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This meeting took place in 2016
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Stromal Cells in Immunity (Q4)
Organizer(s) Shannon J. Turley, Burkhard Ludewig and Melody A. Swartz
February 7—11, 2016
Keystone Resort • Keystone, CO USA
Discounted Abstract Deadline: Oct 8, 2015
Abstract Deadline: Nov 10, 2015
Scholarship Deadline: Oct 8, 2015
Discounted Registration Deadline: Dec 8, 2015
Sponsored by Genentech, Inc.
Joint Meeting:
Fibrosis: From Basic Mechanisms to Targeted Therapies (Q3)
Summary of Meeting:
Within lymphoid organs, non-hematopoietic stromal cells organize and interact with leukocytes in immunologically important ways. In addition to organizing T and B cell segregation and expressing lymphocyte survival factors, stromal cells support the migration of and interactions between antigen-presenting cells and naïve T and B cells during the initiation of immune responses and influence the outcome between tolerance and immunity. Recent studies in rodents, non-human primates and humans have demonstrated that stromal cells also play instrumental roles in coordinating immune responses in non-lymphoid tissues, in inflammatory and autoimmune diseases and in chronic infection. Furthermore, stromal cells are being harnessed for therapeutic applications in a number of different clinical indications, an area that holds great promise for improving human health. Our understanding of stromal cell populations and their contributions to innate and adaptive immunity as well as immunological diseases, cancer and vaccination has grown exponentially over the past few years. This emerging field has gained enormous momentum due to highly sophisticated and in-depth efforts to dissect the fundamental biology and clinical importance of this cellular compartment. These critical advances as well as work that is on the cusp of being published or in the pipeline are the focus of this meeting.
View Scholarships/Awards
Within lymphoid organs, non-hematopoietic stromal cells organize and interact with leukocytes in immunologically important ways. In addition to organizing T and B cell segregation and expressing lymphocyte survival factors, stromal cells support the migration of and interactions between antigen-presenting cells and naïve T and B cells during the initiation of immune responses and influence the outcome between tolerance and immunity. Recent studies in rodents, non-human primates and humans have demonstrated that stromal cells also play instrumental roles in coordinating immune responses in non-lymphoid tissues, in inflammatory and autoimmune diseases and in chronic infection. Furthermore, stromal cells are being harnessed for therapeutic applications in a number of different clinical indications, an area that holds great promise for improving human health. Our understanding of stromal cell populations and their contributions to innate and adaptive immunity as well as immunological diseases, cancer and vaccination has grown exponentially over the past few years. This emerging field has gained enormous momentum due to highly sophisticated and in-depth efforts to dissect the fundamental biology and clinical importance of this cellular compartment. These critical advances as well as work that is on the cusp of being published or in the pipeline are the focus of this meeting.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, February 7 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 11 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, February 12 in order to fully experience the meeting.
SUNDAY, FEBRUARY 7
MONDAY, FEBRUARY 8
TUESDAY, FEBRUARY 9
WEDNESDAY, FEBRUARY 10
THURSDAY, FEBRUARY 11
FRIDAY, FEBRUARY 12
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, February 7 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 11 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, February 12 in order to fully experience the meeting.
SUNDAY, FEBRUARY 7
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:30
Welcome and Keynote Session (Joint)
*
Robert Lafyatis,
University of Pittsburgh Medical Center, USA
*
Shannon J. Turley,
Genentech, Inc., USA
Ronald N. Germain,
NIAID, National Institutes of Health, USA
Imaging the Immune Cell–Stromal Interface in Lymphoid Tissues and Beyond
Imaging the Immune Cell–Stromal Interface in Lymphoid Tissues and Beyond
Fiona M. Watt,
King's College London School of Medicine, UK
Contribution of Different Fibroblast Lineages to Skin Fibrosis
Contribution of Different Fibroblast Lineages to Skin Fibrosis
09:50—12:00
Stromal Cells in Inflammatory Disease (Joint)
*
Burkhard Ludewig,
Kantonsspital St. Gallen, Switzerland
Fibroblastric Reticular Cells: Phenotype Follows Function
Fibroblastric Reticular Cells: Phenotype Follows Function
Timothy W. Schacker,
University of Minnesota, USA
Lymphoid Tissue Fibrosis in HIV Infection
Lymphoid Tissue Fibrosis in HIV Infection
*
Robert Lafyatis,
University of Pittsburgh Medical Center, USA
Dermal Fibroblast Heterogeneity and Fibrosis in Systemic Sclerosis
Dermal Fibroblast Heterogeneity and Fibrosis in Systemic Sclerosis
Mo Ebrahimkhani,
Arizona State University, USA
Short Talk: Engineering Human Organoids with Multiple Subsets of Stromal Cells
Short Talk: Engineering Human Organoids with Multiple Subsets of Stromal Cells
Jeffrey L. Browning,
Boston University School of Medicine, USA
Short Talk: Fibroblasts in the Skin of Systemic Sclerosis Patients Share Characteristics with FRC in Lymphoid Organs
Short Talk: Fibroblasts in the Skin of Systemic Sclerosis Patients Share Characteristics with FRC in Lymphoid Organs
14:30—16:30
Workshop 1
*
Jeffrey L. Browning,
Boston University School of Medicine, USA
*
Shannon J. Turley,
Genentech, Inc., USA
Florent Carrette,
Sanford Burnham Prebys Medical Discovery Institute, USA
CD44 is a New Immune Checkpoint that Promotes T Cell Exhaustion and Chronic Viral Infection through Expression on Fibroblastic Reticular Cells
CD44 is a New Immune Checkpoint that Promotes T Cell Exhaustion and Chronic Viral Infection through Expression on Fibroblastic Reticular Cells
Alice E. Denton,
Babraham Institute, UK
Lymph Node Stromal Cells Derive from a Distinct Embryonic FAP+ Progenitor
Lymph Node Stromal Cells Derive from a Distinct Embryonic FAP+ Progenitor
Juan Dubrot,
Broad Institute, USA
MHCII-mediated Antigen-presentation by Lymph Node Stromal Cells in Peripheral Tolerance
MHCII-mediated Antigen-presentation by Lymph Node Stromal Cells in Peripheral Tolerance
Henrike Fleige,
Hannover Medical School, Germany
The Role of Stromal Cells in Pathogen-induced BALT
The Role of Stromal Cells in Pathogen-induced BALT
Amanda Lund,
New York University, USA
Lymphatic Vessels are Required for Efficient Viral Clearance and Adaptive Immune Induction Following Epicutaneous Vaccinia Infection
Lymphatic Vessels are Required for Efficient Viral Clearance and Adaptive Immune Induction Following Epicutaneous Vaccinia Infection
Anna-Carin Andersson Lundell,
Göteborg University, Sweden
Type I and II Interferons Induce BAFF Production from Human Decidual Stromal Cells
Type I and II Interferons Induce BAFF Production from Human Decidual Stromal Cells
Helen M. McGettrick,
University of Birmingham, UK
Identification of a Transitional Fibroblast Functional Phenotype in Early Rheumatoid Arthritis
Identification of a Transitional Fibroblast Functional Phenotype in Early Rheumatoid Arthritis
Sarajo Mohanta,
Ludwig-Maximilians University Munich, Germany
Chameleons in the Arterial Wall: Vascular Smooth Muscle Cells Transdifferentiate into Lymphoid Tissue Organizer Cells and Control Atherosclerosis Immunity
Chameleons in the Arterial Wall: Vascular Smooth Muscle Cells Transdifferentiate into Lymphoid Tissue Organizer Cells and Control Atherosclerosis Immunity
17:00—19:15
Stromal Cell Function in the Initiation of Adaptive Immunity
*
Theresa T. Lu,
Hospital for Special Surgery/Weill Cornell Medicine, USA
Regulating Lymph Node Vascular-Stromal Growth and Survival in Immunity
Regulating Lymph Node Vascular-Stromal Growth and Survival in Immunity
Antal Rot,
University of York, UK
Expression and Function of Atypical Chemokine Receptor 4 in Salivary Glands
Expression and Function of Atypical Chemokine Receptor 4 in Salivary Glands
*
Michael C. Carroll,
Boston Children's Hospital, Harvard Medical School, USA
Lymph Node Fibroblast Reticular Cells in Regulation of Humoral Immunity
Lymph Node Fibroblast Reticular Cells in Regulation of Humoral Immunity
Mark C. Coles,
University of Oxford, UK
Short Talk: Role of microRNA Mediated Stromal Remodeling in Vaccine Efficacy
Short Talk: Role of microRNA Mediated Stromal Remodeling in Vaccine Efficacy
Sanjiv A. Luther,
University of Lausanne, Switzerland
Short Talk: Identification of a New Fibroblast Subset Forming Plasma Cell Survival Niches in Activated Lymph Nodes
Short Talk: Identification of a New Fibroblast Subset Forming Plasma Cell Survival Niches in Activated Lymph Nodes
17:00—19:00
Metabolic Stress and Fibrogenesis
*
Mauricio Rojas,
University of Pittsburgh, USA
*
Maria Trojanowska,
Boston University School of Medicine, USA
Timothy S. Blackwell,
Vanderbilt University School of Medicine, USA
ER Stress in Lung Fibrosis
ER Stress in Lung Fibrosis
Ana L. Mora,
University of Pittsburgh, USA
Fibrosis as a Disease of Aging and Mitochondrial Dysfunction
Fibrosis as a Disease of Aging and Mitochondrial Dysfunction
Philipp E. Scherer,
University of Texas Southwestern Medical Center, USA
Fat Inflammation, Fibrosis and Remodeling
Fat Inflammation, Fibrosis and Remodeling
Kamran Atabai,
University of California, San Francisco, USA
Short Talk: Functional Genomic Screen Identifies Novel Mediators of Collagen Uptake
Short Talk: Functional Genomic Screen Identifies Novel Mediators of Collagen Uptake
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Stromal Cells in Lymphoid Development
Andrea Brendolan,
Ospedale San Raffaele srl, Italy
Transcriptional Control of Retinoic Acid Metabolism in Stromal Progenitors is Required to Ensure Spleen Development
Transcriptional Control of Retinoic Acid Metabolism in Stromal Progenitors is Required to Ensure Spleen Development
Marc Bajénoff,
Centre d'Immunologie Marseille-Luminy, France
Dynamics of Lymphoid Stromal Cells
Dynamics of Lymphoid Stromal Cells
Yang-Xin Fu,
University of Texas Southwestern Medical Center, USA
Targeting Tumor Stromal Microenvironment to Reprogram Tumor Immunity
Targeting Tumor Stromal Microenvironment to Reprogram Tumor Immunity
*
Jorge H. Caamano,
College of Medicine - Univ. of Birmingham, UK
Development and function of Fat-Associated Lymphoid Clusters
Development and function of Fat-Associated Lymphoid Clusters
Susan R. Schwab,
New York University School of Medicine, USA
Short Talk: A Map of Sphingosine 1-Phosphate Distribution in the Spleen
Short Talk: A Map of Sphingosine 1-Phosphate Distribution in the Spleen
08:00—11:15
Extracellular Matrix Composition and Stiffness in Regulation of Cell Phenotype
*
Dean Sheppard,
University of California, San Francisco, USA
*
Daniel Tschumperlin,
Mayo Clinic, USA
Dennis E. Discher,
University of Pennsylvania, USA
Fractal Heterogeneity of Model Scars Modulates Stiff-Niche Stem-Cell Responses via Nuclear Exit of a Mechanorepressor
Fractal Heterogeneity of Model Scars Modulates Stiff-Niche Stem-Cell Responses via Nuclear Exit of a Mechanorepressor
Peter Bitterman,
University of Minnesota, USA
IPF Extracellular Matrix Activates a Profibrotic Feedback Loop by Deregulating MicroRNA-29 at a Post-Processing Step
IPF Extracellular Matrix Activates a Profibrotic Feedback Loop by Deregulating MicroRNA-29 at a Post-Processing Step
Andrew M. Tager,
Massachusetts General Hospital, USA
Mitochondrial Priming by Matrix Stiffness Sensitizes Myofibroblasts to BH3 Mimetic-induced Apoptosis in Scleroderma Fibrosis
Mitochondrial Priming by Matrix Stiffness Sensitizes Myofibroblasts to BH3 Mimetic-induced Apoptosis in Scleroderma Fibrosis
Victoria Smith,
Gilead Sciences, USA
Allosteric Targeting of LOXL2
Allosteric Targeting of LOXL2
Brendon M. Baker,
Boston University, USA
Short Talk: Cell-Mediated Fiber Recruitment Drives Extracellular Matrix Mechanosensing in Engineered Fibrillar Microenvironments
Short Talk: Cell-Mediated Fiber Recruitment Drives Extracellular Matrix Mechanosensing in Engineered Fibrillar Microenvironments
Tanya Kalin,
Cincinnati Children's Hospital Medical Center, USA
Short Talk: FoxF1 Inhibits Pulmonary Fibrosis by Preventing Differentiation of Normal Lung Fibroblasts into Myofibroblasts
Short Talk: FoxF1 Inhibits Pulmonary Fibrosis by Preventing Differentiation of Normal Lung Fibroblasts into Myofibroblasts
14:30—16:30
Workshop: Assessing and Treating Human Fibrosis
*
Benjamin D. Humphreys,
Washington University, USA
*
David A. Schwartz,
University of Colorado Denver, USA
Philip A. Waghorn,
Martinos Biomedical Imaging Center, USA
Non-Invasive Imaging of Fibrogenesis using Magnetic Resonance Imaging (MRI)
Non-Invasive Imaging of Fibrogenesis using Magnetic Resonance Imaging (MRI)
Daryle J. DePianto,
Genentech, Inc., USA
An in vitro Co-Culture System Recapitulating Epithelial-Mesenchymal Communication as a Tool for Investigating Mechanisms of IPF Pathogenesis
An in vitro Co-Culture System Recapitulating Epithelial-Mesenchymal Communication as a Tool for Investigating Mechanisms of IPF Pathogenesis
Alan C. Mullen,
Harvard Medical School, USA
Long Noncoding RNAs Expressed in Human Hepatic Stellate Cells form Networks with Extracellular Matrix Proteins
Long Noncoding RNAs Expressed in Human Hepatic Stellate Cells form Networks with Extracellular Matrix Proteins
Tatsuya Tsukui,
University of California, San Francisco, USA
Intratracheal Cell Transfer Demonstrates the Profibrotic Potential of Resident Fibroblasts in Pulmonary Fibrosis
Intratracheal Cell Transfer Demonstrates the Profibrotic Potential of Resident Fibroblasts in Pulmonary Fibrosis
Shuyu Ren,
, USA
Multiple Domains of CTGF Amplify Pericyte Activation to Become Pathological Matrix Producing Cells
Multiple Domains of CTGF Amplify Pericyte Activation to Become Pathological Matrix Producing Cells
Claude Jourdan Le Saux,
University of California, San Francisco, USA
Janus Kinase-1 Inhibitor Prevents Senescence in Mouse Lung Bleomycin Model Leading to Reduce Fibrosis
Janus Kinase-1 Inhibitor Prevents Senescence in Mouse Lung Bleomycin Model Leading to Reduce Fibrosis
Claude Jourdan Le Saux,
University of California, San Francisco, USA
Janus Kinase-1 Inhibitor Prevents Senescence in Mouse Lung Bleomycin Model Leading to Reduce Fibrosis
Janus Kinase-1 Inhibitor Prevents Senescence in Mouse Lung Bleomycin Model Leading to Reduce Fibrosis
Resat Cinar,
NIAAA, National Institutes of Health, USA
Improved Antifibrotic Efficacy and Safety of Hybrid Inhibitors of Peripheral CB1 Receptors and iNOS
Improved Antifibrotic Efficacy and Safety of Hybrid Inhibitors of Peripheral CB1 Receptors and iNOS
Gerlinde Wernig,
Institute for Regenerative Medicine and Stem Cell Research, USA
c-JUN is a Critical Mediator of Multi-Organ Fibrosis
c-JUN is a Critical Mediator of Multi-Organ Fibrosis
17:00—19:00
Stromal Cell-Immune Cell Interactions in Non-Lymphoid Tissues
*
Gwendalyn J. Randolph,
Washington University, USA
Collecting Vessel Permeability and Fibrosis: Regulation by CCR7 and IRF4-Dependent Dendritic Cells
Collecting Vessel Permeability and Fibrosis: Regulation by CCR7 and IRF4-Dependent Dendritic Cells
Scott N. Mueller,
University of Melbourne, Australia
Dynamic Responses of Lymphoid Stromal Cells to Infection
Dynamic Responses of Lymphoid Stromal Cells to Infection
*
Andrea Cerutti,
Mount Sinai School of Medicine, USA
Role of Stromal Cells in Innate-Like Antibody Responses
Role of Stromal Cells in Innate-Like Antibody Responses
Joana Campos,
University of Birmingham, UK
Short Talk: ICOS-ICOSL Interaction Regulates Lymphotoxin-alpha Expression and Maturation of Lymphoid-like Stromal Cells during Inflammation
Short Talk: ICOS-ICOSL Interaction Regulates Lymphotoxin-alpha Expression and Maturation of Lymphoid-like Stromal Cells during Inflammation
17:00—19:00
Adaptive Immunity, TH2 and IL-13 Fibrosis
*
Lucie Peduto,
Institut Pasteur, France
*
Thomas A. Wynn,
Pfizer, USA
Padraic Fallon,
Trinity College Dublin, Ireland
Innate Lymphoid Cells and Fibrosis
Innate Lymphoid Cells and Fibrosis
Joseph R. Arron,
Genentech, Inc., USA
Targeting IL13 in Idiopathic Pulmonary Fibrosis
Targeting IL13 in Idiopathic Pulmonary Fibrosis
Richard Lee Gieseck III,
NIAID, National Institutes of Health, USA
Short Talk: IL-13 Drives Distinct Cellular Pathways Directing Biliary Proliferation, Steatosis, and Fibrosis
Short Talk: IL-13 Drives Distinct Cellular Pathways Directing Biliary Proliferation, Steatosis, and Fibrosis
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Stromal Cells in Tumor-Promoting Inflammation and Anti-Tumor Immunity
*
Melody A. Swartz,
University of Chicago, USA
Immune Regulation by Tumor Lymphangiogenesis
Immune Regulation by Tumor Lymphangiogenesis
Shannon J. Turley,
Genentech, Inc., USA
Stromal Cell Coordination of Leukocyte Function and Spatiality
Stromal Cell Coordination of Leukocyte Function and Spatiality
Karin Tarte,
INSERM U917 Université de Rennes 1, France
Lymphoid Stromal Cells in B-Cell Lymphoma
Lymphoid Stromal Cells in B-Cell Lymphoma
Jenny Rudnick,
University of California, San Francisco, USA
Short Talk: Autophagy Regulates the Tumor Promoting State of Mammary Fibroblasts
Short Talk: Autophagy Regulates the Tumor Promoting State of Mammary Fibroblasts
Jacqui Shields,
University of Cambridge, UK
Short Talk: Tumor-Associated Stromal Cells Contribute to Immune Dysfunction Via Antigen-specific Deletion of CD8+ T Cells and Transcriptional Reprogramming
Short Talk: Tumor-Associated Stromal Cells Contribute to Immune Dysfunction Via Antigen-specific Deletion of CD8+ T Cells and Transcriptional Reprogramming
08:00—11:00
Perivascular Mesenchymal Cells and Vascular Niches: Versatile Cells in Health and Disease
*
Theresa T. Lu,
Hospital for Special Surgery/Weill Cornell Medicine, USA
*
Jeremy S. Duffield,
Vertex Pharmaceuticals, USA
Lucie Peduto,
Institut Pasteur, France
Perivascular Stromal Lineages in Fibrosis and Cancer
Perivascular Stromal Lineages in Fibrosis and Cancer
Benjamin D. Humphreys,
Washington University, USA
Mesenchymal Stem Cells in Organ Fibrosis
Mesenchymal Stem Cells in Organ Fibrosis
Paul S. Frenette,
Albert Einstein College of Medicine, USA
Mesenchymal Stromal Subsets and Vascular Niches in the Bone Marrow
Mesenchymal Stromal Subsets and Vascular Niches in the Bone Marrow
Lorin Olson,
Oklahoma Medical Research Foundation, USA
Short Talk: Adipose Tissue Fibrosis Driven by PDGFRalpha-Induced Cell Fate Switch in Fibro-Adipogenic Progenitor Cells
Short Talk: Adipose Tissue Fibrosis Driven by PDGFRalpha-Induced Cell Fate Switch in Fibro-Adipogenic Progenitor Cells
Irina Alexandra Leaf,
Biogen, USA
Short Talk: Targeting MyD88-Dependent Signaling in Pericytes is Protective Against Tissue Injury and Fibrosis
Short Talk: Targeting MyD88-Dependent Signaling in Pericytes is Protective Against Tissue Injury and Fibrosis
17:00—19:00
Stromal Cell Function in Chronic Inflammation
*
Michael B. Brenner,
Harvard Medical School, USA
Targeting and Sub-setting Fibroblasts to Treat Tissue Degradation and Fibrosis
Targeting and Sub-setting Fibroblasts to Treat Tissue Degradation and Fibrosis
*
Fiona M. Powrie,
University of Oxford, UK
Innate Lymphoid Cells, Fibrosis and Inflammatory Bowel Disease
Innate Lymphoid Cells, Fibrosis and Inflammatory Bowel Disease
Christopher D. Buckley,
University of Birmingham, UK
The Role of Stromal Cells in Chronic Inflammation
The Role of Stromal Cells in Chronic Inflammation
César Nombela-Arrieta,
University Hospital Zurich, Switzerland
Short Talk: Chronic Viral Infections Induce Major Disruption of Bone Marrow Stromal Microarchitecture and Function
Short Talk: Chronic Viral Infections Induce Major Disruption of Bone Marrow Stromal Microarchitecture and Function
17:00—19:00
Fibrotic Muscle Disease
*
Paolo G. V. Martini,
Moderna, USA
*
Elisabeth Barton,
University of Florida, USA
Fibrosis in Muscular Dystrophy
Fibrosis in Muscular Dystrophy
Bruce M. Wentworth,
BMW Research Consulting, USA
Phosphorodiamidate Morpholino Oligomers (PMOs) in Development for the Treatment of Duchenne Muscular Dystrophy (DMD)
Phosphorodiamidate Morpholino Oligomers (PMOs) in Development for the Treatment of Duchenne Muscular Dystrophy (DMD)
Barbora Malecova,
Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: Single Cell Analysis Reveals Dynamic Transitions within Distinct Subpopulations of Fibro-Adipogenic Progenitors (FAPs) Implicated in Skeletal Muscle Regeneration or Fibrosis
Short Talk: Single Cell Analysis Reveals Dynamic Transitions within Distinct Subpopulations of Fibro-Adipogenic Progenitors (FAPs) Implicated in Skeletal Muscle Regeneration or Fibrosis
Daniel Tschumperlin,
Mayo Clinic, USA
Short Talk: RNAi Screening to Identify Genes Essential for Myofibroblast Activation
Short Talk: RNAi Screening to Identify Genes Essential for Myofibroblast Activation
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Stromal Cells in Immune Regulation, Tolerance and Autoimmunity
Henrique Veiga-Fernandes,
Champalimaud Research, Portugal
Environmental Sensing by Blood Cells
Environmental Sensing by Blood Cells
*
Jennifer L. Gommerman,
University of Toronto, Canada
The Lymphotoxin Network and Stromal Cell Remodeling
The Lymphotoxin Network and Stromal Cell Remodeling
Ross M. Kedl,
University of Colorado Denver, USA
Antigen Archiving by Lymph Node Stroma: A Novel Function for the Lymphatic Endothelium
Antigen Archiving by Lymph Node Stroma: A Novel Function for the Lymphatic Endothelium
*
Paul P. Tak,
GlaxoSmithKline, UK
Towards Therapeutic Targeting of the Epigenome in Rheumatoid Arthritis
Towards Therapeutic Targeting of the Epigenome in Rheumatoid Arthritis
Kaisa Auvinen,
University of Turku, Finland
Short Talk: The Endothelial Protein PLVAP in Lymphatics Controls the Entry of Antigens into the Lymph Nodes
Short Talk: The Endothelial Protein PLVAP in Lymphatics Controls the Entry of Antigens into the Lymph Nodes
Ivan Maillard,
University of Michigan, USA
Short Talk: Stromal Cell Niches in Secondary Lymphoid Organs Drive T Cell Alloimmunity through Delta-Like1/4-Mediated Notch Signals
Short Talk: Stromal Cell Niches in Secondary Lymphoid Organs Drive T Cell Alloimmunity through Delta-Like1/4-Mediated Notch Signals
08:00—11:15
Immunity in Fibrotic Diseases
*
Peter D. R. Higgins,
University of Michigan, USA
Florian Rieder,
Cleveland Clinic, USA
Scarring in Inflammatory Bowel Disease
Scarring in Inflammatory Bowel Disease
Jaap M. Van Laar,
UMC Utrecht, Netherlands
Stem Cell Transplant, Blocking Fibrosis in Systemic Sclerosis by Resetting the Immune System
Stem Cell Transplant, Blocking Fibrosis in Systemic Sclerosis by Resetting the Immune System
Ivan G. Gomez,
Biogen, USA
Short Talk: TNF Superfamily Receptor Fn14 Activates Myofibroblasts to Drive Progression of Fibrotic Disease of the Kidney
Short Talk: TNF Superfamily Receptor Fn14 Activates Myofibroblasts to Drive Progression of Fibrotic Disease of the Kidney
Boris Hinz,
University of Toronto, Canada
Short Talk: Direct Adhesion of Macrophages Promotes Myofibroblast Differentiation by Establishing a Niche of Active TGF-Beta1
Short Talk: Direct Adhesion of Macrophages Promotes Myofibroblast Differentiation by Establishing a Niche of Active TGF-Beta1
14:30—16:30
Workshop 2
*
Mark C. Coles,
University of Oxford, UK
*
Sanjiv A. Luther,
University of Lausanne, Switzerland
Chris G. Mueller,
University of Strasbourg, France
Distinct and Overlapping Roles of RANKL and Lymphotoxin in the Regulation of CD169+ Lymph Node Macrophages
Distinct and Overlapping Roles of RANKL and Lymphotoxin in the Regulation of CD169+ Lymph Node Macrophages
Rafael de Queiroz Prado,
NIAID, National Institutes of Health, USA
Distinct Role for IL-4/IL-13 Activated Monocytes/Macrophages during Type 2 Cytokine-driven Pulmonary Fibrosis
Distinct Role for IL-4/IL-13 Activated Monocytes/Macrophages during Type 2 Cytokine-driven Pulmonary Fibrosis
Lauren B. Rodda,
University of Washington, USA
Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-expressing Reticular Cells
Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-expressing Reticular Cells
Katarzyna Sitnik,
Danish Technical University, Veterinary Institute, Denmark
Context Dependent Development of Lymphoid Stroma from BP3-PDPN+PDGFRalpha+/beta+CD34+ Adult Vascular Adventitial Cells
Context Dependent Development of Lymphoid Stroma from BP3-PDPN+PDGFRalpha+/beta+CD34+ Adult Vascular Adventitial Cells
Nathalie Steinthal,
University of Birmingham, UK
Cd248 Plays an Important Role in Controlling the Differentiation of Mesenchymal Stem Cells to Adult Lymphoid Stromal Cells
Cd248 Plays an Important Role in Controlling the Differentiation of Mesenchymal Stem Cells to Adult Lymphoid Stromal Cells
Seddon Thomas,
NIEHS, National Institutes of Health, USA
Dendritic and Epithelial Cell Crosstalk in the Lung Orchestrates Immune Responses to Inhaled Allergens
Dendritic and Epithelial Cell Crosstalk in the Lung Orchestrates Immune Responses to Inhaled Allergens
Carolyn A. Thomson,
University of Glasgow, UK
Novel Insights into the Intestinal Stromal Cells Network, Revealed by Selective Expression of the Atypical Chemokine Receptor ACKR4
Novel Insights into the Intestinal Stromal Cells Network, Revealed by Selective Expression of the Atypical Chemokine Receptor ACKR4
Alice Anna Tomei,
Diabetes Research Institute, USA
CCL21 Expression in Beta Cells Induces Lymph Node Mimicry in the Pancreas and Prevents Autoimmune Diabetes
CCL21 Expression in Beta Cells Induces Lymph Node Mimicry in the Pancreas and Prevents Autoimmune Diabetes
17:00—19:00
Therapeutic Application and Modulation of Stromal Cell Function
*
Dhavalkumar D. Patel,
UCB S.A., Belgium
Stromal-Immune Cell Cross-Talk in Autoimmune Disease: Roles in Therapeutic Interventions
Stromal-Immune Cell Cross-Talk in Autoimmune Disease: Roles in Therapeutic Interventions
Biju Parekkadan,
Rutgers University, USA
Stromal Cell Therapy
Stromal Cell Therapy
*
Katarina Le Blanc,
Karolinska Institute, Sweden
Bringing Mesenchymal Stem Cells into the Clinic
Bringing Mesenchymal Stem Cells into the Clinic
Nisarg Shah,
Harvard University, USA
Short Talk: Recapitulating the Bone Marrow Stroma to Drive Immune Reconstitution
Short Talk: Recapitulating the Bone Marrow Stroma to Drive Immune Reconstitution
17:00—18:45
Emerging Antifibrotic Therapies
*
Lori Morton,
Regeneron Pharmaceuticals, Inc., USA
Dean Sheppard,
University of California, San Francisco, USA
Integrin-Mediated TGFbeta Activation
Integrin-Mediated TGFbeta Activation
Luca Richeldi,
University of Southampton, UK
Nintedanib
Nintedanib
Jörg H.W. Distler,
University of Erlangen-Nuremberg, Germany
Upstream and Downstream Targeting of TGFbeta Signaling in Fibrosis
Upstream and Downstream Targeting of TGFbeta Signaling in Fibrosis
19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Melody A. Swartz,
University of Chicago, USA
Burkhard Ludewig,
Kantonsspital St. Gallen, Switzerland
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
We gratefully acknowledge support for this conference from:
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
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We gratefully acknowledge the generous grant for this conference provided by:
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
Click here to view more of these organizations
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If your organization is interested in joining these entities in support of Keystone
Symposia, please contact: Sarah Lavicka,
Director of Corporate Relations, Email: sarahl@keystonesymposia.org, Phone:+1 970-262-2690 Click here for more information on Industry Support and Recognition Opportunities. If you are interested in becoming an advertising/marketing in-kind partner, please contact: Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org, Phone:+1 970-262-1179 |
