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This meeting took place in 2015
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
The Golden Anniversary of B Cell Discovery (X6)
Organizer(s) Patrick C. Wilson, Michael P. Cancro and Anne Durandy
March 22—27, 2015
Fairmont Banff Springs • Banff, AB Canada
Discounted Abstract Deadline: Nov 19, 2014
Abstract Deadline: Dec 17, 2014
Scholarship Deadline: Nov 19, 2014
Discounted Registration Deadline: Jan 20, 2015
Sponsored by BioLegend, Inc., Genmab A/S and Roche
Joint Meeting:
HIV Vaccines (X5)
Summary of Meeting:
The B cell Keystone Symposia meeting is the premiere venue for B cell biologists and those interested in learning more about B cells. The 2015 meeting is unusually noteworthy, because it marks the golden anniversary of the discovery of B cells by Max Cooper and Robert Good in their classic Nature paper. Accordingly, the meeting will honor the past 50 years of B cell study while focusing on the most up-to-date advances in B cell biology and antibody-meditated immunity. Each topical session will begin with a commentary on the history of the area, followed by presentations on the most current advances. Particular emphasis will be placed on B cell immunopoiesis in germinal centers, on the interaction of B cells with follicular-helper T cells, on antibody-mediated immunity to HIV and influenza, and on plasma and memory B cell biology. The goal is to showcase the latest breakthroughs in B cell biology, antibody technologies and the potential for B cell/antibody-mediated vaccine development. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent Keystone Symposia meeting on "HIV Vaccines," which will share a keynote address and three plenary sessions with this meeting.
View Scholarships/Awards
The B cell Keystone Symposia meeting is the premiere venue for B cell biologists and those interested in learning more about B cells. The 2015 meeting is unusually noteworthy, because it marks the golden anniversary of the discovery of B cells by Max Cooper and Robert Good in their classic Nature paper. Accordingly, the meeting will honor the past 50 years of B cell study while focusing on the most up-to-date advances in B cell biology and antibody-meditated immunity. Each topical session will begin with a commentary on the history of the area, followed by presentations on the most current advances. Particular emphasis will be placed on B cell immunopoiesis in germinal centers, on the interaction of B cells with follicular-helper T cells, on antibody-mediated immunity to HIV and influenza, and on plasma and memory B cell biology. The goal is to showcase the latest breakthroughs in B cell biology, antibody technologies and the potential for B cell/antibody-mediated vaccine development. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent Keystone Symposia meeting on "HIV Vaccines," which will share a keynote address and three plenary sessions with this meeting.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, MARCH 22
MONDAY, MARCH 23
TUESDAY, MARCH 24
WEDNESDAY, MARCH 25
THURSDAY, MARCH 26
FRIDAY, MARCH 27
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, MARCH 22
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:30
Keynote Session (Joint)
*
Patrick C. Wilson,
University of Chicago, USA
*
Giuseppe Pantaleo,
Centre Hospitalier Universitaire Vaudois, Switzerland
Max D. Cooper,
Emory University, USA
Comparative Analysis of Alternative Adaptive Immune Systems
Comparative Analysis of Alternative Adaptive Immune Systems
Anthony S. Fauci,
NIAID, National Institutes of Health, USA
Toward an HIV Vaccine: A Scientific Journey
Toward an HIV Vaccine: A Scientific Journey
09:50—11:45
Antibody Therapy (Joint)
Jeffrey V. Ravetch,
Rockefeller University, USA
Fc Effector Functions
Fc Effector Functions
Gary J. Nabel,
Sanofi, USA
The Challenges and Promise of Broadly Neutralizing Abs for HIV Prevention and Treatment
The Challenges and Promise of Broadly Neutralizing Abs for HIV Prevention and Treatment
Michel C. Nussenzweig,
HHMI/Rockefeller University, USA
Passive Immunization
Passive Immunization
14:30—16:30
Workshop 1: B1 Cell Biology
*
Thomas L. Rothstein,
Western Michigan University, USA
*
Gregg J. Silverman,
New York University Langone Medical Center, USA
Cecilia B. Cavazzoni,
Federal University of Rio de Janeiro, Brazil
Characterization of the Repertoire of Natural Antibodies Anti-HSC70
Characterization of the Repertoire of Natural Antibodies Anti-HSC70
Gudrun F. Debes,
Thomas Jefferson University, USA
IL-10 Producing Innate-Like B Cells Are Part of the Skin Immune System and Require alpha4-beta1 Integrin to Migrate between the Peritoneum and Inflamed Skin
IL-10 Producing Innate-Like B Cells Are Part of the Skin Immune System and Require alpha4-beta1 Integrin to Migrate between the Peritoneum and Inflamed Skin
Stephanie Glaesener,
Hannover Medical School, Germany
Pneumovax23© Directly Stimulates B Cells in vivo Generating a Predominant IgA Response Early after Vaccination
Pneumovax23© Directly Stimulates B Cells in vivo Generating a Predominant IgA Response Early after Vaccination
Benchang Guo,
Feinstein Institute for Medical Research, USA
RasGRP1 Shapes Autoreactive Receptor Repertoire in B1a Cells which Prevents Autoimmune Disease
RasGRP1 Shapes Autoreactive Receptor Repertoire in B1a Cells which Prevents Autoimmune Disease
Matthias Hahn,
University Medical Center Mainz, Germany
Over-Expression of an Alternative Splice Variant of the Negative NF-kappaB Regulator CYLD Leads to the Development of B-CLL in Mice
Over-Expression of an Alternative Splice Variant of the Negative NF-kappaB Regulator CYLD Leads to the Development of B-CLL in Mice
Nichol E. Holodick,
WMU Medical School, USA
Age-Related Decline in Natural IgM Function: Diversification and Selection of the B-1a Cell Pool with Age
Age-Related Decline in Natural IgM Function: Diversification and Selection of the B-1a Cell Pool with Age
Rudolf Übelhart,
National Center for Tumor Diseases, Germany
Structural Differences between IgD and IgM Control B Cell Responsiveness and the Activation of Innate-Like B1 Cells
Structural Differences between IgD and IgM Control B Cell Responsiveness and the Activation of Innate-Like B1 Cells
Andre M. Vale,
Universidade Federal do Rio de Janeiro, Brazil
Maintenance of B Cells with Hydrophobic CDR-H3 Intervals within the Peritoneal Cavity
Maintenance of B Cells with Hydrophobic CDR-H3 Intervals within the Peritoneal Cavity
14:30—16:30
Workshop 1: Envelope Structure and Immunogen Design Efforts
*
Leonidas Stamatatos,
Fred Hutchinson Cancer Research Center, USA
*
John P. Moore,
Weill Medical College of Cornell University, USA
Production and Properties of Multiple Native-Like SOSIP.664 Trimers
Production and Properties of Multiple Native-Like SOSIP.664 Trimers
Gabriel Ozorowski,
The Scripps Research Institute, USA
Characterization and Design of HIV-1 Env SOSIP gp140 Trimers
Characterization and Design of HIV-1 Env SOSIP gp140 Trimers
Jose Maximiliano Medina-Ramírez,
University of Amsterdam, Netherlands
A Native-Like HIV-1 Envelope Trimer that Engages Multiple Germline Precursors of Broadly Neutralizing Antibodies
A Native-Like HIV-1 Envelope Trimer that Engages Multiple Germline Precursors of Broadly Neutralizing Antibodies
Guillaume B.E. Stewart-Jones,
National Institutes of Health, USA
Crystal Structures of Glycosylated JR-FL and BG505 SOSIP Trimers at 3.7Å Resolution Reveal how N-Linked Glycosylation Shield the Glycan Free CD4 Binding Site
Crystal Structures of Glycosylated JR-FL and BG505 SOSIP Trimers at 3.7Å Resolution Reveal how N-Linked Glycosylation Shield the Glycan Free CD4 Binding Site
M. Gordon Joyce,
US Military HIV Research Program, USA
Designed HIV-1 Env Molecules from Multiple Clades that Display Structural and Antigenic Characteristics of the Mature Prefusion HIV-1 Env
Designed HIV-1 Env Molecules from Multiple Clades that Display Structural and Antigenic Characteristics of the Mature Prefusion HIV-1 Env
Javier Guenaga,
IAVI Neutralizing Antibody Center at TSRI, USA
Structure-Guided Identification of gp120 Residues that Increase the Propensity of Env Sequences to Form Native-Like Soluble Trimers
Structure-Guided Identification of gp120 Residues that Increase the Propensity of Env Sequences to Form Native-Like Soluble Trimers
Richard T. Wyatt,
IAVI Neutralizing Antibody Center, The Scripps Research Institute, USA
Identification of New HR1 Proline Substitutions that Stabilize the Cleavage-Independent, Well-Ordered, Native Flexibly Linked (NFL) Trimers
Identification of New HR1 Proline Substitutions that Stabilize the Cleavage-Independent, Well-Ordered, Native Flexibly Linked (NFL) Trimers
Wei Cheng,
University of Michigan, USA
Optical Trapping Virometry Reveals the Positive Cooperativity of HIV-1 Envelope Glycoproteins in Mediating Viral Infection
Optical Trapping Virometry Reveals the Positive Cooperativity of HIV-1 Envelope Glycoproteins in Mediating Viral Infection
14:30—16:30
Workshop 2: B Cell Selection and Tolerance
*
Eric Meffre,
Yale University School of Medicine, USA
*
David J. Rawlings,
University of Washington, Seattle Children's Hospital Research Institute, USA
Lars Nitschke,
University of Erlangen, Germany
Siglec-G: A B Cell Inhibitory Receptor Controlling Autoimmunity
Siglec-G: A B Cell Inhibitory Receptor Controlling Autoimmunity
Martin S. Naradikian,
University of Pennsylvania, USA
IL-4 and IL-21 Reciprocally Regulate T-BET Expression in Activated B Cells
IL-4 and IL-21 Reciprocally Regulate T-BET Expression in Activated B Cells
Jean-Nicolas Schickel,
Adimab, LLC, USA
AID Expression in Human B Cell Precursors Is Essential for Central B-Cell Tolerance
AID Expression in Human B Cell Precursors Is Essential for Central B-Cell Tolerance
Masayuki Kuraoka,
Duke University, USA
BCR and TLR Synergy Elicits High Levels of AID Expression in Immature/T1 B Cells to Ensure Central B-Cell Tolerance
BCR and TLR Synergy Elicits High Levels of AID Expression in Immature/T1 B Cells to Ensure Central B-Cell Tolerance
Kristin M.S. Schroeder,
National Jewish Health, USA
B Cell Tolerance Mechanisms Limit Protective HIV Antibody Responses
B Cell Tolerance Mechanisms Limit Protective HIV Antibody Responses
Thomas Hägglöf,
Karolinska Institutet, Sweden
Neutrophils License NKT Cells to Regulate Self-Reactive B Cell Responses
Neutrophils License NKT Cells to Regulate Self-Reactive B Cell Responses
Christopher M. Tipton,
Emory University, USA
Diversity, Cellular Origin and Autoreactivity of Antibody-Secreting Cell Expansions in Acute Systemic Lupus Erythematosus
Diversity, Cellular Origin and Autoreactivity of Antibody-Secreting Cell Expansions in Acute Systemic Lupus Erythematosus
Aaron J. Marshall,
University of Manitoba, Canada
TAPP Adaptors Control Akt-Dependent Metabolic Activation of B Cells and Suppress Autoimmunity via Binding to the SHIP Product PI(3,4)P2
TAPP Adaptors Control Akt-Dependent Metabolic Activation of B Cells and Suppress Autoimmunity via Binding to the SHIP Product PI(3,4)P2
17:00—19:15
Peripheral B Cell Development and Function
*
Michael P. Cancro,
University of Pennsylvania, USA
New Paths to Peripheral B Cell Tolerance and Differentiation
New Paths to Peripheral B Cell Tolerance and Differentiation
Andrea Cerutti,
Mount Sinai School of Medicine, USA
Marginal Zone B Cells
Marginal Zone B Cells
Stuart G. Tangye,
Garvan Institute of Medical Research, Australia
Molecular Requirements for Productive Humoral Immunity in Humans - The Power of PIDs
Molecular Requirements for Productive Humoral Immunity in Humans - The Power of PIDs
Michael G. McHeyzer-Williams,
The Scripps Research Institute, USA
Molecular Dynamics of Memory B Cell Responses
Molecular Dynamics of Memory B Cell Responses
Claude-Agnès Reynaud,
Necker-Paris Medical School, France
Short Talk: High Throughput Ig Sequencing of Paired Blood and Spleen Samples Allows a Redefinition of IgM Memory Subsets in Humans
Short Talk: High Throughput Ig Sequencing of Paired Blood and Spleen Samples Allows a Redefinition of IgM Memory Subsets in Humans
17:00—19:00
Natural and Vaccine-Induced Development of Antibody Response
*
Susan Zolla-Pazner,
Icahn School of Medicine at Mount Sinai, USA
Antonio Lanzavecchia,
Vir Biotechnology, Inc., USA
Developmental Pathways of Broadly Neutralizing Antibodies
Developmental Pathways of Broadly Neutralizing Antibodies
Pamela J. Bjorkman,
California Institute of Technology, USA
Overcoming HIV-1 Evasion of Antibody Avidity with Intra-Spike Crosslinking Reagents
Overcoming HIV-1 Evasion of Antibody Avidity with Intra-Spike Crosslinking Reagents
Gunilla B. Karlsson Hedestam,
Karolinska Institutet, Sweden
Diversity and Evolution of HIV Env Vaccine-Induced B Cell Responses
Diversity and Evolution of HIV Env Vaccine-Induced B Cell Responses
Todd C. Bradley,
Children's Mercy Kansas City, USA
Short Talk: HIV-1 CD4 Binding Site-Directed Autologous Tier-2 Neutralizing Antibody Lineage Elicited by Immunization with a Swarm of HIV-1 Envs from an African Individual
Short Talk: HIV-1 CD4 Binding Site-Directed Autologous Tier-2 Neutralizing Antibody Lineage Elicited by Immunization with a Swarm of HIV-1 Envs from an African Individual
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
B/T Cell Interactions (Joint)
*
Jason G. Cyster,
HHMI/University of California, San Francisco, USA
B Cell Guidance Cues and the Antibody Response
B Cell Guidance Cues and the Antibody Response
*
Shane Crotty,
La Jolla Institute for Immunology, USA
T Cell Help to B Cells: Follicular Helper CD4 T Cell (Tfh) Biology
T Cell Help to B Cells: Follicular Helper CD4 T Cell (Tfh) Biology
Giuseppe Pantaleo,
Centre Hospitalier Universitaire Vaudois, Switzerland
T Follicular Helper (Tfh) Cells in Health and Chronic HIV Infection
T Follicular Helper (Tfh) Cells in Health and Chronic HIV Infection
Claudia Cicala,
NIAID, National Institutes of Health, USA
Short Talk: Targeting alpha4beta7 Integrin Reduces Mucosal Transmission and Dissemination of SIV
Short Talk: Targeting alpha4beta7 Integrin Reduces Mucosal Transmission and Dissemination of SIV
Gabriel D. Victora,
Rockefeller University, USA
Short Talk: Clonal Dynamics and Evolution in Germinal Centers
Short Talk: Clonal Dynamics and Evolution in Germinal Centers
David J. Rawlings,
University of Washington, Seattle Children's Hospital Research Institute, USA
Short Talk: Distinct Impact of B Cell-Intrinsic Type 1 vs Type 2 Interferon Signals in GC B Cell Tolerance
Short Talk: Distinct Impact of B Cell-Intrinsic Type 1 vs Type 2 Interferon Signals in GC B Cell Tolerance
14:30—16:30
Workshop 3: Vaccines and Immunity
*
Bonnie B. Blomberg,
University of Miami School of Medicine, USA
Paul V. Thomas,
NIAID, National Institutes of Health, USA
Structural Definition of a Novel Set of Converged Broadly Neutralizing Influenza Antibodies Elicited in H5N1 Vaccinees
Structural Definition of a Novel Set of Converged Broadly Neutralizing Influenza Antibodies Elicited in H5N1 Vaccinees
Goetz R. Ehrhardt,
University of Toronto, Canada
Biomarker Discovery on Memory B Cells and Plasma Cells Using Monoclonal VLR Antibodies
Biomarker Discovery on Memory B Cells and Plasma Cells Using Monoclonal VLR Antibodies
Carole Henry,
University of Chicago, USA
Pre-Existing Human Antibodies Neutralize the Novel Influenza H7N9 Strain
Pre-Existing Human Antibodies Neutralize the Novel Influenza H7N9 Strain
Mattias Forsell,
Umeå University, Sweden
Activation of Circulating Platelets Leads to the Release of Potent Antiviral IgG
Activation of Circulating Platelets Leads to the Release of Potent Antiviral IgG
Hana Golding,
US Food and Drug Administration, USA
Exploring Antibody Repertoires and Affinity Maturation Against Pandemic Influenza Vaccines: Impact of Adjuvants and Prime-Boost Approaches
Exploring Antibody Repertoires and Affinity Maturation Against Pandemic Influenza Vaccines: Impact of Adjuvants and Prime-Boost Approaches
Gregory C. Ippolito,
University of Texas at Austin, USA
New Molecular and Proteomic Techniques for the "Deep" Profiling of Vaccine-Elicited Cellular and Serological Antibody Repertoires
New Molecular and Proteomic Techniques for the "Deep" Profiling of Vaccine-Elicited Cellular and Serological Antibody Repertoires
Greg A. Kirchenbaum,
Vaccine and Gene Therapy Institute of Florida, USA
Longitudinal Profiling of Young and Elderly Individuals in Response to Seasonal Influenza Vaccination
Longitudinal Profiling of Young and Elderly Individuals in Response to Seasonal Influenza Vaccination
Ignacio Sanz,
Emory University, School of Medicine, USA
Identification of Long-lived Plasma Cells in Human Bone Marrow
Identification of Long-lived Plasma Cells in Human Bone Marrow
14:30—16:30
Workshop 2: New Immunization Tactics
*
Nicole A. Doria-Rose,
NIAID, National Institutes of Health, USA
*
Gunilla B. Karlsson Hedestam,
Karolinska Institutet, Sweden
Rena D. Astronomo,
Fred Hutchinson Cancer Research Center, USA
Low Concentrations of Broadly-Neutralizing Antibodies (bnAbs) Protect Against Early Events of Mucosal HIV-1 Infection in a Human ex vivo Vaginal Explant Model
Low Concentrations of Broadly-Neutralizing Antibodies (bnAbs) Protect Against Early Events of Mucosal HIV-1 Infection in a Human ex vivo Vaginal Explant Model
Jinghe Huang,
NIAID, National Institutes of Health, USA
Isolation of a Broad and Potent CD4-Binding Site Monoclonal Antibody with Novel Binding Characteristics
Isolation of a Broad and Potent CD4-Binding Site Monoclonal Antibody with Novel Binding Characteristics
Joseph G. Jardine,
The Scripps Research Institute, USA
In vivo Activation of GL-VRC01 Class Antibodies in Transgenic Mice by Germline-Targeted Immunizations
In vivo Activation of GL-VRC01 Class Antibodies in Transgenic Mice by Germline-Targeted Immunizations
Huaxin Liao,
Duke University Medical Center, USA
HIV-1 CH505 Env Immunogens Initiated CD4 Binding Site Antibody Lineage in Rhesus macaques
HIV-1 CH505 Env Immunogens Initiated CD4 Binding Site Antibody Lineage in Rhesus macaques
Aaron Louie,
National Institutes of Health, USA
HIV-Specific Antibodies Derived from Exhausted Memory B Cells of Infected Individuals Show Deficiencies in Neutralization and Somatic Hypermutation
HIV-Specific Antibodies Derived from Exhausted Memory B Cells of Infected Individuals Show Deficiencies in Neutralization and Somatic Hypermutation
Delphine C. Malherbe,
Oregon Health & Science University, USA
Early Breadth Clade C Env Immunogens Elicit Cross-Clade NAbs and Env-Specific Tfh Responses
Early Breadth Clade C Env Immunogens Elicit Cross-Clade NAbs and Env-Specific Tfh Responses
Jose M. Martinez-Navio,
University of Miami - LSTP, USA
Host Anti-Antibody Responses following AAV-Mediated Delivery of Antibodies Against HIV and SIV
Host Anti-Antibody Responses following AAV-Mediated Delivery of Antibodies Against HIV and SIV
Rogier W. Sanders,
University of Amsterdam and Weill Cornell Medical College, Netherlands
HIV Neutralizing Antibodies Induced by Native-Like Envelope Trimers
HIV Neutralizing Antibodies Induced by Native-Like Envelope Trimers
14:30—16:30
Workshop 4: B Cell Development and Signaling
Julia Jellusova,
University of Freiburg, Germany
GSK3 Regulates B Cell Metabolism, Cell Growth and Proliferation
GSK3 Regulates B Cell Metabolism, Cell Growth and Proliferation
Nikita S. Kolhatkar,
University of Washington, USA
The Role of Altered Antigen Receptor Signaling in Wiskott Aldrich Syndrome
The Role of Altered Antigen Receptor Signaling in Wiskott Aldrich Syndrome
Ai Kotani,
Tokai University, Japan
A Single miRNA Substitutes for Requirement of EBF1 in B Lineage Commitment
A Single miRNA Substitutes for Requirement of EBF1 in B Lineage Commitment
Jinmin Lee,
NIAID, National Institutes of Health, USA
Defining the Oligomeric State on B Cell Receptors on the Surfaces of Human Naïve and Memory B Cells Using Super-Resolution Fluorescence Microscopy
Defining the Oligomeric State on B Cell Receptors on the Surfaces of Human Naïve and Memory B Cells Using Super-Resolution Fluorescence Microscopy
Stephen K. H. Li,
Western University, Canada
Identification of a Negative Regulatory Role for the E26 Transformation-Specific Transcription Factor Spi-C in the Murine B Cell Lineage
Identification of a Negative Regulatory Role for the E26 Transformation-Specific Transcription Factor Spi-C in the Murine B Cell Lineage
Hongsheng Wang,
NIAID, National Institutes of Health, USA
An Essential Role of Transcription Factors PU.1 and IRF8 in Follicular B Cell Development and the Germinal Center Response
An Essential Role of Transcription Factors PU.1 and IRF8 in Follicular B Cell Development and the Germinal Center Response
*
Duane R. Wesemann,
Harvard Medical School, USA
Role of Environment in the Shaping of the Primary Immunoglobulin Repertoire
Role of Environment in the Shaping of the Primary Immunoglobulin Repertoire
Maryaline Coffre,
New York University School of Medicine, USA
Dicer-Dependent Non-Coding RNAs Are Essential for B Cell Development and Maturation
Dicer-Dependent Non-Coding RNAs Are Essential for B Cell Development and Maturation
17:00—19:15
Memory and Plasma Cell Differentiation and Fate
*
Andreas Radbruch,
Deutsches Rheuma-Forschungszentrum, Germany
Patrick C. Wilson,
University of Chicago, USA
Immune Memory Shapes B Cell Responses to Influenza
Immune Memory Shapes B Cell Responses to Influenza
David M. Allman,
University of Pennsylvania, USA
Plasma Cell Subpopulations in the Bone Marrow
Plasma Cell Subpopulations in the Bone Marrow
Mark J. Shlomchik,
University of Pittsburgh School of Medicine, USA
Signaling and Selection in GC B Cells
Signaling and Selection in GC B Cells
Kim Good-Jacobson,
Monash University, Australia
Short Talk: c-Myb Establishes a Transcriptional Network in Germinal Center B Cells that Controls T-bet, Class Selection and Long-Term Immunity
Short Talk: c-Myb Establishes a Transcriptional Network in Germinal Center B Cells that Controls T-bet, Class Selection and Long-Term Immunity
17:00—19:00
Predictors of Response to Vaccines
*
Dennis R. Burton,
The Scripps Research Institute, USA
Rafick Sekaly,
Emory University, USA
Genetic and Epigenetic Determinants of Vaccine Responses
Genetic and Epigenetic Determinants of Vaccine Responses
Tobias R. Kollmann,
Telethon Kids Institute, Australia
Predictors of Vaccine Responses in Children
Predictors of Vaccine Responses in Children
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Anti-Viral B Cell Responses (Joint)
Barton F. Haynes,
Duke University Medical Center, USA
Ontogenicity of Broadly Neutralizing Antibodies during HIV-1 Infection
Ontogenicity of Broadly Neutralizing Antibodies during HIV-1 Infection
John R. Mascola,
NIAID, National Institutes of Health, USA
Antibody Responses to HIV
Antibody Responses to HIV
*
Leonidas Stamatatos,
Fred Hutchinson Cancer Research Center, USA
Characterization of Recombinant HIV-1 Envelopes that Bind Germline Forms of Broadly Neutralizing Antibodies
Characterization of Recombinant HIV-1 Envelopes that Bind Germline Forms of Broadly Neutralizing Antibodies
Ian A. Wilson,
The Scripps Research Institute, USA
Broad Neutralization of Influenza Viruses
Broad Neutralization of Influenza Viruses
Pia Dosenovic,
Karolinska Institutet, Sweden
Short Talk: Development of HIV-1 Broadly Neutralizing Antibodies in Human Variable Region Knock-In Mice
Short Talk: Development of HIV-1 Broadly Neutralizing Antibodies in Human Variable Region Knock-In Mice
Scott D. Boyd,
Stanford University, USA
Short Talk: Storage and Recall of Anti-Influenza Antibodies in Younger and Older Adults
Short Talk: Storage and Recall of Anti-Influenza Antibodies in Younger and Older Adults
11:15—12:15
Meet the Editors
*
Catarina Sacristán,
Cell Press, USA
Alison Farrell,
Springer Nature, USA
Fabiola V. Rivas,
Cell Press, USA
Liz Thompson,
Immunity, Cell Press, USA
Sri Devi Narasimhan,
Cell Press, USA
Gabriel A. Gasque,
PLOS Biology, USA
Kristen L. Mueller,
Science Magazine, USA
14:30—16:30
Workshop 5: Affinity Maturation and Class Switch
*
Kim Good-Jacobson,
Monash University, Australia
*
Garnett H. Kelsoe,
Duke University and Medical Center, USA
Alexander D. Gitlin,
Rockefeller University, USA
Clonal Selection in the Germinal Center by Regulated Proliferation and Hypermutation
Clonal Selection in the Germinal Center by Regulated Proliferation and Hypermutation
Stephen P. Methot,
Institut de Recherches Cliniques de Montreal, Canada
Consecutive Interactions with HSP90 and eEF1A1 Underlie a Functional Maturation and Storage Pathway of AID in the Cytoplasm
Consecutive Interactions with HSP90 and eEF1A1 Underlie a Functional Maturation and Storage Pathway of AID in the Cytoplasm
Heping Xu,
Cincinnati Children's Hospital Medical Center, USA
Regulation of Bifurcating B Cell Responses by IRF4 and IRF8-Mediated Reciprocal Feedback
Regulation of Bifurcating B Cell Responses by IRF4 and IRF8-Mediated Reciprocal Feedback
Zhiyong Yang,
University of California, San Francisco, USA
Plasma Cell Differentiation Driven by Antigen-Independent Signaling Activity of the IgE B Cell Receptor
Plasma Cell Differentiation Driven by Antigen-Independent Signaling Activity of the IgE B Cell Receptor
Rushad Pavri,
Institute for Molecular Pathology, Austria
The Role of the Mcm Complex in Class Switch Recombination
The Role of the Mcm Complex in Class Switch Recombination
Jennifer L. Yates,
New York State Department of Health, USA
Innate iNKT Cells Provide T-Dependent Type 2 Help for B Cells: Expanding the Helper Paradigm
Innate iNKT Cells Provide T-Dependent Type 2 Help for B Cells: Expanding the Helper Paradigm
Jing H. Wang,
University of Colorado Anschutz Medical Campus, USA
The Imbalanced Signaling between PTEN and Phosphoinositide 3-Kinase Impairs Class Switch Recombination
The Imbalanced Signaling between PTEN and Phosphoinositide 3-Kinase Impairs Class Switch Recombination
Nobuo Sakaguchi,
Kumamoto University, Japan
Regulation of Selective Non-Coding RNA Species Involved in B-Cell Maturation by AID-Interacting Molecule GANP
Regulation of Selective Non-Coding RNA Species Involved in B-Cell Maturation by AID-Interacting Molecule GANP
14:30—16:30
Workshop 3: B Cell Pathogenesis and BCR Repertoire Session
*
Susan Moir,
NIAID, National Institutes of Health, USA
*
Matthieu Perreau,
University Hospital of Lausanne, Switzerland
James J. Knox,
University of Pennsylvania, USA
HIV Infection Induces the Expansion of T-Bet Expressing B Lymphocytes
HIV Infection Induces the Expansion of T-Bet Expressing B Lymphocytes
Thomas Liechti,
Institute of Medical Virology, Switzerland
Tracing B Cell Subset Changes during Acute and Chronic HIV-1 Infection and Restoration upon ART Initiation
Tracing B Cell Subset Changes during Acute and Chronic HIV-1 Infection and Restoration upon ART Initiation
Chung Park,
NIAID, National Institutes of Health, USA
Lymph Node B Cells Survey Interfollicular SIGN-R1+ Macrophages that Capture HIV-1 gp120
Lymph Node B Cells Survey Interfollicular SIGN-R1+ Macrophages that Capture HIV-1 gp120
D. Noah Sather,
Center for Infectious Disease Research, USA
Repertoire Analysis of the B Cell Receptor-Encoding Loci in Humans and Rhesus macaques by Next Generation Sequencing
Repertoire Analysis of the B Cell Receptor-Encoding Loci in Humans and Rhesus macaques by Next Generation Sequencing
Chaim A. Schramm,
NIAID, National Institutes of Health, USA
Longitudinal Deep-Sequencing of the VRC01-Antibody Lineage Reveals High Evolutionary Rate and Extraordinary Diversity
Longitudinal Deep-Sequencing of the VRC01-Antibody Lineage Reveals High Evolutionary Rate and Extraordinary Diversity
Zizhang Sheng,
Columbia University, USA
Evolutionary Rate Dynamics of HIV-1 Broadly Neutralizing Antibody Lineages
Evolutionary Rate Dynamics of HIV-1 Broadly Neutralizing Antibody Lineages
14:30—16:30
Workshop 4: Ab Based Therapy for Prevention and for Cure
*
Richard A. Koup,
NIAID, National Institutes of Health, USA
*
M. Juliana McElrath,
Fred Hutchinson Cancer Research Center, USA
Sara Ferrando-Martinez,
NIAID, National Institutes of Health, USA
Follicular CD8 T Cells Have Superior Cytolytic Capacity and Mediate a Redirected Killing of HIV-Infected Cells by Bispecific Antibodies
Follicular CD8 T Cells Have Superior Cytolytic Capacity and Mediate a Redirected Killing of HIV-Infected Cells by Bispecific Antibodies
M. Anthony Moody,
Duke University Medical Center, USA
Elevated Prevalence of Autoantibodies in HIV-Infected Individuals with Plasma Broadly Reactive Neutralizing Antibodies (bnAbs) Compared to Infected Individuals Lacking Plasma bnAbs
Elevated Prevalence of Autoantibodies in HIV-Infected Individuals with Plasma Broadly Reactive Neutralizing Antibodies (bnAbs) Compared to Infected Individuals Lacking Plasma bnAbs
Ariel Halper-Stromberg,
Rockefeller University, USA
Targeting the HIV-1 Reservoir in Humanized Mice Using Broadly Neutralizing Antibodies and Viral Inducers
Targeting the HIV-1 Reservoir in Humanized Mice Using Broadly Neutralizing Antibodies and Viral Inducers
Ann J. Hessell,
Oregon Health & Science University, USA
Post-Exposure Treatment with Neutralizing mAbs Ablates SHIV Infection in Infant Rhesus macaques and Limits Establishment of Latent Viral Reservoirs
Post-Exposure Treatment with Neutralizing mAbs Ablates SHIV Infection in Infant Rhesus macaques and Limits Establishment of Latent Viral Reservoirs
Smita S. Iyer,
Emory University, USA
Co-Delivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CD4+ T Follicular Helper Cell Response in Rhesus macaques
Co-Delivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CD4+ T Follicular Helper Cell Response in Rhesus macaques
Amarendra Pegu,
NIAID, National Institutes of Health, USA
Efficacy of Antibody Therapy in Acute SHIV-Infected Macaques
Efficacy of Antibody Therapy in Acute SHIV-Infected Macaques
Akshaya Ramesh,
Boston University School of Medicine, USA
Macaque Immunogenetics through de-novo Genome Assemblies
Macaque Immunogenetics through de-novo Genome Assemblies
Veronika Schmid,
University of Regensburg, Germany
Characterization of Anti-HIV-1 Envelope Antibodies Using a FACS Based High Throughput Mapping Platform
Characterization of Anti-HIV-1 Envelope Antibodies Using a FACS Based High Throughput Mapping Platform
17:00—19:30
Antibody Maturation and Class Switch
*
Tasuku Honjo,
Kyoto University Graduate School of Medicine, Japan
Molecular Mechanism of AID-Mediated SHM and SCR
Molecular Mechanism of AID-Mediated SHM and SCR
Frederick W. Alt,
Boston Children's Hospital, USA
Mechanisms that Direct Specificity and Outcome of Activation-Induced Cytidine Deaminase (AID) Activity
Mechanisms that Direct Specificity and Outcome of Activation-Induced Cytidine Deaminase (AID) Activity
Rafael Casellas,
NIAMS-NCI, National Institutes of Health, USA
AID Targeting
AID Targeting
Patricia J. Gearhart,
NIA, National Institutes of Health, USA
Short Talk: DNA Polymerases Iota and Zeta Standoff during Antibody Hypermutation
Short Talk: DNA Polymerases Iota and Zeta Standoff during Antibody Hypermutation
Uttiya Basu,
, USA
Short Talk: In B Cells, High-Throughput Proteomic Screen Identifies Co-Factors for RNA Exosome that Facilitates AID Access to Both Strands of Transcribed DNA
Short Talk: In B Cells, High-Throughput Proteomic Screen Identifies Co-Factors for RNA Exosome that Facilitates AID Access to Both Strands of Transcribed DNA
Kevin M. McBride,
University of Texas MD Anderson Cancer Center, USA
Short Talk: Uracil DNA Glycosylase of Gammaherpesvirus Alters B Cell Class Switch Recombination
Short Talk: Uracil DNA Glycosylase of Gammaherpesvirus Alters B Cell Class Switch Recombination
17:00—19:00
Envelope Structure
*
Peter D. Kwong,
NIAID, National Institutes of Health, USA
Dennis R. Burton,
The Scripps Research Institute, USA
Envelope-Glycosylation and Antibody-Recognition
Envelope-Glycosylation and Antibody-Recognition
Walther Mothes,
Yale University School of Medicine, USA
Conformational Dynamics of Single HIV-1 Envelope Trimers on Native Virions
Conformational Dynamics of Single HIV-1 Envelope Trimers on Native Virions
Andrew B. Ward,
The Scripps Research Institute, USA
Short Talk: High-Resolution Cryo-EM Studies of HIV-1 Envelope
Short Talk: High-Resolution Cryo-EM Studies of HIV-1 Envelope
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:30
B Cell Immune Deficiencies
*
Anne Durandy,
Institut Imagine, France
Immunoglobulin Class Switch Recombination Deficiencies: An Update
Immunoglobulin Class Switch Recombination Deficiencies: An Update
Klaus Warnatz,
University Clinic Freiburg, Germany
NF-kappaB in B Cell Differentiation - From an Immunodeficient Standpoint
NF-kappaB in B Cell Differentiation - From an Immunodeficient Standpoint
Mary Ellen Conley,
Rockefeller University, USA
Defects in Early B Cell Development
Defects in Early B Cell Development
Lennart Hammarström,
Karolinska Institute, Sweden
Defects in Late B Cell Development - Lessons from WES and WGS
Defects in Late B Cell Development - Lessons from WES and WGS
Jacob M. Rosenberg,
Harvard University, USA
Short Talk: The Landscape and Function of Anti-Cytokine Autoantibodies in Health and Primary Immunodeficiency
Short Talk: The Landscape and Function of Anti-Cytokine Autoantibodies in Health and Primary Immunodeficiency
Fabienne Mackay,
Monash University, Australia
Short Talk: The TACI Receptor Regulates T-Independent Marginal Zone B Cell Responses through Innate Activation-Induced Cell Death
Short Talk: The TACI Receptor Regulates T-Independent Marginal Zone B Cell Responses through Innate Activation-Induced Cell Death
Jayanta Chaudhuri,
Memorial Sloan Kettering Cancer Center, USA
Short Talk: Non-Coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNA
Short Talk: Non-Coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNA
08:00—11:00
HIV Vaccine Clinical Development
*
Peggy Johnston,
Bill & Melinda Gates Foundation, USA
*
M. Juliana McElrath,
Fred Hutchinson Cancer Research Center, USA
Overview of HIV Clinical Vaccine Development
Overview of HIV Clinical Vaccine Development
Nathalie Garçon,
Bioaster, France
Challenges in the Preclinical and Clinical Development of Novel Adjuvants
Challenges in the Preclinical and Clinical Development of Novel Adjuvants
Kristin L. Boswell,
NIAID, National Institutes of Health, USA
Short Talk: Characterization of CD150 Expression and Function on SHIV-Specific TFH Cells
Short Talk: Characterization of CD150 Expression and Function on SHIV-Specific TFH Cells
Rebecca M. Lynch,
George Washington University, USA
Short Talk: Virologic Impact of VRC01-Infusion in HIV-1 Infected Subjects
Short Talk: Virologic Impact of VRC01-Infusion in HIV-1 Infected Subjects
14:30—16:30
Workshop 6: System Immunology and Modeling
*
Sarah Cobey,
University of Chicago, USA
*
Uri Hershberg,
Drexel University, USA
Brandon DeKosky,
University of Kansas, USA
Paired VH:VL Analysis of Naïve B-Cell Repertoires and Comparison to Antigen-Experienced B-Cell Repertoires in Healthy Human Donors
Paired VH:VL Analysis of Naïve B-Cell Repertoires and Comparison to Antigen-Experienced B-Cell Repertoires in Healthy Human Donors
Thomas B. Kepler,
Boston University, USA
B Cell Clonal Dynamics during Sequential Immunizations
B Cell Clonal Dynamics during Sequential Immunizations
Frederick A. Matsen IV,
Fred Hutchinson Cancer Research Center, USA
Quantifying Evolutionary Constraints on B Cell Affinity Maturation
Quantifying Evolutionary Constraints on B Cell Affinity Maturation
Lauren M. Childs,
Virginia Tech, USA
Affinity Maturation of B Cells in the Presence of Competing Antigens
Affinity Maturation of B Cells in the Presence of Competing Antigens
Jason Anthony Vander Heiden,
Genetech, Inc., USA
High-Throughput Immunoglobulin Sequencing Informatics: Insights into B Cell Trafficking Patterns in Multiple Sclerosis
High-Throughput Immunoglobulin Sequencing Informatics: Insights into B Cell Trafficking Patterns in Multiple Sclerosis
Gregory W. Schwartz,
University of Pennsylvania, USA
Conserved Amino Acid Diversity in B Cell Repertoires Connects between Selection at the Germline and Somatic Levels
Conserved Amino Acid Diversity in B Cell Repertoires Connects between Selection at the Germline and Somatic Levels
Tom MacCarthy,
Stony Brook University, USA
The Number of Overlapping AID Hotspots within Germline Immunoglobulin Heavy Chain V-Regions Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia
The Number of Overlapping AID Hotspots within Germline Immunoglobulin Heavy Chain V-Regions Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia
Rajagopal Murugan,
German Cancer Research Institute, Germany
High Throughput Analysis of B Cell Clonal Expansion and Antibody Selection to Controlled Plasmodium falciparum Infection
High Throughput Analysis of B Cell Clonal Expansion and Antibody Selection to Controlled Plasmodium falciparum Infection
14:30—16:30
Workshop 5: B/T Cell Interactions
*
Rama Rao Amara,
Emory University, USA
Robert Abbott,
La Jolla Institute for Allergy and Immunology, USA
The A2a Adenosine Receptor Is Required for Affinity Maturation in the Germinal Center
The A2a Adenosine Receptor Is Required for Affinity Maturation in the Germinal Center
Atef F. Allam,
Walter Reed Institute of Research, USA
TFH Cells Accumulate in the Female Reproductive Tract and in Peyer’s Patches of Humanized DRAG Mice, Are Highly Permissive to HIV-1, and Show Impaired Cytokine Production Over the Course of HIV-1 Infection
TFH Cells Accumulate in the Female Reproductive Tract and in Peyer’s Patches of Humanized DRAG Mice, Are Highly Permissive to HIV-1, and Show Impaired Cytokine Production Over the Course of HIV-1 Infection
John P. Barton,
University of California, Riverside, USA
Computational Prediction of Intra-Individual HIV Evolution to Evade Cellular Immune Selection Pressure
Computational Prediction of Intra-Individual HIV Evolution to Evade Cellular Immune Selection Pressure
Thorsten Demberg,
NCI, National Institutes of Health, USA
Persistent Loss and Dysregulation of Marginal Zone B-Cells after SHIVSF162P4 Challenge Despite Control of Viremia
Persistent Loss and Dysregulation of Marginal Zone B-Cells after SHIVSF162P4 Challenge Despite Control of Viremia
Colin Havenar-Daughton,
Vir Biotechnology, USA
T Follicular Helper Cell and Germinal Center B Cell Responses to HIV gp140 Protein + TLR-Encapsulated Nanoparticle Immunization in Rhesus macaques
T Follicular Helper Cell and Germinal Center B Cell Responses to HIV gp140 Protein + TLR-Encapsulated Nanoparticle Immunization in Rhesus macaques
Joyce K. Hu,
La Jolla Institute of Allergy and Immunology, USA
Characterization of Antibody and Tfh Cell Responses after BG505 SOSIP.664 Trimer Immunizations in Mice
Characterization of Antibody and Tfh Cell Responses after BG505 SOSIP.664 Trimer Immunizations in Mice
Yin Xu,
University of New South Wales, Australia
HIV Entry into T Follicular Helper (Tfh) Cells May Be Associated with CCR5+ Pre-Tfh Cells in Lymph Nodes
HIV Entry into T Follicular Helper (Tfh) Cells May Be Associated with CCR5+ Pre-Tfh Cells in Lymph Nodes
14:30—16:30
Workshop 7: B Cell Related Diseases
*
Ignacio Sanz,
Emory University, School of Medicine, USA
*
Fabienne Mackay,
Monash University, Australia
John H. Kehrl,
NIAID, National Institutes of Health, USA
B Lymphocyte Specific Loss of Ric-8A Causes a Galpha Protein Deficit and Severe Humoral Immunodeficiency
B Lymphocyte Specific Loss of Ric-8A Causes a Galpha Protein Deficit and Severe Humoral Immunodeficiency
Cindy Eunhee Lee,
Australian National University, Australia
Autosomal Dominant B Cell Deficiency with Alopecia Due to a Mutation in NF-kappaB2 that Results in Unprocessable p100
Autosomal Dominant B Cell Deficiency with Alopecia Due to a Mutation in NF-kappaB2 that Results in Unprocessable p100
Nadine Hövelmeyer,
University of Mainz, Germany
The Transcription Factor Bcl-3 Regulates the Development of Marginal Zone, Germinal Center and B1 B Cells
The Transcription Factor Bcl-3 Regulates the Development of Marginal Zone, Germinal Center and B1 B Cells
Wanli Liu,
Tsinghua University, China
Membrane Sequestration of the mIgG Cytoplasmic Tail Confers a Safety Trigger Mechanism for the Enhanced Activation of IgG-Memory B Cell
Membrane Sequestration of the mIgG Cytoplasmic Tail Confers a Safety Trigger Mechanism for the Enhanced Activation of IgG-Memory B Cell
Jürgen Wienands,
Georg August University of Goettingen, Germany
Absence of CIN85 Expression Presents with X-Chromosome-Linked Antibody Deficiency in Humans
Absence of CIN85 Expression Presents with X-Chromosome-Linked Antibody Deficiency in Humans
Lynnea Rae Waters,
University of California, Los Angeles, USA
T Follicular Helper Cell Differentiation Is Blocked by Lkb1 Inhibition of NF-kappaB in B Cells
T Follicular Helper Cell Differentiation Is Blocked by Lkb1 Inhibition of NF-kappaB in B Cells
Wei Cao,
UT MD Anderson Cancer Center, USA
Humoral Autoimmunity Is Promoted by Type I Interferon-Induced Interferon gamma but Restricted by ROS-Producing Neutrophils
Humoral Autoimmunity Is Promoted by Type I Interferon-Induced Interferon gamma but Restricted by ROS-Producing Neutrophils
17:00—19:00
B Cell Autoimmunity
*
Martin G. Weigert,
University of Chicago, USA
Ann Marshak-Rothstein,
University of Massachusetts Medical School, USA
Endosomal and Cytosolic Nucleic Acid Sensors in Autoimmunity
Endosomal and Cytosolic Nucleic Acid Sensors in Autoimmunity
Hedda Wardemann,
German Cancer Research Center, Germany
Single Cell-Based High-Throughput Analysis of Human B Cell Antibody Responses
Single Cell-Based High-Throughput Analysis of Human B Cell Antibody Responses
Michael C. Carroll,
Boston Children's Hospital, Harvard Medical School, USA
Follicular Dendritic Cells Are Essential for Maintenance of Autoreactive B Cells
Follicular Dendritic Cells Are Essential for Maintenance of Autoreactive B Cells
Haochu Huang,
Genentech, Inc., USA
Short Talk: Spontaneous B Cell Class Switching in the Thymus and Tolerance
Short Talk: Spontaneous B Cell Class Switching in the Thymus and Tolerance
17:00—19:00
HIV Functional Cure and/or Eradication
*
Giuseppe Pantaleo,
Centre Hospitalier Universitaire Vaudois, Switzerland
Persephone Borrow,
University of Oxford, UK
Relationship between CD4+ T Cell Subsets and the Neutralization Breadth of the Antibody Response Generated during HIV-1 Infection
Relationship between CD4+ T Cell Subsets and the Neutralization Breadth of the Antibody Response Generated during HIV-1 Infection
Matthieu Perreau,
University Hospital of Lausanne, Switzerland
Combined Immunological/Virological Therapies for HIV Functional Cure/Eradication
Combined Immunological/Virological Therapies for HIV Functional Cure/Eradication
Michael Farzan,
The Scripps Research Institute, USA
AAV-Expressed eCD4-Ig Provides Durable Protection from Multiple SHIV Challenges
AAV-Expressed eCD4-Ig Provides Durable Protection from Multiple SHIV Challenges
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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