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This meeting took place in 2015
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The Biological Code of Cell Signaling: A Tribute to Tony Pawson (F1)
Organizer(s) Tony Hunter and Rune Linding
January 11—16, 2015
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Discounted Abstract Deadline: Sep 23, 2014
Abstract Deadline: Oct 15, 2014
Scholarship Deadline: Sep 23, 2014
Discounted Registration Deadline: Nov 12, 2014
Sponsored by the Journal of Molecular Cell Biology (JMCB), Regeneron Pharmaceuticals, Inc., Roche and Thermo Fisher Scientific Inc.
Summary of Meeting:
Prompted by the recent loss of one of the brightest stars in the life sciences, this Keystone Symposia meeting has been designed to honor the memory of Tony Pawson. The aim of the meeting is to provide a forward-looking symposium rooted in his prodigious scientific legacy. It constitutes a natural evolution of previous symposia he organized (such as the “Omics Meets Cell Biology” series and “The Evolution of Protein Phosphorylation”). As such, the scientific focus of the symposium is on the role of post-translational modifications (PTMs), modular protein domains and signaling networks as driving forces of human evolution and disease. The cellular world that Tony, with others, unlocked consists of dynamic protein networks created through the interactions of different protein modules, which together drive almost every intra- and inter-cellular decision process we know today. His most important contribution in this field is undoubtedly his discovery of the first protein interaction module, the SH2 domain, but numerous other interaction domains followed, leading to current investigations of how the dysregulation of these networks leads to new signaling states in disease that are critical for processes in, for instance, cancer, such as tumor progression, or drug resistance. The symposium thus spans the entire spectrum of fields that have been touched by Tony Pawson's prolific and inspiring research, while maintaining a strong forward-looking perspective.
View Scholarships/Awards
Prompted by the recent loss of one of the brightest stars in the life sciences, this Keystone Symposia meeting has been designed to honor the memory of Tony Pawson. The aim of the meeting is to provide a forward-looking symposium rooted in his prodigious scientific legacy. It constitutes a natural evolution of previous symposia he organized (such as the “Omics Meets Cell Biology” series and “The Evolution of Protein Phosphorylation”). As such, the scientific focus of the symposium is on the role of post-translational modifications (PTMs), modular protein domains and signaling networks as driving forces of human evolution and disease. The cellular world that Tony, with others, unlocked consists of dynamic protein networks created through the interactions of different protein modules, which together drive almost every intra- and inter-cellular decision process we know today. His most important contribution in this field is undoubtedly his discovery of the first protein interaction module, the SH2 domain, but numerous other interaction domains followed, leading to current investigations of how the dysregulation of these networks leads to new signaling states in disease that are critical for processes in, for instance, cancer, such as tumor progression, or drug resistance. The symposium thus spans the entire spectrum of fields that have been touched by Tony Pawson's prolific and inspiring research, while maintaining a strong forward-looking perspective.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, JANUARY 11
MONDAY, JANUARY 12
TUESDAY, JANUARY 13
WEDNESDAY, JANUARY 14
THURSDAY, JANUARY 15
FRIDAY, JANUARY 16
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, JANUARY 11
08:00—11:00
Tony Pawson: More than 35 Years of Research Discovery
Opening session providing a global overview of Tony’s scientific legacy by scientists who can deliver personal, exciting and emotional retrospectives, mixed with an overview of their own research.
*
Rune Linding,
University of Copenhagen, Denmark
Tony Hunter,
The Salk Institute for Biological Sciences, USA
A Tale of Two Tonys: Forty Years of Scientific Crosstalk
A Tale of Two Tonys: Forty Years of Scientific Crosstalk
Alan Bernstein,
Canadian Institute for Advanced Research, Canada
Tony Pawson: Wonderful Scientist, Colleague and True Friend
Tony Pawson: Wonderful Scientist, Colleague and True Friend
John D. Scott,
University of Washington, USA
Guiding Signals through Anchored Enzyme Complexes
Guiding Signals through Anchored Enzyme Complexes
Nina Jones,
University of Guelph, Canada
Short Talk: Phosphotyrosine Signaling at the Kidney Slit Diaphragm
Short Talk: Phosphotyrosine Signaling at the Kidney Slit Diaphragm
Marius Sudol,
National University of Singapore, Singapore
Poster Talk: Signaling by WW and SH2 Domain-Containing Proteins
Poster Talk: Signaling by WW and SH2 Domain-Containing Proteins
Arthur Weiss,
University of California, San Francisco, USA
Intercellular Signaling by Transmembrane Proteins
Intercellular Signaling by Transmembrane Proteins
17:00—19:00
Modular Protein Domains - Past, Present and Future
From SH2 to all other building blocks of signaling networks.
Peer Bork,
European Molecular Biology Laboratory, Germany
Predicting Biological Function at Different Spatial Scales
Predicting Biological Function at Different Spatial Scales
Sachdev S. Sidhu,
University of Toronto, Canada
Modulation of Cell Signaling with Synthetic Proteins
Modulation of Cell Signaling with Synthetic Proteins
*
Bruce J. Mayer,
University of Connecticut Health Center, USA
SH2 Domains Three Ways: The Dynamics of Receptor Tyrosine Kinase Signaling
SH2 Domains Three Ways: The Dynamics of Receptor Tyrosine Kinase Signaling
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Protein Modules and Drugs
How to perturb domains and target them for medical intervention.
*
Giulio Superti-Furga,
Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Integration of Individual Signaling Domains into Increasingly Complex Layers of Regulation: From the ABL Tyrosine Kinase to the Mechanism of Action of Anticancer Drugs
Integration of Individual Signaling Domains into Increasingly Complex Layers of Regulation: From the ABL Tyrosine Kinase to the Mechanism of Action of Anticancer Drugs
Shohei Koide,
New York University Langone Health, USA
Poster Talk: Controlling Signaling Networks with Monobody Inhibitors against Modular Interaction Domains
Poster Talk: Controlling Signaling Networks with Monobody Inhibitors against Modular Interaction Domains
Rudolf H. Aebersold,
Institute of Molecular Systems Biology, ETH Zürich, Switzerland
Genetic Variability and the Quantitative Proteome
Genetic Variability and the Quantitative Proteome
Frank Sicheri,
Lunenfeld-Tanenbaum Research Institute, Canada
Structural Basis for Poly-Ubiquitin Chain Cleavage: Lessons Learned from OTUB1 and OTULIN/Gumby
Structural Basis for Poly-Ubiquitin Chain Cleavage: Lessons Learned from OTUB1 and OTULIN/Gumby
Xiaolei Su,
University of California, San Francisco, USA
Poster Talk: Reconstituting TCR Signaling Pathways Reveals a Role for T Cell Microclusters
Poster Talk: Reconstituting TCR Signaling Pathways Reveals a Role for T Cell Microclusters
17:00—19:00
Kinome Biology
Kinase signaling networks - phosphorylation-based signaling.
Edward Y. Skolnik,
New York University Medical Center, USA
Poster Talk: Regulation of Pancreatic b Cells by Protein Histidine Phosphorylation
Poster Talk: Regulation of Pancreatic b Cells by Protein Histidine Phosphorylation
Susan S. Taylor,
University of California, San Diego, USA
PKA: Evolution of a Dynamic Macromolecular Switch
PKA: Evolution of a Dynamic Macromolecular Switch
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
From Modules and Networks to Cellular Phenotypes
How changes in protein modules and signaling networks translate into cellular switches.
*
John Kuriyan,
University of California, Berkeley, USA
Control of Catalytic Activity in the EGF Receptor
Control of Catalytic Activity in the EGF Receptor
Ivan Dikic,
Goethe University Medical School, Germany
Linear Ubiquitination in Regulation of Inflammation
Linear Ubiquitination in Regulation of Inflammation
Michael Tyers,
, Canada
From Large Networks to Small Molecules
From Large Networks to Small Molecules
Lee Bardwell,
University of California, Irvine, USA
Poster Talk: Synergy, Interdependency and Redundancy in Multi-Site Phosphorylation
Poster Talk: Synergy, Interdependency and Redundancy in Multi-Site Phosphorylation
James E. Ferrell Jr.,
Stanford University, USA
Trigger Waves in Mitosis and Apoptosis
Trigger Waves in Mitosis and Apoptosis
17:00—19:00
Evolution of Phosphorylation, PTMs and Modular Protein Domains
How cells evolved to function the way they do
*
Gerard Manning,
Genentech, Inc., USA
Evolutionary Comparisons to Explore the Function and Diversity of Signaling Biology
Evolutionary Comparisons to Explore the Function and Diversity of Signaling Biology
Chris Tan,
CeMM Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Short Talk: Co-Evolution of Protein Phosphorylation and Protein-Protein Interaction Networks
Short Talk: Co-Evolution of Protein Phosphorylation and Protein-Protein Interaction Networks
Liam J. Holt,
University of California, Berkeley, USA
Poster Talk: Ancestral Resurrection Reveals Evolutionary Mechanisms of Kinase Plasticity
Poster Talk: Ancestral Resurrection Reveals Evolutionary Mechanisms of Kinase Plasticity
Benjamin G. Neel,
Ontario Cancer Institute, Canada
PTP1B Promotes Survival of HER2+ Breast Cancer in Hypoxia by Regulating Moyamoya Disease-Associated E3 Ligase, RNF213 and Cellular Dioxygenase Activity
PTP1B Promotes Survival of HER2+ Breast Cancer in Hypoxia by Regulating Moyamoya Disease-Associated E3 Ligase, RNF213 and Cellular Dioxygenase Activity
Robert Rottapel,
Princess Margaret Hospital, Toronto Medical Discovery Tower, Canada
Short Talk: Abl Mediates a TAZ:RUNZ2 Self-Reinforcing Feedback Loop Required for Osteoblastogenesis
Short Talk: Abl Mediates a TAZ:RUNZ2 Self-Reinforcing Feedback Loop Required for Osteoblastogenesis
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Network Medicine - Targeting Signaling Networks
Relating knowledge of signaling networks to advances in patients’ outcomes.
*
Michael B. Yaffe,
Massachusetts Institute of Technology, USA
Using Systems Biology to Target Cancer
Using Systems Biology to Target Cancer
Douglas A. Lauffenburger,
Massachusetts Institute of Technology, USA
Crosstalk and Feedback in Receptor Tyrosine Kinase Signaling Networks
Crosstalk and Feedback in Receptor Tyrosine Kinase Signaling Networks
Ruth H. Palmer,
University of Gothenburg, Sweden
Poster Talk: Investigation of Anaplastic Lymphoma Kinase Signaling
Poster Talk: Investigation of Anaplastic Lymphoma Kinase Signaling
Johannes L. Bos,
University Medical Center Utrecht, Netherlands
Targeting Spatial and Temporal Control of Endothelial Barrier Function
Targeting Spatial and Temporal Control of Endothelial Barrier Function
Oliver Hantschel,
Swiss Federal Institute of Technology Lausanne, Switzerland
Poster Talk: The SH2 Domain of ABL Kinases Regulates Kinase Autophosphorylation by Controlling Activation Loop Accessibility
Poster Talk: The SH2 Domain of ABL Kinases Regulates Kinase Autophosphorylation by Controlling Activation Loop Accessibility
Michael K. Rosen,
University of Texas Southwestern Medical Center, USA
Phase Separation of Multi-Valent Signaling Proteins
Phase Separation of Multi-Valent Signaling Proteins
17:00—19:00
Signaling Networks Driving Disease Progression and Resistance to Drugs
Current limitations in our understanding of disease progression and potential solutions.
*
Joan S. Brugge,
Harvard Medical School, USA
Signaling Pathways that Regulate Adaptive Resistance to Cancer Therapies
Signaling Pathways that Regulate Adaptive Resistance to Cancer Therapies
Richard M. Marais,
Cancer Research UK Manchester Institute, UK
NRAS and BRAF Signaling in Melanoma: From Basic Biology to Clinical Efficacy
NRAS and BRAF Signaling in Melanoma: From Basic Biology to Clinical Efficacy
Clark D. Wells,
Indiana University School of Medicine, USA
Differential Roles of Angiomotin Proteins in the Development of Breast Cancer
Differential Roles of Angiomotin Proteins in the Development of Breast Cancer
19:00—19:30
Closing Remarks: Tony Pawson’s Legacy
*
Tony Hunter,
The Salk Institute for Biological Sciences, USA
19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
We gratefully acknowledge support for this conference from:
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