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This meeting took place in 2016
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Stem Cells and Cancer (C1)
Organizer(s) Austin Gurney, Connie J. Eaves and Jane E. Visvader
March 6—10, 2016
Beaver Run Resort • Breckenridge, CO USA
Discounted Abstract Deadline: Nov 4, 2015
Abstract Deadline: Dec 7, 2015
Scholarship Deadline: Nov 4, 2015
Discounted Registration Deadline: Jan 6, 2016
Sponsored by Bayer HealthCare Pharmaceuticals, BioLegend, Inc., Journal of Molecular Cell Biology (JMCB), OncoMed Pharmaceuticals, Inc. and Roche
Summary of Meeting:
Cancer stem cells have now been recognized in a wide variety of human tumors. The existence of cancer stem cells poses both tremendous challenges and tantalizing potential for our ability to successfully combat cancer. This Keystone Symposia meeting aims to bring together scientists who are interested in better understanding the mechanisms by which cancer stem cells contribute to tumor heterogeneity, self-renewal and drug resistance. One area of emphasis will be intercellular communication. Cellular context and microenvironment establish the tumor niche and shape the interaction of the tumor with the immune system. In addition, developmental signal transduction pathways such as Hippo, Notch and Wnt, frequently deregulated in cancer, increasingly offer tangible opportunities for therapeutic intervention. Another important area of emphasis will be efforts to better understand the mechanisms and importance of tumor heterogeneity. Techniques such as clonal analysis and barcoding are shedding important light on the interplay between tumor evolution, differentiation, miRNA control and epigenetics. This is an era of rapid progress in understanding cancer stem cell biology with great potential to benefit human health.
View Scholarships/Awards
Cancer stem cells have now been recognized in a wide variety of human tumors. The existence of cancer stem cells poses both tremendous challenges and tantalizing potential for our ability to successfully combat cancer. This Keystone Symposia meeting aims to bring together scientists who are interested in better understanding the mechanisms by which cancer stem cells contribute to tumor heterogeneity, self-renewal and drug resistance. One area of emphasis will be intercellular communication. Cellular context and microenvironment establish the tumor niche and shape the interaction of the tumor with the immune system. In addition, developmental signal transduction pathways such as Hippo, Notch and Wnt, frequently deregulated in cancer, increasingly offer tangible opportunities for therapeutic intervention. Another important area of emphasis will be efforts to better understand the mechanisms and importance of tumor heterogeneity. Techniques such as clonal analysis and barcoding are shedding important light on the interplay between tumor evolution, differentiation, miRNA control and epigenetics. This is an era of rapid progress in understanding cancer stem cell biology with great potential to benefit human health.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, March 6 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 10 with a keynote address and closing plenary session from 17:00 to 19:30, followed by a social hour and entertainment. We recommend return travel on Friday, March 11 in order to fully experience the meeting.
SUNDAY, MARCH 6
MONDAY, MARCH 7
TUESDAY, MARCH 8
WEDNESDAY, MARCH 9
THURSDAY, MARCH 10
FRIDAY, MARCH 11
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, March 6 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 10 with a keynote address and closing plenary session from 17:00 to 19:30, followed by a social hour and entertainment. We recommend return travel on Friday, March 11 in order to fully experience the meeting.
SUNDAY, MARCH 6
08:00—09:00
Welcome and Keynote Address
Provide a stimulating and dynamic overview of some of the major ideas and trends shaping the field.
*
Jane E. Visvader,
Walter and Eliza Hall Institute of Medical Research, Australia
Sean J. Morrison,
University of Texas Southwestern Medical Center, USA
Oxidative Stress Inhibits Distant Metastasis by Human Melanoma Cells
Oxidative Stress Inhibits Distant Metastasis by Human Melanoma Cells
09:00—11:15
Stem Cell Concepts and Models
Stability and reversibility of the stem cell state, lessons from model systems, comparisons with normal stem cells and self-renewal.
*
Jane E. Visvader,
Walter and Eliza Hall Institute of Medical Research, Australia
Deciphering the Mammary Epithelial Hierarchy
Deciphering the Mammary Epithelial Hierarchy
Eirini P. Papapetrou,
Icahn School of Medicine at Mount Sinai, USA
Modeling Myeloid Malignancies with Human Pluripotent Stem Cells
Modeling Myeloid Malignancies with Human Pluripotent Stem Cells
Ali Turhan,
University Paris Sud 11, France
Modeling Cancer Using Human iPSC
Modeling Cancer Using Human iPSC
Marc Leushacke,
Agency for Science, Technology and Research (A*STAR), Singapore
Short Talk: Lgr5+ Stem Cells in Epithelial Homeostasis and Disease of the Stomach
Short Talk: Lgr5+ Stem Cells in Epithelial Homeostasis and Disease of the Stomach
17:00—19:00
Intercellular Interactions: Non-Cell Autonomous CSC Biology
Cooperativity, niche and immune interaction.
*
Carla F. Kim,
Boston Children's Hospital, USA
Lung Cancer Stem Cells
Lung Cancer Stem Cells
Dominique A. Bonnet,
Francis Crick Institute, UK
Modulation of Mesenchymal Stroma Cells by Acute Myeloid Leukemia
Modulation of Mesenchymal Stroma Cells by Acute Myeloid Leukemia
Christian Steidl,
University of British Columbia, Canada
Targeting the Tumor-Host Cellular Interface in Lymphoid Malignancies
Targeting the Tumor-Host Cellular Interface in Lymphoid Malignancies
Takahiko Murayama,
University of Tokyo, Japan
Short Talk: CD74-NRG1, a Fusion Gene Product, Leads to ErbB-NFkappaB-IGF2 Autocrine/Paracrine Circuit and Confers Cancer Stem Cell Properties
Short Talk: CD74-NRG1, a Fusion Gene Product, Leads to ErbB-NFkappaB-IGF2 Autocrine/Paracrine Circuit and Confers Cancer Stem Cell Properties
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Tumorigenesis
Control of birth, dormancy and expansion of normal and malignant stem cells/de novo human tumorigenesis.
*
Connie J. Eaves,
British Columbia Cancer Agency, Canada
Barcoding to Analyze De Novo Generated and Established Human Breast Cancers
Barcoding to Analyze De Novo Generated and Established Human Breast Cancers
Hanno Glimm,
National Center for Tumor Diseases, Germany
Stem Cell Kinetics in Gastrointestinal Cancers
Stem Cell Kinetics in Gastrointestinal Cancers
Emmanuelle Passegué,
Columbia University, USA
Hijacking of Emergency Myelopoiesis Pathways in Myeloid Leukemia
Hijacking of Emergency Myelopoiesis Pathways in Myeloid Leukemia
Xiling Shen,
Duke University
Short Talk: lncRNA and microRNA Synergize to Regulate Colon Cancer Stem Cell Asymmetry and Plasticity
Short Talk: lncRNA and microRNA Synergize to Regulate Colon Cancer Stem Cell Asymmetry and Plasticity
14:30—16:30
Workshop
*
Nagarajan Kannan,
BC Cancer Research Center, Canada
Human Mammary Luminal Progenitor Cells use Oxidative Stress Signals to Regulate Signaling and Growth
Human Mammary Luminal Progenitor Cells use Oxidative Stress Signals to Regulate Signaling and Growth
Alexander T. Pearson,
University of Michigan, USA
Using Single-Cell Observations and Mathematical Modeling to Predict Tumor Cell Growth and Cancer Stem Cell Proportion In-Vitro and In-Vivo
Using Single-Cell Observations and Mathematical Modeling to Predict Tumor Cell Growth and Cancer Stem Cell Proportion In-Vitro and In-Vivo
Bryan A. Smith,
University of California, Los Angeles, USA
A Basal Stem Cell Signature Identifies Aggressive Prostate Cancer Phenotypes
A Basal Stem Cell Signature Identifies Aggressive Prostate Cancer Phenotypes
Min Wang,
OncoMed Pharmaceuticals, USA
Identification of a Pancreatic Tumorigenic CSC Gene Signature and Demonstration of its Suppression in Pancreas PDX Models and in Patient Tumors by Treatment with an Anti-CSC Antibody, Tarextumab (TRXT)
Identification of a Pancreatic Tumorigenic CSC Gene Signature and Demonstration of its Suppression in Pancreas PDX Models and in Patient Tumors by Treatment with an Anti-CSC Antibody, Tarextumab (TRXT)
Nils Degrauwe,
University of Lausanne, Switzerland
IMP2 Provides an Alternative to LIN28B for Glioma Stem Cell Maintenance
IMP2 Provides an Alternative to LIN28B for Glioma Stem Cell Maintenance
Tuomas Tammela,
Koch Institute for Integrative Cancer Research at MIT, USA
Molecular Mechanisms Orchestrating Intratumoral Heterogeneity in Kras-Driven Carcinomas
Molecular Mechanisms Orchestrating Intratumoral Heterogeneity in Kras-Driven Carcinomas
Diwakar R. Pattabiraman,
Geisel School of Medicine, Dartmouth College, USA
Activation of PKA Induces a Mesenchymal-to-Epithelial Transition and Loss of Tumor-Initiating Ability of Breast Carcinomas
Activation of PKA Induces a Mesenchymal-to-Epithelial Transition and Loss of Tumor-Initiating Ability of Breast Carcinomas
Jatin Roper,
Koch Institute for Integrative Cancer Research at MIT, USA
Sequential Genome Editing in CRISPR/Cas9-based Colorectal Cancer Mouse Models
Sequential Genome Editing in CRISPR/Cas9-based Colorectal Cancer Mouse Models
17:00—19:00
Disregulation of Stem/Developmental Pathways
Exploration of the role of developmental pathways (eg. Notch, Wnt, Hippo, BMP, RSPO) in CSC biology.
*
Stefano Piccolo,
University of Padua, Italy
Yap/Taz Regulation in Stem Cells and Cancer
Yap/Taz Regulation in Stem Cells and Cancer
Jon C. Aster,
Brigham and Women's Hospital, USA
Myb-Notch-p63 Transcriptional Hierarchies in Adenoid Cystic Carcinoma
Myb-Notch-p63 Transcriptional Hierarchies in Adenoid Cystic Carcinoma
Florian R. Greten,
Institute for Tumor Biology and Experimental Therapy, Germany
Mechanisms Influencing Intestinal Tumorigenesis
Mechanisms Influencing Intestinal Tumorigenesis
Zahra Kabiri,
Duke University, USA
Short Talk: RSPO3 is the Gatekeeper of Wnt/Beta-Catenin Signaling in Intestinal Stem Cell Niche
Short Talk: RSPO3 is the Gatekeeper of Wnt/Beta-Catenin Signaling in Intestinal Stem Cell Niche
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Understanding Tumor Heterogeneity
EMT, plasticity, lineage tracing, clonal tracking and tumors as evolving ecosystems.
*
Michael F. Clarke,
Stanford University, USA
Clinical Implications of Regulators of Self-Renewal in Cancer
Clinical Implications of Regulators of Self-Renewal in Cancer
Dean G. Tang,
Roswell Park Cancer Institute, USA
Prostate Cancer Stem Cells: Molecular Understanding and Clinical Implications
Prostate Cancer Stem Cells: Molecular Understanding and Clinical Implications
Samuel Aparicio,
University of British Columbia, Canada
Genomic and Clonal Analysis of Breast Cancer
Genomic and Clonal Analysis of Breast Cancer
Catherine A. O'Brien,
University Health Network, Canada
Regulation of Self-Renewal in Colon Cancer Stem Cells
Regulation of Self-Renewal in Colon Cancer Stem Cells
Devraj Basu,
University of Pennsylvania, USA
Short Talk: Transition Between Two Distinct Stem Cell-Like States in Head and Neck Cancer is Mediated by JARID1B
Short Talk: Transition Between Two Distinct Stem Cell-Like States in Head and Neck Cancer is Mediated by JARID1B
17:00—19:00
Emerging Targets
New therapeutic opportunities to target CSCs.
Tak W. Mak,
Campbell Family Institute for Breast Cancer, Canada
Metabolic Adaptation in Cancer Cells-Exploiting Cancer Metabolic Vulnerabilities
Metabolic Adaptation in Cancer Cells-Exploiting Cancer Metabolic Vulnerabilities
*
Tessa L. Holyoake,
University of Glasgow, UK
CML - Aiming for Cure
CML - Aiming for Cure
Biniam Adane,
University of Colorado School of Medicine, USA
Short Talk: The Role of NADPH Oxidase 2 in Normal and Malignant Hematopoiesis
Short Talk: The Role of NADPH Oxidase 2 in Normal and Malignant Hematopoiesis
Jingwei Cheng,
Dana-Farber Cancer Institute, USA
Short Talk: TRRAP-EP400-Tip60 Complex and Max Interaction is Required in iPS Generation and Oncogenesis Promotion
Short Talk: TRRAP-EP400-Tip60 Complex and Max Interaction is Required in iPS Generation and Oncogenesis Promotion
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Targeting Cancer Stem Cells: Trials and Translation
Therapeutic strategies for targeting CSC in the clinic.
*
Austin Gurney,
Napa Biotechnology Consulting, USA
Therapeutic Agents Targeting the Wnt, Notch, and RSPO/LGR Pathways in Cancer
Therapeutic Agents Targeting the Wnt, Notch, and RSPO/LGR Pathways in Cancer
Jonathan A. Pachter,
Verastem, USA
Targeting Cancer Stem Cells with Selective Inhibitors of FAK and PI3K/mTOR
Targeting Cancer Stem Cells with Selective Inhibitors of FAK and PI3K/mTOR
Feng Cong,
Novartis Institutes for BioMedical Research, USA
Small Molecule Inhibitors of Wnt Signaling for Cancer
Small Molecule Inhibitors of Wnt Signaling for Cancer
Scott J. Dylla,
Stemcentrx, Inc., USA
Short Talk: A DLL3-targeted ADC Eradicates High-Grade Pulmonary Neuroendocrine Tumor-Initiating Cells
Short Talk: A DLL3-targeted ADC Eradicates High-Grade Pulmonary Neuroendocrine Tumor-Initiating Cells
17:00—17:45
Keynote Address
*
Tak W. Mak,
Campbell Family Institute for Breast Cancer, Canada
17:45—19:30
New Horizons
CSC metabolism, ROS involvement-control, epigenetics and miRNA.
*
Tak W. Mak,
Campbell Family Institute for Breast Cancer, Canada
Huiping Liu,
Northwestern University, USA
MicroRNAs Regulating Breast Cancer Stem Cells and Metastasis
MicroRNAs Regulating Breast Cancer Stem Cells and Metastasis
Luke Gilbert,
University of California, San Francisco, USA
Retooling CRISPR to Turn Genes On and Off
Retooling CRISPR to Turn Genes On and Off
David M. Gilbert,
Florida State University, USA
Investigations of Altered DNA Replication Timing in Human Pediatric Leukemia
Investigations of Altered DNA Replication Timing in Human Pediatric Leukemia
19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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