Keystone Symposia

Hilton Santa Fe Historic Plaza Hotel Floorplan

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This meeting took place in 2015

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Biology of Sirtuins (C3)

Organizer(s) Raul Mostoslavsky, Shin-ichiro Imai, Marcia C. Haigis, Eric M. Verdin
March 8—12, 2015
Hilton Santa Fe Historic Plaza Hotel • Santa Fe, NM USA
Discounted Abstract Deadline: Nov 6, 2014
Abstract Deadline: Dec 9, 2014
Scholarship Deadline: Nov 6, 2014
Discounted Registration Deadline: Jan 8, 2015

Supported by the Directors' Fund

Summary of Meeting:
The biology of sirtuins, a unique class of NAD+-dependent enzymes that modify diverse protein substrates, has rapidly emerged in the past decade as regulators of critical biological processes, and the field will further evolve into many interdisciplinary areas of biomedical science in coming years. Furthermore, sirtuins are now clearly recognized as important targets for preventive and therapeutic interventions against a wide variety of diseases. Therefore, this second Keystone Symposia meeting on sirtuin biology will particularly focus on integrative aspects of diverse sirtuin functions, featuring eight interdisciplinary sessions and one workshop. Because there is an increasing enthusiasm for sirtuin biology across the globe, it is critical to provide such a forum where the significance of the “integrative biology of sirtuins” can be fully discussed and interdisciplinary interactions will be stimulated among people from many different fields.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


Arrival and Registration

Welcome Mixer
No registration fees are used to fund alcohol served at this function.




Keynote Address

Mesa A-B
John M. Denu, University of Wisconsin-Madison, USA
Life and Times in the Sirtuin Field

Sirtuins in Metabolism and Signaling Pathways

Mesa A-B
David B. Lombard, University of Michigan, USA
Roles for the Sirtuin SIRT5 in Tumor Metabolism

Stephen L. Helfand, Brown University, USA
Sirtuins in the Fly: Effect on Mitochondria, Gene Regulation and Chromatin Maintenance Controls Metabolism and Longevity

* Shin-ichiro Imai, Washington University School of Medicine, USA
The NAD World Reloaded: The Importance of the Inter-Tissue Communication Mediated by NAMPT/NAD+/SIRT1 in Mammalian Aging/Longevity Control

Charles Brenner, University of Iowa, USA
Short Talk: How Nicotinamide Riboside Promotes Weight Loss

Joseph A. Garcia, Columbia University Medical Center, USA
Short Talk: An Acetate Switch Links Dynamic Changes in Intermediary Metabolism with Stress Signaling in Mammals

Coffee Break

Poster Setup

Mesa C
Poster Viewing

Mesa C
On Own for Lunch

Coffee Available

Biochemistry and Structure of Sirtuins

Mesa A-B
* John M. Denu, University of Wisconsin-Madison, USA

David A. Sinclair, Harvard Medical School, USA
Evidence for an Epigenetic Cause of Aging and Age-Related Diseases

Anthony A. Sauve, Weill Cornell Medical College, USA
Studies of Sirtuin Mechanism and Function Using Chemical Tools

Hening Lin, Cornell University, USA
Sirtuin Inhibitors as Anticancer Agents

Clemens Steegborn, University of Bayreuth, Germany
Short Talk: Novel Substrates and Inhibitors for Sirtuins 4 and 5 through Structural, Biochemical and Mass Spectrometry Studies

Lulu A. Cambronne, Oregon Health & Sciences University, USA
Short Talk: A Genetically-Encoded Fluorescent NAD+ Sensor

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Poster Session 1

Mesa C



Poster Setup

Mesa C
Poster Viewing

Mesa C
Sirtuins and Cancer

Mesa A-B
* Raul Mostoslavsky, Harvard Medical School, USA
Linking Epigenetics, Metabolism and Cancer: SIRT6 Provides Some Clues

Michael Ristow, Swiss Federal Institute of Technology Zurich - ETH, Switzerland
Mitohormesis: How Reactive Oxygen Species (ROS) Promote Healthspan

Marcia C. Haigis, Harvard Medical School, USA
New Roles for Sirtuins in Mitochondrial Homeostasis

David Gius, Northwestern University Feinberg School of Medical, USA
Short Talk: Loss of SIRT3 Activity and MnSOD Acetylation Results in Endocrine Breast Tumor Cell Resistance

Berta N. Vazquez, Rutgers University, USA
Short Talk: SIRT7 Promotes Genome Integrity by Regulating Non-Homologous End Joining DNA Repair

Marty W. Mayo, University of Virginia, USA
Short Talk: NAD+-Dependent Deacetylases SIRT1 and SIRT2 Regulate the Mitogen-Activated Protein Kinase Kinase (MEK)-1 Alternative Pathway

Christina M. Ferrer, Drexel University College of Medicine, USA
Short Talk: O-GlcNAcylation Regulates Breast Cancer Cell Invasion via the NAD+-Dependent Deacetylase SIRT1

Coffee Break


Poster Session 2

Mesa C
Workshop: Emerging Concepts in Sirtuin Biology

Mesa A-B
* David A. Sinclair, Harvard Medical School, USA

Matthew D. Hirschey, Duke University, USA
Chemical Reactivity and Novel Post-Translational Modifications Regulated by Mitochondrial Sirtuins

Zhen Tong, Cornell University, USA
SIRT7 Regulates the Activation of RALA via Defatty-Acylation

Natalie E. de Picciotto, University of Colorado Boulder, USA
SIRT1 Activation with Nicotinamide Mononucleotide Improves Vascular Function in Old Male Mice

Mark Y. Jeng, University of California, San Francisco, USA
Loss of SIRT1 Mediates Metabolic Reprogramming in Memory T Cells during Aging and Chronic Infections

Pavlos Pissios, NGM Bio, USA
Nicotinamide N-Methyltransferase Regulates Hepatic Nutrient Metabolism through N1-Methylnicotinamide

X. Charlie Dong, Indiana University School of Medicine, USA
Sirt6 Regulates Insulin Secretion from the Pancreatic Beta Cells

Alison Ringel, Harvard Medical School, USA
Alternate Deacylating Specificities for the Archaeal Sirtuins Sir2Af1 and Sir2Af2

Coffee Available

Sirtuins and Mitochondrial Biology

Mesa A-B
* Eric M. Verdin, Buck Institute for Research on Aging, USA
SIRT1, CD4 T Cell Subsets and Autoimmunity

Brian K. Kennedy, National University of Singapore, Singapore
Sirtuins and mTOR as Modulators of Metabolic Responses

Hiroshi Itoh, Keio University School of Medicine, Japan
Sirt1 Function in Kidney

Joseph T. Bass, Northwestern University, USA
Circadian Rhythms in Mitochondrial Function

On Own for Dinner



Sirtuins, Neurobiology and Neurodegeneration

Mesa A-B
Leonard P. Guarente, Massachusetts Institute of Technology, USA
Sirtuins, NAD and Aging

* Ruth Luthi-Carter, University of Leicester, UK
Sirtuins as Therapeutic Targets Against Neurodegeneration

Katrin F. Chua, Stanford University Medical Center, USA
Chromatin Regulation and Genome Maintenance by Mammalian SIRT6 and SIRT7

Lindsey B. Gano, University of Colorado, Anschutz Medical Campus, USA
Short Talk: SIRT3 Dysfunction in Experimental Temporal Lobe Epilepsy

Tatyana Gudz, Medical University of South Carolina, USA
Short Talk: SIRT3-Mediated Deacetylation of Ceramide Synthase Promotes Mitochondrial Dysfunction and Brain Injury after Stroke

Colleen A. Stoyas, University of California, San Diego, USA
Short Talk: Does Sirt1 Dysregulation Contribute to Pathogenesis of the Neurodegenerative Disorder Spinocerebellar Ataxia Type 7?

Coffee Break

On Own for Lunch

Coffee Available

Sirtuins as Targets for Therapeutic Purposes

Mesa A-B
* Marcia C. Haigis, Harvard Medical School, USA

James L. Ellis, GlaxoSmithKline, USA
Sirtuin Modulators as Therapeutic Agents for Metabolic and Inflammatory Diseases

Eriko Michishita-Kioi, Daiichi Sankyo Co., Ltd., Japan
Targeting Metabolic Enzymes

Yousin Suh, Albert Einstein College of Medicine, USA
Molecular Mechanisms Underlying SIRT1 Disease Risk Variants

Xiaoling Li, NIEHS, National Institutes of Health, USA
SIRT1 in Metabolism, Tissue Homeostasis and Human Diseases

Manfred Jung, University of Freiburg, Germany
Short Talk: Selective Inhibition of the NAD-Dependent Histone Deacetylase hSirt2 by Ligand-Induced Rearrangement of the Active Site

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Promenade/Mesa Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Mesa Ballroom



*Session Chair †Invited, not yet responded.

We gratefully acknowledge support for this conference from:

Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1R13AG049581-01

Funding for this conference was made possible (in part) by Grant # 1R13AG049581-01 from the National Institute on Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



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