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This meeting took place in 2016
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Chromatin and Epigenetics (C2)
Organizer(s) Luciano Di Croce and Yang Shi
March 20—24, 2016
Whistler Conference Centre • Whistler, BC Canada
Discounted Abstract Deadline: Nov 18, 2015
Abstract Deadline: Dec 16, 2015
Scholarship Deadline: Nov 18, 2015
Discounted Registration Deadline: Jan 20, 2016
Sponsored by Cell Research, Cell Signaling Technology, Inc., Constellation Pharmaceuticals, Incyte Corporation, Janssen R&D: Pharmaceutical Companies of Johnson & Johnson and Merck & Co., Inc.
Summary of Meeting:
The DNA of eukaryotic cells is organized into chromatin fibers, where the nucleosome is the basic repeating unit. Chromatin is thus at the core of fundamental processes such as gene regulation, stem cell fate determination and cancer. By and large, these topics have traditionally been covered by separated meetings. However, recent literature indicates that the boundaries among these various disciplines are becoming less clear. This meeting will bring together scientists studying chromatin structure, epigenetics, stem cell biology and cancer. The talks will cover a broad range of topics, including chromosome organization, long-range interactions, chromatin assembly, stem cell regulation/differentiation, RNA-based mechanisms and transcription regulation. Speakers have been selected to broadly reflect lessons learned from a variety of model organisms and experimental approaches. Young scientists will be able to present their work through a large number of short talks selected from submitted abstracts as well as through poster presentation. There will also be ample time for exchanging ideas and discussing novel hypothesis at the end of each session, as well as time for informal interactions and networking.
View Scholarships/Awards
The DNA of eukaryotic cells is organized into chromatin fibers, where the nucleosome is the basic repeating unit. Chromatin is thus at the core of fundamental processes such as gene regulation, stem cell fate determination and cancer. By and large, these topics have traditionally been covered by separated meetings. However, recent literature indicates that the boundaries among these various disciplines are becoming less clear. This meeting will bring together scientists studying chromatin structure, epigenetics, stem cell biology and cancer. The talks will cover a broad range of topics, including chromosome organization, long-range interactions, chromatin assembly, stem cell regulation/differentiation, RNA-based mechanisms and transcription regulation. Speakers have been selected to broadly reflect lessons learned from a variety of model organisms and experimental approaches. Young scientists will be able to present their work through a large number of short talks selected from submitted abstracts as well as through poster presentation. There will also be ample time for exchanging ideas and discussing novel hypothesis at the end of each session, as well as time for informal interactions and networking.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, March 20 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 24 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, March 25 in order to fully experience the meeting.
SUNDAY, MARCH 20
MONDAY, MARCH 21
TUESDAY, MARCH 22
WEDNESDAY, MARCH 23
THURSDAY, MARCH 24
FRIDAY, MARCH 25
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, March 20 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 24 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, March 25 in order to fully experience the meeting.
SUNDAY, MARCH 20
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Epigenetic Pathways
*
Luciano Di Croce,
CRG - Center for Genomic Regulation, Spain
Shelley L. Berger,
University of Pennsylvania, USA
Histone Acetylation Pathways in Learning and Memory
Histone Acetylation Pathways in Learning and Memory
Yang Shi,
Children's Hospital Boston, Harvard Medical School, USA
Histone Methylation Regulation, Recognition and Link to Human Disease
Histone Methylation Regulation, Recognition and Link to Human Disease
Tony Kouzarides,
University of Cambridge, UK
Role of ncRNAs in Transcription and Cancer
Role of ncRNAs in Transcription and Cancer
Salvador Aznar Benitah,
ICREA and Institute for Research in Biomedicine, Spain
Epigenetic Regulation of Adult Stem Cell Function in Homeostasis, Aging and Cancer
Epigenetic Regulation of Adult Stem Cell Function in Homeostasis, Aging and Cancer
Ian Chambers,
University of Edinburgh, UK
Short Talk: Extinction of Esrrb Triggers the Dismantling of Naïve Pluripotency and Marks Commitment to Differentiation
Short Talk: Extinction of Esrrb Triggers the Dismantling of Naïve Pluripotency and Marks Commitment to Differentiation
14:30—15:30
Workshop 1: ENCODE Data Analysis and Visualization
*
Feng Yue,
Pennsylvania State University, USA
15:30—16:30
Workshop 2: Epigenomic Annotation of Genetic Variants using the Washington University Epigenome Browser
*
Ting Wang,
Washington University, USA
17:00—19:00
DNA Methylation in Stem Cells
*
Wolf Reik,
Babraham Institute, UK
Bing Ren,
Ludwig Institute for Cancer Research, USA
Global Analysis of Transcriptional Enhancers in Embryonic Stem Cells
Global Analysis of Transcriptional Enhancers in Embryonic Stem Cells
Anjana Rao,
La Jolla Institute for Allergy and Immunology, USA
TET Proteins and 5-Methylcytosine Oxidation
TET Proteins and 5-Methylcytosine Oxidation
Or P. Gozani,
Stanford University, USA
New Roles for Lysine Methylation Signaling in Epigenetic and Disease Regulation
New Roles for Lysine Methylation Signaling in Epigenetic and Disease Regulation
Sandra Peiró,
Fundació IMIM, Spain
Short Talk: H3K4ox-mediated Chromatin Condensation Protects Breast Cancer Cells from the DNA Damage Repair Machinery
Short Talk: H3K4ox-mediated Chromatin Condensation Protects Breast Cancer Cells from the DNA Damage Repair Machinery
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Epigenetic Chromatin Complexes
*
Giacomo Cavalli,
Institute of Human Genetics, France
Anne Brunet,
Stanford University, USA
Epigenetic Regulation of Aging
Epigenetic Regulation of Aging
Danny F. Reinberg,
HHMI/New York University, USA
Chromatin Regulation by Polycomb Complexes
Chromatin Regulation by Polycomb Complexes
Luciano Di Croce,
CRG - Center for Genomic Regulation, Spain
Polycomb Orchestrates Gene Regulation Dynamics in Cell Differentiation and Cancer
Polycomb Orchestrates Gene Regulation Dynamics in Cell Differentiation and Cancer
Yujiang Geno Shi,
Harvard Medical School, USA
Glucose Signaling to Reprogramming Chromatin via a Molecular Switch on TET2
Glucose Signaling to Reprogramming Chromatin via a Molecular Switch on TET2
Adrian P. Bracken,
Trinity College Dublin, Ireland
Short Talk: Polycomb Repressive Complex 2 (PRC2) in Proliferation Control and Cancer
Short Talk: Polycomb Repressive Complex 2 (PRC2) in Proliferation Control and Cancer
Mafalda Almeida,
University of Oxford, UK
Short Talk: Mechanisms of Xist-dependent Polycomb Recruitment
Short Talk: Mechanisms of Xist-dependent Polycomb Recruitment
14:30—16:30
Workshop 3: Connecting ncRNA, Stem Cells and Higher-Ordered Chromatin Structure
Rebecca Berrens,
Babraham Institute, UK
Acute Demethylation of Transposons in ES Cells Reveals Regulation by Small RNA Pathways
Acute Demethylation of Transposons in ES Cells Reveals Regulation by Small RNA Pathways
*
M. Ryan Corces,
Stanford University, USA
Lineage-specific and Single Cell Chromatin Accessibility Charts Human Hematopoiesis and Leukemia Evolution
Lineage-specific and Single Cell Chromatin Accessibility Charts Human Hematopoiesis and Leukemia Evolution
Alessandro Bonetti,
Karolinska Institutet, Sweden
Identification and Characterization of Non-coding RNAs Associated with Chromatin in Pluripotency
Identification and Characterization of Non-coding RNAs Associated with Chromatin in Pluripotency
Paula Freire-Pritchett,
Babraham Institute, UK
Global Rewiring of Enhancer-promoter Interactions during Early Lineage Commitment in Human Embryonic Stem Cells
Global Rewiring of Enhancer-promoter Interactions during Early Lineage Commitment in Human Embryonic Stem Cells
Kunle Demuren,
Massachusetts Institute of Technology, USA
Determining Molecular Mediators of Enhancer Activation during Cardiomyocyte Differentiation
Determining Molecular Mediators of Enhancer Activation during Cardiomyocyte Differentiation
17:00—19:00
Chromatin Organization
*
Shelley L. Berger,
University of Pennsylvania, USA
François Fuks,
Université Libre de Bruxelles, Belgium
Mechanisms of TETs & Hydroxymethylation
Mechanisms of TETs & Hydroxymethylation
Francois Aymard,
University of Toulouse, France
Short Talk: Chromosome and Chromatin Dynamics during Double Strand Break Repair
Short Talk: Chromosome and Chromatin Dynamics during Double Strand Break Repair
Abraham S. Weintraub,
Cedilla Therapeutics, USA
Short Talk: Activation of Proto-Oncogenes by Disruption of Chromosome Neighborhoods
Short Talk: Activation of Proto-Oncogenes by Disruption of Chromosome Neighborhoods
Robert A. Martienssen,
Cold Spring Harbor Laboratory, USA
Replication-Coupled Silencing and Spreading with RNAi
Replication-Coupled Silencing and Spreading with RNAi
Tian Tian,
Center for Genomic Regulation, Spain
Short Talk: Whsc1 is Required for the Exit from Pluripotency and Efficient Meso-endoderm Differentiation
Short Talk: Whsc1 is Required for the Exit from Pluripotency and Efficient Meso-endoderm Differentiation
08:00—11:15
Chromatin in Stem Cells
*
Salvador Aznar Benitah,
ICREA and Institute for Research in Biomedicine, Spain
Kristian Helin,
University of Copenhagen and Memorial Sloan Kettering Cancer Center, Denmark
Histone Methylation in Transcriptional Regulation, Differentiation and Cancer
Histone Methylation in Transcriptional Regulation, Differentiation and Cancer
Giacomo Cavalli,
Institute of Human Genetics, France
Genome Regulation by Polycomb Proteins, between Epigenetic Inheritance and Dynamic Gene Regulation
Genome Regulation by Polycomb Proteins, between Epigenetic Inheritance and Dynamic Gene Regulation
Wolf Reik,
Babraham Institute, UK
Epigenetic Reprogramming in Mammalian Development
Epigenetic Reprogramming in Mammalian Development
Rab K. Prinjha,
GlaxoSmithKline, UK
Epigenetic Targets for the Treatment of Human Diseases
Epigenetic Targets for the Treatment of Human Diseases
Alexander J. Ruthenburg,
University of Chicago, USA
Short Talk: Biochemical Fractionation Reveals Highly Selective Binding Partners for 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in DNA
Short Talk: Biochemical Fractionation Reveals Highly Selective Binding Partners for 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in DNA
Chao Lu,
Columbia University, USA
Short Talk: Oncohistone Mutations Reprogram Chromatin Landscape to Impair Cell Differentiation
Short Talk: Oncohistone Mutations Reprogram Chromatin Landscape to Impair Cell Differentiation
14:30—16:30
Workshop 4: How RNA Modifications Impact Chromatin Structure and Stem Cell Fate
E. Megan Flynn,
Genentech, Inc., USA
Specificity of Human Bromodomains for Histone H3, H4 Peptides
Specificity of Human Bromodomains for Histone H3, H4 Peptides
Felice Frey,
Max-Planck Institute of Biohemistry, Germany
Molecular Basis for Targeting PRC1 to Polycomb Response Elements
Molecular Basis for Targeting PRC1 to Polycomb Response Elements
Yoshihiro Matsumura,
University of Tokyo, Japan
H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipogenesis
H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipogenesis
Yuanyuan Li,
Tsinghua University, School of Medicine, China
Journal of Biological Chemistry, Herb Tabor Young Investigator: Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain
Journal of Biological Chemistry, Herb Tabor Young Investigator: Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain
Sharmistha Kundu,
Massachusetts General Hospital, USA
3D-Architecture Remodeling of Chromatin by PRC1
3D-Architecture Remodeling of Chromatin by PRC1
*
Marc-Werner Dobenecker,
Rockefeller University, USA
The Role of PRC2 in Systemic Inflammation and Autoimmunity
The Role of PRC2 in Systemic Inflammation and Autoimmunity
17:00—19:00
Chromatin and Cancer
*
Or P. Gozani,
Stanford University, USA
Johnathan R. Whetstine,
Fox Chase Cancer Center, USA
Epigenetic Mechanisms Driving Copy Number Alterations and Drug Resistant Gene Selection
Epigenetic Mechanisms Driving Copy Number Alterations and Drug Resistant Gene Selection
Robert J. Sims,
Constellation Pharmaceuticals, USA
Bromodomain Inhibition as a Strategy to Target Oncogenic Signaling Pathways
Bromodomain Inhibition as a Strategy to Target Oncogenic Signaling Pathways
Bradley E. Bernstein,
Massachusetts General Hospital, USA
Epigenetic Mechanisms of Brain Tumor Initiation and Evolution
Epigenetic Mechanisms of Brain Tumor Initiation and Evolution
Prathamesh Thangaraj Nadar Ponniah,
Technion Israel Institute of Technology, Israel
Short Talk: RNA-dependent Chromatin Localization of KDM4D Lysine Demethylase Promotes H3K9me3 Demethylation
Short Talk: RNA-dependent Chromatin Localization of KDM4D Lysine Demethylase Promotes H3K9me3 Demethylation
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
ncRNA and Enhancers
*
Tony Kouzarides,
University of Cambridge, UK
Victor G. Corces,
Emory University School of Medicine, USA
The Role of Architectural Proteins in the 3D Organization of the Genome
The Role of Architectural Proteins in the 3D Organization of the Genome
Saverio Minucci,
IEO Milan, Italy
Chromatin Alterations in Leukemogenesis
Chromatin Alterations in Leukemogenesis
James J. Morrow,
Case Western Reserve University School of Medicine, USA
Short Talk: Positively Selected Enhancer Elements Endow Tumor Cells with Metastatic Competence
Short Talk: Positively Selected Enhancer Elements Endow Tumor Cells with Metastatic Competence
Jacques Drouin,
Institut de Recherches Cliniques de Montréal, Canada
Short Talk: Talk Title to be Announced
Short Talk: Talk Title to be Announced
Eileen E.M. Furlong,
European Molecular Biology Laboratory, Germany
Chromatin Topology during Embryonic Development
Chromatin Topology during Embryonic Development
Keiko Ozato,
NICHD, National Institutes of Health, USA
Short Talk: Epigenetic Chromatin Marks in Innate Immune Responses: Functional Consequences
Short Talk: Epigenetic Chromatin Marks in Innate Immune Responses: Functional Consequences
Kiyomi Raye Kaneshiro,
University of California, Santa Cruz, USA
Short Talk: Transmission of Gamete-Inherited Chromatin States
Short Talk: Transmission of Gamete-Inherited Chromatin States
17:00—19:00
Regulation of Transcription in Stem Cells
*
Yang Shi,
Children's Hospital Boston, Harvard Medical School, USA
Jeannie T. Lee,
Massachusetts General Hospital / Harvard Medical School, USA
The Roles of Long Noncoding RNA in Epigenetic Regulation
The Roles of Long Noncoding RNA in Epigenetic Regulation
Masami Horikoshi,
University of Tokyo, Japan
Short Talk: Uncovering Ancient Transcription Systems with a Novel Evolutionary Indicator
Short Talk: Uncovering Ancient Transcription Systems with a Novel Evolutionary Indicator
Melanie A. Eckersley-Maslin,
Babraham Institute, UK
Short Talk: MERVL Endogenous Retrovirus Activation Induces Genome-Wide DNA Demethylation
Short Talk: MERVL Endogenous Retrovirus Activation Induces Genome-Wide DNA Demethylation
Raja Jothi,
NIEHS, National Institutes of Health, USA
Short Talk: Transcription at Intragenic Enhancers Attenuate Gene Expression
Short Talk: Transcription at Intragenic Enhancers Attenuate Gene Expression
Chuan He,
University of Chicago, USA
Reversible RNA Methylation in Gene Expression Regulation
Reversible RNA Methylation in Gene Expression Regulation
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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