Keystone Symposia

Royal Dublin Society Floorplan

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This meeting took place in 2015

Here are the related meetings in 2020:
Hypoxia: Molecules, Mechanisms and Disease (A3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Hypoxia: From Basic Mechanisms to Therapeutics (E3)

Organizer(s) Cormac T. Taylor, M. Celeste Simon, Sean P. Colgan and Roland H. Wenger
May 12—17, 2015
Royal Dublin Society • Dublin 4, Ireland
Discounted Abstract Deadline: Jan 13, 2015
Abstract Deadline: Feb 12, 2015
Scholarship Deadline: Jan 13, 2015
Discounted Registration Deadline: Mar 12, 2015

Organized in Collaboration with Science Foundation Ireland. Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc.

Summary of Meeting:
Tissue hypoxia occurs in a range of physiologic and pathophysiologic states. Consequently, the cellular response to hypoxia has important implications for both health and for diseases including (but not limited to) cancer, ischemia and chronic inflammation. Recently, the discovery and elucidation of specific hypoxia-inducible pathways has raised the possibility of developing new strategies for therapeutic benefit based on targeting hypoxia-sensitive pathways. The aim of this meeting is to disseminate up to date information on basic mechanisms of the cellular hypoxic response, discuss the impact of this response for health and disease and highlight the potential for developing new therapeutics based on our understanding of the pathways involved. It is anticipated that outcomes of this meeting will include the dissemination of new scientific knowledge, the discussion of new methodologies, the education of graduate students and fellows in the state-of-the-art and promoting new collaborations between clinicians, basic researchers and industrial partners. The Keystone Symposia Hypoxia meeting is widely accepted as the world’s leading conference addressing the topic and is a key date on the calendar for all researchers interested in this topic. We will bring together academic, clinical and industrial researchers to drive synergy through collaboration in developing the translational potential of targeting the HIF pathway for therapeutic benefit. This meeting will be held in conjunction with the European HypoxiaNET consortium.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


Arrival and Registration

Hall 4 (Industries Hall)
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Hall 4 (Industries Hall)



Individual Hotel
Poster Setup

Hall 4 (Industries Hall)
Poster Viewing

Hall 4 (Industries Hall)
Keynote Address

Hall 1 (Main Hall)
* Cormac Taylor, University College Dublin, Ireland

Peter F. Carmeliet, University of Leuven, VIB, Belgium
Oxygen and Nutrient Metabolism in Neurovascular Processes in Health and Disease

Hypoxia and Disease-Specific Targets

Hall 1 (Main Hall)
* Roland H. Wenger, University of Zürich, Switzerland

Cormac Taylor, University College Dublin, Ireland
Regulation of Inflammatory Pathways by Hypoxia

Sean P. Colgan, University of Colorado Denver, USA
HIF as a Target in Mucosal Inflammation

Randall S. Johnson, University of Cambridge, UK
HIF and Vascular Disease

Judith Sluimer, Maastricht University, Netherlands
Short Talk: Myeloid PHD2 Deficiency Impairs Collagen Degradation Enhancing Murine Atherosclerotic Plaque Stability

Claudia Gerri, Max Planck Institute for Heart and Lung Research, Germany
Short Talk: Role of the HIF Pathway in Cardiovascular System Development in Zebrafish

M. Celeste Simon, University of Pennsylvania, USA
Hypoxia, Lipids and Cancer: Surviving the Harsh Tumor Microenvironment

Coffee Break

Hall 4 (Industries Hall)

Hall 4 (Industries Hall)
Poster Session 1

Hall 4 (Industries Hall)
HypoxiaNET Workshop 1: Targeting Hypoxia-Sensitive Pathways

Hall 1 (Main Hall)
* Christopher J. Schofield, University of Oxford, UK
Perspectives on Iron Oxygenases as Therapeutic Targets

Gail Walkinshaw, FibroGen, USA
Therapeutic Applications for HIF Prolyl Hydroxylase Inhibitors

Laura Demopoulos, GlaxoSmithKline, USA
The Promise of HIF Prolyl Hydroxylase Inhibitors: Clinical Applications

Ingo Flamme, Bayer Pharma AG, Germany
Mimicking Hypoxia to Treat Anemia: HIF-Stabilizer BAY 85-3934 (Molidustat)

Ivan Coulter, Sigmoid Pharma, Ireland
SmPill® Gastrointestinal Targeted Hydroxylase Inhibitors: HIF Where it Hurts

Coffee Available

Hall 4 (Industries Hall)
Hypoxia and Cancer

Hall 1 (Main Hall)
* Margaret Ashcroft, University of Cambridge, UK

Julie-Aurore Losman, Dana-Farber Cancer Institute, USA
Targeting Leukemia Cell Metabolism: Insights Gained from Studies of Mutant IDH

Till Acker, University of Giessen, Germany
PHDs and Hallmarks of Cancer

Amato J. Giaccia, Stanford University, USA
Suppression of PGC-1alpha Links the Clear Cell Phenotype with Tumor Growth in Renal Cell Carcinoma

Emin Maltepe, University of California, San Francisco, USA
Short Talk: HIGD1A Regulation of Tumor Metabolism and Growth

Cormac Taylor, University College Dublin, Ireland
Introduction to Salvador Moncada

Salvador Moncada, University of Manchester, UK
Pursuing the Biology of O2/NO2 Interactions: Where Are We Now?

On Own for Dinner



Individual Hotel
Poster Setup

Hall 4 (Industries Hall)
Poster Viewing

Hall 4 (Industries Hall)
HIF-Dependent Pathways

Hall 1 (Main Hall)
* Drorit Neumann, Tel-Aviv University, Israel

Richard K. Bruick, University of Texas Southwestern Medical Center, USA
Administration of a Small Molecule HIF-2 Inhibitor Reduces Iron Overload in a Mouse Model of Hemochromatosis

Jacques Pouysségur, University of Nice, France
Hypoxic Microenvironment and Control of Tumor Metabolism

Gregg L. Semenza, Johns Hopkins University School of Medicine, USA
Hypoxia-Inducible Factors Support the Breast Cancer Stem Cell Phenotype

Frank S. Lee, University of Pennsylvania School of Medicine, USA
Oxygen Sensing by PHD2

Werner J. Kovacs, ETH Zurich, Switzerland
Short Talk: Hif-2alpha Promotes Degradation of Mammalian Peroxisomes by Selective Autophagy

Cunming Duan, University of Michigan, USA
Short Talk: Dissecting Oxygen-Dependent and -Independent Actions of Hypoxia-Inducible Factor 3 Using CRISPR/Cas9-Based Gene Editing

Coffee Break

Hall 4 (Industries Hall)

Hall 4 (Industries Hall)
Poster Session 2

Hall 4 (Industries Hall)
HypoxiaNET Workshop 2

Hall 1 (Main Hall)
* Chris W. Pugh, University of Oxford, UK

Eoin Cummins, University College Dublin, Ireland
Oxygen and Carbon Dioxide Cross-Talk in the HIF Pathway

Louise E. Glover, University of Colorado, USA
Metabolic Regulation of Epithelial Autophagy in Mucosal Inflammation

David R. Mole, University of Oxford, UK
Pangenomic Studies of the HIF Transcriptional Response

Julián Aragonés Lopez, Research Institute Princesa, Spain
Role of HIF2alpha in Airway Response to Oxygen Fluctuations

Martin Schneider, University of Heidelberg, Germany
PHD-Inhibition in Surgery for Metastatic Colorectal Cancer

Edurne Berra, CIC bioGUNE, Spain
New Insights into HIF Homeostasis

Norbert Weissmann, Justus-Liebig-University Giessen, Germany
Identification of Mechanisms Driving Hypoxia-Induced Pulmonary Hypertension and its Reversal

Coffee Available

Hall 4 (Industries Hall)
HIF-Independent Pathways

Hall 1 (Main Hall)
* Edwin R. Chilvers, Cambridge University, UK

Navdeep S. Chandel, Northwestern University, USA
Mitochondria Regulate Hypoxic Signal Transduction

Joachim Fandrey, University Duisburg-Essen, Germany

Moira K. Whyte, University of Edinburgh, Queen's Medical Research Institute, UK
Regulation of Neutrophil Energetics by Hypoxia and the HIF/Hydroxylase Pathway: Consequences for Innate Immune Responses

Safia Thaminy, ETH Zürich, Switzerland
Short Talk: A Systems-Based Approach to Understand the Mechanisms of Cancer Progression Under Hypoxia

On Own for Dinner



Individual Hotel
Poster Setup

Hall 4 (Industries Hall)
Poster Viewing

Hall 4 (Industries Hall)
Hydroxylases and the Hypoxia Response

Hall 1 (Main Hall)
* L. Eric Huang, University of Utah, USA

Peter J. Ratcliffe, University of Oxford, UK
Genomic Analysis of the Response to Hypoxia

Sonia Rocha, University of Liverpool, UK
Role of Prolyl-Hydroxylases in the Control of the Cell Cycle and Related Processes

Johanna Myllyharju, University of Oulu, Finland
Prolyl 4-Hydroxylases and the Hypoxic Response

Daniel J. Peet, University of Adelaide, Australia
Hypoxic Signaling by FIH-Mediated Asparaginyl Hydroxylation

Mathew Coleman, University of Birmingham, UK
Short Talk: Characterization of FIH-Related Protein Hydroxylases

Qing Zhang, UT Southwestern Medical Center, USA
Short Talk: Control of NRF-PGC1alpha Complex and Mitochondrial Function by EglN2 in Breast Cancer

Coffee Break

Hall 4 (Industries Hall)

Hall 4 (Industries Hall)
Poster Session 3

Hall 4 (Industries Hall)
HypoxiaNET Workshop 3

Hall 1 (Main Hall)
* Patrick Henry Maxwell, University of Cambridge, UK
Will HIF Hydroxylase Inhibitors Be Useful Medicines?

Agnes Görlach, German Heart Center Munich, TU Munich, Germany
MAP Kinase Signaling and the Response to Hypoxia

Ben Wielockx, Technical University of Dresden, Germany
The PHD2-HIF2alpha-EPO Axis: A Central Regulator of Erythropoiesis and Beyond

Peppi Koivunen, University of Oulu, Finland
HIF Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis

Eric L. Campbell, , UK
Epithelial-Derived HIF-Dependent Factors Coordinate Resolution of Colitis

Thomas Kietzmann, University of Oulu, Finland
Fbw7 and USP28-Dependent Degradation of HIFs: Old Features and Novel Aspects

Sarah R. Walmsley, University of Edinburgh, Queen's Medical Research Institute, UK
How Hypoxia and Hypoxic Pre-Conditioning Modify Outcomes of Bacterial Infection

Silvia Pastorekova, Biomedical Research Center, Slovak Academy of Sciences, Slovakia
Soluble Ectodomain of the Hypoxia-Induced Carbonic Anhydrase IX: More than a Circulating Cancer Biomarker

Coffee Available

Hall 4 (Industries Hall)
Hypoxia and Genetics

Hall 1 (Main Hall)
* Peter A. Robbins, University of Oxford, UK

Roland H. Wenger, University of Zürich, Switzerland
Regulation of the EPO Gene

Lorenz Poellinger, Karolinska Institutet, Sweden
Epigenetic Mechanisms Regulating the Hypoxic Response

Josef Prchal, University of Utah, USA
HIF as a Target in Erythropoiesis

Ian Frew, University of Zürich, Switzerland
Short Talk: Hif1a and Hif2a Are Both Required for the Formation of Vhl-Deficient Renal Cysts and Tumours

Michail Sitkovsky, Northeastern University, USA
Short Talk: Conceptually Novel “Anti-A2A-Adenosinergic” Molecular Motivation to Oxygenate Hypoxic Tumors in Combination with Immunotherapies of Cancer

On Own for Dinner



Individual Hotel
Physiology of Hypoxic Pathways

Hall 1 (Main Hall)
* Paul McLoughlin, University College Dublin, Ireland

Max Gassmann, University of Zürich, Switzerland
Erythropoietin through Evolution, a Speculative View

Dörthe M. Katschinski, Georg August University, Germany
Impact of Hypoxia and the Prolyl-4-Hydroxylase Domain Enzymes on Endocytosis and Cell Migration

José López-Barneó, University of Seville, Spain
Carotid Body Oxygen Sensing

Volker H. Haase, Vanderbilt University, USA
Mouse Models of Disrupted Oxygen Sensing

Nanduri R. Prabhakar, University of Chicago, USA
Interplay between Gas Messengers: A Key Step in Carotid Body O2 Sensing

Paul Moynagh, National University of Ireland, Maynooth, Ireland
Short Talk: The E3 Ubiquitin Ligase Pellino3 Acts as a Regulator of HIF-1alpha and IL-1beta Expression in Insulin Resistance

Elizabeth J. Campbell, University of Otago, Christchurch, New Zealand
Short Talk: Using Physiological and Pharmacological Ascorbate to Manipulate HIF-1 Activity in Gulo-/- Mice

Coffee Break

Hall 4 (Industries Hall)
On Own for Lunch

Coffee Available

Hall 4 (Industries Hall)
Hypoxia and Inflammation

Hall 1 (Main Hall)
* Thorsten Cramer, RWTH Aachen University, Germany

Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Metabolic Reprogramming in Innate Immunity and Inflammation - A Critical Role for HIF-1alpha

Yatrik Shah, University of Michigan, USA
Intestinal HIF2alpha Signaling: A Critical Regulator of Intestinal Inflammation and Colon Cancer

Massimiliano Mazzone, KU Leuven – VIB, Belgium
Influence on Vessel Shape of Macrophage Metabolism in the Tumor Hypoxic Niche

Christian Stockmann, University of Zurich, Switzerland
Short Talk: The Hypoxic Response in Natural Killer Cells: Impact on Cancer Immune Surveillance and Tumor Angiogenesis

Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Hall 1 (Main Hall)
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Hall 4 (Industries Hall)
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Hall 4 (Industries Hall)



*Session Chair †Invited, not yet responded.

We gratefully acknowledge support for this conference from:

Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

BioLegend, Inc. Boehringer Ingelheim Pharmaceuticals, Inc.
Science Foundation Ireland

We gratefully acknowledge additional support for this conference from:

Baker Ruskinn BMG LABTECH Ltd.
Coy Laboratory Products Inc. Don Whitley Scientific Limited
Dove Medical Press Ltd Fáilte Ireland
FibroGen Incorporated Luxcel BioSciences Ltd.
Merck Serono/Merck Oxford Optronix Ltd.

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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