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This meeting took place in 2015
Here are the related meetings in 2021:
Precision Engineering of the Genome, Epigenome and Transcriptome (X1)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Precision Genome Engineering and Synthetic Biology (A1)
Organizer(s) Philip D. Gregory, Jennifer A. Doudna and Ron Weiss
January 11—16, 2015
Big Sky Resort • Big Sky, MT USA
Discounted Abstract Deadline: Sep 22, 2014
Abstract Deadline: Oct 14, 2014
Scholarship Deadline: Sep 22, 2014
Discounted Registration Deadline: Nov 11, 2014
Sponsored by Agilent Technologies, Inc., Editas Medicine, Regeneron Pharmaceuticals, Inc., Sangamo BioSciences, Inc. and Thermo Fisher Scientific Inc.
Summary of Meeting:
The fields of precision genome engineering and synthetic biology are undergoing a revolution. Building on the rich resource of published genome sequences from a range of organisms (including humans), new enzymatic tools for the purposeful and precise modification of these genomes in vivo are enabling researchers to interrogate the complexity of genetic variation and determine the cause or consequence of mutations with unprecedented speed. Together with rapidly developing tools in synthetic biology, it is now possible to introduce mutations to evaluate gene function, generate models of human genetic disease, perform gene correction, chromosomally integrate synthetic gene networks that perform complex regulatory functions, and redesign genome structure or build whole genomes from scratch. This conference will bring together scientists who are: 1) Developing tools for precision genome engineering; 2) Using those tools for specific purposes in a wide range of organisms, including humans; 3) Engineering cells with novel pathways and properties; and 4) Creating whole synthetic genomes with prospects for wholesale reengineering. This meeting should attract world experts in the development and application of synthetic biology and gene engineering – two fields that could benefit directly from the exchange of ideas, methods, problems and solutions to usher in a new era of investigational biology. In addition, the meeting will provide an outstanding forum for students, postdoctoral fellows and senior investigators who envision careers in genome and pathway design.
View Scholarships/Awards
The fields of precision genome engineering and synthetic biology are undergoing a revolution. Building on the rich resource of published genome sequences from a range of organisms (including humans), new enzymatic tools for the purposeful and precise modification of these genomes in vivo are enabling researchers to interrogate the complexity of genetic variation and determine the cause or consequence of mutations with unprecedented speed. Together with rapidly developing tools in synthetic biology, it is now possible to introduce mutations to evaluate gene function, generate models of human genetic disease, perform gene correction, chromosomally integrate synthetic gene networks that perform complex regulatory functions, and redesign genome structure or build whole genomes from scratch. This conference will bring together scientists who are: 1) Developing tools for precision genome engineering; 2) Using those tools for specific purposes in a wide range of organisms, including humans; 3) Engineering cells with novel pathways and properties; and 4) Creating whole synthetic genomes with prospects for wholesale reengineering. This meeting should attract world experts in the development and application of synthetic biology and gene engineering – two fields that could benefit directly from the exchange of ideas, methods, problems and solutions to usher in a new era of investigational biology. In addition, the meeting will provide an outstanding forum for students, postdoctoral fellows and senior investigators who envision careers in genome and pathway design.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, JANUARY 11
MONDAY, JANUARY 12
TUESDAY, JANUARY 13
WEDNESDAY, JANUARY 14
THURSDAY, JANUARY 15
FRIDAY, JANUARY 16
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, JANUARY 11
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—08:15
Welcome Remarks
Philip D. Gregory,
Bluebird Bio, USA
Jennifer A. Doudna,
HHMI/University of California, Berkeley, USA
Ron Weiss,
Massachusetts Institute of Technology, USA
08:15—09:15
Keynote Address
*
Jennifer A. Doudna,
HHMI/University of California, Berkeley, USA
Dana Carroll,
University of Utah School of Medicine, USA
Mutations on Demand – A Perspective on Genome Editing
Mutations on Demand – A Perspective on Genome Editing
09:15—11:45
Editing and Control at Whole-Genome Scale: The Challenge
*
Blake Wiedenheft,
Montana State University, USA
Jennifer A. Doudna,
HHMI/University of California, Berkeley, USA
CRISPR-Cas Genome Surveillance: From Basic Biology to Transformative Technology
CRISPR-Cas Genome Surveillance: From Basic Biology to Transformative Technology
Feng Zhang,
Broad Institute of MIT and Harvard University, USA
Development and Applications of CRISPR-Cas9 for Genome Editing
Development and Applications of CRISPR-Cas9 for Genome Editing
J. Keith Joung,
Massachusetts General Hospital, USA
Targeted Genome and Epigenome Editing Using CRISPR-Cas and TALE Technologies
Targeted Genome and Epigenome Editing Using CRISPR-Cas and TALE Technologies
Haoquan Wu,
Texas Tech University Health Sciences Center, USA
Short Talk: A CRISPR-Cas9-Based Screen for Human Genes Essential for West Nile Virus-Induced Cell Death
Short Talk: A CRISPR-Cas9-Based Screen for Human Genes Essential for West Nile Virus-Induced Cell Death
Sidi Chen,
Yale University, USA
Short Talk: Modeling Competition of Multiple Cancer Mutations in vivo Using a Conditional CRISPR-Cas9 Mouse
Short Talk: Modeling Competition of Multiple Cancer Mutations in vivo Using a Conditional CRISPR-Cas9 Mouse
14:30—16:30
Workshop 1: Advances in Genome Editing
*
Andrew May,
Sana Biotechnology, Inc., USA
Yinan Kan,
eGenesis.Inc, USA
The Mechanism of Cas9/CRISPR-Mediated Gene Targeting Using ssODNs: Cleavases, Nickases and Paired-Nickases
The Mechanism of Cas9/CRISPR-Mediated Gene Targeting Using ssODNs: Cleavases, Nickases and Paired-Nickases
Mehmet Fatih Bolukbasi,
University of Massachusetts Medical School, USA
Improved Genome Targeting Precision Using a Chimeric Cas9 Nuclease
Improved Genome Targeting Precision Using a Chimeric Cas9 Nuclease
Tilmann Bürckstümmer,
Haplogen Genomics, Austria
Evidence from more than 700 Genome Editing Experiments Using CRISPR/Cas – Lessons Learned
Evidence from more than 700 Genome Editing Experiments Using CRISPR/Cas – Lessons Learned
Paul D. Donohoue,
Caribou Biosciences, Inc., USA
Modulation of Cas9 Activity through Single Guide RNA Engineering
Modulation of Cas9 Activity through Single Guide RNA Engineering
Emily Crawford,
University of California, San Francisco, USA
Editing the Plasmodium falciparum Genome by Transfection of Cas9-sgRNA Ribonucleoprotein
Editing the Plasmodium falciparum Genome by Transfection of Cas9-sgRNA Ribonucleoprotein
Mo Mandegar,
Tenaya Therapeutics, USA
A Doxycycline-Inducible CRISPR Inhibition iPS Cell Reporter Line for Cardiac Disease Modeling
A Doxycycline-Inducible CRISPR Inhibition iPS Cell Reporter Line for Cardiac Disease Modeling
Pankaj K. Mandal,
Harvard University/Boston Children's Hospital, USA
CRISPR/Cas9 Mediated Ablation of Clinically Relevant Genes in Human CD34+ HSPCs and CD4+ T Cells
CRISPR/Cas9 Mediated Ablation of Clinically Relevant Genes in Human CD34+ HSPCs and CD4+ T Cells
17:00—19:00
Design Principles and Practice of Basic Parts to Large Scale Circuits
*
Jacquin C. Niles,
Massachusetts Institute of Technology, USA
Christopher Voigt,
Massachusetts Institute of Technology, USA
Programmable Cell Technologies
Programmable Cell Technologies
Adam P. Arkin,
University of California, Berkeley, USA
Knowledge, Context and Process: Building a Foundational Infrastructure for Engineering Cells for Use in an Uncertain World
Knowledge, Context and Process: Building a Foundational Infrastructure for Engineering Cells for Use in an Uncertain World
Benjamin Jester,
University of Washington, USA
Short Talk: Biosensors Engineered from Conditionally Stable Ligand-Binding Domains
Short Talk: Biosensors Engineered from Conditionally Stable Ligand-Binding Domains
Patrick Guye,
InSphero AG, Switzerland
Short Talk: Engineering a Self-Organizing Liver Bud-Like Hematopoietic Niche from Human Pluripotent Stem Cells
Short Talk: Engineering a Self-Organizing Liver Bud-Like Hematopoietic Niche from Human Pluripotent Stem Cells
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Beyond On-and-Off: Analog Circuits, Non-Transcriptional Regulation
*
June I. Medford,
Colorado State University, USA
Timothy K. Lu,
Massachusetts Institute of Technology, USA
Synthetic Analog Computing and Memory in Living Cells
Synthetic Analog Computing and Memory in Living Cells
Ron Weiss,
Massachusetts Institute of Technology, USA
Mammalian Synthetic Biology: From Parts to Modules to Therapeutic Systems
Mammalian Synthetic Biology: From Parts to Modules to Therapeutic Systems
Andrew D. Ellington,
University of Texas at Austin, USA
Targetrons as Genome Engineering Tools
Targetrons as Genome Engineering Tools
Kathy Y. Wei,
Stanford University, USA
Short Talk: Programmable RNA-Based Tools for Conditional Control over Gene Expression
Short Talk: Programmable RNA-Based Tools for Conditional Control over Gene Expression
Daniel Woodsworth,
Genome Sciences Centre, Canada
Short Talk: A Lymphocyte-Based Cell-to-Cell Therapeutic Delivery System
Short Talk: A Lymphocyte-Based Cell-to-Cell Therapeutic Delivery System
Alexander S. Beliaev,
Pacific Northwest National Laboratory, USA
Short Talk: Engineering RNA Aptamer-Based Gene Circuits for Control of Microbial Interactions
Short Talk: Engineering RNA Aptamer-Based Gene Circuits for Control of Microbial Interactions
17:00—19:00
Found in Translation: Disease Modeling in Cells and Animals
*
Paula M. Cannon,
University of Southern California, Keck School of Medicine, USA
Jennifer E. Phillips-Cremins,
University of Pennsylvania, USA
Unraveling 3-D Folding Principles of the Pluripotent Genome
Unraveling 3-D Folding Principles of the Pluripotent Genome
Howard J. Jacob,
HudsonAlpha Institute for Bioltechnology, USA
Genome-Edited Rats as Models for Human Disease
Genome-Edited Rats as Models for Human Disease
Jacquin C. Niles,
Massachusetts Institute of Technology, USA
Gene Regulatory Devices for Malaria
Gene Regulatory Devices for Malaria
Marcus C.S. Lee,
Columbia University, USA
Short Talk: CRISPR-Mediated Genome Editing and Gene Regulation in Plasmodium falciparum Malaria Parasites
Short Talk: CRISPR-Mediated Genome Editing and Gene Regulation in Plasmodium falciparum Malaria Parasites
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
The Genome-Edited Cell as a Window onto Biological Mechanism
*
Dana Carroll,
University of Utah School of Medicine, USA
Maria Jasin,
Memorial Sloan Kettering Cancer Center, USA
Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining
Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining
Danilo Maddalo,
Memorial Sloan-Kettering Cancer Center, USA
Short Talk: In vivo Engineering of Oncogenic Chromosomal Rearrangements Using the CRISPR/Cas9 System
Short Talk: In vivo Engineering of Oncogenic Chromosomal Rearrangements Using the CRISPR/Cas9 System
Yannick Doyon,
Laval University, Canada
Short Talk: Charting the Path from Oncogenic Rearrangement to Epigenomic Outcome via Genome Editing
Short Talk: Charting the Path from Oncogenic Rearrangement to Epigenomic Outcome via Genome Editing
Dirk Hockemeyer,
University of California, Berkeley, USA
Elucidating Telomerase Function in Human Tumor and Stem Cell Biology Using Genetically Defined Cell Models
Elucidating Telomerase Function in Human Tumor and Stem Cell Biology Using Genetically Defined Cell Models
Laura Vian,
NIAMS, National Institutes of Health, USA
Short Talk: Using Genome Editing Techniques to Uncover Rules of “CTCF Code”
Short Talk: Using Genome Editing Techniques to Uncover Rules of “CTCF Code”
Danwei Huangfu,
Memorial Sloan Kettering Cancer Institute, USA
Short Talk: hESC-Based Functional Human Genetics for Studying Pancreatic Development and Diabetes
Short Talk: hESC-Based Functional Human Genetics for Studying Pancreatic Development and Diabetes
Michele P. Calos,
Stanford University School of Medicine, USA
Genome Engineering in a Stem Cell Therapy for Muscular Dystrophy
Genome Engineering in a Stem Cell Therapy for Muscular Dystrophy
17:00—19:00
Health 2025: On the Path to the Clinic
*
Howard J. Jacob,
HudsonAlpha Institute for Bioltechnology, USA
Thomas Armel,
Quantitative Scientific Solutions, USA
Talk Title to be Announced
Talk Title to be Announced
Bruce R. Conklin,
University of California, San Francisco, USA
Precise Genome Engineering in Human iPS Cells for Disease Modeling and Therapy
Precise Genome Engineering in Human iPS Cells for Disease Modeling and Therapy
Paejonette Jacobs,
NIAID, National Institutes of Health, USA
Short Talk: A Novel Cure Strategy for WHIM Syndrome by Targeted Genome Engineering of CXCR4 to Convey a Competitive Advantage to Hematopoietic Stem Cells
Short Talk: A Novel Cure Strategy for WHIM Syndrome by Targeted Genome Engineering of CXCR4 to Convey a Competitive Advantage to Hematopoietic Stem Cells
Paula M. Cannon,
University of Southern California, Keck School of Medicine, USA
Using Targeted Nucleases to Create an HIV-Resistant Immune System
Using Targeted Nucleases to Create an HIV-Resistant Immune System
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Protein, Enzyme and Metabolic Engineering: "Tools and Fuels"
*
Timothy K. Lu,
Massachusetts Institute of Technology, USA
John Glass,
J. Craig Venter Institute, USA
Building and Using a Minimal Microbial Cell to Understand the 1st Principles of Cellular Life
Building and Using a Minimal Microbial Cell to Understand the 1st Principles of Cellular Life
David Baker,
University of Washington, USA
Design of Novel Protein Structures, Functions and Assemblies
Design of Novel Protein Structures, Functions and Assemblies
Kristala Jones Prather,
Massachusetts Institute of Technology, USA
Metabolite Valves: Dynamic Control of Metabolic Flux for Pathway Engineering
Metabolite Valves: Dynamic Control of Metabolic Flux for Pathway Engineering
Michelle C. Chang,
University of California, Berkeley, USA
Designing New Biosynthetic Pathways for in vivo Cellular Production of Biofuels and Pharmaceuticals
Designing New Biosynthetic Pathways for in vivo Cellular Production of Biofuels and Pharmaceuticals
Andrew Horwitz,
Amyris, Inc., USA
Short Talk: One-Step Engineering of Complete Metabolic Pathways in Yeasts Using CRISPR-Cas9
Short Talk: One-Step Engineering of Complete Metabolic Pathways in Yeasts Using CRISPR-Cas9
David F. Savage,
University of California, Berkeley, USA
Short Talk: Rapid Construction of Metabolite Biosensors
Short Talk: Rapid Construction of Metabolite Biosensors
14:30—15:30
Workshop 2: BioCAD Tools: Design and Mapping to Biological Circuits
*
Douglas Densmore,
Boston University, USA
Hyun-Seob Song,
Pacific Northwest National Laboratory, USA
Dynamic Metabolic Modeling as a Design Tool for Synthetic Microbial Consortia
Dynamic Metabolic Modeling as a Design Tool for Synthetic Microbial Consortia
Kevin Clancy,
Thermo Fisher Scientific, USA
Vector NTI Express Designer - A Synthetic Biology Design Software
Vector NTI Express Designer - A Synthetic Biology Design Software
Kamalakar Chatla,
Mayo Clinic, USA
The Zebrafish Genome Editing Toolkit for Precision Medicine
The Zebrafish Genome Editing Toolkit for Precision Medicine
15:30—16:30
BioCAD Hands-On Tutorial
Douglas Densmore,
Boston University, USA
Victor Dillard,
Desktop Genetics, UK
17:00—18:45
Earth 2025: Edited Life Forms for a Better World
*
John Glass,
J. Craig Venter Institute, USA
Zhan-Bin Liu,
Corteva Agriscience, USA
Short Talk: Genome Engineering in Soybean
Short Talk: Genome Engineering in Soybean
Nicholas D. Bonawitz,
Dow AgroSciences, LLC, USA
Short Talk: Targeted Transgene Insertion in Maize via Non-Homologous End Joining at a Zinc Finger Nuclease-Induced Double Strand Break
Short Talk: Targeted Transgene Insertion in Maize via Non-Homologous End Joining at a Zinc Finger Nuclease-Induced Double Strand Break
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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