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This meeting took place in 2016
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Positive-Strand RNA Viruses (N1)
Organizer(s) Raul Andino and Peter D. Nagy
May 1—5, 2016
Hyatt Regency Austin • Austin, TX USA
Discounted Abstract Deadline: Jan 6, 2016
Abstract Deadline: Feb 3, 2016
Scholarship Deadline: Jan 6, 2016
Discounted Registration Deadline: Mar 2, 2016
Sponsored by Merck & Co., Inc.
Summary of Meeting:
Positive-stranded RNA viruses are significant and emerging human pathogens worldwide. Virus-host interactions and innate responses by the host are intensively studied areas, which promise novel, broad-range and durable antiviral approaches. Topics covered by the meeting include basic advances in research on viral replication structures, virus entry and virus evolution; virus-host interactions, discussed from the virus view on changing the host (including systems biology) and host responses and defense mechanisms; and emerging therapeutics. It is anticipated that rapidly emerging new concepts on virus-host interactions will help the participants to test various host factors for a large number of positive-strand RNA viruses to expand the arsenal of antiviral approaches. This meeting will bring together experts on positive-stranded RNA viruses that will facilitate the rapid progress and dissemination of new concepts in the complex field of virus-host interactions. Also, speakers who are expert with other groups of viruses will be invited to facilitate cross-talk with other areas in virology. Among the speakers will be interdisciplinary scientists who would not normally meet with this group of researchers. Virology, cell biology, genetics, evolution, macromolecular structures/assembly, systems biology and imaging will all be brought together.
View Scholarships/Awards
Positive-stranded RNA viruses are significant and emerging human pathogens worldwide. Virus-host interactions and innate responses by the host are intensively studied areas, which promise novel, broad-range and durable antiviral approaches. Topics covered by the meeting include basic advances in research on viral replication structures, virus entry and virus evolution; virus-host interactions, discussed from the virus view on changing the host (including systems biology) and host responses and defense mechanisms; and emerging therapeutics. It is anticipated that rapidly emerging new concepts on virus-host interactions will help the participants to test various host factors for a large number of positive-strand RNA viruses to expand the arsenal of antiviral approaches. This meeting will bring together experts on positive-stranded RNA viruses that will facilitate the rapid progress and dissemination of new concepts in the complex field of virus-host interactions. Also, speakers who are expert with other groups of viruses will be invited to facilitate cross-talk with other areas in virology. Among the speakers will be interdisciplinary scientists who would not normally meet with this group of researchers. Virology, cell biology, genetics, evolution, macromolecular structures/assembly, systems biology and imaging will all be brought together.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, May 1 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, May 5 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, May 6 in order to fully experience the meeting.
SUNDAY, MAY 1
MONDAY, MAY 2
TUESDAY, MAY 3
WEDNESDAY, MAY 4
THURSDAY, MAY 5
FRIDAY, MAY 6
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, May 1 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, May 5 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, May 6 in order to fully experience the meeting.
SUNDAY, MAY 1
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:30—09:30
Welcome and Keynote Address
*
Raul Andino,
University of California, San Francisco, USA
Anna Marie Pyle,
Yale University, USA
Viral RNA Structure and its Recognition by Host and Viral Proteins
Viral RNA Structure and its Recognition by Host and Viral Proteins
09:30—11:45
Systems Biology: From “Omics” to Function
Host-virus interaction uncovered by integration of large data sets (genomics, proteomics, functional genomics, etc.).
*
Peter D. Nagy,
University of Kentucky, USA
Priya S. Shah,
University of California, Davis, USA
Proteomics, Functional Genomics, eMAPs on Dengue Virus Replicating in Humans and Mosquitoes
Proteomics, Functional Genomics, eMAPs on Dengue Virus Replicating in Humans and Mosquitoes
Benjamin R. TenOever,
Icahn School of Medicine at Mount Sinai, USA
Functional Antiviral Genomics through in vivo RNAi Screens
Functional Antiviral Genomics through in vivo RNAi Screens
Jan E. Carette,
Stanford University, USA
Short Talk: Genetic Knockout Screens Identify Host Genes Required For Dengue Virus Replication
Short Talk: Genetic Knockout Screens Identify Host Genes Required For Dengue Virus Replication
Sunnie R. Thompson,
University of Alabama, Birmingham, USA
Short Talk: Identification of Host Factors that Interact with Dengue Virus RNA in Cell Culture
Short Talk: Identification of Host Factors that Interact with Dengue Virus RNA in Cell Culture
14:30—16:30
Workshop 1: Recombination and Replication Fidelity, RdRp Structure
*
Karla A. Kirkegaard,
Stanford University School of Medicine, USA
David J. Barton,
University of Colorado Denver, USA
Polymerase Structure-Function and Picornavirus RNA Recombination
Polymerase Structure-Function and Picornavirus RNA Recombination
Patrick T. Dolan,
Stanford University, USA
Population Sequencing Reveals the Host-Specific Adaptive Landscapes of Dengue Virus
Population Sequencing Reveals the Host-Specific Adaptive Landscapes of Dengue Virus
Gonzalo Moratorio,
Institut Pasteur, France
Cornering RNA Viruses by Constraining their Sequence Space
Cornering RNA Viruses by Constraining their Sequence Space
Alexander E. Gorbalenya,
Leiden University Medical Center, Netherlands
NiRAN, Nidovirus RdRp-Associated Nucleotidyltransferase: First Enzyme Exclusively Associated with an Order of +RNA Viruses
NiRAN, Nidovirus RdRp-Associated Nucleotidyltransferase: First Enzyme Exclusively Associated with an Order of +RNA Viruses
James Bert Flanegan,
University of Florida, USA
Poliovirus Multifunctional Precursor Proteins Required for Replication Complex Assembly, VPgpUpU Synthesis and RNA Replication
Poliovirus Multifunctional Precursor Proteins Required for Replication Complex Assembly, VPgpUpU Synthesis and RNA Replication
Kay Choi,
University of Texas Medical Branch, USA
Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface
Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface
Chloé Jaubert,
Universite de Bordeaux, France
RNA Genomic Dimerization and Hepatitis C Virus Replication
RNA Genomic Dimerization and Hepatitis C Virus Replication
17:00—19:00
Entry, Trafficking and Exiting
Virus receptor interactions, intracellular trafficking, and mechanisms of egress.
*
Andres Merits,
University of Tartu, Estonia
Félix Rey,
Institut Pasteur, France
Eliciting Cross-Reactive Antibodies Neutralizing Dengue Virus: A Structural View
Eliciting Cross-Reactive Antibodies Neutralizing Dengue Virus: A Structural View
Carolyn B. Coyne,
University of Pittsburgh, USA
Roadblocks: Polarized Cells as Barriers to RNA Virus Entry and Infection
Roadblocks: Polarized Cells as Barriers to RNA Virus Entry and Infection
Julie K. Pfeiffer,
University of Texas Southwestern Medical Center, USA
Enteroviruses and the Microbiota
Enteroviruses and the Microbiota
Maria Guadalupe Martinez,
Centre de Recherche en Cancerologie. INSERM 1052 CNRS 5286, France
Short Talk: Alphavirus Budding: How Viruses Remodel the Cell During Exit
Short Talk: Alphavirus Budding: How Viruses Remodel the Cell During Exit
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:30
Replication Organelles, Membranes, Proteins, Lipids and Stuff...
How do virus construct alter the cell architecture to create a RNA replication favorable environment.
*
Raul Andino,
University of California, San Francisco, USA
Ralf Bartenschlager,
Heidelberg University, Germany
Cell Biology of Viral Replication Cycles: A Comparison of Hepatitis C Virus and Dengue Virus
Cell Biology of Viral Replication Cycles: A Comparison of Hepatitis C Virus and Dengue Virus
Richard J. Kuhn,
Purdue University, USA
Structure-Function Studies of Flavivirus Replication Proteins
Structure-Function Studies of Flavivirus Replication Proteins
Frank van Kuppeveld,
Utrecht University, Netherlands
Short Talk: An Enterovirus Mutant that can Replicate in the Absence of Replication Organelles
Short Talk: An Enterovirus Mutant that can Replicate in the Absence of Replication Organelles
Paul Ahlquist,
University of Wisconsin-Madison, USA
Protein, RNA and Membrane Interactions in Positive-Strand RNA virus Genome Replication
Protein, RNA and Membrane Interactions in Positive-Strand RNA virus Genome Replication
Michael S. Diamond,
Washington University School of Medicine, USA
A Genome-Wide CRISPR/Cas9 Screen Identifies Novel Host Factors Required for Flavivirus Infection
A Genome-Wide CRISPR/Cas9 Screen Identifies Novel Host Factors Required for Flavivirus Infection
Hongliang Wang,
University of Michigan, USA
Short Talk: Pulse-Chase Imaging Reveals Continuous and Rapid Turnover of Hepatitis C Virus Replication Organelles
Short Talk: Pulse-Chase Imaging Reveals Continuous and Rapid Turnover of Hepatitis C Virus Replication Organelles
17:00—19:00
Replication Enzymes and Other Factors
Both viral and cellular proteins and RNAs catalyzing the formation of RNA progeny.
*
Richard William Hardy,
Indiana University, USA
K. Andrew White,
York University, Canada
Regulation of Tombusvirus Processes by Long-range RNA-RNA Interactions
Regulation of Tombusvirus Processes by Long-range RNA-RNA Interactions
Eric J. Snijder,
Leiden University Medical Center, Netherlands
An Unprecedented Protein-Stimulated -2/-1 Ribosomal Frameshift Mechanism in Arteriviruses
An Unprecedented Protein-Stimulated -2/-1 Ribosomal Frameshift Mechanism in Arteriviruses
John T. Patton,
Indiana University, USA
How Rotaviruses Do It? RNA Synthesis in Double-Stranded RNA Viruses
How Rotaviruses Do It? RNA Synthesis in Double-Stranded RNA Viruses
Tero Ahola,
University of Helsinki, Finland
Short Talk: There is One Defined Pathway for Alphavirus RNA Replication
Short Talk: There is One Defined Pathway for Alphavirus RNA Replication
Eric Poeschla,
University of Colorado School of Medicine, USA
Short Talk: Broad Spectrum Antiviral Protection via Positive Strand RNA Virus RdRp-Mediated Stable Activation of RIG-I-Like Receptor-dependent Innate Immunity
Short Talk: Broad Spectrum Antiviral Protection via Positive Strand RNA Virus RdRp-Mediated Stable Activation of RIG-I-Like Receptor-dependent Innate Immunity
08:30—11:30
Virus Modulations of Host Pathways
Host-virus interactions.
*
Ralf Bartenschlager,
Heidelberg University, Germany
Peter D. Nagy,
University of Kentucky, USA
Tombusvirus Replicase Complex Usurps the Glycolytic Pathway for Robust Replication
Tombusvirus Replicase Complex Usurps the Glycolytic Pathway for Robust Replication
Sean P. Whelan,
Harvard Medical School, USA
VSV Polymerase Architecture and Activity Regulated by Host Cell Factors
VSV Polymerase Architecture and Activity Regulated by Host Cell Factors
William Jackson,
University of Maryland School of Medicine, USA
Short Talk: A Novel Signaling Mechanism Induces Autophagy in Poliovirus-Infected Cells
Short Talk: A Novel Signaling Mechanism Induces Autophagy in Poliovirus-Infected Cells
Karla A. Kirkegaard,
Stanford University School of Medicine, USA
Noncoding RNAs and Virus Infection
Noncoding RNAs and Virus Infection
Michael Gale, Jr.,
University of Washington, USA
Pathogen Sensing and Response in RNA Virus Infection
Pathogen Sensing and Response in RNA Virus Infection
Tristan X. Jordan,
University of Chicago, USA
Short Talk: AMPK Inhibition of mTOR Activity is Required for Dengue Virus-Induced Lipophagy
Short Talk: AMPK Inhibition of mTOR Activity is Required for Dengue Virus-Induced Lipophagy
14:30—16:30
Workshop 2: Emerging Concepts and Landscapes
*
Eva Harris,
University of California, Berkeley, USA
Craig B. Wilen,
Washington University, USA
Discovery of a Proteinaceous Cellular Receptor for a Norovirus
Discovery of a Proteinaceous Cellular Receptor for a Norovirus
Sue E. Crawford,
Baylor College of Medicine, USA
Human Noroviruses Replicate in Stem-cell Derived Human Intestinal Enteroids
Human Noroviruses Replicate in Stem-cell Derived Human Intestinal Enteroids
Jason Mackenzie,
University of Melbourne, Australia
Norovirus Translation: Control at the Stress Granule-PKR-p-elf2Alpha axis
Norovirus Translation: Control at the Stress Granule-PKR-p-elf2Alpha axis
Alexandra Schafer,
University of North Carolina at Chapel Hill, USA
The Epigenetic Landscape during MERS-CoV Infection
The Epigenetic Landscape during MERS-CoV Infection
Mohsan Saeed,
Rockefeller University, USA
Development of an Efficient Pan-Genotype Cell Culture System for Hepatitis C Virus
Development of an Efficient Pan-Genotype Cell Culture System for Hepatitis C Virus
Ann Palmenberg,
University of Wisconsin-Madison, USA
Atomic Resolution Structures of Rhinovirus C15a by Cryo-EM Show Unique Topographies and Virion Properties
Atomic Resolution Structures of Rhinovirus C15a by Cryo-EM Show Unique Topographies and Virion Properties
Jessica L. Smith,
Oregon Health and Sciences University, USA
A microRNA Screen Identifies the miR-34 Family as Potent Inhibitors of Flavivirus Infection and Reveals an Intersection Between the Wnt and Interferon Signaling Pathways
A microRNA Screen Identifies the miR-34 Family as Potent Inhibitors of Flavivirus Infection and Reveals an Intersection Between the Wnt and Interferon Signaling Pathways
Shangmei Hou,
University of Alberta, Canada
Flavivirus Infection Impairs Peroxisome Biogenesis and Early Anti-Viral Signaling
Flavivirus Infection Impairs Peroxisome Biogenesis and Early Anti-Viral Signaling
17:00—19:15
Evolution, Adaptation and Virus Fitness
Experimental and theoretical approaches to understanding mechanisms of virus evolution.
*
Craig E. Cameron,
UNC School of Medicine, USA
Claus Wilke,
University of Texas at Austin, USA
Next-Gen Virology: Use of Microfluidics and Live-Cell Imaging to Study Poliovirus Replication at the Single-Cell Level
Next-Gen Virology: Use of Microfluidics and Live-Cell Imaging to Study Poliovirus Replication at the Single-Cell Level
Paul E. Turner,
Yale University, USA
Rate of Novel Host Invasion affects Adaptability of Evolving RNA Virus Lineages
Rate of Novel Host Invasion affects Adaptability of Evolving RNA Virus Lineages
Raul Andino,
University of California, San Francisco, USA
RNA Virus Population Dynamics and the Mechanisms of Adaptation
RNA Virus Population Dynamics and the Mechanisms of Adaptation
Johan Neyts,
University of Leuven, Belgium
Towards Antivirals against Flavi-, Picorna-, Alpha- and Noroviruses
Towards Antivirals against Flavi-, Picorna-, Alpha- and Noroviruses
Mark R. Denison,
Vanderbilt University Medical Center, USA
Short Talk: Identification of Coronavirus Fidelity Determinants Following Long-Term Passage of Murine Hepatitis Virus Lacking nsp14-ExoN Mediated Fidelity
Short Talk: Identification of Coronavirus Fidelity Determinants Following Long-Term Passage of Murine Hepatitis Virus Lacking nsp14-ExoN Mediated Fidelity
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:30
Immunity and Stress Responses
Virus are under pressure to replicate and in doing so cell host detect them inducing innate immunity. Is stress involved in the process? How viruses deal with stress and innate immunity responses?
*
Michael Gale, Jr.,
University of Washington, USA
Nihal Altan-Bonnet,
NHLBI, National Institutes of Health, USA
Intercellular Transmission of Viral Populations with Vesicles
Intercellular Transmission of Viral Populations with Vesicles
Scott Benjamin Biering,
University of Chicago, USA
Short Talk: Replication Complexes of Positive-Strand RNA Viruses are Disrupted by Interferon-Gamma Inducible GTPases
Short Talk: Replication Complexes of Positive-Strand RNA Viruses are Disrupted by Interferon-Gamma Inducible GTPases
Maria-Carla Saleh,
Institut Pasteur, France
Systemic Spread of Antiviral RNAi Immunity through Extracellular Vesicles Containing Viral RNAs
Systemic Spread of Antiviral RNAi Immunity through Extracellular Vesicles Containing Viral RNAs
Eva Harris,
University of California, Berkeley, USA
Short Talk: Mechanisms of Dengue Virus NS1-Induced Endothelial Permeability and Vascular Leak
Short Talk: Mechanisms of Dengue Virus NS1-Induced Endothelial Permeability and Vascular Leak
15:00—16:30
Workshop 3: Discussion on the Emergence of ZIKA Virus and Other Flaviviruses
*
Michael S. Diamond,
Washington University School of Medicine, USA
Nicholas Barrows,
Duke University, USA
Repurposed Drug Candidates to Treat Zika Virus Infection in Pregnancy
Repurposed Drug Candidates to Treat Zika Virus Infection in Pregnancy
Bryan C. Mounce,
Institut Pasteur, France
Interferon-induced Spermidine-spermine N1-Acetyltransferase and Polyamine Depletion Restrict Chikungunya and Zika Virus Transcription and Translation
Interferon-induced Spermidine-spermine N1-Acetyltransferase and Polyamine Depletion Restrict Chikungunya and Zika Virus Transcription and Translation
Hengli Tang,
Florida State University, USA
Zika Virus Infection Leads to Cell Cycle Arrest and Stunted Growth of Human Cortical Neural Progenitors
Zika Virus Infection Leads to Cell Cycle Arrest and Stunted Growth of Human Cortical Neural Progenitors
Douglas G. Widman,
University of North Carolina at Chapel Hill, USA
A Reverse Genetics Platform to Generate Zika Virus Infectious Clones and Evaluate Viral Determinants of Pathogenesis
A Reverse Genetics Platform to Generate Zika Virus Infectious Clones and Evaluate Viral Determinants of Pathogenesis
Devika Sirohi,
Purdue University, USA
The Cryo-EM Structure of Zika Virus
The Cryo-EM Structure of Zika Virus
17:00—18:45
Therapeutic Interventions
Novel interventions targeting virus and host factors.
*
Maria-Carla Saleh,
Institut Pasteur, France
Susan C. Baker,
Loyola University Chicago, USA
Targeting Coronavirus Papain-like Proteases to Block Viral Replication and Pathogenesis
Targeting Coronavirus Papain-like Proteases to Block Viral Replication and Pathogenesis
Matthew Frieman,
University of Maryland, USA
Short Talk: Identification and Characterization of ABL Kinase Inhibitors as Potent Inhibitors of SARS-CoV and MERS-CoV Fusion
Short Talk: Identification and Characterization of ABL Kinase Inhibitors as Potent Inhibitors of SARS-CoV and MERS-CoV Fusion
Ying Kai Chan,
Harvard Medical School, USA
Short Talk: Dengue Virus NS3 Antagonizes Innate Immunity Using a Phosphomimetic-Based Mechanism
Short Talk: Dengue Virus NS3 Antagonizes Innate Immunity Using a Phosphomimetic-Based Mechanism
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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International Symposium on Positive Strand RNA Viruses |
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