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This meeting took place in 2016
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Nucleic Acid Sensing Pathways: Innate Immunity, Immunobiology and Therapeutics (E2)
Organizer(s) Thomas Tuschl, Veit Hornung and Karl-Peter Hopfner
May 8—12, 2016
Maritim Hotel & International Congress Center Dresden • Dresden, Germany
Discounted Abstract Deadline: Jan 7, 2016
Abstract Deadline: Feb 9, 2016
Scholarship Deadline: Jan 7, 2016
Discounted Registration Deadline: Mar 8, 2016
Sponsored by DFG Deutsche Forschungsgemeinschaft
Summary of Meeting:
Human cells possess intricate nucleic acid recognition processes for monitoring cellular stress and pathogen infection, which trigger the production and release of interferons and cytokines to alert neighboring cells including cells of the immune system. Various classes of nucleic acid sensors, each specific to detecting modified or unmodified, structured or unstructured DNA or RNA, have been identified and are characterized by distinct subcellular localization and also cell-type-specific expression patterns. These sensors include various nucleotidyl transferases producing second messenger small ribonucleic nucleic acid molecules as well as membrane-bound receptors ultimately leading to phosphorylation of transcription factors driving cytokine and interferon expression. This meeting focuses on cytoplasmic DNA and RNA sensors and the function of their linear and circular oligonucleotide second messenger cGAMP and 2’,5’-oligoadenylate produced upon activation. Substantial progress has been made in identification of the structures of these sensors, their nucleic acid ligands and second messenger molecules, as well as the underlying molecular pathways leading to transcriptional activation. Animal models inactivating various pathways of innate immunity have been developed. This progress has enabled targeted development of antagonists and agonists of cytokine and interferon production for therapeutic targeting of inflammatory diseases and vaccine adjuvant development, respectively. An international group of academic and industry scientists and clinicians with expertise in biochemistry and structural biology, nucleic acid chemistry, immunology, human genetics, virology, rheumatology and vaccine development will converge at this meeting to discuss the latest developments in this field.
View Scholarships/Awards
Human cells possess intricate nucleic acid recognition processes for monitoring cellular stress and pathogen infection, which trigger the production and release of interferons and cytokines to alert neighboring cells including cells of the immune system. Various classes of nucleic acid sensors, each specific to detecting modified or unmodified, structured or unstructured DNA or RNA, have been identified and are characterized by distinct subcellular localization and also cell-type-specific expression patterns. These sensors include various nucleotidyl transferases producing second messenger small ribonucleic nucleic acid molecules as well as membrane-bound receptors ultimately leading to phosphorylation of transcription factors driving cytokine and interferon expression. This meeting focuses on cytoplasmic DNA and RNA sensors and the function of their linear and circular oligonucleotide second messenger cGAMP and 2’,5’-oligoadenylate produced upon activation. Substantial progress has been made in identification of the structures of these sensors, their nucleic acid ligands and second messenger molecules, as well as the underlying molecular pathways leading to transcriptional activation. Animal models inactivating various pathways of innate immunity have been developed. This progress has enabled targeted development of antagonists and agonists of cytokine and interferon production for therapeutic targeting of inflammatory diseases and vaccine adjuvant development, respectively. An international group of academic and industry scientists and clinicians with expertise in biochemistry and structural biology, nucleic acid chemistry, immunology, human genetics, virology, rheumatology and vaccine development will converge at this meeting to discuss the latest developments in this field.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, May 8 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, May 12 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, May 13 in order to fully experience the meeting.
SUNDAY, MAY 8
MONDAY, MAY 9
TUESDAY, MAY 10
WEDNESDAY, MAY 11
THURSDAY, MAY 12
FRIDAY, MAY 13
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, May 8 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, May 12 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, May 13 in order to fully experience the meeting.
SUNDAY, MAY 8
16:00—20:00
Arrival and Registration
Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
Foyer
07:30—08:30
Breakfast
Individual Hotels
08:00—08:30
Poster Setup
Saal 4/5
08:30—19:00
Poster Viewing
Saal 4/5
08:30—09:30
Welcome and Keynote Address
Key Discoveries
Saal 4/5
*
Thomas Tuschl,
HHMI/Rockefeller University, USA
Zhijian "James" Chen,
University of Texas Southwestern Medical Center, USA
The cGAS Pathway of Cytosolic DNA Sensing and Its Role in Health and Diseases
The cGAS Pathway of Cytosolic DNA Sensing and Its Role in Health and Diseases
09:30—12:00
Sensing of Microbial and Viral RNA and DNA by the Innate Immune System
Saal 4/5
Kensuke Miyake,
Institute of Medical Science, University of Tokyo, Japan
RNA-Sensing and Trafficking of TLR7 in Plasmacytoid Dendritic Cells
RNA-Sensing and Trafficking of TLR7 in Plasmacytoid Dendritic Cells
*
Kate A. Fitzgerald,
University of Massachusetts Medical School, USA
Regulation of Inflammation by Long Non-Coding RNAs
Regulation of Inflammation by Long Non-Coding RNAs
Petro Starokadomskyy,
University of Texas Southwestern Medical Center, USA
Short Talk: DNA Polymerase-alpha Regulates Type I Interferon Activation through Cytosolic RNA:DNA Synthesis
Short Talk: DNA Polymerase-alpha Regulates Type I Interferon Activation through Cytosolic RNA:DNA Synthesis
Kachiko Hayashi,
Yale University, USA
Short Talk: Toll-Like Receptor 9 Trafficking and Signaling for Type I Interferons Requires PIKfyve Activity
Short Talk: Toll-Like Receptor 9 Trafficking and Signaling for Type I Interferons Requires PIKfyve Activity
10:10—10:30
Coffee Break
Foyer
12:00—12:45
Lunch
Conference Ctr Restaurant
12:30—14:30
Poster Session 1
Saal 4/5
16:30—17:00
Coffee Available
Foyer
17:00—19:00
Sensing of Microbial and Viral RNA and DNA by the Innate Immune System II
Saal 4/5
*
Veit Hornung,
Ludwig-Maximilians-University Munich, Germany
Molecular Mechanisms of Nucleic Acid Pattern Recognition
Molecular Mechanisms of Nucleic Acid Pattern Recognition
Timothy W. Behrens,
Genentech, Inc., USA
Nucleic Acid Sensing and Interferon Signatures
Nucleic Acid Sensing and Interferon Signatures
Russell E. Vance,
University of California, Berkeley, USA
No Perfect PAMPs? Innate Immune Recognition of Nucleic Acids versus Proteins
No Perfect PAMPs? Innate Immune Recognition of Nucleic Acids versus Proteins
Tan Nguyen,
Walter and Eliza Hall Institute, Australia
Short Talk: Sidt2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition
Short Talk: Sidt2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition
19:00
On Own for Dinner
07:30—08:30
Breakfast
Individual Hotels
08:30—11:45
Structural Biology of Innate Immune Sensing
Saal 4/5
*
Karl-Peter Hopfner,
Ludwig-Maximilians-University Munich, Germany
Integrated ATP Dependent Mechanism for RIG-I’s Distinction between Self and Non-Self RNA
Integrated ATP Dependent Mechanism for RIG-I’s Distinction between Self and Non-Self RNA
Sun Hur,
Harvard Medical School, USA
Molecular Mechanism of RIG-I-Like Receptors
Molecular Mechanism of RIG-I-Like Receptors
Hao Wu,
Harvard Medical School, Boston Children's Hospital, USA
Structural Elucidation of Inflammasome Activation and Regulation
Structural Elucidation of Inflammasome Activation and Regulation
Pingwei Li,
Texas A&M University, USA
Short Talk: The Structural Basis of IRF-3 Recruitment, Activation, and Targeting in Innate Immunity
Short Talk: The Structural Basis of IRF-3 Recruitment, Activation, and Targeting in Innate Immunity
Philip J. Kranzusch,
University of California, Berkeley, USA
Short Talk: Ancient cGAS-STING Pathways Reveal Evolution of Human Innate Immunity
Short Talk: Ancient cGAS-STING Pathways Reveal Evolution of Human Innate Immunity
09:50—10:10
Coffee Break
Foyer
11:45—15:00
On Own for Lunch
11:45—13:00
Poster Setup
Saal 4/5
13:00—20:30
Poster Viewing
Saal 4/5
15:00—15:30
Coffee Available
Foyer
15:30—17:30
Virology and Innate Inflammatory Responses
Saal 4/5
Jae U. Jung,
Keck School of Medicine of University of Southern California, USA
Host Nucleic Acid Sensing and Viral Evasion
Host Nucleic Acid Sensing and Viral Evasion
Ian Thomas Lamborn,
NIAID, National Institutes of Health, USA
Short Talk: Human MDA5 Protects Against Severe Respiratory Infections
Short Talk: Human MDA5 Protects Against Severe Respiratory Infections
Fanxiu Zhu,
Florida State University, USA
Short Talk: KicGAS, KSHV Inhibitor of cGAS
Short Talk: KicGAS, KSHV Inhibitor of cGAS
Kareen Bartsch,
Christian-Albrechts-University, Germany
Short Talk: RNaseH2 Deficiency Leads to Cytosolic Accumulation of Immunostimulatory DNA that is Removed by Autophagy
Short Talk: RNaseH2 Deficiency Leads to Cytosolic Accumulation of Immunostimulatory DNA that is Removed by Autophagy
17:30—18:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
Conference Ctr Restaurant
18:00—20:30
Poster Session 2
Saal 4/5
07:30—08:30
Breakfast
Individual Hotels
07:30—08:00
Poster Setup
Saal 4/5
08:00—17:00
Poster Viewing
Saal 4/5
08:30—11:30
Nucleic Acid Chemistry and Biology in Stress and Innate Immune Response
Saal 4/5
Thomas Tuschl,
HHMI/Rockefeller University, USA
Intra- and Extracellular Diagnostic RNAseq Approaches and Their Use in Inflammatory Diseases
Intra- and Extracellular Diagnostic RNAseq Approaches and Their Use in Inflammatory Diseases
Dinshaw J. Patel,
Memorial Sloan Kettering Cancer Center, USA
Structure and Function of Innate Immune Sensors and Adaptors
Structure and Function of Innate Immune Sensors and Adaptors
Charles E. Samuel,
University of California, Santa Barbara, USA
Roles of A-to-I RNA Editing by Adenosine Deaminase ADAR1 in Innate Immunity RNA Sensing
Roles of A-to-I RNA Editing by Adenosine Deaminase ADAR1 in Innate Immunity RNA Sensing
*
Andreas Pichlmair,
Max-Planck Institute of Biochemistry, Germany
Defects in mRNA Maturation and Localization
Defects in mRNA Maturation and Localization
Swapnil Devarkar,
Rutgers University, USA
Short Talk: Structural and Mechanistic Basis for Self Versus Non-self RNA Discrimination by the Innate Immune Receptor RIG-I
Short Talk: Structural and Mechanistic Basis for Self Versus Non-self RNA Discrimination by the Innate Immune Receptor RIG-I
09:50—10:10
Coffee Break
Foyer
11:30—12:30
Lunch
Conference Ctr Restaurant
12:00—14:30
Poster Session 3
Saal 4/5
16:30—17:00
Coffee Available
Foyer
17:00—19:00
Nucleic Acid Drug Developments and Strategies to Suppress Innate Immunity Responses
Saal 4/5
Gunther Hartmann,
Universitätsklinikum Bonn, Germany
Targeting RIG-I for the Immunotherapy of Cancer
Targeting RIG-I for the Immunotherapy of Cancer
Thomas W. Dubensky, Jr.,
Tempest Therapeutics, USA
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
*
Regina Heidenreich,
CureVac GmbH, Germany
mRNA Vaccination for the Immunotherapy of Infectious Diseases and Cancer
mRNA Vaccination for the Immunotherapy of Infectious Diseases and Cancer
Manuel Ascano, Jr.,
Vanderbilt University, USA
Short Talk: Towards the Small Molecule Modulation of Cyclic GMP-AMP Synthase Activity
Short Talk: Towards the Small Molecule Modulation of Cyclic GMP-AMP Synthase Activity
19:00
On Own for Dinner
07:30—08:30
Breakfast
Individual Hotels
08:30—11:30
Inborn Genetic Defects in Nucleic Acid Sensing I
Saal 4/5
Raphaela Theresia Goldbach-Mansky,
NIAID, National Institutes of Health, USA
Activated STING in a Vascular and Pulmonary Syndrome (SAVI) and Treatment Strategies Reducing Interferon Signaling
Activated STING in a Vascular and Pulmonary Syndrome (SAVI) and Treatment Strategies Reducing Interferon Signaling
Yanick Crow,
University of Edinburgh, UK
Human Type I Interferonopathies
Human Type I Interferonopathies
Min Ae Lee-Kirsch,
Technische Universität Dresden, Germany
Human Genetic Alterations Contributing to Systemic Lupus Erythematosus
Human Genetic Alterations Contributing to Systemic Lupus Erythematosus
*
Virginia Pascual,
Cornell University, USA
Novel Insights into the Role of Innate Immunity in Human SLE
Novel Insights into the Role of Innate Immunity in Human SLE
Rayk Behrendt,
Faculty of Medicine Carl Gustav Carus TU Dresden, Germany
Short Talk: SAMHD1-Deficiency causes Simultaneous Stimulation of the RLR and cGAS-STING Pathways
Short Talk: SAMHD1-Deficiency causes Simultaneous Stimulation of the RLR and cGAS-STING Pathways
09:50—10:10
Coffee Break
Foyer
11:30—17:00
On Own for Lunch
16:30—17:00
Coffee Available
Foyer
17:00—18:45
Inborn Genetic Defects in Nucleic Acid Sensing II
Saal 4/5
Gerald S. Shadel,
The Salk Institute for Biological Studies, USA
Mitochondrial DNA Stress in Innate Immune Signalling and Cancer
Mitochondrial DNA Stress in Innate Immune Signalling and Cancer
*
Andrew Jackson,
University of Edinburgh, UK
RNase H2 mutations Lead to Defective Ribonucleotide Excision Repair and cGAS/STING-Dependent Innate Immune Activation
RNase H2 mutations Lead to Defective Ribonucleotide Excision Repair and cGAS/STING-Dependent Innate Immune Activation
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Saal 4/5
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
Saal 3
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Saal 3
Departure
*Session Chair †Invited, not yet responded.
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