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This meeting took place in 2015
Here are the related meetings in 2021:
MEETING CHANGE TO VIRTUAL: Diabetes: Many Faces of the Disease (J6)
Diabetes: Many Faces of the Disease (EK18)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Diabetes and Metabolic Dysfunction (J6)
Organizer(s) Jeffrey E. Pessin, Alan R. Saltiel and Deborah M. Muoio
January 27—February 1, 2015
Santa Fe Community Convention Center • Santa Fe, NM USA
Discounted Abstract Deadline: Oct 1, 2014
Abstract Deadline: Oct 28, 2014
Scholarship Deadline: Oct 1, 2014
Discounted Registration Deadline: Nov 25, 2014
Sponsored by Intercept Pharmaceuticals, Inc., the Journal of Molecular Cell Biology (JMCB), MedImmune, Novo Nordisk A/S and Pfizer Inc. Supported by an educational donation provided by Amgen.
Joint Meeting:
Mitochondria, Metabolism and Heart Failure (J5)
Summary of Meeting:
Diabetes and obesity-related complications and associated metabolic disorders are major public health problems at the local, national and global levels. These metabolic defects underlie the basis for multiple debilitating diseases including heart disease, stroke, blindness, kidney disease, hypertension, neural degeneration, wound healing, amputations, periodontal disease and birth defects. This meeting will address several cutting-edge aspects of molecular, cellular, tissue and integrative system metabolism that account for the metabolic defects that occur in diabetes and obesity. Several of these themes overlap with the concurrent meeting on Mitochondria, Metabolism and Heart Failure and four concurrent sessions are planned addressing distinct and novel aspects of normal and dysregulation muscle (skeletal and cardiac) intracellular signaling, mitochondria function/dynamics, aging and energy balance. Leaders in each of these respective areas will not only address basic and integrative mechanisms in model systems, but several will address these issues in human pathology. The diabetes-specific sessions reflect several key aspects of metabolic dysregulation in which novel information is currently forthcoming, causing a paradigm shift compared to our previous understanding of these processes. These include new information about tissue cross-talk, the inter-relationship between the control of glucose production and fatty acid synthesis that underlies selective insulin resistance and the role of normal and dysregulated circadian rhythms on metabolic processes. These cutting-edge advances will provide a foundation for identifying future research directions.
View Scholarships/Awards
Diabetes and obesity-related complications and associated metabolic disorders are major public health problems at the local, national and global levels. These metabolic defects underlie the basis for multiple debilitating diseases including heart disease, stroke, blindness, kidney disease, hypertension, neural degeneration, wound healing, amputations, periodontal disease and birth defects. This meeting will address several cutting-edge aspects of molecular, cellular, tissue and integrative system metabolism that account for the metabolic defects that occur in diabetes and obesity. Several of these themes overlap with the concurrent meeting on Mitochondria, Metabolism and Heart Failure and four concurrent sessions are planned addressing distinct and novel aspects of normal and dysregulation muscle (skeletal and cardiac) intracellular signaling, mitochondria function/dynamics, aging and energy balance. Leaders in each of these respective areas will not only address basic and integrative mechanisms in model systems, but several will address these issues in human pathology. The diabetes-specific sessions reflect several key aspects of metabolic dysregulation in which novel information is currently forthcoming, causing a paradigm shift compared to our previous understanding of these processes. These include new information about tissue cross-talk, the inter-relationship between the control of glucose production and fatty acid synthesis that underlies selective insulin resistance and the role of normal and dysregulated circadian rhythms on metabolic processes. These cutting-edge advances will provide a foundation for identifying future research directions.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, JANUARY 27
WEDNESDAY, JANUARY 28
THURSDAY, JANUARY 29
FRIDAY, JANUARY 30
SATURDAY, JANUARY 31
SUNDAY, FEBRUARY 1
Conference Program Print | View meeting in 12 hr (am/pm) time
TUESDAY, JANUARY 27
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
15:00—16:00
Welcome and Keynote Address (Joint)
*
Jeffrey E. Pessin,
Albert Einstein College of Medicine, USA
*
Richard N. Kitsis,
Albert Einstein College of Medicine, USA
Helen H. Hobbs,
University of Texas Southwestern Medical Center, USA
Journal of Lipid Research Lectureship Introduced by JLR Associate Editor, Ira Goldberg. Orchestrating Fatty Acid Flux to Adipose Tissue during Feast and Famine
Journal of Lipid Research Lectureship Introduced by JLR Associate Editor, Ira Goldberg. Orchestrating Fatty Acid Flux to Adipose Tissue during Feast and Famine
16:00—19:00
Regulation of Metabolism (Joint)
*
Rong Tian,
University of Washington, USA
Christopher B. Newgard,
Duke University Medical Center, USA
Role of the Gut Microbiota in the Pathogenesis and Treatment of Cardiometabolic Diseases
Role of the Gut Microbiota in the Pathogenesis and Treatment of Cardiometabolic Diseases
E. Dale Abel,
University of Iowa, Carver College of Medicine, USA
Insulin Signaling in the Heart
Insulin Signaling in the Heart
Eric N. Olson,
University of Texas Southwestern Medical Center, USA
Muscular "Mediators" of Metabolism
Muscular "Mediators" of Metabolism
Lawrence Kazak,
McGill University, Canada
Regulation of Heat Production by Various Shades of Fat: A Novel Thermogenic Pathway in Beige Fat
Regulation of Heat Production by Various Shades of Fat: A Novel Thermogenic Pathway in Beige Fat
08:00—12:00
Mitochondrial Quality Control (Joint)
*
Heidi M. McBride,
McGill University, Canada
Richard J. Youle,
NINDS, National Institutes of Health, USA
Damage Control: How PINK1 and Parkin Survey Mitochondrial Fidelity and Respond with Selective Autophagy
Damage Control: How PINK1 and Parkin Survey Mitochondrial Fidelity and Respond with Selective Autophagy
Jennifer A. Lippincott-Schwartz,
Howard Hughes Medical Institute - Janelia Farm, USA
Roles of Lipid Droplet Lipolysis, Autophagy and Mitochondrial Fusion Dynamics in Fatty Acid Trafficking within Cells
Roles of Lipid Droplet Lipolysis, Autophagy and Mitochondrial Fusion Dynamics in Fatty Acid Trafficking within Cells
Orian S. Shirihai,
University of California, Los Angeles, USA
Mitochondrial Dynamics and Quality Control, a Conflict of Interest
Mitochondrial Dynamics and Quality Control, a Conflict of Interest
Gerald W. Dorn, II,
Washington University School of Medicine, USA
Mitochondrial Dynamics, Mitochondrial Quality Control and Heart Disease
Mitochondrial Dynamics, Mitochondrial Quality Control and Heart Disease
Luca Scorrano,
University of Padova, Italy
Keeping Mitochondria Cristae in Shape to Control Organ Damage and Metabolism
Keeping Mitochondria Cristae in Shape to Control Organ Damage and Metabolism
Peipei Ping,
University of California, Los Angeles, USA
Data Science Approaches for Mitochondrial Discoveries
Data Science Approaches for Mitochondrial Discoveries
16:30—19:20
Mechanisms of Dysregulated Glucogenogenesis
*
Alan R. Saltiel,
University of California, San Diego, USA
Deborah M. Muoio,
Duke University Medical Center, USA
Nutrient-Induced Mitochondrial Stress and Metabolic Inflexibility in Skeletal Muscle
Nutrient-Induced Mitochondrial Stress and Metabolic Inflexibility in Skeletal Muscle
Morris J. Birnbaum,
Uninversity of Pennsylvania and Pfizer, Inc
Non-Autonomous Regulation of Hepatic Glucose Output by Insulin
Non-Autonomous Regulation of Hepatic Glucose Output by Insulin
Marc R. Montminy,
The Salk Institute for Biological Studies, USA
Regulation of Hepatic Gluconeogenesis by the CREB Pathway
Regulation of Hepatic Gluconeogenesis by the CREB Pathway
Carl S. Thummel,
University of Utah School of Medicine, USA
Short Talk: The Molecular Basis of MODY1 and its Regulation by HNF4
Short Talk: The Molecular Basis of MODY1 and its Regulation by HNF4
Alexander S. Banks,
Harvard Medical School, USA
Short Talk: Therapeutic Resolution of Insulin Resistance via MEK/ERK Inhibition and Reversal of PPARgamma Serine 273 Phosphorylation
Short Talk: Therapeutic Resolution of Insulin Resistance via MEK/ERK Inhibition and Reversal of PPARgamma Serine 273 Phosphorylation
16:30—19:00
Metabolism Under Stress in Heart Disease and Diabetes
*
Sihem Boudina,
University of Utah School of Medicine, USA
Rong Tian,
University of Washington, USA
Metabolic Remodeling of the Heart
Metabolic Remodeling of the Heart
E. Douglas Lewandowski,
University of Illinois at Chicago College of Medicine, USA
Remodeled Metabolism In and Around the Failing Heart
Remodeled Metabolism In and Around the Failing Heart
Edward T. Chouchani,
Dana-Farber Cancer Institute, USA
Short Talk: Ischemic Accumulation of Succinate Controls Reperfusion Injury through Mitochondrial ROS
Short Talk: Ischemic Accumulation of Succinate Controls Reperfusion Injury through Mitochondrial ROS
Benjamin A. Olenchock,
Brigham and Women’s Hospital, USA
Short Talk: Inhibition of the Prolyl Hydroxylase EglN1 Is Sufficient for Local and Remote Cardiac Ischemic Protection: Role of Tryptophan Metabolism
Short Talk: Inhibition of the Prolyl Hydroxylase EglN1 Is Sufficient for Local and Remote Cardiac Ischemic Protection: Role of Tryptophan Metabolism
19:05—20:05
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:20
Emerging Synergy between Metabolism and the Gut Microbiome
*
Christopher B. Newgard,
Duke University Medical Center, USA
Ronald M. Evans,
HHMI/The Salk Institute, USA
Nuclear Receptors and the Hunger Game: From Feast to Famine
Nuclear Receptors and the Hunger Game: From Feast to Famine
John F. Rawls,
Duke University, USA
Microbial Regulation of Intestinal Lipid Metabolism and Gene Expression
Microbial Regulation of Intestinal Lipid Metabolism and Gene Expression
C. Ronald Kahn,
Joslin Diabetes Center and Harvard Medical School, USA
New Insights into Insulin Signaling and Insulin Action in Muscle through Genetic Manipulation
New Insights into Insulin Signaling and Insulin Action in Muscle through Genetic Manipulation
Gökhan S. Hotamisligil,
Harvard School of Public Health, USA
Endoplasmic Reticulum and Mitochondria Integration in Response to Metabolic Stress
Endoplasmic Reticulum and Mitochondria Integration in Response to Metabolic Stress
Gerard Karsenty,
Columbia University Medical Center, USA
A Crosstalk between Glucose Uptake and Runx2 Determines the Onset of Osteoblast Differentiation and the Extent of Bone Formation
A Crosstalk between Glucose Uptake and Runx2 Determines the Onset of Osteoblast Differentiation and the Extent of Bone Formation
08:00—11:50
Cardiac Autophagy
*
Konstantinos Drosatos,
Temple University School of Medicine, USA
Roberta A. Gottlieb,
Cedars-Sinai Medical Center, USA
Autophagy in Cardioprotection and Impact of Metabolic Syndrome
Autophagy in Cardioprotection and Impact of Metabolic Syndrome
Åsa B. Gustafsson,
University of California, San Diego, USA
MCL-1 as a Critical Regulator of Mitochondrial Function and Cell Death
MCL-1 as a Critical Regulator of Mitochondrial Function and Cell Death
Elizabeth Murphy,
Cardiac Physiology Section Vascular Medicine Branch, NHLBI, NIH, USA
Calcium Regulation of Mitochondrial Function
Calcium Regulation of Mitochondrial Function
Junichi Sadoshima,
Rutgers New Jersey Medical School, USA
Ulk1 Plays a Crucial Role in Mitochondrial Autophagy in Cardiomyocytes
Ulk1 Plays a Crucial Role in Mitochondrial Autophagy in Cardiomyocytes
Christoph Maack,
Universitätsklinikum des Saarlandes, Germany
Impact of the Mitochondrial/SR Interaction for Redox Regulation
Impact of the Mitochondrial/SR Interaction for Redox Regulation
Saptarsi M. Haldar,
University of California, San Francisco, USA
Short Talk: Glucocorticoids Elicit Ergogenic Effects in Muscle via a Defined Transcriptional Pathway
Short Talk: Glucocorticoids Elicit Ergogenic Effects in Muscle via a Defined Transcriptional Pathway
Anja Karlstaedt,
University of Texas Medical School at Houston, USA
Short Talk: Regulation of mTOR Activation during Acute Increases of Heart Work: The Role of Endogenous Substrates
Short Talk: Regulation of mTOR Activation during Acute Increases of Heart Work: The Role of Endogenous Substrates
14:30—16:30
Workshop: Big Data to Knowledge (BD2K) (Joint)
*
Jeffrey E. Pessin,
Albert Einstein College of Medicine, USA
Ronald N. Margolis,
NIDDK, National Institutes of Health, USA
Biomedical Big Data: Data Discovery and the Digital Enterprise
Biomedical Big Data: Data Discovery and the Digital Enterprise
Abdelilah Arredouani,
Qatar Foundation, Qatar
Non-Targeted Metabolomic Profiling Score Improves the Early Prediction of Type 2 Diabetes in the Prospective D.E.S.I.R. Study
Non-Targeted Metabolomic Profiling Score Improves the Early Prediction of Type 2 Diabetes in the Prospective D.E.S.I.R. Study
Ida Donkin,
Copenhagen University, Denmark
Spermatozoa from Lean and Obese Humans Carry Distinct Epigenetic Signatures
Spermatozoa from Lean and Obese Humans Carry Distinct Epigenetic Signatures
Olga Gupta,
University of Texas Southwestern Medical Center, USA
Transcriptome Profiling of Omental Adipose Mesothelial Cells Reveals Differentially Expressed Transcripts Related to Inflammation
Transcriptome Profiling of Omental Adipose Mesothelial Cells Reveals Differentially Expressed Transcripts Related to Inflammation
Ondrej Kuda,
Academy of Sciences of the Czech Republic, Czech Republic
Metabolipidomical Profiling of Adipose Tissue during Fatty Acid Re-Esterification
Metabolipidomical Profiling of Adipose Tissue during Fatty Acid Re-Esterification
Xiaofeng Xin,
Massachusetts Institute of Technology, USA
Systems Biology of Obesity-Induced Hepatic Insulin Resistance
Systems Biology of Obesity-Induced Hepatic Insulin Resistance
Adam R. Wende,
University of Alabama at Birmingham, USA
DNA Methylation and Corresponding Gene Expression Changes in the Diabetic Heart
DNA Methylation and Corresponding Gene Expression Changes in the Diabetic Heart
Dietrich Rein,
Metanomics Health, Germany
Validation of a Metabolomics-Based Biomarker for Heart Failure with Reduced Ejection Fraction
Validation of a Metabolomics-Based Biomarker for Heart Failure with Reduced Ejection Fraction
16:30—19:05
Mechanisms of Dysregulated Lipogenesis
*
C. Ronald Kahn,
Joslin Diabetes Center and Harvard Medical School, USA
Barbara B. Kahn,
Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Discovery of a Novel Class of Naturally-Occurring Lipids with Anti-Diabetic and Anti-Inflammatory Effects
Discovery of a Novel Class of Naturally-Occurring Lipids with Anti-Diabetic and Anti-Inflammatory Effects
Michael P. Czech,
University of Massachusetts Medical School, USA
Adipose Lipogenesis in Control of Glucose Tolerance
Adipose Lipogenesis in Control of Glucose Tolerance
Catherine Postic,
INSERM Institut Cochin, France
ChREBP and Liver Steatosis
ChREBP and Liver Steatosis
Alan R. Saltiel,
University of California, San Diego, USA
Energy Expenditure Mediated by the Non-Canonical IKB Kinases
Energy Expenditure Mediated by the Non-Canonical IKB Kinases
Praveen Sethupathy,
Cornell University, USA
Short Talk: MicroRNA-Mediated Control of Metabolic Homeostasis
Short Talk: MicroRNA-Mediated Control of Metabolic Homeostasis
16:30—19:00
Mitochondria and Endoplasmic Reticulum-Mediated Cell Death
*
Qiangrong Liang,
New York Institute of Technology, College of Osteopathic Medicine, USA
Paolo Bernardi,
University of Padova Medical School, Italy
The Mitochondrial Permeability Transition Pore
The Mitochondrial Permeability Transition Pore
Jeffery D. Molkentin,
Cincinnati Children's Hospital Medical Center, USA
New Model of Mitochondrial Permeability Transition Pore (MPTP) Formation and Regulated Necrosis in the Heart
New Model of Mitochondrial Permeability Transition Pore (MPTP) Formation and Regulated Necrosis in the Heart
Kinya Otsu,
, UK
Mitochondria, Cell Death and Inflammation
Mitochondria, Cell Death and Inflammation
Wendy M. McKimpson,
Columbia University, USA
The Apoptosis Inhibitor ARC Alleviates the ER Stress Response to Promote Beta-Cell Survival in Diabetes
The Apoptosis Inhibitor ARC Alleviates the ER Stress Response to Promote Beta-Cell Survival in Diabetes
Maik Hüttemann,
Wayne State University, USA
Short Talk: Regulation of Mitochondrial Respiration and Apoptosis by Cytochrome c Phosphorylation
Short Talk: Regulation of Mitochondrial Respiration and Apoptosis by Cytochrome c Phosphorylation
19:05—20:05
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Mitochondria, Metabolism and Aging (Joint)
*
Deborah M. Muoio,
Duke University Medical Center, USA
David A. Sinclair,
Harvard Medical School, USA
Coupling Nuclear and Mitochondrial Transcription
Coupling Nuclear and Mitochondrial Transcription
Douglas C. Wallace,
Children's Hospital of Philadelphia, USA
Mitochondrial Mutations and Human Disease
Mitochondrial Mutations and Human Disease
Johan Auwerx,
École Polytechnique Fédérale de Lausanne, Switzerland
Mitochondrial Function, Metabolism and Aging
Mitochondrial Function, Metabolism and Aging
Heidi M. McBride,
McGill University, Canada
Redox Control of Mitochondrial Plasticity, Uncovering New Mechanisms that Link Function to Form
Redox Control of Mitochondrial Plasticity, Uncovering New Mechanisms that Link Function to Form
Peter S. Rabinovitch,
University of Washington, USA
Short Talk: Short-Term Treatment with Mitochondrial Protective Peptide SS-31 Reverses Cardiac Aging in Mice
Short Talk: Short-Term Treatment with Mitochondrial Protective Peptide SS-31 Reverses Cardiac Aging in Mice
14:00—16:00
Workshop: Inflammation in Diabetes, Obesity and Insulin Resistance
*
Jeffrey E. Pessin,
Albert Einstein College of Medicine, USA
Hyokjoon Kwon,
Albert Einstein College of Medicine, USA
High Fat Diet-Induced Interleukin-13 Modulates Inflammation and Insulin Resistance
High Fat Diet-Induced Interleukin-13 Modulates Inflammation and Insulin Resistance
Yun Sok Lee,
University of California, San Diego, USA
Saturated Fatty Acids Induce Uncoupled Mitochondrial Respiration and Trigger HIF-1alpha Causing Inflammation and Insulin Resistance in Obesity
Saturated Fatty Acids Induce Uncoupled Mitochondrial Respiration and Trigger HIF-1alpha Causing Inflammation and Insulin Resistance in Obesity
Rubén García-Martín,
Dresden University of Technology, Germany
Adipocyte Hypoxia-Inducible Factor 2 Protects from Whitening of the Brown Adipose Tissue and Metabolic Dysregulation in the Course of Diet-Induced Obesity
Adipocyte Hypoxia-Inducible Factor 2 Protects from Whitening of the Brown Adipose Tissue and Metabolic Dysregulation in the Course of Diet-Induced Obesity
Sagar P. Bapat,
University of California, San Francisco, USA
Fat Regulatory T Cells Drive Age-Associated Insulin Resistance
Fat Regulatory T Cells Drive Age-Associated Insulin Resistance
Prameladevi Chinnasamy,
Einstein College of Medicine, Montefiore Medical Center, USA
Allograft Inflammatory Factor-1 in Obesity and Type II Diabetes
Allograft Inflammatory Factor-1 in Obesity and Type II Diabetes
Caroline Tao,
Amgen, USA
Dichotomous Role of Adipocyte Toll-Like Receptor 4 on Insulin Sensitivity
Dichotomous Role of Adipocyte Toll-Like Receptor 4 on Insulin Sensitivity
Sojin Lee,
University of Pittsburgh School of Medicine, Children's Hosp of Pittsburgh, USA
FoxO1 Dictates M1 vs. M2 Polarization and Integrates Inflammation to Insulin Resistance in Diabetes
FoxO1 Dictates M1 vs. M2 Polarization and Integrates Inflammation to Insulin Resistance in Diabetes
Hye Eun Lee,
Catholic University of Korea, South Korea
Suppression of NLRP3 Inflammasome Activation by Caffeic Acid Phenethyl Ester and its Significance in Modulation of Metabolic Diseases
Suppression of NLRP3 Inflammasome Activation by Caffeic Acid Phenethyl Ester and its Significance in Modulation of Metabolic Diseases
16:30—18:45
Circadian Rhythms in Metabolic Networks
*
Michael P. Czech,
University of Massachusetts Medical School, USA
Mitchell A. Lazar,
Perelman School of Medicine, University of Pennsylvania, USA
Integrating Metabolism Around the Clock
Integrating Metabolism Around the Clock
Jorge L. Ruas,
Karolinska Institutet, Sweden
Short Talk: A Molecular Mechanism for Skeletal Muscle - Brain Crosstalk that Protects from Stress-Induced Depression
Short Talk: A Molecular Mechanism for Skeletal Muscle - Brain Crosstalk that Protects from Stress-Induced Depression
16:30—18:30
Toxins and Protectors of the Myocardium
*
Maha Abdellatif,
University of Medicine & Dentistry of New Jersey, USA
Ira J. Goldberg,
New York University, USA
Lipid Uptake, the Route to Lipid Droplet Formation and Cardiomyocyte Toxicity
Lipid Uptake, the Route to Lipid Droplet Formation and Cardiomyocyte Toxicity
Kenneth Walsh,
University of Virginia School of Medicine, USA
Molecular Links between Metabolic and Cardiovascular Diseases
Molecular Links between Metabolic and Cardiovascular Diseases
Lorrie A. Kirshenbaum,
University of Manitoba, Canada
Bnip3 Mediated Loss of Mitochondrial UCP3-Cytochrome c Oxidase Complexes Underlies Respiratory Defects and Cardiac Failure in Anthracycline Cardiotoxicity
Bnip3 Mediated Loss of Mitochondrial UCP3-Cytochrome c Oxidase Complexes Underlies Respiratory Defects and Cardiac Failure in Anthracycline Cardiotoxicity
18:45—19:45
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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