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This meeting took place in 2016
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Autophagy: Molecular and Physiological Mechanisms (V1)
Organizer(s) Sharon A. Tooze, Ana Maria Cuervo and Noboru Mizushima
June 5—9, 2016
Whistler Conference Centre • Whistler, BC Canada
Discounted Abstract Deadline: Feb 4, 2016
Abstract Deadline: Mar 8, 2016
Scholarship Deadline: Feb 4, 2016
Discounted Registration Deadline: Apr 5, 2016
Sponsored by Novartis Institutes for BioMedical Research
Summary of Meeting:
Autophagy, an evolutionarily conserved pathway, is required for homeostasis, growth and survival in eukaryotic cells. Deregulation of autophagy is implicated in many human diseases, and mutations in autophagy genes are known to be a direct cause of severe human disorders. There are global efforts to understand the role of autophagy in disease pathogenesis and to develop therapeutic strategies to control the autophagic response. However, the latter is hampered by the lack of biomarkers, and disease-specific, selective autophagy targets. Overcoming this barrier in development of therapeutics will require a better understanding of basic autophagy biology. This meeting will specifically address the basic molecular pathway to increase our knowledge of the genes, proteins and signaling pathways involved in autophagy. The program will assemble experts in the molecular details of the diverse autophagic pathways and therefore provide clinicians and pharmaceutical companies with information to develop new, specific targets.
View Scholarships/Awards
Autophagy, an evolutionarily conserved pathway, is required for homeostasis, growth and survival in eukaryotic cells. Deregulation of autophagy is implicated in many human diseases, and mutations in autophagy genes are known to be a direct cause of severe human disorders. There are global efforts to understand the role of autophagy in disease pathogenesis and to develop therapeutic strategies to control the autophagic response. However, the latter is hampered by the lack of biomarkers, and disease-specific, selective autophagy targets. Overcoming this barrier in development of therapeutics will require a better understanding of basic autophagy biology. This meeting will specifically address the basic molecular pathway to increase our knowledge of the genes, proteins and signaling pathways involved in autophagy. The program will assemble experts in the molecular details of the diverse autophagic pathways and therefore provide clinicians and pharmaceutical companies with information to develop new, specific targets.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, June 5 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, June 9 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, June 10 in order to fully experience the meeting.
SUNDAY, JUNE 5
MONDAY, JUNE 6
TUESDAY, JUNE 7
WEDNESDAY, JUNE 8
THURSDAY, JUNE 9
FRIDAY, JUNE 10
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, June 5 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, June 9 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, June 10 in order to fully experience the meeting.
SUNDAY, JUNE 5
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:30—11:45
Molecular Mechanisms of Autophagy I
*
Vojo Deretic,
University of New Mexico Health Sciences Center, USA
Tamotsu Yoshimori,
Osaka University, Japan
Regulation of Membrane Dynamics in Autophagy; Its Implication in Diseases
Regulation of Membrane Dynamics in Autophagy; Its Implication in Diseases
Sharon A. Tooze,
Francis Crick Institute, UK
Molecular Pathways and Vesicular Traffic during Autophagosome Formation
Molecular Pathways and Vesicular Traffic during Autophagosome Formation
Coffee Break
Noboru Mizushima,
University of Tokyo, Japan
The Life of the Autophagosome
The Life of the Autophagosome
Fulvio Reggiori,
University Medical Centre Groningen, Netherlands
Spatial Atg8 Deconjugation Depends on the Regulation of Atg4 Function by Atg1 Phosphorylation and Phosphatidylinositol-3-Phosphate Levels
Spatial Atg8 Deconjugation Depends on the Regulation of Atg4 Function by Atg1 Phosphorylation and Phosphatidylinositol-3-Phosphate Levels
Josh Lyon Andersen,
Brigham Young University, USA
Short Talk: Regulation of mAtg9A Phosphorylation by an AMPK/ULK1/LIMD1 Complex
Short Talk: Regulation of mAtg9A Phosphorylation by an AMPK/ULK1/LIMD1 Complex
Roarke A. Kamber,
Harvard University, USA
Short Talk: Local Control of Autophagy Receptor Activation
Short Talk: Local Control of Autophagy Receptor Activation
14:30—16:30
Workshop 1: Selective and Non-Canonical Autophagy Pathways
Allyson Anding,
University of Massachusetts Medical School, USA
A Novel and Conserved Ubiquitin Receptor that is Required for Parkin-Dependent Mitophagy
A Novel and Conserved Ubiquitin Receptor that is Required for Parkin-Dependent Mitophagy
*
Li-Lin Du,
National Institute of Biological Sciences, China
Fission Yeast Nbr1 Acts as a Cargo Receptor in an ESCRT-Dependent Vacuolar Targeting Pathway
Fission Yeast Nbr1 Acts as a Cargo Receptor in an ESCRT-Dependent Vacuolar Targeting Pathway
Oliver Florey,
Babraham Institute, UK
Novel Mechanisms of ATG16L1 Recruitment in Non-Canonical Autophagy
Novel Mechanisms of ATG16L1 Recruitment in Non-Canonical Autophagy
*
Katarzyna Zientara-Rytter,
University of California, San Diego, USA
New Roles of Atg37 and Pex3 in Assembly of the Pexophagic Receptor Protein Complex
New Roles of Atg37 and Pex3 in Assembly of the Pexophagic Receptor Protein Complex
Jakob Mejlvang,
UiT The Arctic University of Norway, Norway
The Immediate Autophagic Response to Starvation (IARS) is Independent of Canonical Macroautophagy but Dependent on ESCRT-III and Vps4
The Immediate Autophagic Response to Starvation (IARS) is Independent of Canonical Macroautophagy but Dependent on ESCRT-III and Vps4
Jina Lee,
Hannam University, South Korea
Development of a New Autophagosome Sensor with an LC3-Interacting Region (LIR) Motif and a Hydrophobic Domain
Development of a New Autophagosome Sensor with an LC3-Interacting Region (LIR) Motif and a Hydrophobic Domain
17:00—19:00
Molecular Mechanisms of Autophagy II
To establish the key questions in autophagy.
*
Sascha Martens,
University of Vienna, Austria
Nicholas Ktistakis,
Babraham Institute, UK
Starvation-Induced and Selective Autophagy: The First 3 Minutes
Starvation-Induced and Selective Autophagy: The First 3 Minutes
Francesco Cecconi,
University of Rome Tor Vergata, Italy
AMBRA1 Negative Control at the Crossroads among Autophagy, Cell Proliferation and Cell Death
AMBRA1 Negative Control at the Crossroads among Autophagy, Cell Proliferation and Cell Death
Claudine Kraft,
University of Freiburg, Germany
EMBO Young Investigator Lecture: Molecular Regulation of Autophagy: Signaling and Beyond
EMBO Young Investigator Lecture: Molecular Regulation of Autophagy: Signaling and Beyond
Carsten Sachse,
Forschungszentrum Jülich, Germany
Short Talk: Higher-Order Assemblies of Polymeric and Oligomeric Cargo Receptor Complexes form the Membrane Scaffold for Selective Autophagy
Short Talk: Higher-Order Assemblies of Polymeric and Oligomeric Cargo Receptor Complexes form the Membrane Scaffold for Selective Autophagy
08:30—11:45
Autophagy and Diseases of Aging
To exchange scientific information between autophagy and aging community.
*
Alicia Melendez,
Queens College - CUNY, USA
Ana Maria Cuervo,
Albert Einstein College of Medicine, USA
Chaperone-mediated Autophagy in the Fight against Aging
Chaperone-mediated Autophagy in the Fight against Aging
David C. Rubinsztein,
Cambridge Institute for Medical Research, UK
Autophagy, Neurodegeneration and Neurodevelopment
Autophagy, Neurodegeneration and Neurodevelopment
Coffee Break
Anne Simonsen,
University of Oslo, Norway
Regulation of Autophagosome Biogenesis by Lipid-Binding Proteins
Regulation of Autophagosome Biogenesis by Lipid-Binding Proteins
Peter C. Butler,
University of California, Los Angeles, USA
Autophagy and Diabetes
Autophagy and Diabetes
Jessica Chang,
Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: Spatial and Temporal Regulation of Autophagy during C. Elegans Aging
Short Talk: Spatial and Temporal Regulation of Autophagy during C. Elegans Aging
Patricia Boya,
Centro de Investigaciones Biológicas, CSIC, Spain
Short Talk: Lysosomal Cell Death in Animal Models of Neurodegenerative Diseases
Short Talk: Lysosomal Cell Death in Animal Models of Neurodegenerative Diseases
11:45—13:15
Chewing the Fat: Panel and Discussion about Autophagy and Future Directions of the Autophagy Field
Eric Baehrecke, Ana Maria Cuervo, Vojo Deretic and Leon Murphy met to discuss their interests in autophagy. Topics included some history, current and future areas of research interests, possible controversies, and speculation about the future directions of the autophagy field. Come enjoy a short video of their discussion, and be prepared to ask them questions.
*
Eric H. Baehrecke,
University of Massachusetts Medical School, USA
*
Ana Maria Cuervo,
Albert Einstein College of Medicine, USA
*
Vojo Deretic,
University of New Mexico Health Sciences Center, USA
*
Leon O. Murphy,
Casma Therapeutics, USA
17:00—19:00
Regulation of Autophagic Processes
To build upon session 1 and 2 data and start to explore regulation of autophagy.
*
Thomas Melia,
Yale School of Medicine, USA
Hong Zhang,
Chinese Academy of Sciences, China
Differential Function of the Four WIPIs in Autophagy
Differential Function of the Four WIPIs in Autophagy
Leon O. Murphy,
Casma Therapeutics, USA
Regulation of Selective Autophagy
Regulation of Selective Autophagy
Zvulun Elazar,
Weizmann Institute of Science, Israel
Role of Lipids in Autophagy
Role of Lipids in Autophagy
Hemmo Meyer,
University Duisburg-Essen, Germany
Short Talk: A Role of the Ubiquitin-directed VCP/p97 AAA-ATPase in Autophagy
Short Talk: A Role of the Ubiquitin-directed VCP/p97 AAA-ATPase in Autophagy
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:45
Molecular Reconstitution of Autophagy Machinery
Structural and reconstitution of autophagic proteins.
*
Zvulun Elazar,
Weizmann Institute of Science, Israel
Thomas Melia,
Yale School of Medicine, USA
Membrane Recognition by the Atg4 Family of Proteases
Membrane Recognition by the Atg4 Family of Proteases
Sascha Martens,
University of Vienna, Austria
EMBO Young Investigator Lecture: Molecular Mechanisms of Selective Autophagy
EMBO Young Investigator Lecture: Molecular Mechanisms of Selective Autophagy
Coffee Break
Thomas Wollert,
Institut Pasteur Paris, France
EMBO Young Investigator Lecture: How to Make an Autophagosome – Membrane Remodeling in Autophagy
EMBO Young Investigator Lecture: How to Make an Autophagosome – Membrane Remodeling in Autophagy
Lindsey Young,
University of California, San Diego, USA
Short Talk: Structural Insights into Autophagy Initiation by PI3K Complex I
Short Talk: Structural Insights into Autophagy Initiation by PI3K Complex I
Mary Lilly,
NICHD, National Institutes of Health, USA
Short Talk: The GATOR2 Complex Regulates Lysosome Acidification and Autophagic Flux Independent of TORC1 Activity
Short Talk: The GATOR2 Complex Regulates Lysosome Acidification and Autophagic Flux Independent of TORC1 Activity
17:00—19:00
Autophagy in Conserved Homeostatic Pathways
*
Claudine Kraft,
University of Freiburg, Germany
Gabor Juhasz,
Biological Research Center, HAS, Hungary
Autophagosome and Endosome Maturation in Drosophila
Autophagosome and Endosome Maturation in Drosophila
Masaaki Komatsu,
Juntendo University School of Medicine, Japan
Autophagy-Adaptors Regulate Cellular Metabolism through Multiple Transcription-Factor Pathways
Autophagy-Adaptors Regulate Cellular Metabolism through Multiple Transcription-Factor Pathways
Alicia Melendez,
Queens College - CUNY, USA
Autophagy in C. elegans Development and Aging
Autophagy in C. elegans Development and Aging
Tamiza Nanji,
University of British Columbia, Canada
Short Talk: Molecular Organization and Interactions of the Fission Yeast Atg1 Complex
Short Talk: Molecular Organization and Interactions of the Fission Yeast Atg1 Complex
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:45
Autophagy in Human Pathophysiology
To explore the role of autophagy in infection and immunity, and other physiological situations.
*
Anne Simonsen,
University of Oslo, Norway
Janice Lee,
Foghorn Therapeutics, USA
Targeting Autophagy for Cancer Therapy
Targeting Autophagy for Cancer Therapy
Vojo Deretic,
University of New Mexico Health Sciences Center, USA
Talk and Crosstalk between Immune Response and Autophagy
Talk and Crosstalk between Immune Response and Autophagy
Coffee Break
Herbert (Skip) W. Virgin,
Vir Biotechnology, USA
Regulation of Inflammation and Immunity by Autophagy Genes
Regulation of Inflammation and Immunity by Autophagy Genes
Véronik Lachance,
Icahn School of Medicine at Mount Sinai, USA
Short Talk: Mutation of Vps11 Causes a New Class of Leukoencephalopathy and Autophagy Impairment
Short Talk: Mutation of Vps11 Causes a New Class of Leukoencephalopathy and Autophagy Impairment
Rhea M. Sumpter, Jr.,
University of Texas Southwestern Medical Center, USA
Short Talk: Fanconi Anemia Tumor Suppressor Genes Function in Selective Autophagy, Immunity and Mitochondrial Homeostasis
Short Talk: Fanconi Anemia Tumor Suppressor Genes Function in Selective Autophagy, Immunity and Mitochondrial Homeostasis
14:30—16:30
Workshop 2: Challenges in Measuring and Manipulating Autophagy in Humans
*
Janice Lee,
Foghorn Therapeutics, USA
*
Peter C. Butler,
University of California, Los Angeles, USA
Joo Yun Jun,
NICHD, National Institutes of Health, USA
Melanocortin 3 Receptor (MC3R), A Novel Regulator of Hepatic Autophagy in Obesity
Melanocortin 3 Receptor (MC3R), A Novel Regulator of Hepatic Autophagy in Obesity
Anatoliy I. Masyuk,
Mayo Clinic, USA
Dysregulated Autophagy in Cholangiocytes Contributes to the Progression of Polycystic Liver Disease
Dysregulated Autophagy in Cholangiocytes Contributes to the Progression of Polycystic Liver Disease
Katrin Panzitt,
Medical University Graz, Austria
The Autophagy Inhibitor Rubicon is a Direct Target of the Bile Acid Receptor FXR in Human Liver and is Induced in Human Cholestasis
The Autophagy Inhibitor Rubicon is a Direct Target of the Bile Acid Receptor FXR in Human Liver and is Induced in Human Cholestasis
Christos E. Zois,
University of Oxford, UK
Targeting VPS34 to Enhance Anticancer Therapy
Targeting VPS34 to Enhance Anticancer Therapy
Shankar J. Chinta,
Touro University California, USA
High Potency Miscible Activators of TFEB and Clearance of Toxic Alpha-Synuclein Oligomers; Implications for Parkinson’s Disease
High Potency Miscible Activators of TFEB and Clearance of Toxic Alpha-Synuclein Oligomers; Implications for Parkinson’s Disease
17:00—19:00
Autophagy and Cancer
To connect the molecular aspects to human disease.
*
Ana Maria Cuervo,
Albert Einstein College of Medicine, USA
Andrew M. Thorburn,
University of Colorado AMC, USA
Autophagy and Cancer Therapy
Autophagy and Cancer Therapy
Kevin M. Ryan,
Beatson Institute for Cancer Research, UK
Mechanism of Autophagy in Cell Death and Cancer
Mechanism of Autophagy in Cell Death and Cancer
Sharon Gorski,
BC Cancer Research Centre, Canada
Short Talk: Evaluation of ATG4B Expression and Function in Breast Cancer Subtypes
Short Talk: Evaluation of ATG4B Expression and Function in Breast Cancer Subtypes
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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