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This meeting took place in 2015
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Transcriptional and Epigenetic Influences on Stem Cell States (C9)
Organizer(s) Thomas P. Zwaka, Rudolf Jaenisch and Joanna Wysocka
March 23—28, 2015
Sheraton Steamboat Resort • Steamboat Springs, CO USA
Discounted Abstract Deadline: Nov 20, 2014
Abstract Deadline: Dec 19, 2014
Scholarship Deadline: Nov 20, 2014
Discounted Registration Deadline: Jan 22, 2015
Sponsored by Cell Research, Incyte Corporation, Journal of Molecular Cell Biology (JMCB) and Thermo Fisher Scientific Inc.
Summary of Meeting:
An ambitious goal in modern biology is to understand stem cell states. Although much is known about both the behavior of stem cells under various conditions and the molecular details of stem cell identity, there is a gap between these two bodies of knowledge. This meeting sets out to bridge this gap, with a focus on transcriptional and epigenetic control of stem cell function. Advances in these areas will enable us to devise new strategies not only to probe stem cell biology more deeply, but to model disease and to develop cellular therapies. This Keystone Symposia meeting will bring together researchers who strive to: 1) Describe transcriptional and epigenetic mechanisms that control specific stem cell behaviors; 2) Generate predictive models of stem cell fate determination; 3) Delineate the influence of cell cycle and signaling on stem cell state; and 4) Understand mechanisms governing cell fate change, including differentiation, reprogramming and transdifferentiation. Ultimately, the meeting will provide an opportunity to view copious empirical data on stem cell behavior through a molecular lens, and will bring together scientists from basic research fields, such as transcriptional control, chromatin modification and developmental biology, with disease-oriented and translational researchers who are developing therapies or modeling specific diseases.
View Scholarships/Awards
An ambitious goal in modern biology is to understand stem cell states. Although much is known about both the behavior of stem cells under various conditions and the molecular details of stem cell identity, there is a gap between these two bodies of knowledge. This meeting sets out to bridge this gap, with a focus on transcriptional and epigenetic control of stem cell function. Advances in these areas will enable us to devise new strategies not only to probe stem cell biology more deeply, but to model disease and to develop cellular therapies. This Keystone Symposia meeting will bring together researchers who strive to: 1) Describe transcriptional and epigenetic mechanisms that control specific stem cell behaviors; 2) Generate predictive models of stem cell fate determination; 3) Delineate the influence of cell cycle and signaling on stem cell state; and 4) Understand mechanisms governing cell fate change, including differentiation, reprogramming and transdifferentiation. Ultimately, the meeting will provide an opportunity to view copious empirical data on stem cell behavior through a molecular lens, and will bring together scientists from basic research fields, such as transcriptional control, chromatin modification and developmental biology, with disease-oriented and translational researchers who are developing therapies or modeling specific diseases.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
MONDAY, MARCH 23
TUESDAY, MARCH 24
WEDNESDAY, MARCH 25
THURSDAY, MARCH 26
FRIDAY, MARCH 27
SATURDAY, MARCH 28
Conference Program Print | View meeting in 12 hr (am/pm) time
MONDAY, MARCH 23
08:00—09:00
Keynote Address
*
Thomas P. Zwaka,
Icahn School of Medicine at Mount Sinai, USA
Azim Surani,
University of Cambridge, UK
Mammalian Germline: Specification and Reprogramming for Totipotency and Development
Mammalian Germline: Specification and Reprogramming for Totipotency and Development
09:00—11:30
Transcriptional Control of Stemness
*
Joanna Wysocka,
Stanford University, USA
Richard A. Young,
Whitehead Institute for Biomedical Research, USA
Connecting Enhancers and Transcriptional Control
Connecting Enhancers and Transcriptional Control
Jacob H. Hanna,
Weizmann Institute of Science, Israel
EMBO Young Investigator Lecture: Molecular Mechanisms for Inducing and Maintaining Distinct Pluripotent States
EMBO Young Investigator Lecture: Molecular Mechanisms for Inducing and Maintaining Distinct Pluripotent States
Kristian Helin,
University of Copenhagen and Memorial Sloan Kettering Cancer Center, Denmark
Role of Polycomb Group Proteins and Histone Demethylases in Transcriptional Regulation and Stemness
Role of Polycomb Group Proteins and Histone Demethylases in Transcriptional Regulation and Stemness
Jennifer E. Phillips-Cremins,
University of Pennsylvania, USA
Short Talk: 3-D Genome Folding Is Partially Reprogrammed in Induced Pluripotent Stem Cells
Short Talk: 3-D Genome Folding Is Partially Reprogrammed in Induced Pluripotent Stem Cells
Joe Q. Zhou,
Weill Cornell Medical College, USA
Short Talk: Reprogramming Gastrointestinal Stem Cells to Provide a Renewable Source of Insulin+ beta Cells
Short Talk: Reprogramming Gastrointestinal Stem Cells to Provide a Renewable Source of Insulin+ beta Cells
17:00—19:00
Epigenetic Memories in the Germline
*
Azim Surani,
University of Cambridge, UK
Margaret T. Fuller,
Stanford University, USA
Cell Type-Specific Transcriptional Repression Programs Proper Differentiation of a Stem Cell Lineage
Cell Type-Specific Transcriptional Repression Programs Proper Differentiation of a Stem Cell Lineage
Bradley R. Cairns,
HHMI/University of Utah, USA
Chromatin-Transcription Dynamics in Developing Germline Stem Cells
Chromatin-Transcription Dynamics in Developing Germline Stem Cells
Stephen Dalton,
University of Georgia, USA
Signaling Pathways and the Cell Cycle Converge to Regulate Epigenetics and Cell Fate Decisions in Stem Cells
Signaling Pathways and the Cell Cycle Converge to Regulate Epigenetics and Cell Fate Decisions in Stem Cells
Fredrik Lanner,
Karolinska Institutet, Sweden
Short Talk: Single Cell Transcriptional Analysis: Delineating Cell Lineage and Pluripotency during Human Blastocyst Formation
Short Talk: Single Cell Transcriptional Analysis: Delineating Cell Lineage and Pluripotency during Human Blastocyst Formation
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Chromatin Features and Stem Cell Identity
*
Richard A. Young,
Whitehead Institute for Biomedical Research, USA
Joanna Wysocka,
Stanford University, USA
Epigenetic Regulation of Differentiation
Epigenetic Regulation of Differentiation
Magdalena D. Zernicka-Goetz,
Caltech and University of Cambridge, UK
Mechanisms for Determining Cell Identity and Embryo Architecture
Mechanisms for Determining Cell Identity and Embryo Architecture
Kathrin Plath,
University of California, Los Angeles, USA
Understanding how the "Yamanaka" Factors Induce Pluripotency
Understanding how the "Yamanaka" Factors Induce Pluripotency
Ulrich Elling,
Institute of Molecular Biotechnology, Austria
Short Talk: A Systematic Multiplex Analysis of Chromatin Factors Identifies Roadblocks of Reprogramming
Short Talk: A Systematic Multiplex Analysis of Chromatin Factors Identifies Roadblocks of Reprogramming
Ichiro Hiratani,
RIKEN Center for Developmental Biology, Japan
Short Talk: Identifying Novel Regulators of the Inactive X Chromosome Architecture
Short Talk: Identifying Novel Regulators of the Inactive X Chromosome Architecture
17:00—19:00
Modeling Stem Cell States
*
Kathrin Plath,
University of California, Los Angeles, USA
Ihor R. Lemischka,
Icahn School of Medicine at Mount Sinai, USA
Transcriptional Complexity in Stem Cells
Transcriptional Complexity in Stem Cells
Alexander van Oudenaarden,
Hubrecht Institute, Netherlands
Single-Cell mRNA Sequencing Reveals Rare Intestinal Cell Types
Single-Cell mRNA Sequencing Reveals Rare Intestinal Cell Types
Fernando D. Camargo,
Boston Children's Hospital, USA
Transcriptional Regulation by the Hippo/YAP Signaling Pathway
Transcriptional Regulation by the Hippo/YAP Signaling Pathway
Victor C. Li,
Harvard Medical School, USA
Short Talk: A Role for Cell Cycle-Associated Processes in Embryonic Stem Cell Differentiation
Short Talk: A Role for Cell Cycle-Associated Processes in Embryonic Stem Cell Differentiation
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Signaling in Stem Cells
Alexander Meissner,
Max Planck Institute for Molecular Genetics, Germany
Regulation of DNA Methylation in Stem Cells
Regulation of DNA Methylation in Stem Cells
Lorenz Studer,
Memorial Sloan Kettering Cancer Center, USA
Neural Differentiation of Embryonic Stem Cells
Neural Differentiation of Embryonic Stem Cells
Austin Smith,
University of Cambridge, UK
Embryonic Stem Cells: Of Mouse and Man
Embryonic Stem Cells: Of Mouse and Man
Tonis Org,
University of California, Los Angeles, USA
Short Talk: Scl Dictates Hematopoietic versus Cardiac Fate Choice in Mesoderm via Primed Enhancers
Short Talk: Scl Dictates Hematopoietic versus Cardiac Fate Choice in Mesoderm via Primed Enhancers
Elena Ezhkova,
Icahn School of Medicine at Mount Sinai, USA
Short Talk: An Unconventional Polycomb Repressive Mechanism Regulates Skin Stem Cell Maintenance and Differentiation
Short Talk: An Unconventional Polycomb Repressive Mechanism Regulates Skin Stem Cell Maintenance and Differentiation
14:30—16:30
Workshop: Functional Chromatin Domains in Stem Cells
*
Kenneth S. Zaret,
University of Pennsylvania, USA
Yan Xu,
Guangzhou Institutes of Biomedicine and Health, China
Transcriptional Pause Release Is a Rate-Limiting Step for Somatic Cell Reprogramming
Transcriptional Pause Release Is a Rate-Limiting Step for Somatic Cell Reprogramming
Kathryn E. Malecek,
Whitehead Institute, USA
Characterization and Function of Novel Oxidized-Methylcytosine Binding Proteins
Characterization and Function of Novel Oxidized-Methylcytosine Binding Proteins
Jean-Pierre Etchegaray,
Massachusetts General Hospital, Harvard Medical School, USA
The Histone Deacetylase SIRT6 Controls Embryonic Stem Cell Fate via TET-Dependent Oxidation of 5mC into 5hmC
The Histone Deacetylase SIRT6 Controls Embryonic Stem Cell Fate via TET-Dependent Oxidation of 5mC into 5hmC
Guang Hu,
NIEHS, National Institutes of Health, USA
The INO80 Chromatin Remodeling Complex Promotes Pluripotency Gene Activation in ESC Self-Renewal
The INO80 Chromatin Remodeling Complex Promotes Pluripotency Gene Activation in ESC Self-Renewal
Kihyun Lee,
Memorial Sloan Kettering Institute/Cornell University, USA
Divergent Role of GATA Factors in Human Pancreatic and Cardiac Development
Divergent Role of GATA Factors in Human Pancreatic and Cardiac Development
Yechiel Elkabetz,
Max Planck Institute for Molecular Genetics, Germany
Consecutive Building Blocks of Human Neural Stem Cell Ontogeny Derived from Pluripotent Stem Cells: Fundamentals and Implications
Consecutive Building Blocks of Human Neural Stem Cell Ontogeny Derived from Pluripotent Stem Cells: Fundamentals and Implications
Elizabeth Anne Mason,
University of Melbourne, Australia
Gene Expression Variability Is a Unifying Element of the Pluripotency Network and Stem Cell Sub-Populations
Gene Expression Variability Is a Unifying Element of the Pluripotency Network and Stem Cell Sub-Populations
17:00—19:00
Cell Cycle and Growth Regulation
*
Magdalena D. Zernicka-Goetz,
Caltech and University of Cambridge, UK
Thomas P. Zwaka,
Icahn School of Medicine at Mount Sinai, USA
Cell Competition in Pluripotent Stem Cells
Cell Competition in Pluripotent Stem Cells
Amanda G. Fisher,
Imperial College London, UK
Linking Epigenetics and Signaling in the Early Mammalian Embryo
Linking Epigenetics and Signaling in the Early Mammalian Embryo
Raga Krishnakumar,
University of California, San Francisco, USA
Short Talk: Foxd3 Regulates Developmental Timing of Gene Expression by Simultaneously Establishing and Repressing Enhancers
Short Talk: Foxd3 Regulates Developmental Timing of Gene Expression by Simultaneously Establishing and Repressing Enhancers
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Challenging Fate: Reprogramming and Transdifferentiation
*
Thomas P. Zwaka,
Icahn School of Medicine at Mount Sinai, USA
Rudolf Jaenisch,
Whitehead Institute for Biomedical Research, USA
iPS Cell Technology, Gene Editing and Disease Research
iPS Cell Technology, Gene Editing and Disease Research
Marius Wernig,
Stanford University, USA
Mechanisms and Applications of Direct Lineage Neuronal Reprogramming
Mechanisms and Applications of Direct Lineage Neuronal Reprogramming
George Q. Daley,
HHMI/Boston Children's Hospital, USA
CellNet: Enhancing Cellular Engineering through Network Biology
CellNet: Enhancing Cellular Engineering through Network Biology
Jaclyn J. Ho,
Tenaya Therapeutics, USA
Short Talk: Regulation of DNA Demethylation by the XPC DNA Repair Complex during Human Somatic Cell Reprogramming
Short Talk: Regulation of DNA Demethylation by the XPC DNA Repair Complex during Human Somatic Cell Reprogramming
Eirini P. Papapetrou,
Icahn School of Medicine at Mount Sinai, USA
Short Talk: Modeling Disease-Associated Chromosomal Deletions in Human Pluripotent Stem Cells
Short Talk: Modeling Disease-Associated Chromosomal Deletions in Human Pluripotent Stem Cells
17:00—18:45
Mechanisms of Differentiation and Identity Choice
*
Rudolf Jaenisch,
Whitehead Institute for Biomedical Research, USA
Wolf Reik,
Babraham Institute, UK
Epigenetic Reprogramming in Mammalian Development
Epigenetic Reprogramming in Mammalian Development
Kenneth S. Zaret,
University of Pennsylvania, USA
Chromatin Features that Facilitate and Impede Cellular Reprogramming
Chromatin Features that Facilitate and Impede Cellular Reprogramming
Daniel A. Lim,
University of California, San Francisco, USA
Epigenetic Determinants of Neural Stem Cells
Epigenetic Determinants of Neural Stem Cells
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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