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This meeting took place in 2015
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Neural Control of Metabolic Physiology and Diseases (D4)
Organizer(s) Dongsheng Cai and Martin G. Myers, Jr.
April 12—17, 2015
Snowbird Resort • Snowbird, UT USA
Discounted Abstract Deadline: Dec 4, 2014
Abstract Deadline: Jan 13, 2015
Scholarship Deadline: Dec 4, 2014
Discounted Registration Deadline: Feb 12, 2015
Sponsored by Arena Pharmaceuticals, Inc. and Merck & Co., Inc.
Summary of Meeting:
The central nervous system, including the hypothalamus in particular, is important for the control of energy balance and metabolic homeostasis. Current research continues to generate important new understanding of the molecular, cellular, and neural mechanisms underlying this control. From a disease perspective, dysregulation of these processes appears to be crucial for the development and progression of the metabolic syndrome- including obesity, glucose intolerance/diabetes and hypertension- as well as the pathogenesis associated with aging. Recent research has begun to define and characterize the neural pathways involved in these processes. This symposium will bring together breaking research advances from both the basic science and translational realms, including new knowledge of neural circuits, plasticity and signaling, as well as insights into roles for hypothalamic/brain pathways in disease development. Also importantly, several new areas will be addressed, including state-of-art technologies for neuroscience research, adult neural stem cells, neural degeneration, microglia, aging, and related alterations of metabolic resilience.
View Scholarships/Awards
The central nervous system, including the hypothalamus in particular, is important for the control of energy balance and metabolic homeostasis. Current research continues to generate important new understanding of the molecular, cellular, and neural mechanisms underlying this control. From a disease perspective, dysregulation of these processes appears to be crucial for the development and progression of the metabolic syndrome- including obesity, glucose intolerance/diabetes and hypertension- as well as the pathogenesis associated with aging. Recent research has begun to define and characterize the neural pathways involved in these processes. This symposium will bring together breaking research advances from both the basic science and translational realms, including new knowledge of neural circuits, plasticity and signaling, as well as insights into roles for hypothalamic/brain pathways in disease development. Also importantly, several new areas will be addressed, including state-of-art technologies for neuroscience research, adult neural stem cells, neural degeneration, microglia, aging, and related alterations of metabolic resilience.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, APRIL 12
MONDAY, APRIL 13
TUESDAY, APRIL 14
WEDNESDAY, APRIL 15
THURSDAY, APRIL 16
FRIDAY, APRIL 17
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, APRIL 12
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Keynote Address
*
Martin G. Myers, Jr.,
University of Michigan, USA
Jeffrey M. Friedman,
Rockefeller University, USA
Transcriptional Control of Hypothalamic Neurons
Transcriptional Control of Hypothalamic Neurons
09:00—11:15
Hypothalamic Circuits
*
Joel K. Elmquist,
University of Texas Southwestern Medical Center, USA
*
William F. Colmers,
University of Alberta, Canada
Martin G. Myers, Jr.,
University of Michigan, USA
The Transcriptome of LepRb Neurons and its Regulation
The Transcriptome of LepRb Neurons and its Regulation
Scott M. Sternson,
HHMI/Janelia Research Campus, USA
Neural Circuits and Motivational Mechanisms for Hunger
Neural Circuits and Motivational Mechanisms for Hunger
Michael Krashes,
NIDDK, National Institutes of Health, USA
A Neural Basis for Melanocortin-4 Receptor-Regulated Appetite
A Neural Basis for Melanocortin-4 Receptor-Regulated Appetite
14:30—16:30
Workshop 1: The CNS as a Therapeutic Target for Pharmacologic Intervention
*
Lora K. Heisler,
Rowett Institute, University of Aberdeen, UK
*
James Trevaskis,
Gilead, USA
Arian F. Baquero,
Novo Nordisk Inc., USA
Functional Actions of FGF19 in Arcuate Nucleus Neurons
Functional Actions of FGF19 in Arcuate Nucleus Neurons
Daniela Herrera Moro Chao,
Paris-Diderot 7, France
Hypothalamus-Brainstem Circuits Are Needed for the Therapeutic Effects of Iminosugars on Metabolic Syndrome
Hypothalamus-Brainstem Circuits Are Needed for the Therapeutic Effects of Iminosugars on Metabolic Syndrome
Lenka Maletinská,
Academy of Sciences of the Czech Republic, Czech Republic
Anti-Obesity Effects of Lipidized PrRP Analogs after Peripheral Administration
Anti-Obesity Effects of Lipidized PrRP Analogs after Peripheral Administration
Brian Finan,
Novo Nordisk, USA
Using GLP-1 to Carry Dexamethasome to Treat Hypothalamic Inflammation and Metabolic Diseases
Using GLP-1 to Carry Dexamethasome to Treat Hypothalamic Inflammation and Metabolic Diseases
Nicole Bellefontaine,
University of Michigan, USA
nNOS-NO Signaling Is Involved in Diet-Induced Obesity
nNOS-NO Signaling Is Involved in Diet-Induced Obesity
17:00—19:00
Nutrient Sensing and Hypothalamus
*
Gary J. Schwartz,
Albert Einstein College of Medicine, USA
Alan G. Watts,
University of Southern California, USA
Catecholaminergic Neurons and the Regulation of Glycemia: The Importance of Hindbrain-Hypothalamic Interactions
Catecholaminergic Neurons and the Regulation of Glycemia: The Importance of Hindbrain-Hypothalamic Interactions
Darleen A. Sandoval,
University of Colorado, USA
Using Genetics and Pharmacology to Understand GLP-1 Physiology
Using Genetics and Pharmacology to Understand GLP-1 Physiology
Tony K.T. Lam,
Toronto General Research Institute, Canada
Nutrient and Hormonal Signaling in the Small Intestine
Nutrient and Hormonal Signaling in the Small Intestine
Alain J. De Solis,
Max Planck Institute for Metabolism, Germany
Short Talk: Impact of Postnatal Undernutrition on Developing AgRP/NPY Neurons
Short Talk: Impact of Postnatal Undernutrition on Developing AgRP/NPY Neurons
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Hypothalamic Circuits and Signaling
*
Andrew Butler,
St. Louis University, USA
*
Al S. Garfield,
Pfizer Inc., USA
Harvey J. Grill,
University of Pennsylvania, USA
Role of CNS GLP-1R Signaling in Mediating the Feeding Inhibitory Effects of Systemically Delivered and Endogenous GLP-1R Ligands
Role of CNS GLP-1R Signaling in Mediating the Feeding Inhibitory Effects of Systemically Delivered and Endogenous GLP-1R Ligands
Shane T. Hentges,
Colorado State University, USA
Amino Acid Transmitters in Hypothalamic Circuits Regulating Energy Balance
Amino Acid Transmitters in Hypothalamic Circuits Regulating Energy Balance
Maribel Rios,
Tufts University School of Medicine, USA
The Role of Brain-Derived Neurotrophic Factor in Hypothalamic Feeding Circuits
The Role of Brain-Derived Neurotrophic Factor in Hypothalamic Feeding Circuits
David Olson,
University of Michigan, USA
Functional Analysis of PVH Neurons in Energy Balance
Functional Analysis of PVH Neurons in Energy Balance
Baoji Xu,
The Scripps Research Institute Florida, USA
Short Talk: Control of Body Weight via BDNF-Expressing Neurons in the Paraventricular Hypothalamus
Short Talk: Control of Body Weight via BDNF-Expressing Neurons in the Paraventricular Hypothalamus
Clemence Girardet,
St. Louis University, USA
Short Talk: Melanocortin-3 Receptors and the Appetitive Response to Weight Loss
Short Talk: Melanocortin-3 Receptors and the Appetitive Response to Weight Loss
14:30—16:30
Workshop 2: Hypothalamic Injuries and Immunity in Obesity
*
Joshua Thaler,
University of Washington, USA
*
George Stratigopoulos,
Columbia University, USA
Yuanqing Gao,
Helmholtz Zentrum München, Germany
Advanced Glycation End Products (AGEs) and Hypothalamic Innate Immune Response
Advanced Glycation End Products (AGEs) and Hypothalamic Innate Immune Response
Kazuhito Sai,
North Carolina State University, USA
TAK1 Links Hypothalamic Inflammation and ER Stress in Causing Obesity
TAK1 Links Hypothalamic Inflammation and ER Stress in Causing Obesity
Suneil K. Koliwad,
University of California, San Francisco, USA
Microglia Mediate the Impact of Saturated Fat on Hypothalamic Inflammation and Metabolic Control
Microglia Mediate the Impact of Saturated Fat on Hypothalamic Inflammation and Metabolic Control
Lea Decarie-Spain,
University of Montreal Hospital Research Centre, Canada
Saturated Fat Induces Neural Inflammation in Nucleaus Accumbens
Saturated Fat Induces Neural Inflammation in Nucleaus Accumbens
Mauricio D. Dorfman,
University of Washington, USA
Cx3cr1 Signaling Modulates Microglial Activation and Protects Against Diet-Induced Obesity
Cx3cr1 Signaling Modulates Microglial Activation and Protects Against Diet-Induced Obesity
17:00—19:00
Therapies for Targeting the CNS Mechanisms of Obesity and Diabetes
*
Qingchun Tong,
University of Texas Medical School, USA
*
Simon M. Luckman,
University of Manchester, UK
Matthias H. Tschöp,
Helmholtz Zentrum München and Technische Universität München, Germany
GLP1 Manipulation for Control of Obesity and Diabetes
GLP1 Manipulation for Control of Obesity and Diabetes
Roger D. Cone,
University of Michigan, USA
Novel Sites and Modalities of Melanocortin-4 Receptor Signaling
Novel Sites and Modalities of Melanocortin-4 Receptor Signaling
Randy J. Seeley,
University of Michigan, USA
Key Systems Mediating the Response to Bariatric Surgery
Key Systems Mediating the Response to Bariatric Surgery
Luke K. Burke,
University of Cambridge, UK
Short Talk: Lorcaserin Promotes Anorectic and Glycemic effects via Divergent Neurocircuits
Short Talk: Lorcaserin Promotes Anorectic and Glycemic effects via Divergent Neurocircuits
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Hypothalamic or Brain Dysfunction in Metabolic Control
*
Dongsheng Cai,
Albert Einstein College of Medicine, USA
*
Sebastien G. Bouret,
Inserm U1172, France
Jens C. Brüning,
Max Planck Institute for Metabolism Research, Germany
Novel Regulators of AgRP-Neuron Activity
Novel Regulators of AgRP-Neuron Activity
Tamas L. Horvath,
Yale School of Medicine, USA
Hypothalamic Control of Integrative Physiology and Health
Hypothalamic Control of Integrative Physiology and Health
Kevin L. Grove,
Novo Nordisk, USA
Development of Functional Inputs into NPY/AgRP/GABA (NAG) and POMC Neurons in the Hypothalamus
Development of Functional Inputs into NPY/AgRP/GABA (NAG) and POMC Neurons in the Hypothalamus
Chun-Xia Yi,
Helmholtz Zentrum München, Germany
Short Talk: Microglial TNFalpha Induces Mitochondrial Stress to Cause Obesity and Diabetes
Short Talk: Microglial TNFalpha Induces Mitochondrial Stress to Cause Obesity and Diabetes
Eglantine Balland,
Monash University, Australia
Short Talk: Many Causes of Leptin Resistance in Obesity
Short Talk: Many Causes of Leptin Resistance in Obesity
11:15—11:40
NIDDK Workshop on NIH Common Fund Initiatives
Philip F. Smith,
NIDDK, National Institutes of Health, USA
Resources and Funding Opportunities
Resources and Funding Opportunities
17:00—19:00
Brain Mechanisms of Diabetes: Neuroinflammation and Others
*
Vincent Prevot,
INSERM University of Lille, France
Dongsheng Cai,
Albert Einstein College of Medicine, USA
Hypothalamic Microinflammation in Diabetes
Hypothalamic Microinflammation in Diabetes
Michael W. Schwartz,
University of Washington, USA
Cooperation between Brain and Islet in Glucose Homeostasis and Diabetes
Cooperation between Brain and Islet in Glucose Homeostasis and Diabetes
Suzanne DeLaMonte,
Brown University, USA
Type 3 Diabetes: Metabolic Basis of Alzheimer’s Diseases
Type 3 Diabetes: Metabolic Basis of Alzheimer’s Diseases
Kevin W. Williams,
University of Texas Southwestern Medical Center, USA
Short Talk: IRE1alpha/XBP1s Connects ER Stress with Dysregulation of Energy Balance and Glucose Homeostasis
Short Talk: IRE1alpha/XBP1s Connects ER Stress with Dysregulation of Energy Balance and Glucose Homeostasis
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Cellular Signaling in the CNS
*
Christoph Buettner,
Mount Sinai School of Medicine, USA
Joel K. Elmquist,
University of Texas Southwestern Medical Center, USA
SF-1 in the Hypothalamus: A Molecular Link between Energy Balance Regulation and Exercise
SF-1 in the Hypothalamus: A Molecular Link between Energy Balance Regulation and Exercise
Heike Münzberg,
Pennington Biomedical Research Center, USA
Central Circuits of Thermoregulatory Leptin Action
Central Circuits of Thermoregulatory Leptin Action
Barbara B. Kahn,
Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Hypothalamic AMPK and Mediators
Hypothalamic AMPK and Mediators
Carol F. Elias,
University of Michigan, USA
Hypothalamic Signals and Circuits Linking Metabolism and Reproduction
Hypothalamic Signals and Circuits Linking Metabolism and Reproduction
Qingchun Tong,
University of Texas Medical School, USA
Short Talk: GABAergic Projections from Lateral Hypothalamus to Paraventricular Hypothalamic Nucleus Promote Feeding
Short Talk: GABAergic Projections from Lateral Hypothalamus to Paraventricular Hypothalamic Nucleus Promote Feeding
Yong Xu,
Baylor College of Medicine, USA
Short Talk: SRC-2 in POMC Neurons Mediates Energy Reserving Effects of FOXO1
Short Talk: SRC-2 in POMC Neurons Mediates Energy Reserving Effects of FOXO1
14:30—16:30
Workshop 3: New Directions in Understanding the Central Regulation of Metabolism
*
Christa M. Patterson,
University of Michigan, USA
*
Herbert Herzog,
Garvan Institute, Australia
Angela M. Ramos-Lobo,
University of São Paulo, Brazil
Long-Term Consequences of the Absence of Leptin Action in Early Life
Long-Term Consequences of the Absence of Leptin Action in Early Life
Ceren Ozek,
University of Pennsylvania, USA
On “Trk”: The Role of Intact Hypothalamus and Hindbrain TrkB Signaling in Central Regulation of Energy Balance
On “Trk”: The Role of Intact Hypothalamus and Hindbrain TrkB Signaling in Central Regulation of Energy Balance
Liliia Butiaeva,
McGill University, Canada
Time-Lapse Imaging of Hypothalamic Leptin Receptor Neurons in Living Mice
Time-Lapse Imaging of Hypothalamic Leptin Receptor Neurons in Living Mice
John N. Campbell,
University of Virginia, USA
Single Cell RNA-Seq of AgRP Neurons Reveals Novel Subpopulations with Unique Gene Signatures
Single Cell RNA-Seq of AgRP Neurons Reveals Novel Subpopulations with Unique Gene Signatures
Haijiang Cai,
University of Arizona, USA
Central Amygdala Circuits Mediate the Influence of Multiple Anorexigenic Signals
Central Amygdala Circuits Mediate the Influence of Multiple Anorexigenic Signals
17:00—19:00
Rewarding and Ingestive Behaviors
*
Hans Rudolf Berthoud,
Pennington Biomedical Research Center, USA
*
Ralph DiLeone,
Yale University School of Medicine, USA
Gary J. Schwartz,
Albert Einstein College of Medicine, USA
Gut-Brain Nutrient Sensing and Reward
Gut-Brain Nutrient Sensing and Reward
Jeffrey M. Zigman,
University of Texas Southwestern Medical Center, USA
Ghrelin Control of Food Reward and Related Behaviors
Ghrelin Control of Food Reward and Related Behaviors
Luis de Lecea,
Stanford University, USA
Leptin Modulates Corticosterone Release through an Inhibitory Circuit in the Lateral Hypothalamus
Leptin Modulates Corticosterone Release through an Inhibitory Circuit in the Lateral Hypothalamus
Gwenaël Labouébe,
University of Lausanne, Switzerland
Short Talk: A Novel Thalamo-Accumbal Circuit that Controls Motivated Sucrose-Seeking Behavior
Short Talk: A Novel Thalamo-Accumbal Circuit that Controls Motivated Sucrose-Seeking Behavior
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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