Activation Requires Lysis of Pathogen-Containing Vacuoles by IFN-Induced GTPases
Domagoj Vucic,
Genentech, Inc., USA
IAP Proteins Regulate the Formation of Necrosome and Inflammasome Complexes
IAP Proteins Regulate the Formation of Necrosome and Inflammasome Complexes
Thirumala-Devi Kanneganti,
St. Jude Children's Research Hospital, USA
Inflammasome Control of Disease
Inflammasome Control of Disease
Karina R. Bortoluci,
Federal University of São Paulo, Brazil
Lysosomal Pathway Induced by Cytosolic Flagellin in Cell Death and Immunity
Lysosomal Pathway Induced by Cytosolic Flagellin in Cell Death and Immunity
Igor E. Brodsky,
University of Pennsylvania, USA
Short Talk: RIPK1 and Caspase-8 Catalytic Activity Mediate Caspase-1 Activation in Response to Pathogen Blockade of Innate Immune Signaling
Short Talk: RIPK1 and Caspase-8 Catalytic Activity Mediate Caspase-1 Activation in Response to Pathogen Blockade of Innate Immune Signaling
17:00—19:00
Cell Death and Host Defense II
*
Eric H. Baehrecke,
University of Massachusetts Medical School, USA
Janelle S. Ayres,
The Salk Institute for Biological Studies, USA
Microbiota Control of Infection and Inflammation Induced Pathology
Microbiota Control of Infection and Inflammation Induced Pathology
Gustavo P. Amarante-Mendes,
Universidade de São Paulo, Brazil
Short Talk: Novel Role for Galectin-1 in CTL Killing
Short Talk: Novel Role for Galectin-1 in CTL Killing
Seamus J. Martin,
Trinity College Dublin, Ireland
Cell Death and Inflammation: Revisiting the Danger Model
Cell Death and Inflammation: Revisiting the Danger Model
08:30—11:45
Consequences of Cell Death
*
Peter Vandenabeele,
VIB, Ghent University, Belgium
Kim Newton,
Genentech, Inc., USA
Necroptosis Signaling and Inflammation
Necroptosis Signaling and Inflammation
Andrew Oberst,
University of Washington, USA
Short Talk: Inflammatory and Immune Responses to Apoptosis and Necroptosis
Short Talk: Inflammatory and Immune Responses to Apoptosis and Necroptosis
Will Wood,
University of Edinburgh, UK
Signal Prioritization: Recognizing Death and Damage in vivo
Signal Prioritization: Recognizing Death and Damage in vivo
Eric H. Baehrecke,
University of Massachusetts Medical School, USA
Inflammatory Signaling, Autophagy and Dying Cell Clearance
Inflammatory Signaling, Autophagy and Dying Cell Clearance
Linda Julian,
Beatson Institute for Cancer Research, UK
Short Talk: Apoptotic Blebbing in Tissue Homeostasis and Cancer
Short Talk: Apoptotic Blebbing in Tissue Homeostasis and Cancer
17:00—18:15
Cell Death Therapies
*
Kim Newton,
Genentech, Inc., USA
Simone Fulda,
University Hospital Frankfurt, Germany
Novel Opportunities to Target IAP Proteins for Cancer Therapy
Novel Opportunities to Target IAP Proteins for Cancer Therapy
David Ching Huang,
Walter and Eliza Hall Institute of Medical Research, Australia
Therapeutically Targeting the Bcl-2-Regulated Cell Survival Pathway
Therapeutically Targeting the Bcl-2-Regulated Cell Survival Pathway
18:15—19:15
Closing Keynote Address
*
Gustavo P. Amarante-Mendes,
Universidade de São Paulo, Brazil
Scott W. Lowe,
Memorial Sloan Kettering Cancer Center, USA
Tumor Suppressor and Tumor Maintenance Genes
Tumor Suppressor and Tumor Maintenance Genes
*Session Chair †Invited, not yet responded.
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