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This meeting took place in 2015
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Endoderm Lineages in Development and Disease (B2)
Organizer(s) Lori Sussel, Hans-Willem E. Snoeck, James M. Wells and Aaron M. Zorn
February 8—13, 2015
Keystone Resort • Keystone, CO USA
Discounted Abstract Deadline: Oct 7, 2014
Abstract Deadline: Nov 11, 2014
Scholarship Deadline: Oct 7, 2014
Discounted Registration Deadline: Dec 8, 2014
Supported by the Directors' Fund
Summary of Meeting:
The endoderm gives rise to a vast array of highly specialized epithelial cell types lining the respiratory and gastrointestinal tracts and contributes to associated organs such as the thyroid, thymus, lungs, liver, biliary system and pancreas. Basic studies of endoderm organ development and postnatal function have revealed the molecular basis of human congenital diseases, identified new regenerative pathways and made it possible to grow endoderm organ tissues in vitro. While endoderm organs vary in their form and function, there are many shared mechanisms that govern the development and homeostasis of these organs. This Keystone Symposia meeting will highlight recent advances in our understanding of endoderm organ development during embryogenesis and how this knowledge has led to successful efforts at generating human endoderm organ cells and tissues from pluripotent stem cells. It brings together researchers who span the different endoderm organ systems to compare and contrast molecular mechanisms, experimental approaches and new approaches for translating basic research. Discussions will focus on how success in one organ might be duplicated in other organ systems.
View Scholarships/Awards
The endoderm gives rise to a vast array of highly specialized epithelial cell types lining the respiratory and gastrointestinal tracts and contributes to associated organs such as the thyroid, thymus, lungs, liver, biliary system and pancreas. Basic studies of endoderm organ development and postnatal function have revealed the molecular basis of human congenital diseases, identified new regenerative pathways and made it possible to grow endoderm organ tissues in vitro. While endoderm organs vary in their form and function, there are many shared mechanisms that govern the development and homeostasis of these organs. This Keystone Symposia meeting will highlight recent advances in our understanding of endoderm organ development during embryogenesis and how this knowledge has led to successful efforts at generating human endoderm organ cells and tissues from pluripotent stem cells. It brings together researchers who span the different endoderm organ systems to compare and contrast molecular mechanisms, experimental approaches and new approaches for translating basic research. Discussions will focus on how success in one organ might be duplicated in other organ systems.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, FEBRUARY 8
MONDAY, FEBRUARY 9
TUESDAY, FEBRUARY 10
WEDNESDAY, FEBRUARY 11
THURSDAY, FEBRUARY 12
FRIDAY, FEBRUARY 13
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, FEBRUARY 8
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Keynote Address
*
Hans-Willem E. Snoeck,
Columbia University Medical Center, USA
Brigid L. M. Hogan,
Duke University Medical Center, USA
Development, Maintenance and Repair of the Lung
Development, Maintenance and Repair of the Lung
09:00—11:15
Endoderm Formation
*
Heiko Lickert,
Institute of Diabetes and Regeneration, Germany
Kat Hadjantonakis,
Sloan Kettering Institute, USA
Cell Dynamics and the Emergence of Endoderm in the Early Mouse Embryo
Cell Dynamics and the Emergence of Endoderm in the Early Mouse Embryo
Kyra A. Campbell,
University of Sheffield, UK
Short Talk: The Precise Cellular Behaviors Orchestrated by GATA Factor Activity during Endoderm Formation in Drosophila
Short Talk: The Precise Cellular Behaviors Orchestrated by GATA Factor Activity during Endoderm Formation in Drosophila
Ken W.Y. Cho,
University of California, Irvine, USA
Genome-Wide View of the Early Xenopus Endoderm Regulatory Program
Genome-Wide View of the Early Xenopus Endoderm Regulatory Program
Ludovic Vallier,
Wellcome Trust Sanger Institute, UK
Cell Cycle Controls Endoderm Specification of Human Pluripotent Stem Cells
Cell Cycle Controls Endoderm Specification of Human Pluripotent Stem Cells
17:00—19:15
Endoderm Patterning
*
Elizabeth J. Robertson,
University of Oxford, UK
Aaron M. Zorn,
Cincinnati Children's Hospital Medical Center, USA
Endoderm Patterning and Early Organogenesis
Endoderm Patterning and Early Organogenesis
Francesca M. Spagnoli,
Max Delbrück Center for Molecular Medicine, Germany
Short Talk: Control of Cellular Plasticity between Liver and Pancreas
Short Talk: Control of Cellular Plasticity between Liver and Pancreas
Lori Sussel,
University of Colorado Anschutz Medical Campus, USA
Induction and Maintenance of Pancreatic Endoderm
Induction and Maintenance of Pancreatic Endoderm
Heiko Lickert,
Institute of Diabetes and Regeneration, Germany
Novel Players in Pancreas Formation and Function
Novel Players in Pancreas Formation and Function
Allen Wang,
University of California, San Diego, USA
Short Talk: A Poised Enhancer Landscape Is Indicative of Developmental Competence during Endodermal Lineage Diversification of Human Embryonic Stem Cells
Short Talk: A Poised Enhancer Landscape Is Indicative of Developmental Competence during Endodermal Lineage Diversification of Human Embryonic Stem Cells
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Organ Induction
*
Nancy R. Manley,
University of Georgia, USA
Susan E. Mango,
Harvard University, USA
Higher-Order Organization of the Nucleus as Embryos Transition from Developmental Plasticity to Differentiation
Higher-Order Organization of the Nucleus as Embryos Transition from Developmental Plasticity to Differentiation
John M. Shannon,
Cincinnati Children's Hospital Medical Center, USA
Short Talk: Specification of Respiratory Endoderm Occurs Early in Embryogenesis
Short Talk: Specification of Respiratory Endoderm Occurs Early in Embryogenesis
Elke A. Ober,
University of Copenhagen, Denmark
Cell-Cell Interactions Controlling Liver Bud Morphogenesis
Cell-Cell Interactions Controlling Liver Bud Morphogenesis
Li Chen,
University of Houston, USA
Short Talk: A Molecular Switch Regulating Pancreatic and Heart Development
Short Talk: A Molecular Switch Regulating Pancreatic and Heart Development
Wellington V. Cardoso,
Columbia University Medical Center, USA
Hippo-Yap Control of Lung Epithelial Morphogenesis and Differentiation
Hippo-Yap Control of Lung Epithelial Morphogenesis and Differentiation
14:30—16:30
Workshop 1: Endoderm Tissue Morphogenesis
*
Aaron M. Zorn,
Cincinnati Children's Hospital Medical Center, USA
Nanette M. Nascone-Yoder,
North Carolina State University, USA
A Novel Role for Acetylcholinesterase in Endoderm Morphogenesis
A Novel Role for Acetylcholinesterase in Endoderm Morphogenesis
Nandan L. Nerurkar,
Columbia University, USA
FGF-Mediated Tension Gradients Drive Antero-Posterior Endoderm Movements to Form the Avian Hindgut
FGF-Mediated Tension Gradients Drive Antero-Posterior Endoderm Movements to Form the Avian Hindgut
Tyler R. Huycke,
Harvard Medical School, USA
Generating Morphological Variation in the Developing Chick Gut
Generating Morphological Variation in the Developing Chick Gut
Sonja Nowotschin,
Sloan Kettering Institute, USA
Linking Gut Endoderm Morphogenesis with Germ Layer Segregation
Linking Gut Endoderm Morphogenesis with Germ Layer Segregation
Mitsuru Morimoto,
RIKEN, Center for Developmental Biology, Japan
A Non-Proliferating Tissue Enlargement Controlling the Trachea Tubulogenesis
A Non-Proliferating Tissue Enlargement Controlling the Trachea Tubulogenesis
Darrell N. Kotton,
Boston University, USA
Generation of Functional, Engraftable Thyroid and Lung Organoids via ESC/iPSC-Derived Nkx2-1+ Endodermal Progenitors
Generation of Functional, Engraftable Thyroid and Lung Organoids via ESC/iPSC-Derived Nkx2-1+ Endodermal Progenitors
Mostafa Bakhti,
Helmholtz Zentrum München, Germany
Synaptotagmin13 Regulates Apical-Basal Polarity and Spindle Positioning in Pancreatic Ductal Progenitors for Endocrine Lineage Formation
Synaptotagmin13 Regulates Apical-Basal Polarity and Spindle Positioning in Pancreatic Ductal Progenitors for Endocrine Lineage Formation
Kimberly D. Tremblay,
University of Massachusetts, USA
The Anterior and Posterior Liver Bud each Produce Discreet Portions of the Embryonic Liver
The Anterior and Posterior Liver Bud each Produce Discreet Portions of the Embryonic Liver
17:00—19:15
Organogenesis
*
James M. Wells,
Cincinnati Children's Hospital Research Foundation, USA
Anne Grapin-Botton,
University of Copenhagen, Denmark
Cells Behaving as Communities during Pancreas Development
Cells Behaving as Communities during Pancreas Development
Philip T. Pauerstein,
Stanford University School of Medicine, USA
Short Talk: Peripheral Semaphorin Signals Control Pancreatic Islet Morphogenesis
Short Talk: Peripheral Semaphorin Signals Control Pancreatic Islet Morphogenesis
Deborah L. Gumucio,
University of Michigan, USA
Making Villi
Making Villi
Edward E. Morrisey,
University of Pennsylvania, USA
Molecular Pathways Governing Lung Development
Molecular Pathways Governing Lung Development
Astrid Gillich,
Stanford University School of Medicine, USA
Short Talk: A Model for Alveolar Development in the Mouse Lung
Short Talk: A Model for Alveolar Development in the Mouse Lung
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Postnatal Stem Cells and Regeneration
*
Xin Sun,
University of California, San Diego, USA
Ramesh A. Shivdasani,
Dana-Farber Cancer Institute, USA
Chromatin Modifications in Intestinal Stem and Progenitor Cell Renewal
Chromatin Modifications in Intestinal Stem and Progenitor Cell Renewal
Benjamin Ohlstein,
UT Southwestern Medical Center, USA
Regulating Stem Cell Number in the Drosophila Intestine: You Can Go Home Again
Regulating Stem Cell Number in the Drosophila Intestine: You Can Go Home Again
Linda C. Samuelson,
University of Michigan, USA
Short Talk: Notch Pathway Regulation of Gastrointestinal Stem Cells
Short Talk: Notch Pathway Regulation of Gastrointestinal Stem Cells
Holger Willenbring,
University of California, San Francisco, USA
Regeneration of the Liver
Regeneration of the Liver
Andrew J. Lechner,
University of California, San Francisco, USA
Short Talk: Immune Cell Regulation of Adult Alveologenesis Post-Pneumonectomy
Short Talk: Immune Cell Regulation of Adult Alveologenesis Post-Pneumonectomy
17:00—19:15
Cancer Stem Cells
*
Ben Z. Stanger,
University of Pennsylvania, USA
Trudy G. Oliver,
Huntsman Cancer Institute, USA
Sox2 Cooperates with Lkb1 Loss to Promote Squamous Cell Lung Cancer
Sox2 Cooperates with Lkb1 Loss to Promote Squamous Cell Lung Cancer
Noah Shroyer,
Baylor College of Medicine, USA
Intestinal Stem Cells and Colon Cancer
Intestinal Stem Cells and Colon Cancer
Yoku Hayakawa,
Columbia University, USA
Short Talk: CXCL12-CXCR4 Axis Supports Proximal Gastric Stem Cell Niche and Contributes to Cancer Development
Short Talk: CXCL12-CXCR4 Axis Supports Proximal Gastric Stem Cell Niche and Contributes to Cancer Development
Timothy C. Wang,
Columbia University, USA
Dclk1 Labels Facultative Pancreatic Stem and Cancer-Initiating Cells
Dclk1 Labels Facultative Pancreatic Stem and Cancer-Initiating Cells
Nathan M. Krah,
University of Utah, USA
Short Talk: PTF1A Is a Pancreas-Specific Tumor Suppressor
Short Talk: PTF1A Is a Pancreas-Specific Tumor Suppressor
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Stem Cell-Derived Endoderm Organs
*
Darrell N. Kotton,
Boston University, USA
Hans-Willem E. Snoeck,
Columbia University Medical Center, USA
Development of Human Anterior Foregut Derivatives
Development of Human Anterior Foregut Derivatives
Jason R. Spence,
University of Michigan Health System, USA
Short Talk: In vitro Generation of Human Pluripotent Stem Cell Derived Lung Organoids
Short Talk: In vitro Generation of Human Pluripotent Stem Cell Derived Lung Organoids
James M. Wells,
Cincinnati Children's Hospital Research Foundation, USA
Human Pluripotent Stem Cell-Derived Tissues as Models of Gastrointestinal Development and Disease
Human Pluripotent Stem Cell-Derived Tissues as Models of Gastrointestinal Development and Disease
Valerie Gouon-Evans,
Mount Sinai Hospital, USA
Identification of an Endoderm-Derived KDR+ Progenitor with a Bi-Potent Hepatic and Endothelial Fate
Identification of an Endoderm-Derived KDR+ Progenitor with a Bi-Potent Hepatic and Endothelial Fate
Gordon M. Keller,
University Health Network, MaRS Centre, Canada
Specification of Pancreatic and Hepatic Endoderm from Human Pluripotent Stem Cells
Specification of Pancreatic and Hepatic Endoderm from Human Pluripotent Stem Cells
Danwei Huangfu,
Memorial Sloan Kettering Cancer Institute, USA
Short Talk: hESC-Based Functional Human Genetics for Systematic Interrogation of Mechanisms of Pancreatic Development and Diabetes
Short Talk: hESC-Based Functional Human Genetics for Systematic Interrogation of Mechanisms of Pancreatic Development and Diabetes
14:30—16:30
Workshop 2: Epigenetic and Noncoding RNA Regulation of Endoderm
*
Lori Sussel,
University of Colorado Anschutz Medical Campus, USA
Rui Fan,
Ludwig Maximilian University, Germany
The Histone Methyltransferase Setdb1 Is Essential for Endoderm Development
The Histone Methyltransferase Setdb1 Is Essential for Endoderm Development
Marie-Liesse Asselin-Labat,
Walter and Eliza Hall Institute, Australia
The Histone Methyltransferase Ezh2 Is Essential for Lung Development and Controls Lineage Specification
The Histone Methyltransferase Ezh2 Is Essential for Lung Development and Controls Lineage Specification
Nisha Patel,
Celgene, USA
Chromatin Remodeling Establishes Endocrine Lineage Commitment in Multi-Potent Pancreatic Progenitors
Chromatin Remodeling Establishes Endocrine Lineage Commitment in Multi-Potent Pancreatic Progenitors
Daniel T. Swarr,
Cincinnati Children's Hospital Medical Center, USA
The Long Non-Coding RNA Fanci Directs Early Endoderm and Lung Development by Regulating Expression of Foxa2
The Long Non-Coding RNA Fanci Directs Early Endoderm and Lung Development by Regulating Expression of Foxa2
David M. Ornitz,
Washington University School of Medicine, USA
Micro RNA Regulation of FGF9 in Lung Development Reveals a Link between DICER1 Loss and the Pathogenesis of Pleuropulmonary Blastoma
Micro RNA Regulation of FGF9 in Lung Development Reveals a Link between DICER1 Loss and the Pathogenesis of Pleuropulmonary Blastoma
Kaveh Daneshvar,
Harvard Medical School, USA
TGF-beta Induced Long Non-Coding RNA lncGSC Is a Regulator of Endodermal Differentiation
TGF-beta Induced Long Non-Coding RNA lncGSC Is a Regulator of Endodermal Differentiation
Michael J. Herriges,
University of Pennsylvania, USA
The lincRNA NANCI Is Essential for Nkx2-1 Expression and Lung Development
The lincRNA NANCI Is Essential for Nkx2-1 Expression and Lung Development
17:00—18:45
Endoderm Development and Disease
*
Edward E. Morrisey,
University of Pennsylvania, USA
Didier Stainier,
Max Planck Institute for Heart and Lung Research, Germany
GI Disease Modeling in Zebrafish
GI Disease Modeling in Zebrafish
Elaine Storm,
Genentech, Inc., USA
Short Talk: Targeting Developmental Pathways in Cancer
Short Talk: Targeting Developmental Pathways in Cancer
Gustavo Mostoslavsky,
Boston University, USA
Short Talk: Modeling Familial Adenomatous Polyposis with Induced Pluripotent Stem Cells
Short Talk: Modeling Familial Adenomatous Polyposis with Induced Pluripotent Stem Cells
Ben Z. Stanger,
University of Pennsylvania, USA
Tumor as Embryo: Using the Tools of Development to Understand Cancer Biology
Tumor as Embryo: Using the Tools of Development to Understand Cancer Biology
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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