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This meeting took place in 2015
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Autophagy (E6)
Organizer(s) Eric H. Baehrecke and Jayanta Debnath
June 19—24, 2015
Beaver Run Resort • Breckenridge, CO USA
Discounted Abstract Deadline: Feb 17, 2015
Abstract Deadline: Mar 17, 2015
Scholarship Deadline: Feb 17, 2015
Discounted Registration Deadline: Apr 21, 2015
Sponsored by Cell Research, Merck & Co., Inc. and Novartis Institutes for BioMedical Research
Summary of Meeting:
Autophagy is an essential catabolic process that plays important roles in cell stress management and nutrient homeostasis. Following the landmark discoveries of the molecules controlling autophagy in yeast, genetic studies in multicellular organisms have revealed diverse roles for autophagy in development, physiology and in the etiology and pathogenesis of multiple age-associated disorders. Hence, interest in manipulating autophagy to treat human disease has rapidly intensified. The aims of this conference are to: 1) Gather experts together with junior scientists and researchers new to this field in a setting that supports structured and casual interactions; 2) Promote exchange of cutting edge, innovative and unpublished science relevant to the roles of autophagy in healthy, aging and pathologic cell contexts; and 3) Expedite discoveries that advance mechanistic knowledge of autophagy and facilitate clinical opportunities for the treatment and diagnosis of diseases caused by the mis-regulation of this process. This symposium explores the frontiers of autophagy research, with themes that focus on newly discovered molecules, pathways and mechanisms that specify forms of autophagy in development and disease. We propose multiple novel session topics based on recent discoveries in this field. Emphasis will be placed on how our emerging understanding of autophagy may influence disease. Interdisciplinary leaders of the autophagy field will gather together with junior scientists to share discoveries and exchange ideas. The collegial atmosphere of this conference is designed to enable brainstorming and promote collaborations to advance our understanding of the basic mechanisms controlling autophagy, and how altered autophagy may influence disease course and treatment.
View Scholarships/Awards
Autophagy is an essential catabolic process that plays important roles in cell stress management and nutrient homeostasis. Following the landmark discoveries of the molecules controlling autophagy in yeast, genetic studies in multicellular organisms have revealed diverse roles for autophagy in development, physiology and in the etiology and pathogenesis of multiple age-associated disorders. Hence, interest in manipulating autophagy to treat human disease has rapidly intensified. The aims of this conference are to: 1) Gather experts together with junior scientists and researchers new to this field in a setting that supports structured and casual interactions; 2) Promote exchange of cutting edge, innovative and unpublished science relevant to the roles of autophagy in healthy, aging and pathologic cell contexts; and 3) Expedite discoveries that advance mechanistic knowledge of autophagy and facilitate clinical opportunities for the treatment and diagnosis of diseases caused by the mis-regulation of this process. This symposium explores the frontiers of autophagy research, with themes that focus on newly discovered molecules, pathways and mechanisms that specify forms of autophagy in development and disease. We propose multiple novel session topics based on recent discoveries in this field. Emphasis will be placed on how our emerging understanding of autophagy may influence disease. Interdisciplinary leaders of the autophagy field will gather together with junior scientists to share discoveries and exchange ideas. The collegial atmosphere of this conference is designed to enable brainstorming and promote collaborations to advance our understanding of the basic mechanisms controlling autophagy, and how altered autophagy may influence disease course and treatment.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
FRIDAY, JUNE 19
SATURDAY, JUNE 20
SUNDAY, JUNE 21
MONDAY, JUNE 22
TUESDAY, JUNE 23
WEDNESDAY, JUNE 24
Conference Program Print | View meeting in 12 hr (am/pm) time
FRIDAY, JUNE 19
08:30—09:30
Keynote Address
*
Eric H. Baehrecke,
University of Massachusetts Medical School, USA
Ana Maria Cuervo,
Albert Einstein College of Medicine, USA
Chaperone-Mediated Autophagy: Who Would Have Thought!
Chaperone-Mediated Autophagy: Who Would Have Thought!
09:30—11:45
Regulators of Autophagy
*
Vojo Deretic,
University of New Mexico Health Sciences Center, USA
Sharon A. Tooze,
Francis Crick Institute, UK
Mechanisms Controlling Autophagosome Formation in Mammals
Mechanisms Controlling Autophagosome Formation in Mammals
Hong Zhang,
Chinese Academy of Sciences, China
O-GlcNAc-Modification of SNAP-29 Regulates Autophagosome Maturation
O-GlcNAc-Modification of SNAP-29 Regulates Autophagosome Maturation
Xuejun Jiang,
Memorial Sloan Kettering Cancer Center, USA
Short Talk: Regulation of Autophagy by Coordinated Action of mTORC1 and Protein Phosphatase 2A
Short Talk: Regulation of Autophagy by Coordinated Action of mTORC1 and Protein Phosphatase 2A
Noboru Mizushima,
University of Tokyo, Japan
Novel Insights into Physiological Roles of Autophagy in Mice
Novel Insights into Physiological Roles of Autophagy in Mice
14:30—16:30
Workshop 1: Late-Breaking Topics in Molecular Regulation and Cellular Functions of Autophagy
*
Sharon A. Tooze,
Francis Crick Institute, UK
Michael J. Ragusa,
Dartmouth College, USA
Organizing the Autophagy-Specific Phagophore Assembly Site
Organizing the Autophagy-Specific Phagophore Assembly Site
Megan L. Goodall,
University of Colorado Denver, USA
Autophagy Regulation of Necroptosis
Autophagy Regulation of Necroptosis
Emily S. Bell,
McGill University, Canada
An Autophagy-Mediated Switch in HGF-Induced Cell Migration
An Autophagy-Mediated Switch in HGF-Induced Cell Migration
Weili Cai,
NICHD, National Institutes of Health, USA
Context-Specific Requirements for Individual GATOR2 Subunits in Drosophila
Context-Specific Requirements for Individual GATOR2 Subunits in Drosophila
Josh Lyon Andersen,
Brigham Young University, USA
14-3-3zeta Interactomics Reveals an AMPK- and ULK1-Mediated Phosphorylation on mAtg9A that Governs Induction of Autophagy
14-3-3zeta Interactomics Reveals an AMPK- and ULK1-Mediated Phosphorylation on mAtg9A that Governs Induction of Autophagy
Ian G. Ganley,
University of Dundee, UK
mTOR Activates the VPS34-UVRAG Complex to Regulate Lysosomal Tubulation and Cell Survival during Autophagosome-Lysosome-Reformation
mTOR Activates the VPS34-UVRAG Complex to Regulate Lysosomal Tubulation and Cell Survival during Autophagosome-Lysosome-Reformation
17:00—19:00
New Roles for Lysosomes in Autophagy Regulation
*
Mondira Kundu,
St. Jude Children's Hospital, USA
Li Yu,
Tsinghua University, China
Autophagic Lysosome Reformation: Insight from in vitro Reconstitution
Autophagic Lysosome Reformation: Insight from in vitro Reconstitution
Roberto Zoncu,
University of California, Berkeley, USA
The Lysosome in Nutrient Sensing and Growth Control
The Lysosome in Nutrient Sensing and Growth Control
Alyssa Johnson,
University of California, San Francisco, USA
Short Talk: VCP-Dependent Muscle Degeneration Is Linked to Defects in a Dynamic Tubular Lysosomal Network in vivo
Short Talk: VCP-Dependent Muscle Degeneration Is Linked to Defects in a Dynamic Tubular Lysosomal Network in vivo
Rushika M. Perera,
University of California, San Francisco, USA
Lysosomes and Nutrient Scavenging in Pancreatic Cancer
Lysosomes and Nutrient Scavenging in Pancreatic Cancer
08:30—11:45
Selective Autophagy
*
Ivan Dikic,
Goethe University Medical School, Germany
Suresh Subramani,
University of California, San Diego, USA
Activation of the Pexophagy Receptor via Phosphorylation through Interactions with Peroxisomal Biogenesis and Pexophagy Proteins
Activation of the Pexophagy Receptor via Phosphorylation through Interactions with Peroxisomal Biogenesis and Pexophagy Proteins
Anne Simonsen,
University of Oslo, Norway
Regulation of Selective Autophagy by Nuclear Shuttling of ALFY
Regulation of Selective Autophagy by Nuclear Shuttling of ALFY
Jessica Huber,
Deutsches Krebsforschungszentrum DKFZ, Germany
Short Talk: Specific Interaction of the Human ATG8 Proteins with the KBTBD6 and KBTBD7 LIR Provides a Platform for the Regulation of TIAM1 RAC1 Signaling
Short Talk: Specific Interaction of the Human ATG8 Proteins with the KBTBD6 and KBTBD7 LIR Provides a Platform for the Regulation of TIAM1 RAC1 Signaling
Qing Zhong,
Shanghai Jiao Tong University School of Medicine, China
Mechanism of Autophagy-Regulated Ciliogenesis
Mechanism of Autophagy-Regulated Ciliogenesis
Werner J. Kovacs,
ETH Zurich, Switzerland
Short Talk: Hif-2alpha Promotes Degradation of Mammalian Peroxisomes by Pexophagy
Short Talk: Hif-2alpha Promotes Degradation of Mammalian Peroxisomes by Pexophagy
Tamotsu Yoshimori,
Osaka University, Japan
New Insights into Membrane Dynamics and Role of Autophagy
New Insights into Membrane Dynamics and Role of Autophagy
17:00—19:00
Autophagy, Neuronal Health and Neurodegenerative Disorders
*
Ana Maria Cuervo,
Albert Einstein College of Medicine, USA
Ai Yamamoto,
Columbia University, USA
Exploring the Role of Selective Macroautophagy in the Brain
Exploring the Role of Selective Macroautophagy in the Brain
Zhenyu Yue,
Mount Sinai Medical Center, USA
Regulation of Selective Autophagy through Autophagy Receptors in Neurodegenerative Disease
Regulation of Selective Autophagy through Autophagy Receptors in Neurodegenerative Disease
Constanza J. Cortes,
University of Alabama at Birmingham, USA
Short Talk: TFEB Expression in Skeletal Muscle Enhances Autophagy and Induces Insulin Signaling
Short Talk: TFEB Expression in Skeletal Muscle Enhances Autophagy and Induces Insulin Signaling
Ralph A. Nixon,
New York University, Langone Medical Center, USA
Genetic Pathways to Autophagy Dysfunction in Alzheimer's Disease
Genetic Pathways to Autophagy Dysfunction in Alzheimer's Disease
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:45
Non-Traditional Functions for Autophagy-Related Proteins
*
Herbert (Skip) W. Virgin,
Vir Biotechnology, USA
Douglas R. Green,
St. Jude Children's Research Hospital, USA
Noncanonical Autophagy and Phagocytosis: Two Ancient Pathways Converge on Inflammation, Innate Immunity and Aging
Noncanonical Autophagy and Phagocytosis: Two Ancient Pathways Converge on Inflammation, Innate Immunity and Aging
Monica Kim,
University of California, San Francisco, USA
Autophagy Proteins Regulate Engulfment Mechanisms that Promote Nutrient Scavenging
Autophagy Proteins Regulate Engulfment Mechanisms that Promote Nutrient Scavenging
Min Zhang,
University of California, Berkeley, USA
Short Talk: Molecular Mechanism for Autophagy-Mediated Secretion of Interleukin-1beta
Short Talk: Molecular Mechanism for Autophagy-Mediated Secretion of Interleukin-1beta
Vojo Deretic,
University of New Mexico Health Sciences Center, USA
Role of TRIM Proteins in Autophagy
Role of TRIM Proteins in Autophagy
Akhila Rajan,
Harvard Medical School, USA
Short Talk: Unconventional Autosecretion in Response to Alterations in Lipid Stores Regulates Adipokine Secretion
Short Talk: Unconventional Autosecretion in Response to Alterations in Lipid Stores Regulates Adipokine Secretion
Jayanta Debnath,
University of California, San Francisco, USA
How Autophagy in Stromal Fibroblasts Impacts the Tumor Microenvironment—A Role for Secretion?
How Autophagy in Stromal Fibroblasts Impacts the Tumor Microenvironment—A Role for Secretion?
17:00—19:00
Autophagy and Cancer
*
Andrew M. Thorburn,
University of Colorado AMC, USA
Alec Kimmelman,
New York University Langone Medical Center, USA
Autophagy, Metabolism and Pancreatic Cancer
Autophagy, Metabolism and Pancreatic Cancer
Kevin M. Ryan,
Beatson Institute for Cancer Research, UK
Mechanisms of Autophagy in Cell Death and Cancer
Mechanisms of Autophagy in Cell Death and Cancer
Vinay Verghese Eapen,
Harvard Medical School, USA
Short Talk: Dissection of the DNA Damage-Induced Autophagy Pathway in Budding Yeast
Short Talk: Dissection of the DNA Damage-Induced Autophagy Pathway in Budding Yeast
Eileen P. White,
Rutgers University, USA
Autophagy, Metabolism and Cancer
Autophagy, Metabolism and Cancer
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:45
Ubiquitin and Ubiquitin-Like Molecules in Autophagy
*
Jayanta Debnath,
University of California, San Francisco, USA
Leon O. Murphy,
Casma Therapeutics, USA
NCOA4 and Ferritin Regulation
NCOA4 and Ferritin Regulation
Joseph D. Mancias,
Beth Israel Deaconess Medical Center, USA
Short Talk: Role of NCOA4-Mediated Ferritinophagy in Iron Metabolism
Short Talk: Role of NCOA4-Mediated Ferritinophagy in Iron Metabolism
Ivan Dikic,
Goethe University Medical School, Germany
Regulation of Endoplasmic Reticulum Turnover by Selective Autophagy
Regulation of Endoplasmic Reticulum Turnover by Selective Autophagy
Danielle Sliter,
NINDS, National Institutes of Health, USA
Short Talk: Optineurin and NDP52 Function Upstream of LC3 in PINK1/Parkin-Mediated Mitophagy
Short Talk: Optineurin and NDP52 Function Upstream of LC3 in PINK1/Parkin-Mediated Mitophagy
Eric H. Baehrecke,
University of Massachusetts Medical School, USA
Ubiquitination and Control of Atg7-Independent Autophagy
Ubiquitination and Control of Atg7-Independent Autophagy
14:30—16:30
Workshop 2: Late-Breaking Topics in Autophagy and Disease
*
Kevin M. Ryan,
Beatson Institute for Cancer Research, UK
Christina L. Stallings,
Washington University School of Medicine, USA
Unique Role for ATG5 in Neutrophil-Mediated Immunopathology during Mycobacterium tuberculosis Infection
Unique Role for ATG5 in Neutrophil-Mediated Immunopathology during Mycobacterium tuberculosis Infection
Petra Paul,
University of Zürich, Switzerland
The Role of Macroautophagy in the Immune Response against Influenza A Infection
The Role of Macroautophagy in the Immune Response against Influenza A Infection
Catarina Veltrini Horta,
University of São Paulo - Ribeirão Preto Medical School, Brazil
Pattern Recognition Receptors Favor Autophagy Induction for Restriction of Trypanosoma cruzi Infection
Pattern Recognition Receptors Favor Autophagy Induction for Restriction of Trypanosoma cruzi Infection
Alexandra Boeske,
Forschungszentrum Jülich, Germany
GABARAPs Mediate Anterograde Transport and Secretion of HIV-1 Nef via Mechanisms Related to Unconventional Protein Secretion
GABARAPs Mediate Anterograde Transport and Secretion of HIV-1 Nef via Mechanisms Related to Unconventional Protein Secretion
Sandhya Sanduja,
Whitehead Institute, USA
AMPK-Mediated Autophagy Promotes Drug Tolerance in BRAF Mutant Melanoma
AMPK-Mediated Autophagy Promotes Drug Tolerance in BRAF Mutant Melanoma
Alice C. Newman,
IGMM, University of Edinburgh, UK
Autophagy of TRAF3 Inhibits TGFbeta-Driven Cytokine Expression in Cancer Cells
Autophagy of TRAF3 Inhibits TGFbeta-Driven Cytokine Expression in Cancer Cells
Julian J. Lum,
British Columbia Cancer Agency, Canada
Autophagy-Dependent Reprogramming of Metabolism in CD8+ Effector T Cell Survival and Development of Memory
Autophagy-Dependent Reprogramming of Metabolism in CD8+ Effector T Cell Survival and Development of Memory
17:00—18:45
Autophagy in Infection and Immunity
*
Douglas R. Green,
St. Jude Children's Research Hospital, USA
Jeffery S. Cox,
University of California, Berkeley, USA
cGAS Detects Mycobacterium tuberculosis DNA to Activate both Type I Interferon and Autophagy
cGAS Detects Mycobacterium tuberculosis DNA to Activate both Type I Interferon and Autophagy
Sara R. Cherry,
University of Pennsylvania, USA
Viruses and Autophagy
Viruses and Autophagy
Herbert (Skip) W. Virgin,
Vir Biotechnology, USA
Gene-, Cell-Type-, and Pathogen-Specific Roles of Autophagy Genes in Inflammation and Immunity
Gene-, Cell-Type-, and Pathogen-Specific Roles of Autophagy Genes in Inflammation and Immunity
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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