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This meeting took place in 2015
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Innate Immunity and Determinants of Microbial Pathogenesis (Z3)
Organizer(s) Robert L. Modlin, Jenny P.Y. Ting and Foo Y. Liew
April 19—24, 2015
Resort at Squaw Creek • Olympic Valley, CA USA
Discounted Abstract Deadline: Dec 18, 2014
Abstract Deadline: Jan 21, 2015
Scholarship Deadline: Dec 18, 2014
Discounted Registration Deadline: Feb 19, 2015
Sponsored by BioLegend, Inc.
Joint Meeting:
Mechanisms of Pro-Inflammatory Diseases (Z4)
Summary of Meeting:
With the emergence of drug-resistant organisms, advances in immunology, insights gained from understanding the normal and disease microbiome, and rapid technological advances including high-throughput sequencing and robotics, the time is ripe to hold a second Keystone Symposia meeting on this topic like the one held in 2000. This meeting focuses on innate and adaptive immunity to microbial infections. Microbial infections pose major health problems worldwide, but also represent extraordinary models to study immune regulation. Important advances in immunology have been made in recent years and have led to a new understanding of host-pathogen interactions. This conference explores the interaction of the innate and adaptive immune response in host defense against microbial infection. This meeting aims to bring together immunologists who study basic mechanisms and those who study infectious agents to formulate new strategies to control some of the world’s most deadly diseases.
View Scholarships/Awards
With the emergence of drug-resistant organisms, advances in immunology, insights gained from understanding the normal and disease microbiome, and rapid technological advances including high-throughput sequencing and robotics, the time is ripe to hold a second Keystone Symposia meeting on this topic like the one held in 2000. This meeting focuses on innate and adaptive immunity to microbial infections. Microbial infections pose major health problems worldwide, but also represent extraordinary models to study immune regulation. Important advances in immunology have been made in recent years and have led to a new understanding of host-pathogen interactions. This conference explores the interaction of the innate and adaptive immune response in host defense against microbial infection. This meeting aims to bring together immunologists who study basic mechanisms and those who study infectious agents to formulate new strategies to control some of the world’s most deadly diseases.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, APRIL 19
MONDAY, APRIL 20
TUESDAY, APRIL 21
WEDNESDAY, APRIL 22
THURSDAY, APRIL 23
FRIDAY, APRIL 24
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, APRIL 19
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:30
Keynote Session (Joint)
*
Robert L. Modlin,
University of California, Los Angeles, USA
Introduction
Introduction
Richard A. Flavell,
HHMI/Yale University School of Medicine, USA
Inflammasomes in Health, Dysbiosis and Disease
Inflammasomes in Health, Dysbiosis and Disease
Zhijian "James" Chen,
University of Texas Southwestern Medical Center, USA
Innate Immune Sensing of Cytosolic Nucleic Acids
Innate Immune Sensing of Cytosolic Nucleic Acids
09:50—12:00
Innate Immunity (Joint)
*
Virginia Pascual,
Cornell University, USA
Yong-Jun Liu,
Sanofi, USA
Sensing of DNA and RNA
Sensing of DNA and RNA
Jenny P.Y. Ting,
University of North Carolina at Chapel Hill, USA
NLRs in Inflammasome and Non-Inflammasome Functions
NLRs in Inflammasome and Non-Inflammasome Functions
Scott W. Canna,
Children's Hospital of Pittsburgh, University of Pittsburgh, USA
Short Talk: Activating Mutations in NLRC4 Cause Recurrent Macrophage Activation Syndrome: Blame it on IL-18?
Short Talk: Activating Mutations in NLRC4 Cause Recurrent Macrophage Activation Syndrome: Blame it on IL-18?
14:30—16:30
Workshop 1: IFN
*
Jae U. Jung,
Keck School of Medicine of University of Southern California, USA
Emily M. Eshleman,
University of Colorado School of Medicine, USA
Myeloid Cell IFNGR1 Down Regulation Exacerbates Bacterial Infections
Myeloid Cell IFNGR1 Down Regulation Exacerbates Bacterial Infections
Matteo Gentili,
Institut Curie, France
Intercellular Transmission of Innate Immune Signaling by Packaging of the Second Messenger cGAMP in Viral Particles
Intercellular Transmission of Innate Immune Signaling by Packaging of the Second Messenger cGAMP in Viral Particles
Jarrod S. Johnson,
Seattle Biomedical Research Institute, USA
HIV-1 Alters the Threshold for Type I Interferon Signaling in Dendritic Cells
HIV-1 Alters the Threshold for Type I Interferon Signaling in Dendritic Cells
Ken Chung-Ren Pang,
Walter and Eliza Hall Institute of Medical Research, Australia
Sidt2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition
Sidt2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition
Jan Rehwinkel,
Weatherall Institute of Molecular Medicine, University of Oxford, UK
Lentiviruses Transfer the Antiviral Second Messenger cGAMP between Cells
Lentiviruses Transfer the Antiviral Second Messenger cGAMP between Cells
Beiyun Caitlin Liu,
Tufts University, USA
Type-I IFN-Independent Induction and Activation of Caspase-11 toward L. pneumophila
Type-I IFN-Independent Induction and Activation of Caspase-11 toward L. pneumophila
Clinton J. Bradfield,
NIH, USA
Human GBPs Recognize a New Class of DAMPs to Mobilize Cell-Autonomous Immunity to Bacterial Pathogens
Human GBPs Recognize a New Class of DAMPs to Mobilize Cell-Autonomous Immunity to Bacterial Pathogens
Jessica F. Almine,
University of Dundee, UK
IFI16 and cGAS Co-Operate in DNA Sensing in Human Keratinocytes
IFI16 and cGAS Co-Operate in DNA Sensing in Human Keratinocytes
14:30—16:30
Workshop 1: Innate Immunity and Disease
*
Thirumala-Devi Kanneganti,
St. Jude Children's Research Hospital, USA
Irving C. Allen,
Virginia Tech, USA
NLRX1 Attenuates Inflammation and Tumorigenesis through the Negative Regulation of AKT and NF-kappaB Signaling
NLRX1 Attenuates Inflammation and Tumorigenesis through the Negative Regulation of AKT and NF-kappaB Signaling
Po-Lin Huang,
Academia Sinica, Taiwan
Skeletal Muscle IL-15/IL-15Ralpha Promotes CD8+ T-Cell Function and Autoimmune Myositis
Skeletal Muscle IL-15/IL-15Ralpha Promotes CD8+ T-Cell Function and Autoimmune Myositis
Sebastian Günther,
University of Maryland School of Medicine, USA
Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor
Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor
Teja Celhar,
Singapore Immunology Network, Singapore
Elimination of the NLRP3 Inflammasome Prevents the Development of Lupus-Associated Traits in a Mouse Model of Autoimmunity
Elimination of the NLRP3 Inflammasome Prevents the Development of Lupus-Associated Traits in a Mouse Model of Autoimmunity
Rachel A. Gottschalk,
NIAID, National Institutes of Health, USA
Distinct Sensitivities of NFkappaB and MAPK to TLR Ligation Support Robust Low-Noise Inflammatory Responses
Distinct Sensitivities of NFkappaB and MAPK to TLR Ligation Support Robust Low-Noise Inflammatory Responses
Sebastien Tauzin,
University of Wisconsin-Madison, USA
Redox and Src Family Kinase Signaling Control Macrophage-Mediated Resolution of Inflammation
Redox and Src Family Kinase Signaling Control Macrophage-Mediated Resolution of Inflammation
17:00—19:00
Innate Immune Sensing and Consequences in Microbial Infection
*
Alan Sher,
NIAID, National Institutes of Health, USA
Jae U. Jung,
Keck School of Medicine of University of Southern California, USA
Roles of Pattern Recognizing Receptors and Autophagy in Antiviral Immune Response
Roles of Pattern Recognizing Receptors and Autophagy in Antiviral Immune Response
Stanley M. Lemon,
University of North Carolina at Chapel Hill, USA
Type 1 Interferon Responses Determine Permissiveness and Host Species Range of Human Hepatitis A Virus
Type 1 Interferon Responses Determine Permissiveness and Host Species Range of Human Hepatitis A Virus
Genhong Cheng,
University of California, Los Angeles, USA
Balancing Inflammatory Responses during Acute and Chronic Infections
Balancing Inflammatory Responses during Acute and Chronic Infections
Arun K. Mankan,
University of Bonn, Institute of Molecular Medicine, Germany
Short Talk: Cytosolic RNA:DNA Hybrids Activate the cGAS-STING Axis
Short Talk: Cytosolic RNA:DNA Hybrids Activate the cGAS-STING Axis
17:00—19:00
Innate Triggers of Adaptive Immunity
*
John J. O'Shea,
NIAMS, National Institutes of Health, USA
Mark S. Anderson,
University of California, San Francisco, USA
Control of Immune Tolerance by Aire-Expressing Cells
Control of Immune Tolerance by Aire-Expressing Cells
Hideki Ueno,
Icahn School of Medicine at Mount Sinai, USA
T Follicular Helper Cells in Autoimmunity in Humans
T Follicular Helper Cells in Autoimmunity in Humans
Averil I. Ma,
University of California, San Francisco, USA
Short Talk: A20 Restricts IL1b Ubiquitination and NLRP3 Inflammasome Activity
Short Talk: A20 Restricts IL1b Ubiquitination and NLRP3 Inflammasome Activity
Simone Caielli,
Baylor Institute for Immunology Research, USA
Short Talk: Oxidized Mitochondrial DNA Is a Powerful Activator of Human pDCs and Induces a Lupus-Specific CD4 T Cell Phenotype
Short Talk: Oxidized Mitochondrial DNA Is a Powerful Activator of Human pDCs and Induces a Lupus-Specific CD4 T Cell Phenotype
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Innate Immunity in Inflammation and Disease (Joint)
*
Foo Y. Liew,
University of Glasgow, UK
Akira Shizuo,
Osaka University, Japan
Control of the Inflammatory and Immune Responses by the Ribonuclease, Regnase-1
Control of the Inflammatory and Immune Responses by the Ribonuclease, Regnase-1
Daniel Kastner,
National Institutes of Health, USA
Dissecting New Inflammatory Pathways through Genetics
Dissecting New Inflammatory Pathways through Genetics
Virginia Pascual,
Cornell University, USA
Novel Insights into Human SLE Pathogenesis
Novel Insights into Human SLE Pathogenesis
Robert L. Modlin,
University of California, Los Angeles, USA
Innate Immunity in TB
Innate Immunity in TB
Hubertus Hochrein,
Bavarian Nordic, Germany
Short Talk: IFN-lambda Production of CD8 cDCs in Response to DNA-Viruses, Transfected dsDNA or Cyclic-di-Nucleotides Depends on STING
Short Talk: IFN-lambda Production of CD8 cDCs in Response to DNA-Viruses, Transfected dsDNA or Cyclic-di-Nucleotides Depends on STING
Seth L. Masters,
Walter and Eliza Hall Institute, Australia
Short Talk: Aberrant Actin Depolymerization Triggers the Pyrin Inflammasome and Autoinflammatory Disease that Is Dependent on IL-18, not IL-1beta
Short Talk: Aberrant Actin Depolymerization Triggers the Pyrin Inflammasome and Autoinflammatory Disease that Is Dependent on IL-18, not IL-1beta
14:30—16:30
Workshop 2: Mycobacteria
*
John D. MacMicking,
Yale University, USA
André Alves Dias,
Oswaldo Cruz Foundation, Brazil
The Role of TLR9 Activation in the Host Immune Response during Type II Reaction in Leprosy
The Role of TLR9 Activation in the Host Immune Response during Type II Reaction in Leprosy
Robert O. Watson,
Texas A&M Health Science Center, USA
cGAS Detects Mycobacterium tuberculosis DNA to Activate both Type I Interferon and Autophagy
cGAS Detects Mycobacterium tuberculosis DNA to Activate both Type I Interferon and Autophagy
Trude Helen Flo,
Norwegian University of Science, Norway
Keap1 Regulates Inflammatory Signaling in M. avium-Infected Human Macrophages
Keap1 Regulates Inflammatory Signaling in M. avium-Infected Human Macrophages
Jennifer R. Honda,
National Jewish Health, USA
Polar Lipids of Nontuberculous Mycobacteria Likely Contribute to Neutralization of Cathelicidin
Polar Lipids of Nontuberculous Mycobacteria Likely Contribute to Neutralization of Cathelicidin
Susan Realegeno,
University of California, Los Angeles, USA
Identifying TLR and IFN-g Inducible Antimicrobial Responses Against Mycobacteria in Human Macrophages
Identifying TLR and IFN-g Inducible Antimicrobial Responses Against Mycobacteria in Human Macrophages
Leonardo Ribeiro Batista Silva,
Fundação Oswaldo Cruz, Brazil
Insulin-Like Growth Factor-I (IGF-I) Signaling Pathway Inhibits the STAT1 Activation via SOCS3 in Mycobacterium leprae-Stimulated Macrophases
Insulin-Like Growth Factor-I (IGF-I) Signaling Pathway Inhibits the STAT1 Activation via SOCS3 in Mycobacterium leprae-Stimulated Macrophases
Kirsten E. Wiens,
New York University School of Medicine, USA
Differential Type I Interferon Induction by Distinct Mycobacterium tuberculosis Strains Despite Similar Access to the Host Cytosol
Differential Type I Interferon Induction by Distinct Mycobacterium tuberculosis Strains Despite Similar Access to the Host Cytosol
Chien-Hsiung Yu,
University of Queensland Diamantina Institute, Australia
RP105 Dependent Activation of PI3Kdelta Promotes Cytokine Trafficking in Mycobacteria-Infected Macrophages
RP105 Dependent Activation of PI3Kdelta Promotes Cytokine Trafficking in Mycobacteria-Infected Macrophages
14:30—16:30
Workshop 2: Biomarkers and Mechanisms of Disease
*
Raphaela Theresia Goldbach-Mansky,
NIAID, National Institutes of Health, USA
Nagaraj Kerur,
University of Kentucky, USA
Innate Immune Mechanisms of Alu RNA-Induced Age-Related Macular Degeneration
Innate Immune Mechanisms of Alu RNA-Induced Age-Related Macular Degeneration
Siobhán A-L Smith,
Royal College of Surgeons in Ireland, Ireland
Altered miRNA Expression in Monocytes Contributes to Dysregulated IL-16 Levels in SLE
Altered miRNA Expression in Monocytes Contributes to Dysregulated IL-16 Levels in SLE
Marcel F. Nold,
Monash University, Australia
Serum Interleukin 38 Is Associated with Disease Severity and Organ Involvement in Systemic Lupus Erythematosus
Serum Interleukin 38 Is Associated with Disease Severity and Organ Involvement in Systemic Lupus Erythematosus
Romain F. Banchereau,
Baylor Institute for Immunology Research, USA
Longitudinal Immunoprofiling of SLE Patients Identifies Transcriptional Biomarkers of Disease Activity and Response to Treatment
Longitudinal Immunoprofiling of SLE Patients Identifies Transcriptional Biomarkers of Disease Activity and Response to Treatment
Nelson Gekara,
Umeå University, Sweden
DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity
DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity
Nadia Jeremiah,
Institute Imagine, France
An IntereSTING Germline Mutation Underlying a Familial Inflammatory Syndrome with Lupus-Like Manifestations
An IntereSTING Germline Mutation Underlying a Familial Inflammatory Syndrome with Lupus-Like Manifestations
Dong-Ming Su,
University of North Texas Health Science Center, USA
Thymic Involution Perturbs Negative Selection Leading to Increased Release of Self-Reactive T Cells that Induce Chronic Inflammation in the Elderly
Thymic Involution Perturbs Negative Selection Leading to Increased Release of Self-Reactive T Cells that Induce Chronic Inflammation in the Elderly
Hye-Lin Ha,
NIAID, National Institutes of Health, USA
IL-17 Drives Psoriatic Inflammation via Distinct, Target Cell-Specific Mechanisms
IL-17 Drives Psoriatic Inflammation via Distinct, Target Cell-Specific Mechanisms
17:00—19:00
Innate Regulation of Adaptive Immunity
*
Cathryn R. Nagler,
University of Chicago, USA
Foo Y. Liew,
University of Glasgow, UK
The Role of Cytokines in Infection and Inflammation
The Role of Cytokines in Infection and Inflammation
Alan Sher,
NIAID, National Institutes of Health, USA
Cytokine and Lipid Mediator Cross-Talk in the Innate Immune Response to Mycobacterium tuberculosis
Cytokine and Lipid Mediator Cross-Talk in the Innate Immune Response to Mycobacterium tuberculosis
Marco Colonna,
Washington University School of Medicine, USA
Innate Lymphoid Cells in Immunity
Innate Lymphoid Cells in Immunity
Jesse C. Nussbaum,
University of California, San Francisco, USA
Short Talk: Group 2 Innate Lymphocytes Are Early Effectors that Cooperate with Adaptive Immunity after Helminth Infection
Short Talk: Group 2 Innate Lymphocytes Are Early Effectors that Cooperate with Adaptive Immunity after Helminth Infection
Andrea Ablasser,
Ecole Polytechnique Fédérale de Lausanne, Switzerland
Short Talk:
Short Talk:
17:00—19:15
Sterile Nucleic Acid Sensing and Disease
*
Mark S. Anderson,
University of California, San Francisco, USA
Yanick Crow,
University of Edinburgh, UK
Human Type I Interferonopathies
Human Type I Interferonopathies
Gregory M. Barton,
University of California, Berkeley, USA
Regulation of Toll-Like Receptors
Regulation of Toll-Like Receptors
Glen N. Barber,
University of Miami, USA
STING and Sterile Inflammation
STING and Sterile Inflammation
Matthew G. Blango,
University of Utah, USA
Short Talk: Identification of Hyper-Edited, Immune-Relevant RNA in Activated Macrophages
Short Talk: Identification of Hyper-Edited, Immune-Relevant RNA in Activated Macrophages
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Systems Biology/Immunomics of Innate Immunity
*
Yasmine Belkaid,
NIAID, National Institutes of Health, USA
Alan Aderem,
Center for Infectious Disease Research, USA
A Systems Approach to Dissecting Immunity
A Systems Approach to Dissecting Immunity
Ronald N. Germain,
NIAID, National Institutes of Health, USA
Single Cell and Systems Level Analysis and Modeling of Innate Immunity
Single Cell and Systems Level Analysis and Modeling of Innate Immunity
Iain D.C. Fraser,
NIAID, National Institutes of Health, USA
Interrogating Immune Signaling Systems with High-Throughput, High-Content Screening
Interrogating Immune Signaling Systems with High-Throughput, High-Content Screening
Tsan Sam Xiao,
Case Western Reserve University, USA
Short Talk: Structure and Regulation of IFI16
Short Talk: Structure and Regulation of IFI16
Roi Avraham,
Broad Institute, USA
Short Talk: Single Cell Expression Analysis Reveals Co-Variation of Bacterial and Host Factors that Control Infection Outcome
Short Talk: Single Cell Expression Analysis Reveals Co-Variation of Bacterial and Host Factors that Control Infection Outcome
Johan Van Weyenbergh,
KU Leuven, Belgium
Short Talk: Systemic and in situ Transcriptomics Reveal an Innate/Type I IFN Link between Oxidative Burst, Cell Death and Inflammation in Human Cutaneous Leishmaniasis
Short Talk: Systemic and in situ Transcriptomics Reveal an Innate/Type I IFN Link between Oxidative Burst, Cell Death and Inflammation in Human Cutaneous Leishmaniasis
08:00—11:00
Novel Players in the Control of Inflammation
*
Daniel Kastner,
National Institutes of Health, USA
Luke A. J. O'Neill,
Trinity Biomedical Sciences Institute, Ireland
Metabolic Control of Inflammtion
Metabolic Control of Inflammtion
Michael L. Stitzel,
The Jackson Laboratory for Genomic Medicine, USA
Enhancers and Type II Diabetes
Enhancers and Type II Diabetes
Thirumala-Devi Kanneganti,
St. Jude Children's Research Hospital, USA
Regulators of Inflammatory Responses
Regulators of Inflammatory Responses
Benjamin Fowler,
University of Kentucky, USA
Short Talk: Nucleoside Reverse Transcriptase Inhibitors Possess Intrinsic Anti-Inflammatory Activity
Short Talk: Nucleoside Reverse Transcriptase Inhibitors Possess Intrinsic Anti-Inflammatory Activity
14:30—16:30
Workshop 3: Effector Function
*
Laurel L. Lenz,
University of Colorado, USA
Jon A. Hagar,
University of North Carolina at Chapel Hill, USA
Endotoxin Signaling Potentiates Insulin-Induced Acute Hypoglycemia
Endotoxin Signaling Potentiates Insulin-Induced Acute Hypoglycemia
Damien Arnoult,
Hopital Paul Brousse, France
Endomembranes Act as Platforms for Ubiquitylated Components of NF-kappaB and IRF3 Signaling
Endomembranes Act as Platforms for Ubiquitylated Components of NF-kappaB and IRF3 Signaling
Marina Zaitseva,
Center for Biologics Evaluation and Research, USA
Critical Role of GPR14 Receptor in Prostaglandin Production by Human Monocytes in Response to MDP
Critical Role of GPR14 Receptor in Prostaglandin Production by Human Monocytes in Response to MDP
Sarah E. Clark,
University of Colorado, USA
Regulation of Natural Killer Cell IL-10 Production during Listeria Infection
Regulation of Natural Killer Cell IL-10 Production during Listeria Infection
Mathias S. Dick,
University of Basel, Switzerland
Oligomerization of ASC Serves as Signal Amplification Mechanism for Inflammasomes
Oligomerization of ASC Serves as Signal Amplification Mechanism for Inflammasomes
Naohiro Inohara,
University of Michigan Medical School, USA
Interleukin-22 Bridges Local Inflammation to Systemic Protection Against Pathobionts after Pathogen-Induced Intestinal Damage
Interleukin-22 Bridges Local Inflammation to Systemic Protection Against Pathobionts after Pathogen-Induced Intestinal Damage
Marijke Keestra-Gounder,
University of Colorado Denver, USA
The ER Stress-Induced Pro-Inflammatory Response Is Mediated by the NOD1/NOD2 Signaling Pathway
The ER Stress-Induced Pro-Inflammatory Response Is Mediated by the NOD1/NOD2 Signaling Pathway
Shie-Liang Hsieh,
Academia Sinica, Taiwan
Modulation of Influenza Virus-Induced Macrophage Activation by Decoy Receptor 3 (DcR3)
Modulation of Influenza Virus-Induced Macrophage Activation by Decoy Receptor 3 (DcR3)
14:30—16:30
Workshop 3
*
Yanick Crow,
University of Edinburgh, UK
Sarah L. Doyle,
Trinity College Dublin, Ireland
IL-18 Immunotherapy for Neovascular AMD; Tolerability and Efficacy in Non-Human Primates
IL-18 Immunotherapy for Neovascular AMD; Tolerability and Efficacy in Non-Human Primates
Kate Schroder,
University of Queensland, Australia
Neutrophil Inflammasomes Selectively Drive IL-1beta Maturation but not Cell Death
Neutrophil Inflammasomes Selectively Drive IL-1beta Maturation but not Cell Death
Eric P. Hanson,
National Institutes of Health, USA
Recruitment of A20 by the C-Terminal Ubiquitin-Binding Domain of NEMO Prevents Severe Inflammatory Disease in Humans
Recruitment of A20 by the C-Terminal Ubiquitin-Binding Domain of NEMO Prevents Severe Inflammatory Disease in Humans
Peter R. Bunyard,
Redx Pharma, UK
Genetic Deletion of GPR18 Enhances Immune Responses to Pathogenic and Antigenic Challenge
Genetic Deletion of GPR18 Enhances Immune Responses to Pathogenic and Antigenic Challenge
Todd Douglas,
McGill University, Canada
Inflammatory Caspases in the Pathogenesis of Chronic Proliferative Dermatitis in Mice
Inflammatory Caspases in the Pathogenesis of Chronic Proliferative Dermatitis in Mice
Kiyoshi Hirahara,
Graduate School of Medicine, Chiba University, Japan
Asymmetry of STAT Action in Driving IL-27 and IL-6 Transcriptional Outputs and Cytokine Specificity
Asymmetry of STAT Action in Driving IL-27 and IL-6 Transcriptional Outputs and Cytokine Specificity
Alma-Martina Cepika,
Stanford School of Medicine, USA
A Blood Stimulation Assay Identifies Monocyte Hyperresponsiveness to Pro-Inflammatory Stimuli in Systemic-Onset Juvenile Idiopathic Arthritis
A Blood Stimulation Assay Identifies Monocyte Hyperresponsiveness to Pro-Inflammatory Stimuli in Systemic-Onset Juvenile Idiopathic Arthritis
Irina Alexandra Leaf,
Biogen, USA
Pericyte MyD88 Controls Inflammatory and Fibrotic Responses to Tissue Injury
Pericyte MyD88 Controls Inflammatory and Fibrotic Responses to Tissue Injury
17:00—19:00
Microbiome and Innate Immunity
*
Alan Aderem,
Center for Infectious Disease Research, USA
Cathryn R. Nagler,
University of Chicago, USA
Innate Immune Regulation of Sensitization to Dietary Antigens by Commensal Bacteria
Innate Immune Regulation of Sensitization to Dietary Antigens by Commensal Bacteria
Yasmine Belkaid,
NIAID, National Institutes of Health, USA
T Cell Commensals
T Cell Commensals
Sarkis K. Mazmanian,
California Institute of Technology, USA
The Gut Microbiome Signals through Genetic Pathways Linked to IBD
The Gut Microbiome Signals through Genetic Pathways Linked to IBD
Richard I. Tapping,
University of Illinois, USA
Short Talk: Toll-Like Receptor 10 Is a B-Cell Intrinsic Suppressor of Adaptive Humoral Immune Responses
Short Talk: Toll-Like Receptor 10 Is a B-Cell Intrinsic Suppressor of Adaptive Humoral Immune Responses
17:00—19:00
Epigenetic Control of Inflammation
Howard Y. Chang,
Stanford University, USA
LncRNAs and Inflammation
LncRNAs and Inflammation
Alexander Tarakhovsky,
Rockefeller University, USA
Epigenetic Control of Inflammatory Cascades
Epigenetic Control of Inflammatory Cascades
John J. O'Shea,
NIAMS, National Institutes of Health, USA
Epigenetic Control of T Cell Fate
Epigenetic Control of T Cell Fate
Chrysothemis Brown,
Sloan Kettering Institute, USA
Short Talk: Epigenetic Regulation of Th1 Plasticity by Retinoic Acid: A New Paradigm for the Ontogeny of Pathogenic Th17 Cells
Short Talk: Epigenetic Regulation of Th1 Plasticity by Retinoic Acid: A New Paradigm for the Ontogeny of Pathogenic Th17 Cells
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Intervention/Vaccines
*
Akiko Iwasaki,
HHMI/Yale University School of Medicine, USA
Hana Golding,
US Food and Drug Administration, USA
Impact of Adjuvants on Antibody Repertoires and Affinity Maturation Against Pandemic Influenza Vaccines
Impact of Adjuvants on Antibody Repertoires and Affinity Maturation Against Pandemic Influenza Vaccines
Eva Harris,
Division of Infectious Diseases and Vaccinology, School of Public Health, USA
Antibodies to Dengue Virus Non-Structural Protein 1 Protect Against Endothelial Permeability and Lethal Vascular Leak
Antibodies to Dengue Virus Non-Structural Protein 1 Protect Against Endothelial Permeability and Lethal Vascular Leak
Robert L. Coffman,
Dynavax Technologies, USA
Systems Biology Analysis of the Human Response to Hepatitis B Vaccines Using Alum or CpG Oligonucleotide Adjuvants
Systems Biology Analysis of the Human Response to Hepatitis B Vaccines Using Alum or CpG Oligonucleotide Adjuvants
John D. MacMicking,
Yale University, USA
Discovery of IFN-Induced GBPs in Inflammasome-Mediated Host Defense
Discovery of IFN-Induced GBPs in Inflammasome-Mediated Host Defense
Margherita Coccia,
GlaxoSmithKline Vaccines, Belgium
Short Talk: Innate Immune Mechanisms and Early NK Cell Activation as a Result of MPL and QS-21 Combination Controls the Adjuvant Effect Induced by the Human Adjuvant System AS01
Short Talk: Innate Immune Mechanisms and Early NK Cell Activation as a Result of MPL and QS-21 Combination Controls the Adjuvant Effect Induced by the Human Adjuvant System AS01
Ugo D'Oro,
GlaxoSmithKline Vaccines, Italy
Short Talk: The Novel Adjuvant Alum-TLR7 Is Able to Potentiate the Immune Response to Glycoconjugate Vaccines
Short Talk: The Novel Adjuvant Alum-TLR7 Is Able to Potentiate the Immune Response to Glycoconjugate Vaccines
08:00—11:15
Therapeutic Interventions in Autoinflammation and Autoimmunity
Raphaela Theresia Goldbach-Mansky,
NIAID, National Institutes of Health, USA
Targeted Therapies in Autoinflammatory Diseases
Targeted Therapies in Autoinflammatory Diseases
*
Jacques F. Banchereau,
The Jackson Laboratory for Genomic Medicine, USA
Differential Activation of Myeloid Cells by Vaccines in Humans
Differential Activation of Myeloid Cells by Vaccines in Humans
Dhavalkumar D. Patel,
UCB S.A., Belgium
IL17 Blockade in Psoriasis and Other Autoimmune Diseases
IL17 Blockade in Psoriasis and Other Autoimmune Diseases
Christoph Klein,
Ludwig-Maximilians-University, Germany
Human Genetic Defects Predisposing to Hyperinflammation in the Intestinal Tract
Human Genetic Defects Predisposing to Hyperinflammation in the Intestinal Tract
Donghai Wang,
Duke University Medical Center, USA
Short Talk: From Cholesterol Biosynthesis to Inflammation Molecular Pathogenesis of Mevalonate Kinase Deficiency
Short Talk: From Cholesterol Biosynthesis to Inflammation Molecular Pathogenesis of Mevalonate Kinase Deficiency
John A. Mo,
AstraZeneca, Sweden
Short Talk: Radical Scavenging Nanoparticles for the Treatment of IBD
Short Talk: Radical Scavenging Nanoparticles for the Treatment of IBD
14:30—16:30
Workshop 4: Systems Biology/Cytokine Pathway
*
Sarkis K. Mazmanian,
California Institute of Technology, USA
Manuella Bouttier,
McGill University, Canada
Genomics Analysis Reveals Elevated LXRalpha Signaling Reduces M. tuberculosis Viability
Genomics Analysis Reveals Elevated LXRalpha Signaling Reduces M. tuberculosis Viability
Irina Tikhanovich,
University of Kansas Medical Center, USA
Dynamic Arginine Methylation of TRAF6 Regulates TLR Signaling
Dynamic Arginine Methylation of TRAF6 Regulates TLR Signaling
Sakthimala Jagadeesan,
MGH/Harvard Medical School, USA
Genome-Wide Screen Identifies Genes Involved in Gut Immunity and Homeostasis in C. elegans
Genome-Wide Screen Identifies Genes Involved in Gut Immunity and Homeostasis in C. elegans
Anneliese O. Speak,
Wellcome Trust Sanger Institute, UK
High-Throughput Mutant Mouse Characterization Is a Powerful Tool to Identify Novel Immune Phenotypes
High-Throughput Mutant Mouse Characterization Is a Powerful Tool to Identify Novel Immune Phenotypes
Jacob S. Yount,
Ohio State University, USA
Chemoproteomics Reveals Toll-Like Receptor Fatty Acylation
Chemoproteomics Reveals Toll-Like Receptor Fatty Acylation
Petr Broz,
University of Lausanne, Switzerland
GBPs Promote AIM2 Inflammasome Activation during Francisella Infection by Inducing Cytosolic Bacteriolysis and DNA Release
GBPs Promote AIM2 Inflammasome Activation during Francisella Infection by Inducing Cytosolic Bacteriolysis and DNA Release
Claudia A. Nold-Petry,
MIMR-PHI Institute of Medical Research, Australia
IL-37 Requires the Receptors IL-18Ralpha and IL-1R8 (SIGIRR) to Carry out its Multi-Faceted Anti-Inflammatory Program on Innate Signal Transduction
IL-37 Requires the Receptors IL-18Ralpha and IL-1R8 (SIGIRR) to Carry out its Multi-Faceted Anti-Inflammatory Program on Innate Signal Transduction
Helene Minyi Liu,
National Taiwan University, Taiwan
Deacetylation-Dependent Regulation of RIG-I Activation by the HDAc6 Deacetylase Mediates Innate Anti-Viral Immunity
Deacetylation-Dependent Regulation of RIG-I Activation by the HDAc6 Deacetylase Mediates Innate Anti-Viral Immunity
14:30—16:30
Workshop 4: Novel Therapies for Inflammatory Diseases
*
Christoph Klein,
Ludwig-Maximilians-University, Germany
James S. Rush,
Novartis Pharma AG, Switzerland
A Novel, Blocking, Fc-Silent Anti-CD40 Monoclonal Antibody Prolongs Non-Human Primate Renal Allograft Survival in the Absence of B Cell Depletion
A Novel, Blocking, Fc-Silent Anti-CD40 Monoclonal Antibody Prolongs Non-Human Primate Renal Allograft Survival in the Absence of B Cell Depletion
Gerard M. McGeehan,
Syndax Pharmaceuticals, USA
The RORgammat Blocker, VTP-43742, Suppresses Th17 Activity Providing Greater Benefit than IL-17A Blockade in an EAE Model of Autoimmunity
The RORgammat Blocker, VTP-43742, Suppresses Th17 Activity Providing Greater Benefit than IL-17A Blockade in an EAE Model of Autoimmunity
Xiaoyi Yuan,
Baylor College of Medicine, USA
Complement C1q Regulates Inflammatory Responses in Cigarette Smoke-Induced Emphysema
Complement C1q Regulates Inflammatory Responses in Cigarette Smoke-Induced Emphysema
Holly Legault,
Biogen Idec, USA
Characterization of Novel IRAK4 Small Molecule Inhibitors
Characterization of Novel IRAK4 Small Molecule Inhibitors
Elizabeth K. Brint,
University College Cork, Ireland
An Anti-Tumorigenic Role for the IL-33/ST2 Axis in Colon Cancer
An Anti-Tumorigenic Role for the IL-33/ST2 Axis in Colon Cancer
Sanja Arandjelovic,
University of Virginia, USA
Engulfment Protein ELMO1 as a Novel Regulator of Rheumatoid Arthritis
Engulfment Protein ELMO1 as a Novel Regulator of Rheumatoid Arthritis
Lucile E. Wrenshall,
Wright State University, USA
Dimeric IL-2 Induces Necrosis of Interleukin-2 Receptor Positive Cells
Dimeric IL-2 Induces Necrosis of Interleukin-2 Receptor Positive Cells
Johanna Hol,
Oslo University Hospital, Rikshospitalet, Norway
Inhibition of Endothelial Notch Signaling Attenuates Inflammation
Inhibition of Endothelial Notch Signaling Attenuates Inflammation
17:00—18:45
Targets for Immunotherapy (Joint)
*
Hana Golding,
US Food and Drug Administration, USA
Thomas A. Waldmann,
National Institutes of Health, USA
IL-15 in the Life and Death of Lymphocytes—Implications for Immunotherapy of Cancer and Autoimmune Disease
IL-15 in the Life and Death of Lymphocytes—Implications for Immunotherapy of Cancer and Autoimmune Disease
Maria Grazia Roncarolo,
Stanford University School of Medicine, USA
Tr1 Cells in Inflammatory Diseases
Tr1 Cells in Inflammatory Diseases
Akiko Iwasaki,
HHMI/Yale University School of Medicine, USA
Innate Defense Against Influenza Virus Infection
Innate Defense Against Influenza Virus Infection
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Jenny P.Y. Ting,
University of North Carolina at Chapel Hill, USA
Closing Remarks
Closing Remarks
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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