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This meeting took place in 2017
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Omics Strategies to Study the Proteome (A8)
Organizer(s) Alan Saghatelian, Chuan He and Ileana M. Cristea
January 29—February 2, 2017
Beaver Run Resort • Breckenridge, CO USA
Discounted Abstract Deadline: Sep 28, 2016
Abstract Deadline: Oct 27, 2016
Scholarship Deadline: Sep 28, 2016
Discounted Registration Deadline: Nov 29, 2016
Supported by the Directors' Fund
Summary of Meeting:
Proteins are responsible for controlling the majority of the processes necessary for life, and their translation and regulation are of fundamental and biomedical interest. A variety of different -omics strategies, including innovative sequencing and proteomics approaches, have provided fundamental insights into the composition and regulation of the proteome. This Keystone Symposia meeting will bring diverse group of scientists together to discuss topics ranging from the molecular biology of protein translation to the characterization of enzymes in cell and tissue systems through the development and application of genomics and proteomics methods. Key topics of emphasis include transcriptome and epitranscriptome regulation of translation, proteogenomics and the discovery of novel proteins, quantitative proteomics, protein interactions, and activity-based proteomics.
View Scholarships/Awards
Proteins are responsible for controlling the majority of the processes necessary for life, and their translation and regulation are of fundamental and biomedical interest. A variety of different -omics strategies, including innovative sequencing and proteomics approaches, have provided fundamental insights into the composition and regulation of the proteome. This Keystone Symposia meeting will bring diverse group of scientists together to discuss topics ranging from the molecular biology of protein translation to the characterization of enzymes in cell and tissue systems through the development and application of genomics and proteomics methods. Key topics of emphasis include transcriptome and epitranscriptome regulation of translation, proteogenomics and the discovery of novel proteins, quantitative proteomics, protein interactions, and activity-based proteomics.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, January 29 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 2 with a closing plenary session and keynote address from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, February 3 in order to fully experience the meeting.
SUNDAY, JANUARY 29
MONDAY, JANUARY 30
TUESDAY, JANUARY 31
WEDNESDAY, FEBRUARY 1
THURSDAY, FEBRUARY 2
FRIDAY, FEBRUARY 3
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, January 29 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 2 with a closing plenary session and keynote address from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, February 3 in order to fully experience the meeting.
SUNDAY, JANUARY 29
08:00—09:00
Welcome and Keynote Address (Organizers)
Jonathan S. Weissman,
University of California, San Francisco, USA
Ribosome Profiling
Ribosome Profiling
09:00—11:15
Global RNA and Protein Regulation and Dynamics
*
Chuan He,
University of Chicago, USA
Xiang-Dong Fu,
University of California, San Diego, USA
Novel Mechanism for microRNAs to Target Protein Coding Sequences to Regulate Translation
Novel Mechanism for microRNAs to Target Protein Coding Sequences to Regulate Translation
Coffee Break
Frank L. Conlon,
University of North Carolina at Chapel Hill, USA
Initiating Events in Direct Cardiomyocyte Reprogramming
Initiating Events in Direct Cardiomyocyte Reprogramming
Zijun Zhang,
University of California, Los Angeles, USA
Short Talk: CLIP-Seq Analysis of Multi-Mapped Reads Identifies Novel Functional RNA Regulatory Sites in the Human Transcriptome
Short Talk: CLIP-Seq Analysis of Multi-Mapped Reads Identifies Novel Functional RNA Regulatory Sites in the Human Transcriptome
Manuel D. Leonetti,
CZ Biohub, USA
Short Talk: A Scalable, Cloning-Free Strategy for Endogenous Protein Tagging: Construction of A Genome-Wide Collection of GFP-Tagged Human Cell Lines
Short Talk: A Scalable, Cloning-Free Strategy for Endogenous Protein Tagging: Construction of A Genome-Wide Collection of GFP-Tagged Human Cell Lines
14:30—16:30
Workshop 1: Protein-Protein Interaction
*
Steven P. Gygi,
Harvard Medical School, USA
Simeon Andrews,
Weill Cornell Medicine - Qatar, USA
AVA-Seq: Rapid All-vs-All Proteome Interactions Probed with Next-Generation Sequencing
AVA-Seq: Rapid All-vs-All Proteome Interactions Probed with Next-Generation Sequencing
Tom Casimir Bamberger,
The Scripps Research Institute, USA
In vivo, Proteome-Wide Assessment of Protein Surface Accessibility as a Measure of Protein Structure and Interaction
In vivo, Proteome-Wide Assessment of Protein Surface Accessibility as a Measure of Protein Structure and Interaction
Kevin Drew,
University of Texas at Austin, USA
Human Protein Complex Map: Integration of 10k Mass Spectrometry Experiments
Human Protein Complex Map: Integration of 10k Mass Spectrometry Experiments
Ruth Huttenhain,
University of California, San Francisco, USA
A Proximity Labeling Approach to Capture Temporal and Spatially Resolved Protein Interaction Networks in Living Cells
A Proximity Labeling Approach to Capture Temporal and Spatially Resolved Protein Interaction Networks in Living Cells
Edward L. Huttlin,
Harvard Medical School, USA
BioPlex: A Global Map of the Human Interactome
BioPlex: A Global Map of the Human Interactome
Julian Mintseris,
Harvard Medical School, USA
High-Density Chemical Cross-Linking for Modeling Protein Interactions
High-Density Chemical Cross-Linking for Modeling Protein Interactions
17:00—19:00
Regulation and Functions of RNAs
*
Jonathan S. Weissman,
University of California, San Francisco, USA
Chuan He,
University of Chicago, USA
RNA Methylation in Gene Expression regulation
RNA Methylation in Gene Expression regulation
Christine Mayr,
Memorial Sloan Kettering Cancer Center, USA
3'UTR-Mediated Protein-Protein Interactions Regulate Protein Functions
3'UTR-Mediated Protein-Protein Interactions Regulate Protein Functions
Jagannath Swaminathan,
University of Texas, Austin, USA
Short Talk: Single Molecule Peptide Sequencing
Short Talk: Single Molecule Peptide Sequencing
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Omics Discovery of Novel Polypeptides
*
Alan Saghatelian,
The Salk Institute for Biological Studies, USA
Pinchas Cohen,
University of Southern California, USA
Mitochondrial ORFomics and Peptidomics
Mitochondrial ORFomics and Peptidomics
Alice Y. Ting,
Stanford University, USA
Spatially-Resolved Proteomic and Transcriptomic Mapping in Living Cells
Spatially-Resolved Proteomic and Transcriptomic Mapping in Living Cells
Coffee Break
Kate Carroll,
The Scripps Research Institute, USA
Cysteine-Mediated Redox Signaling: Chemical Tools for Biology Discovery
Cysteine-Mediated Redox Signaling: Chemical Tools for Biology Discovery
Yishai Levin,
Weizmann Institute of Science, Israel
Short Talk: Database Independent Protein Sequencing (DiPS) Enables Full-Length De-Novo Protein and Antibody Sequence Determination
Short Talk: Database Independent Protein Sequencing (DiPS) Enables Full-Length De-Novo Protein and Antibody Sequence Determination
Jennie R. Lill,
Genentech, Inc., USA
Short Talk: Defining the mutated Ligandome: Characterizing MHC Class I and Class II Peptides
Short Talk: Defining the mutated Ligandome: Characterizing MHC Class I and Class II Peptides
17:00—19:15
Quantitative Proteomics and Informatics
*
Anne-Claude Gingras,
Lunenfeld-Tanenbaum Research Institute, Canada
John R. Yates III,
The Scripps Research Institute, USA
Protein-Protein Interactions Studies of Disease Networks
Protein-Protein Interactions Studies of Disease Networks
Olga Vitek,
Northeastern University, USA
Statistical Methods for Quantitative Proteomics
Statistical Methods for Quantitative Proteomics
Olga G. Troyanskaya,
Princeton University, USA
Tissue-Specific Protein Networks for the Study of Human Disease
Tissue-Specific Protein Networks for the Study of Human Disease
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Biological and Clinical Applications of Proteomics
*
Vicki H. Wysocki,
Ohio State University, USA
Ileana M. Cristea,
Princeton University, USA
Virology Meets Proteomics: The Human Organelle Proteome in Space and Time during Viral Infection
Virology Meets Proteomics: The Human Organelle Proteome in Space and Time during Viral Infection
Michael Washburn,
Stowers Institute for Medical Research, USA
Integrated Analyses of Epigenetic Complexes and Networks
Integrated Analyses of Epigenetic Complexes and Networks
Coffee Break
David C. Muddiman,
North Carolina State University, USA
Novel Discoveries in Ovarian Cancer and ALS: From Proteome Profiling to Proteoforms
Novel Discoveries in Ovarian Cancer and ALS: From Proteome Profiling to Proteoforms
Rosa Viner,
Thermo Fisher Scientific Inc, USA
The Cellular Interactome by Proteome-Wide Cross-Linking Mass Spectrometry
The Cellular Interactome by Proteome-Wide Cross-Linking Mass Spectrometry
Marie Anne Brunet,
Université de Sherbrooke, Canada
Short Talk: Discovery of a Novel Peptide Encoded in an Alternative Open Reading Frame of FUS Gene and its Importance in ALS
Short Talk: Discovery of a Novel Peptide Encoded in an Alternative Open Reading Frame of FUS Gene and its Importance in ALS
Gary Wilson,
University of Wisconsin-Madison, USA
Short Talk: Improved Plasma Proteomics Enables the Investigation into Alzheimer's Disease Progression
Short Talk: Improved Plasma Proteomics Enables the Investigation into Alzheimer's Disease Progression
14:30—16:30
Workshop 2: Novel Omics Strategy
*
Alan Saghatelian,
The Salk Institute for Biological Studies, USA
Christian H. Ahrens,
Agroscope, Switzerland
A Generic, Integrative Proteogenomics Approach to Identify the Entire Protein Coding Potential of Prokaryotic Genomes
A Generic, Integrative Proteogenomics Approach to Identify the Entire Protein Coding Potential of Prokaryotic Genomes
Christopher M. Rose,
Genentech, Inc., USA
Real-Time Data Analysis Strategies for Targeted and Discovery Proteomics
Real-Time Data Analysis Strategies for Targeted and Discovery Proteomics
Mark D. Biggin,
Lawrence Berkeley National Laboratory, USA
Quantitating Translational Control: mRNA Abundance-Dependent and Independent Contributions
Quantitating Translational Control: mRNA Abundance-Dependent and Independent Contributions
Brian K. Erickson,
Harvard Medical School, USA
High-Throughput Targeted Proteomics: Combining Sample and Peptide Multiplexing for Drug Discovery and Biomarker Validation
High-Throughput Targeted Proteomics: Combining Sample and Peptide Multiplexing for Drug Discovery and Biomarker Validation
Paul A. Grimsrud,
Duke University Medical Center, USA
Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation
Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation
17:00—19:00
Protein Interactions and Structure
*
Joshua J. Coon,
University of Wisconsin, USA
Thomas Kodadek,
The Scripps Research Institute, USA
Surveying the Immunoproteome Using DNA-Encoded Combinatorial Libraries
Surveying the Immunoproteome Using DNA-Encoded Combinatorial Libraries
Vicki H. Wysocki,
Ohio State University, USA
Development of Native MS: Surface-Induced Dissociation as a Structural Biology Tool
Development of Native MS: Surface-Induced Dissociation as a Structural Biology Tool
Nadia Martinez-Martin,
Genentech, Inc., USA
Short Talk: Decoding Extracellular Protein-Protein Interactions using Genome-Wide Libraries and Complementary Receptor Discovery Platforms
Short Talk: Decoding Extracellular Protein-Protein Interactions using Genome-Wide Libraries and Complementary Receptor Discovery Platforms
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Functional Proteomics
*
Ileana M. Cristea,
Princeton University, USA
Alan Saghatelian,
The Salk Institute for Biological Studies, USA
Cell Biology of sORF Polypeptides
Cell Biology of sORF Polypeptides
Steven P. Gygi,
Harvard Medical School, USA
A Powerful Mouse Model Illuminates the Consequences of Genetic Variation on a Proteome-Wide Scale
A Powerful Mouse Model Illuminates the Consequences of Genetic Variation on a Proteome-Wide Scale
Coffee Break
Christopher G. Parker,
The Scripps Research Institute, USA
Short Talk: Ligand and Target Discovery by Fragment-Based Screening in Human Cells
Short Talk: Ligand and Target Discovery by Fragment-Based Screening in Human Cells
Elyse Freiberger,
University of Wisconsin-Madison, USA
Short Talk: Deep Proteome Analysis of Murine Islets
Short Talk: Deep Proteome Analysis of Murine Islets
17:00—18:15
Emerging Strategies in Proteomics
*
John R. Yates III,
The Scripps Research Institute, USA
James A. Wells,
University of California, San Francisco, USA
Discovering and Modulating How Cell Surfaces Remodel with RAS Transformation
Discovering and Modulating How Cell Surfaces Remodel with RAS Transformation
18:15—19:00
Keynote Address
*
Alan Saghatelian,
The Salk Institute for Biological Studies, USA
Brenda J. Andrews,
University of Toronto, Canada
Yeast Proteome Dynamics and Subcellular Morphology from Single Cell Imaging and Automated Analysis
Yeast Proteome Dynamics and Subcellular Morphology from Single Cell Imaging and Automated Analysis
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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