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This meeting took place in 2015
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T Cells: Regulation and Effector Function (D3)
Organizer(s) Alexander Y. Rudensky, Dan R. Littman and Kristin A. Hogquist
March 29—April 3, 2015
Snowbird Resort • Snowbird, UT USA
Discounted Abstract Deadline: Dec 2, 2014
Abstract Deadline: Jan 7, 2015
Scholarship Deadline: Dec 2, 2014
Discounted Registration Deadline: Jan 28, 2015
Sponsored by Arena Pharmaceuticals, Inc., BioLegend, Inc., Pfizer Inc., Regeneron Pharmaceuticals, Inc., Roche and Takeda Pharmaceutical Company Limited. Supported by an educational donation provided by Amgen.
Summary of Meeting:
T lymphocytes play a pivotal role in the immune system of vertebrate animals as a key regulatory and effector cell type. Recently, a remarkable progress has been made in the understanding of molecular and cellular mechanisms of differentiation and activation of T lymphocytes and in the elucidation of diverse functional T cell subsets and their biological roles in a variety of physiological and pathological settings. This meeting will bring together leading investigators from the academia and industry studying diverse aspects of T cell biology. The overarching goal of this broadly themed meeting is to facilitate development of a synthetic view of increasingly complex mechanisms of T cell differentiation and function and of interactions between diverse types of T lymphocytes and other cells of the immune system in health and disease. By attracting a diverse array of scientists and students this integrative meeting will cover a wide array of topics and stimulate discussions and interactions, and foster collaborations.
View Scholarships/Awards
T lymphocytes play a pivotal role in the immune system of vertebrate animals as a key regulatory and effector cell type. Recently, a remarkable progress has been made in the understanding of molecular and cellular mechanisms of differentiation and activation of T lymphocytes and in the elucidation of diverse functional T cell subsets and their biological roles in a variety of physiological and pathological settings. This meeting will bring together leading investigators from the academia and industry studying diverse aspects of T cell biology. The overarching goal of this broadly themed meeting is to facilitate development of a synthetic view of increasingly complex mechanisms of T cell differentiation and function and of interactions between diverse types of T lymphocytes and other cells of the immune system in health and disease. By attracting a diverse array of scientists and students this integrative meeting will cover a wide array of topics and stimulate discussions and interactions, and foster collaborations.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, MARCH 29
MONDAY, MARCH 30
TUESDAY, MARCH 31
WEDNESDAY, APRIL 1
THURSDAY, APRIL 2
FRIDAY, APRIL 3
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, MARCH 29
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Keynote Address
Wendell A. Lim,
University of California, San Francisco, USA
The Molecular Logic of Cellular Signaling Systems
The Molecular Logic of Cellular Signaling Systems
09:00—12:00
T Cell Development
Thomas Boehm,
Max Planck Institute of Immunobiology and Epigenetics, Germany
Evolutionary Origins of T Lymphocyte Lineages
Evolutionary Origins of T Lymphocyte Lineages
*
Kristin A. Hogquist,
University of Minnesota, USA
T Cell Adolescence
T Cell Adolescence
Avinash S. Bhandoola,
HHS/National Institutes of Health, USA
Transcription Factor T Cell Factor 1 in Adaptive and Innate Lymphoid Cell Development
Transcription Factor T Cell Factor 1 in Adaptive and Innate Lymphoid Cell Development
Ichiro Taniuchi,
RIKEN Center for Integrative Medical Sciences, Japan
Transcriptional Regulation of T Cell Development in the Thymus
Transcriptional Regulation of T Cell Development in the Thymus
Virginia S. Shapiro,
Mayo Graduate School College of Medicine, USA
Short Talk: Immature Recent Thymic Emigrants Are Eliminated by Complement
Short Talk: Immature Recent Thymic Emigrants Are Eliminated by Complement
14:30—16:30
Workshop 1
*
Susan R. Schwab,
New York University School of Medicine, USA
*
Grégoire Altan-Bonnet,
NCI, National Institutes of Health, USA
Brenda Y. Han,
University of California, San Francisco, USA
Zinc Finger Protein Zfp335 Is Required for the Formation of the Naïve T Cell Compartment
Zinc Finger Protein Zfp335 Is Required for the Formation of the Naïve T Cell Compartment
Hiroyuki Takaba,
University of Tokyo, Japan
Identification of a Novel Autoimmune Regulator of Immune Tolerance
Identification of a Novel Autoimmune Regulator of Immune Tolerance
Michal Polonsky,
Weizmann Institute of Science, Israel
Characterizing the Dynamics of T-Helper Cell Differentiation Using Live Cell Imaging Analysis of Small Cell Numbers
Characterizing the Dynamics of T-Helper Cell Differentiation Using Live Cell Imaging Analysis of Small Cell Numbers
Julia M. Marchingo,
Walter and Eliza Hall Institute of Medical Research, Australia
Predicting T Cell Expansion from Quantitative Principles
Predicting T Cell Expansion from Quantitative Principles
Enfu Hui,
University of California, San Francisco, USA
Dissecting the Molecular Mechanism of PD-1 Signaling Using Reconstitution Approaches
Dissecting the Molecular Mechanism of PD-1 Signaling Using Reconstitution Approaches
Adriana M. Mujal,
University of California, San Francisco, USA
Selective Requirement of the Septin Cytoskeleton Differentiates Cytokine- and Antigen-Driven CD8+ T Cell Proliferation
Selective Requirement of the Septin Cytoskeleton Differentiates Cytokine- and Antigen-Driven CD8+ T Cell Proliferation
Katherine Bao,
Duke University, USA
Basic Leucine Zipper Transcription Factor, ATF-Like (BATF) Is Essential for the Development of Protective Immunity Against Parasitic Helminth Infection
Basic Leucine Zipper Transcription Factor, ATF-Like (BATF) Is Essential for the Development of Protective Immunity Against Parasitic Helminth Infection
17:00—19:15
Innate T Cells
*
Wendy L. Havran,
The Scripps Research Institute, USA
gamma delta T Cells and the Regulation of Immune Responses at Epithelial Surfaces
gamma delta T Cells and the Regulation of Immune Responses at Epithelial Surfaces
Albert S. Bendelac,
University of Chicago, USA
Innate and Innate-Like Lymphocytes
Innate and Innate-Like Lymphocytes
Laurent Gapin,
University of Colorado and National Jewish Medical and Research Center, USA
Specificity and Development of iNKT Cells
Specificity and Development of iNKT Cells
Marc-Werner Dobenecker,
Rockefeller University, USA
Short Talk: Coupling of T Cell Receptor Specificity to Natural Killer T Cell Development by Bivalent Histone H3 Methylation
Short Talk: Coupling of T Cell Receptor Specificity to Natural Killer T Cell Development by Bivalent Histone H3 Methylation
Daniel G. Pellicci,
University of Melbourne, Australia
Short Talk: T Cell Recognition of CD1a Presenting Self-Lipid Antigens
Short Talk: T Cell Recognition of CD1a Presenting Self-Lipid Antigens
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
T Cell Recognition and Activation
*
Pamela L. Schwartzberg,
NIAID, NHGRI, National Institutes of Health, USA
Itk-Mediated Integration of T Helper Cell Differentiation
Itk-Mediated Integration of T Helper Cell Differentiation
Bernard Malissen,
Centre d'Immunologie de Marseille-Luminy, France
Toward an Integrative Biology of T Cells and Dendritic Cells
Toward an Integrative Biology of T Cells and Dendritic Cells
Mark M. Davis,
Stanford University School of Medicine, USA
T Cell Recognition and Human Immunology
T Cell Recognition and Human Immunology
Morgan Huse,
Memorial Sloan Kettering Cancer Center, USA
Short Talk: Lipid-Based Control of T Cell Polarity and Function
Short Talk: Lipid-Based Control of T Cell Polarity and Function
Cheng Zhu,
Georgia Institute of Technology, USA
Short Talk: Cooperative TCR–pMHC–CD8 Bond Lifetime Distinguishes Thymocyte Fate
Short Talk: Cooperative TCR–pMHC–CD8 Bond Lifetime Distinguishes Thymocyte Fate
11:00—12:00
Understanding NIH Peer Review
The objective of this workshop is for grant writers to learn to think like reviewers in order to understand how to write for their target audience. Workshop is presented by David Winter, Scientific Review Officer, NIH
17:00—19:15
T Cells at Mucosal Surfaces
*
Dan R. Littman,
HHMI/New York University School of Medicine, USA
Programming of T Cell Effector Functions by the Intestinal Microbiota
Programming of T Cell Effector Functions by the Intestinal Microbiota
Daniel J. Cua,
Merck Research Laboratories, USA
Inflammatory T Cells
Inflammatory T Cells
Mitchell Kronenberg,
La Jolla Institute for Allergy and Immunology, USA
Genetic Control of NKT Cell Differentiation
Genetic Control of NKT Cell Differentiation
Marion Pepper,
University of Washington, USA
Short Talk: The Differentiation and Function of Allergen-Specific Th2 Memory Cells
Short Talk: The Differentiation and Function of Allergen-Specific Th2 Memory Cells
Darina S. Spasova,
La Jolla Institute for Allergy and Immunology, USA
Short Talk: Systemic Viral Infection Fails to Produce Memory T Cells in the Absence of Commensal Microbiota
Short Talk: Systemic Viral Infection Fails to Produce Memory T Cells in the Absence of Commensal Microbiota
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
T Cell Response to Pathogens
*
E. John Wherry,
University of Pennsylvania, USA
Regulating T Cell Responses during Chronic Infection
Regulating T Cell Responses during Chronic Infection
Marc K. Jenkins,
University of Minnesota Medical School, USA
Mechanisms of Immune Memory by CD4+ T Cells
Mechanisms of Immune Memory by CD4+ T Cells
Federica Sallusto,
Università della Svizzera Italiana & ETH Zurich, Switzerland
The Human T Cell Response to Microbes
The Human T Cell Response to Microbes
Christopher A. Hunter,
University of Pennsylvania, USA
Imaging Treg and Plasma Cell Responses to Infection
Imaging Treg and Plasma Cell Responses to Infection
Tianxia Guan,
Yale University, USA
Short Talk: The Transcription Factors Zeb1 and Zeb2 Reciprocally Regulate Memory and Effector CD8+ T Cell Fates during Viral Infection
Short Talk: The Transcription Factors Zeb1 and Zeb2 Reciprocally Regulate Memory and Effector CD8+ T Cell Fates during Viral Infection
Klaas P.J.M. Van Gisbergen,
Sanquin Research, Netherlands
Short Talk: The Transcriptional Regulator Hobit and its Homologue Blimp-1 Cooperatively Establish Tissue-Residency of Lymphocytes
Short Talk: The Transcriptional Regulator Hobit and its Homologue Blimp-1 Cooperatively Establish Tissue-Residency of Lymphocytes
14:30—16:30
Workshop 2
Andreia Da Costa,
University of Washington, USA
Migratory Treg Balance Is Critical to the Maintenance of CD8+ T Cell Homeostasis and Memory Development in West Nile Virus Infected Mice
Migratory Treg Balance Is Critical to the Maintenance of CD8+ T Cell Homeostasis and Memory Development in West Nile Virus Infected Mice
Brian J. Laidlaw,
University of California, San Francisco, USA
Regulatory CD4+ T Cell Derived IL-10 Critical in Promoting Memory CD8+ T Cell Maturation
Regulatory CD4+ T Cell Derived IL-10 Critical in Promoting Memory CD8+ T Cell Maturation
Jyh Liang Hor,
Peter Doherty Institute, University of Melbourne, Australia
Temporal Regulation of T Cell Priming and Cellular Dynamics during Peripheral Viral Infection
Temporal Regulation of T Cell Priming and Cellular Dynamics during Peripheral Viral Infection
Laura K. Mackay,
University of Melbourne, Australia
Transcriptional Regulation of Tissue-Resident Memory T Cell Development
Transcriptional Regulation of Tissue-Resident Memory T Cell Development
*
Dale I. Godfrey,
University of Melbourne, Australia
Identification of Phenotypically and Functionally Heterogeneous Mouse Mucosal Associated Invariant T Cells Using MR1 Tetramers
Identification of Phenotypically and Functionally Heterogeneous Mouse Mucosal Associated Invariant T Cells Using MR1 Tetramers
*
Olivier Lantz,
Institut Curie, France
Distal TCR Valpha Segment Usage Determines the Abundance of MAIT Cells in Mice: A Functional Characterization of Naturally Occurring MAIT Cells
Distal TCR Valpha Segment Usage Determines the Abundance of MAIT Cells in Mice: A Functional Characterization of Naturally Occurring MAIT Cells
Frederic Van Gool,
University of California, San Francisco, USA
Potential Role of Group-2 Innate Lymphoid Cells in Autoimmunity
Potential Role of Group-2 Innate Lymphoid Cells in Autoimmunity
17:00—19:15
T Cell Differentiation, Metabolism and Effector Function
*
Erika L. Pearce,
Max Planck Institute of Immunobiology and Epigenetics, Germany
Metabolic Regulation of T Cell Function and Fate
Metabolic Regulation of T Cell Function and Fate
Grégoire Altan-Bonnet,
NCI, National Institutes of Health, USA
Collective Synchronization and Tuning of Self/Non-Self Discrimination in T Cell Activation
Collective Synchronization and Tuning of Self/Non-Self Discrimination in T Cell Activation
Stephen C. Jameson,
University of Minnesota Medical School, USA
The Transcription Factor KLF2 Regulates CD4+ T Cell Differentiation
The Transcription Factor KLF2 Regulates CD4+ T Cell Differentiation
Shannon M. Kahan,
University of Alabama at Birmingham, USA
Short Talk: IL-2 Production by Activated Naïve and Effector CD8 T Cells Predicts Memory Formation
Short Talk: IL-2 Production by Activated Naïve and Effector CD8 T Cells Predicts Memory Formation
Laura A. Solt,
The Scripps Research Institute, USA
Short Talk: RORa and RORgt Coordinately Regulate Metabolic Processes Essential for TH17 Cell Development and Function
Short Talk: RORa and RORgt Coordinately Regulate Metabolic Processes Essential for TH17 Cell Development and Function
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
T Cell Trafficking and Cellular Interactions
Ronald N. Germain,
NIAID, National Institutes of Health, USA
Imaging Immunity: Creating a Spatiotemporal Understanding of Host Defense
Imaging Immunity: Creating a Spatiotemporal Understanding of Host Defense
Michael L. Dustin,
University of Oxford, UK
Role of Antigen Stop Signal in T Cell Tolerance and Priming
Role of Antigen Stop Signal in T Cell Tolerance and Priming
*
Ulrich H. Von Andrian,
Harvard Medical School, USA
CX3CR1 Identifies Three Distinct Subsets of Antigen-Experienced CD8+ T Cells
CX3CR1 Identifies Three Distinct Subsets of Antigen-Experienced CD8+ T Cells
Susan R. Schwab,
New York University School of Medicine, USA
Chemokine Receptor Signaling and T Cell Survival
Chemokine Receptor Signaling and T Cell Survival
Brian C. Schaefer,
Uniformed Services University, USA
Short Talk: Regulation of T Cell Receptor Signaling to NF-kappaB by Microtubule Transport of Signalosomes to Aggresomes
Short Talk: Regulation of T Cell Receptor Signaling to NF-kappaB by Microtubule Transport of Signalosomes to Aggresomes
Wolfgang Kastenmüller,
University of Bonn, Germany
Short Talk: Multiple Spatially and Temporally Distinct T Cell-Dendritic Cell Interactions Support Effective Anti-Viral Immunity
Short Talk: Multiple Spatially and Temporally Distinct T Cell-Dendritic Cell Interactions Support Effective Anti-Viral Immunity
14:30—16:30
Workshop 3
*
Akihiko Yoshimura,
Keio University, Japan
Treg Induction Mechanism by Gram-Positive Bacterium Clostridium butyricum in the Intestine
Treg Induction Mechanism by Gram-Positive Bacterium Clostridium butyricum in the Intestine
Abby L. Geis,
Arkansas College of Osteopathic Medicine, USA
A Pro-Inflammatory Response of Mucosal Tregs to Enterotoxigenic Bacteroides fragilis Promotes IL-17-Dependent Colon Neoplasia
A Pro-Inflammatory Response of Mucosal Tregs to Enterotoxigenic Bacteroides fragilis Promotes IL-17-Dependent Colon Neoplasia
Reshma Singh,
Novartis Institutes for BioMedical Research, USA
Trafficking and Function of EGFR Variant III Chimeric Antigen Receptor (CAR) T Cells for Glioblastoma
Trafficking and Function of EGFR Variant III Chimeric Antigen Receptor (CAR) T Cells for Glioblastoma
*
Markus Mohrs,
Regeneron Pharmaceuticals, USA
Virtual Memory CD8 T Cells Expand during Helminth Infection and Confer Protection Against Bacterial Challenge
Virtual Memory CD8 T Cells Expand during Helminth Infection and Confer Protection Against Bacterial Challenge
Edward Y. Kim,
Massachusetts General Hospital, Harvard Medical School, USA
Dynamic Treg Interactions with Intratumoral APCs Promote Local CTL Dysfunction
Dynamic Treg Interactions with Intratumoral APCs Promote Local CTL Dysfunction
Sarah Q. Crome,
University Health Network, Canada
Regulatory Innate Lymphocytes Suppress Anti-Tumor T Cells
Regulatory Innate Lymphocytes Suppress Anti-Tumor T Cells
Lokesh A. Kalekar,
University of Minnesota - Twin Cities, USA
Anergy Induction in Polyclonal CD4 T Cells Prevents Autoimmunity and Generates Inducible Regulatory T Cell (iTreg) Intermediates
Anergy Induction in Polyclonal CD4 T Cells Prevents Autoimmunity and Generates Inducible Regulatory T Cell (iTreg) Intermediates
17:00—19:00
T Cell Regulation and Autoimmunity
Alexander Y. Rudensky,
HHMI/Memorial Sloan Kettering Cancer Center, USA
Differentiation and Function of Regulatory T Cells
Differentiation and Function of Regulatory T Cells
Shimon Sakaguchi,
Osaka University, Japan
Control of Immune Responses by Regulatory T Cells
Control of Immune Responses by Regulatory T Cells
Richard M. Siegel,
NIAMS, National Institutes of Health, USA
Short Talk: Fas/CD95 Promotes T Cell Differentiation and Prevents Autoimmunity Independently of its Ability to Induce Cell Death
Short Talk: Fas/CD95 Promotes T Cell Differentiation and Prevents Autoimmunity Independently of its Ability to Induce Cell Death
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:15—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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