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This meeting took place in 2016
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Epigenetic and Metabolic Regulation of Aging and Aging-Related Diseases (E1)
Organizer(s) Anne Brunet, David M. Sabatini and Shelley L. Berger
May 1—5, 2016
Hilton Santa Fe Historic Plaza Hotel • Santa Fe, NM USA
Discounted Abstract Deadline: Jan 5, 2016
Abstract Deadline: Feb 2, 2016
Scholarship Deadline: Jan 5, 2016
Discounted Registration Deadline: Mar 1, 2016
Sponsored by Journal of Molecular Cell Biology (JMCB)
Summary of Meeting:
Aging poses formidable scientific, medical and societal challenges. Old age is the single most important risk factor for a constellation of diseases, including cardiovascular disease, cancer, diabetes and a range of neurodegenerative disorders such as Alzheimer’s disease. Aging is also one of the greatest fundamental mysteries in biology, and arguably its next frontier. Long thought to be inexorable, aging has in fact been shown to be malleable due to specific changes in genes or environment. This Keystone Symposia meeting will cover the most exciting questions at the forefront of the field: How can external stimuli delay aging in a long-lasting, yet reversible, manner? Does the integration of external stimuli to modulate aging differ among cells with vastly diverse functions – somatic maintenance, tissue regeneration and the “immortal” germline? Is aging a synchronous process, and how do the different cells and systems communicate? How do diseases of aging develop, and what can be done to prevent or reverse them? To address these questions, the symposium will gather investigators from completely different areas to bring an interdisciplinary approach to aging. The meeting will focus on the emerging nexus between two key aging regulators – epigenetic states of the genome and metabolic status – and will highlight innovative technologies and the newest discoveries in aging and diseases. This symposium will also address questions from different perspectives, taking advantage of model organisms with drastically divergent lifespans and aging strategies. Importantly, this meeting will particularly discuss human aging and its associated traits – frailty, susceptibility to diseases – and potential aging therapeutics.
View Scholarships/Awards
Aging poses formidable scientific, medical and societal challenges. Old age is the single most important risk factor for a constellation of diseases, including cardiovascular disease, cancer, diabetes and a range of neurodegenerative disorders such as Alzheimer’s disease. Aging is also one of the greatest fundamental mysteries in biology, and arguably its next frontier. Long thought to be inexorable, aging has in fact been shown to be malleable due to specific changes in genes or environment. This Keystone Symposia meeting will cover the most exciting questions at the forefront of the field: How can external stimuli delay aging in a long-lasting, yet reversible, manner? Does the integration of external stimuli to modulate aging differ among cells with vastly diverse functions – somatic maintenance, tissue regeneration and the “immortal” germline? Is aging a synchronous process, and how do the different cells and systems communicate? How do diseases of aging develop, and what can be done to prevent or reverse them? To address these questions, the symposium will gather investigators from completely different areas to bring an interdisciplinary approach to aging. The meeting will focus on the emerging nexus between two key aging regulators – epigenetic states of the genome and metabolic status – and will highlight innovative technologies and the newest discoveries in aging and diseases. This symposium will also address questions from different perspectives, taking advantage of model organisms with drastically divergent lifespans and aging strategies. Importantly, this meeting will particularly discuss human aging and its associated traits – frailty, susceptibility to diseases – and potential aging therapeutics.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, May 1 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, May 5 with a closing plenary session from 17:00 to 20:00, followed by a social hour and entertainment. We recommend return travel on Friday, May 6 in order to fully experience the meeting.
SUNDAY, MAY 1
MONDAY, MAY 2
TUESDAY, MAY 3
WEDNESDAY, MAY 4
THURSDAY, MAY 5
FRIDAY, MAY 6
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, May 1 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, May 5 with a closing plenary session from 17:00 to 20:00, followed by a social hour and entertainment. We recommend return travel on Friday, May 6 in order to fully experience the meeting.
SUNDAY, MAY 1
08:30—09:30
Welcome and Keynote Address
Linda Partridge,
Max Planck Institute for Biology of Ageing, Germany
Manipulating Nutrient-Sensing Signaling to Improve Health During Ageing
Manipulating Nutrient-Sensing Signaling to Improve Health During Ageing
09:30—12:00
Epigenetic Regulation of Aging
*
Anne Brunet,
Stanford University, USA
Shelley L. Berger,
University of Pennsylvania, USA
Acetyl-coA Metabolism by ACSS2 Regulates Neuronal Histone Acetylation and Long-term Memory
Acetyl-coA Metabolism by ACSS2 Regulates Neuronal Histone Acetylation and Long-term Memory
Andrew G. Dillin,
University of California, Berkeley, USA
Epigenetic Control of Mitochondrial Stress Response
Epigenetic Control of Mitochondrial Stress Response
Weiwei Dang,
Baylor College of Medicine, USA
Short Talk: H3K36me3 Promotes Longevity by Suppressing Age-Associated Intragenic Cryptic Transcription
Short Talk: H3K36me3 Promotes Longevity by Suppressing Age-Associated Intragenic Cryptic Transcription
Stefan Horvath,
University of California, Los Angeles, USA
Short Talk: Recent Updates on the Epigenetic Clock
Short Talk: Recent Updates on the Epigenetic Clock
Peter D. Adams,
Sanford Burnham Prebys Medical Discovery Institute, USA
Epigenetics of Cancer and Aging: Mechanisms , interventions and Therapeutic
Epigenetics of Cancer and Aging: Mechanisms , interventions and Therapeutic
17:00—19:15
Transcriptional and Noncoding RNA Networks in Aging
*
Salvador Aznar Benitah,
ICREA and Institute for Research in Biomedicine, Spain
Coleen T. Murphy,
Princeton University, USA
The tissue Specific Roles of Insulin/IGF-1 Like Signaling in Quality of Life
The tissue Specific Roles of Insulin/IGF-1 Like Signaling in Quality of Life
Ramin Shiekhattar,
University of Miami, USA
Integrator in Signaling and Enhancer Function
Integrator in Signaling and Enhancer Function
Irina M. Bochkis,
University of Virginia, USA
Short Talk: Reorganization of Lamin B1 Genomic Regions in Aged Liver Alters Binding of Pioneer Factor Foxa2
Short Talk: Reorganization of Lamin B1 Genomic Regions in Aged Liver Alters Binding of Pioneer Factor Foxa2
Ashley E. Webb,
Brown University, USA
Short Talk: Elucidation of Direct FOXO Networks that Promote Stem Cell Preservation during Aging
Short Talk: Elucidation of Direct FOXO Networks that Promote Stem Cell Preservation during Aging
Ali Shilatifard,
Northwestern University, USA
Enhancer Malfunction in Cancer
Enhancer Malfunction in Cancer
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:45
Epigenetic and Metabolic Regulation of Aging Stem Cells
*
David M. Sabatini,
Whitehead Institute for Biomedical Research, USA
Thomas A. Rando,
Stanford University School of Medicine, USA
Epigenetic Mechanisms of Stem Cell Aging and Rejuvenation
Epigenetic Mechanisms of Stem Cell Aging and Rejuvenation
Marcia C. Haigis,
Harvard Medical School, USA
Rethinking Mitochondrial Biogenesis
Rethinking Mitochondrial Biogenesis
Salvador Aznar Benitah,
ICREA and Institute for Research in Biomedicine, Spain
Short Talk: Adult Stem Cells Undergo Diet-Dependent Circadian Reprogramming during Ageing
Short Talk: Adult Stem Cells Undergo Diet-Dependent Circadian Reprogramming during Ageing
David A. Sinclair,
Harvard Medical School, USA
Is Loss of Epigenetic Resilience a Driver of Aging?
Is Loss of Epigenetic Resilience a Driver of Aging?
Isabel Beerman,
National Institute on Aging, USA
Short Talk: Age-Associated Clonal Dominance of Myeloid-Biased HSC is Underwritten by Unique Transcriptional and Epigenetic Alterations
Short Talk: Age-Associated Clonal Dominance of Myeloid-Biased HSC is Underwritten by Unique Transcriptional and Epigenetic Alterations
Sean J. Morrison,
University of Texas Southwestern Medical Center, USA
Clec11a Is an Osteogenic Factor that Is Necessary for the Maintenance of the Adult Skeleton during Aging
Clec11a Is an Osteogenic Factor that Is Necessary for the Maintenance of the Adult Skeleton during Aging
14:30—16:30
Workshop 1: New Animal Models and Rejuvenation
*
Danica Chen,
University of California, Berkeley, USA
Mitochondrial Regulation of Hematopoietic Stem Cell Aging and Rejuvenation
Mitochondrial Regulation of Hematopoietic Stem Cell Aging and Rejuvenation
Itamar Harel,
Stanford University, USA
Prion-Like Spread of Protein Aggregates in a New Aging Vertebrate Model: The Turquoise Killifish
Prion-Like Spread of Protein Aggregates in a New Aging Vertebrate Model: The Turquoise Killifish
Nora D. Yucel,
University of Pennsylvania, USA
Metabolic Regulation of Muscle Stem Cell Acetylation Landscape during Regeneration
Metabolic Regulation of Muscle Stem Cell Acetylation Landscape during Regeneration
Carsten Merkwirth,
Samumed LLC, USA
Epigenetic Control of Longevity in Response to Mitochondrial Dysfunction
Epigenetic Control of Longevity in Response to Mitochondrial Dysfunction
Geraldine Gontier,
University of California, San Francisco, USA
Role of TET2 in Regulating Neurogenesis and Cognition during Aging
Role of TET2 in Regulating Neurogenesis and Cognition during Aging
Wenke Wang,
Cornell University, USA
The Functions of SET-9 and SET-26 in Longevity and the Germline
The Functions of SET-9 and SET-26 in Longevity and the Germline
Jae-Hyun Yang,
Harvard Medical School, USA
Evidence for Epigenomic Change as a Cause of Mammalian Aging
Evidence for Epigenomic Change as a Cause of Mammalian Aging
Michael Todhunter,
Lawrence Berkeley National Laboratory, USA
Studying Aging via Reconstituted Human Organoid Arrays
Studying Aging via Reconstituted Human Organoid Arrays
17:00—19:15
The Immortal Germline: Reprogramming and Transgenerational Inheritance
*
Malene Hansen,
Sanford Burnham Prebys Medical Discovery Institute, USA
Adam Antebi,
Max Planck Institut für Biologie des Alterns, Germany
Mondo Complexes Regulate TFEB via TOR Inhibition to Promote Longevity in Response to Gonadal Signals
Mondo Complexes Regulate TFEB via TOR Inhibition to Promote Longevity in Response to Gonadal Signals
Anne Brunet,
Stanford University, USA
Long-Lasting Epigenetic Regulation of Aging in Germline and Soma
Long-Lasting Epigenetic Regulation of Aging in Germline and Soma
Rolf Bodmer,
Sanford-Burnham Medical Research Institute, USA
Short Talk: Preserving Heart Function despite Obesity, Aging and Parental Diet
Short Talk: Preserving Heart Function despite Obesity, Aging and Parental Diet
Eric L. Greer,
Harvard Medical School, Boston Children's Hospital, USA
Short Talk: DNA Methylation on N6-Adenine in C. elegans
Short Talk: DNA Methylation on N6-Adenine in C. elegans
Steven E. Artandi,
Stanford University, USA
Immortality in Germline Stem Cells and Somatic Stem Cells
Immortality in Germline Stem Cells and Somatic Stem Cells
08:30—12:00
Autophagy, "Inflammaging" and Metabolism
*
J. Andrew Pospisilik,
Van Andel Institute, USA
David M. Sabatini,
Whitehead Institute for Biomedical Research, USA
mTOR Pathway in Metabolism and Aging
mTOR Pathway in Metabolism and Aging
Malene Hansen,
Sanford Burnham Prebys Medical Discovery Institute, USA
Cellular Recycling: Role of Autophagy in Aging and Disease
Cellular Recycling: Role of Autophagy in Aging and Disease
Theodore T. Ho,
University of California, San Francisco, USA
Short Talk: Activation of Autophagy During Aging Maintains Hematopoietic Stem Cell Metabolism and Functional Capacity
Short Talk: Activation of Autophagy During Aging Maintains Hematopoietic Stem Cell Metabolism and Functional Capacity
Leanne Jones,
University of California, Los Angeles, USA
Mechanisms Underlying Loss of Intestinal Homeostasis with Age
Mechanisms Underlying Loss of Intestinal Homeostasis with Age
Darren J. Baker,
Mayo Clinic, USA
Short Talk: Naturally Occurring p16Ink4a-Positive Cells Shorten Healthy Lifespan
Short Talk: Naturally Occurring p16Ink4a-Positive Cells Shorten Healthy Lifespan
Riekelt H. Houtkooper,
Academic Medical Center, Netherlands
Short Talk: A Sensitive Mass-Spectrometry-Based Platform Identifies Metabolic Changes of Life History Traits in C. elegans
Short Talk: A Sensitive Mass-Spectrometry-Based Platform Identifies Metabolic Changes of Life History Traits in C. elegans
17:00—19:15
Systemic Regulation of Aging
*
Thomas A. Rando,
Stanford University School of Medicine, USA
Tony Wyss-Coray,
Stanford University School of Medicine, USA
Systemic Regulation of Brain Aging and Neurodegeneration
Systemic Regulation of Brain Aging and Neurodegeneration
Amy J. Wagers,
Harvard University, USA
Reversing Dysfunction in Aging Tissues through Systemic Mediators
Reversing Dysfunction in Aging Tissues through Systemic Mediators
Louis R. Lapierre,
Brown University, USA
Short Talk: Limiting Lipid Secretion Promotes Lipophagy and Longevity
Short Talk: Limiting Lipid Secretion Promotes Lipophagy and Longevity
Constanza J. Cortes Rodriguez,
University of Alabama at Birmingham, USA
Short Talk: Skeletal Muscle Control of Systemic Metabolism: A Role for Transcription Factor E-B (TFEB) Signaling
Short Talk: Skeletal Muscle Control of Systemic Metabolism: A Role for Transcription Factor E-B (TFEB) Signaling
Amita Sehgal,
University of Pennsylvania Perelman School of Medicine, USA
Circadian Rhythms and Aging
Circadian Rhythms and Aging
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:45
Epigenetics of Age-Related Diseases
*
Lauren Booth,
Stanford University, USA
Li-Huei Tsai,
Massachusetts Institute of Technology, USA
Demystifying Innate Immune Response in Alzheimer's Like Neurodegeneration
Demystifying Innate Immune Response in Alzheimer's Like Neurodegeneration
Tony Kouzarides,
University of Cambridge, UK
Role of ncRNAs in Transcription and Cancer
Role of ncRNAs in Transcription and Cancer
J. Andrew Pospisilik,
Van Andel Institute, USA
Epigenetic Determinants of Phenotypic Variation and Metabolic Disease: Intergenerational and Stochastic Effects
Epigenetic Determinants of Phenotypic Variation and Metabolic Disease: Intergenerational and Stochastic Effects
James Dowell,
Wisconsin Institutes for Discovery, USA
Short Talk: Aberrant H3.3 Methylation and H2A.Z Acetylation in Alzheimer’s Disease
Short Talk: Aberrant H3.3 Methylation and H2A.Z Acetylation in Alzheimer’s Disease
Christin A. Glorioso,
Massachusetts Institute of Technology, USA
Short Talk:Brain Aging and APOE4 are Independent Additive Predictors of Neurological Function and Alzheimer’s Disease
Short Talk:Brain Aging and APOE4 are Independent Additive Predictors of Neurological Function and Alzheimer’s Disease
Margaret A. Goodell,
Baylor College of Medicine, USA
Epigenetic Alterations and Aging of Hematopoietic Stem Cells
Epigenetic Alterations and Aging of Hematopoietic Stem Cells
14:30—16:30
Workshop 2: Therapeutic Approaches and Aging Biomarkers
Shahaf Peleg,
Ludwig Maximilian University, Germany
The Metabolism-Chromatin Connectivity during Ageing
The Metabolism-Chromatin Connectivity during Ageing
Brian H. Chen,
National Institute on Aging, USA
Longitudinal Changes in DNA Methylation Levels at Epigenetic Clock Loci
Longitudinal Changes in DNA Methylation Levels at Epigenetic Clock Loci
Berenice Anath Benayoun,
University of Southern California, USA
Epigenomes and Transcriptomes across Tissues during Mouse Aging
Epigenomes and Transcriptomes across Tissues during Mouse Aging
Hongbo Zhang,
École Polytechnique Fédérale de Lausanne, Switzerland
Improving Mitochondrial Function by NAD+ Repletion Rejuvenates Adult Stem Cells and Enhances Lifespan
Improving Mitochondrial Function by NAD+ Repletion Rejuvenates Adult Stem Cells and Enhances Lifespan
Lauren Hillary Kodroff,
Tulane University, USA
Impact of Microbiome Manipulation on Age-Related Inflammation and Immune System Dysfunction
Impact of Microbiome Manipulation on Age-Related Inflammation and Immune System Dysfunction
Erik Ben van den Akker,
Leiden University Medical Center, Netherlands
Uncompromised Ten-Year Survival of Oldest Old Carrying Somatic Mutations in DNMT3A and TET2
Uncompromised Ten-Year Survival of Oldest Old Carrying Somatic Mutations in DNMT3A and TET2
Aaron Mark Robitaille,
Thermo Fisher Scientific, USA
Identification of Small Molecules that Target Conserved Regulators of Lifespan
Identification of Small Molecules that Target Conserved Regulators of Lifespan
*
Duygu Ucar,
The Jackson Laboratory, USA
An Epigenomic Signature of Human Immune Aging in Circulating Lymphocytes/Leukocytes
An Epigenomic Signature of Human Immune Aging in Circulating Lymphocytes/Leukocytes
17:00—19:00
Human Aging and Therapeutics
*
Shelley L. Berger,
University of Pennsylvania, USA
P. Eline Slagboom,
Leiden University, Netherlands
Determinants of Human Lifespan
Determinants of Human Lifespan
Trey Ideker,
University of California, San Diego, USA
Epigenetic Prediction of Aging and Aging Acceleration for HIV+ Individuals
Epigenetic Prediction of Aging and Aging Acceleration for HIV+ Individuals
Joseph M. Castellano,
Stanford University School of Medicine, USA
Short Talk: Human Umbilical Cord Plasma Proteins Revitalize Hippocampal Function in Aged Mice
Short Talk: Human Umbilical Cord Plasma Proteins Revitalize Hippocampal Function in Aged Mice
Cynthia Kenyon,
Calico, USA
How can Nature Counteract Aging?
How can Nature Counteract Aging?
20:00—21:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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