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This meeting took place in 2017
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Autophagy Network Integration in Health and Disease (B2)
Organizer(s) Ivan Dikic, Katja Simon and J. Wade Harper
February 12—16, 2017
Copper Mountain Resort • Copper Mountain, Colorado USA
Discounted Abstract Deadline: Oct 11, 2016
Abstract Deadline: Nov 15, 2016
Scholarship Deadline: Oct 11, 2016
Discounted Registration Deadline: Dec 23, 2016
Sponsored by Cell Research, Novartis Institutes for BioMedical Research and Shire Human Genetic Therapies
Summary of Meeting:
Autophagy is a quality control mechanism that plays an important role in health and disease, including neurodegeneration, cancer, infection and inflammation. The core autophagy machinery has been identified and studied in detail. In addition, integration and cross-talk with other cellular pathways is becoming clearer, providing a rationale for why autophagy is linked to so many diverse physiological functions. Future challenges are focused on integrative structural, molecular and system approaches that are able to provide a much more refined understanding of autophagy regulatory networks. This meeting will highlight basic molecular and network insights in the autophagy system that are critical in life processes and multiple disease areas, and will examine the prospects for therapeutic targeting of the autophagy system. The meeting will bring together a variety of investigators exploring different facets of autophagy, and their interactions will expand our knowledge of fundamental autophagic mechanisms in different physiological and pathological settings.
View Scholarships/Awards
Autophagy is a quality control mechanism that plays an important role in health and disease, including neurodegeneration, cancer, infection and inflammation. The core autophagy machinery has been identified and studied in detail. In addition, integration and cross-talk with other cellular pathways is becoming clearer, providing a rationale for why autophagy is linked to so many diverse physiological functions. Future challenges are focused on integrative structural, molecular and system approaches that are able to provide a much more refined understanding of autophagy regulatory networks. This meeting will highlight basic molecular and network insights in the autophagy system that are critical in life processes and multiple disease areas, and will examine the prospects for therapeutic targeting of the autophagy system. The meeting will bring together a variety of investigators exploring different facets of autophagy, and their interactions will expand our knowledge of fundamental autophagic mechanisms in different physiological and pathological settings.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, February 12 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 16 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 17 in order to fully experience the meeting.
SUNDAY, FEBRUARY 12
MONDAY, FEBRUARY 13
TUESDAY, FEBRUARY 14
WEDNESDAY, FEBRUARY 15
THURSDAY, FEBRUARY 16
FRIDAY, FEBRUARY 17
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, February 12 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 16 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 17 in order to fully experience the meeting.
SUNDAY, FEBRUARY 12
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
*
Ivan Dikic,
Goethe University Medical School, Germany
*
Katja Simon,
University of Oxford, UK
Herbert (Skip) W. Virgin,
Vir Biotechnology, USA
Autophagy Genes in Inflammation, Infection and Immunity
Autophagy Genes in Inflammation, Infection and Immunity
09:00—12:00
Autophagy Systems
*
Ivan Dikic,
Goethe University Medical School, Germany
*
Katja Simon,
University of Oxford, UK
J. Wade Harper,
Harvard Medical School, USA
Digitizing Ubiquitin Signaling for Mitophagy
Digitizing Ubiquitin Signaling for Mitophagy
Coffee Break
Sharon A. Tooze,
Francis Crick Institute, UK
Distinct Roles of the Centrosomal Pool of GABARAP in Autophagy
Distinct Roles of the Centrosomal Pool of GABARAP in Autophagy
Li Yu,
Tsinghua University, China
Regulation and Function of Energy Deprivation Induced Autophagy
Regulation and Function of Energy Deprivation Induced Autophagy
Liang Ge,
Tsinghua University, China
Mechanism of Autophagic Membrane Generation from the Endomembrane
Mechanism of Autophagic Membrane Generation from the Endomembrane
Kiren Baines,
University of Bristol, UK
Short Talk: The ATG5-ATG12 Conjugate Regulates Clathrin-Mediated Endocytosis to Control the Internalisation of Specific Cell Surface Proteins
Short Talk: The ATG5-ATG12 Conjugate Regulates Clathrin-Mediated Endocytosis to Control the Internalisation of Specific Cell Surface Proteins
14:30—16:30
Workshop 1: Autophagy Networks in Biology
*
Vladimir Denic,
Harvard University, USA
*
Erika L. F. Holzbaur,
University of Pennsylvania, USA
Michael J. Morgan,
University of Colorado Denver, USA
Selection for Metastasis Leads to Increased Sensitivity to Lysosomal Inhibitors
Selection for Metastasis Leads to Increased Sensitivity to Lysosomal Inhibitors
David P. Waterman,
Brandeis University, USA
Autophagy in Response to DNA Damage
Autophagy in Response to DNA Damage
Lisa M. Lindqvist,
Walter and Eliza Hall Institute of Medical Research, Australia
Autophagy Induced During the Early Stages of Mitochondrial-Mediated Apoptosis Helps to Keep Apoptotic Cells Immunologically Silent
Autophagy Induced During the Early Stages of Mitochondrial-Mediated Apoptosis Helps to Keep Apoptotic Cells Immunologically Silent
Thomas Riffelmacher,
Kennedy Institute, University of Oxford, UK
Autophagy in the Control of Granulocytic Differentiation
Autophagy in the Control of Granulocytic Differentiation
Song-Fa Zhang,
Zhejiang University, China
Autophagy Maintains Ovarian Cancer Stem Cells Characteristics by Regulating FOXA2 expression
Autophagy Maintains Ovarian Cancer Stem Cells Characteristics by Regulating FOXA2 expression
Chieko Kishi-Itakura,
University of Cambridge, UK
Ultrastructural Insights into Pathogen Clearance by Autophagy
Ultrastructural Insights into Pathogen Clearance by Autophagy
Anuradha Bhukel,
Freie University of Berlin, Germany
Reduced Autophagy Mediates Memory Impairment in a Cell Non-Autonomous Manner in Drosophila
Reduced Autophagy Mediates Memory Impairment in a Cell Non-Autonomous Manner in Drosophila
17:00—19:00
Structural and Molecular Anatomy of Autophagy Pathway
*
Eric H. Baehrecke,
University of Massachusetts Medical School, USA
*
Michel Desjardins,
University of Montreal, Canada
Vladimir Denic,
Harvard University, USA
A Membrane-Associated Autophagy Signaling Pathway for Controlling Peroxisome Fate
A Membrane-Associated Autophagy Signaling Pathway for Controlling Peroxisome Fate
James H. Hurley,
University of California, Berkeley, USA
Regulation and Scaffolding of Autophagy Initiation
Regulation and Scaffolding of Autophagy Initiation
Zvulun Elazar,
Weizmann Institute of Science, Israel
The Role of Autophagy in the Regulation of the TNF Receptor, FN14
The Role of Autophagy in the Regulation of the TNF Receptor, FN14
Simon Wilkinson,
MRC Institute of Genetics and Molecular Medicine, UK
Short Talk: Pancreatic Enzyme Biosynthesis is Quality Controlled by an ER-resident LC3- and FIP200-binding scaffold protein
Short Talk: Pancreatic Enzyme Biosynthesis is Quality Controlled by an ER-resident LC3- and FIP200-binding scaffold protein
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Conventional and Unconventional Autophagy Networks
*
Felix Randow,
Medical Research Council, UK
*
Michel Desjardins,
University of Montreal, Canada
Noboru Mizushima,
University of Tokyo, Japan
Novel Methods for Monitoring Autophagosome Maturation and Autophagic Flux
Novel Methods for Monitoring Autophagosome Maturation and Autophagic Flux
Coffee Break
Christian Behrends,
Ludwig Maximilians University München, Germany
Regulatory Circuits in Autophagy: Exploring the Function of SMCR8
Regulatory Circuits in Autophagy: Exploring the Function of SMCR8
Aditya Murthy,
Genentech, Inc., USA
Regulation of Endosomal Toll-Like Receptor Signaling by Autophagy
Regulation of Endosomal Toll-Like Receptor Signaling by Autophagy
Paula Coelho,
McGill University, Canada
Short Talk: Decreased LC3C Expression in Cancers Uncouples Met RTK from Autophagic Regulation
Short Talk: Decreased LC3C Expression in Cancers Uncouples Met RTK from Autophagic Regulation
17:00—19:00
Autophagy Crosstalk with Other Pathways
*
Patricia Boya,
Centro de Investigaciones Biológicas, CSIC, Spain
*
David C. Rubinsztein,
Cambridge Institute for Medical Research, UK
Malene Hansen,
Sanford Burnham Prebys Medical Discovery Institute, USA
Cellular Recycling: Role of Autophagy in Aging and Disease
Cellular Recycling: Role of Autophagy in Aging and Disease
Eric H. Baehrecke,
University of Massachusetts Medical School, USA
Vps13D Encodes a Ubiquitin Binding Protein that is Required for Mitochondrial Dynamics and Parkin-Dependent Mitophagy
Vps13D Encodes a Ubiquitin Binding Protein that is Required for Mitochondrial Dynamics and Parkin-Dependent Mitophagy
Marja Jäättelä,
Danish Cancer Society Research Center, Denmark
Lysosomal Control of Chromosome Segregation
Lysosomal Control of Chromosome Segregation
Catherine Greene,
University of Calgary, Canada
Short Talk: Novel Late Stage Phagolysosomal Events are Modulated by Key Autophagic Machinery
Short Talk: Novel Late Stage Phagolysosomal Events are Modulated by Key Autophagic Machinery
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Selective Autophagy
*
Zvulun Elazar,
Weizmann Institute of Science, Israel
*
Marja Jäättelä,
Danish Cancer Society Research Center, Denmark
Felix Randow,
Medical Research Council, UK
How Autophagy Defends the Cytosol Against Bacterial Invasion
How Autophagy Defends the Cytosol Against Bacterial Invasion
Coffee Break
Ivan Dikic,
Goethe University Medical School, Germany
Conventional and Non-conventional Ubiquitination in Antibacterial Autophagy
Conventional and Non-conventional Ubiquitination in Antibacterial Autophagy
Trey Ideker,
University of California, San Diego, USA
Active Interaction Mapping Reveals the Hierarchical Organization of Autophagy
Active Interaction Mapping Reveals the Hierarchical Organization of Autophagy
Anja Barbara Hoffmann,
Ruprecht Karls Universität Heidelberg, Germany
Short Talk: The Autophagic Pathway in Uukuniemi Virus Infection
Short Talk: The Autophagic Pathway in Uukuniemi Virus Infection
14:30—16:30
Workshop 2: Technology Talks
*
Trey Ideker,
University of California, San Diego, USA
Erik Verschueren,
Genentech, Inc., USA
Discovery of Specific Autophagy Signaling Adaptors through Quantitative Multiplexed Proteomics
Discovery of Specific Autophagy Signaling Adaptors through Quantitative Multiplexed Proteomics
Vinay Verghese Eapen,
Harvard Medical School, USA
Defining the Role of Selective Autophagy Receptor-Cargo Interactions in Pancreatic Cancer Pathogenesis
Defining the Role of Selective Autophagy Receptor-Cargo Interactions in Pancreatic Cancer Pathogenesis
Ben Loos,
Stellenbosch University, South Africa
Mapping out the Autophagy Machinery - A Super-Resolution Approach
Mapping out the Autophagy Machinery - A Super-Resolution Approach
Alexandra Stolz,
Goethe University Medical School, Germany
Fluorescence-Based ATG8 Sensors Monitor Localization and Function of LC3/GABARAP Proteins
Fluorescence-Based ATG8 Sensors Monitor Localization and Function of LC3/GABARAP Proteins
Andreas Jenny,
Albert Einstein College of Medicine, USA
A Genetic Model for Selective Endosomal Microautophagy in Drosophila
A Genetic Model for Selective Endosomal Microautophagy in Drosophila
Mariam Aghajan,
Ionis Pharmaceuticals, USA
ASO-Mediated Inhibition of Autophagy Protects Against Acetaminophen-Induced Liver Injury
ASO-Mediated Inhibition of Autophagy Protects Against Acetaminophen-Induced Liver Injury
Piyush Mishra,
Jawaharlal Nehru Centre for Advanced Scientific Research, India
Discovery of Pan Autophagy Inhibitors through a High Throughput Screen Highlights Macroautophagy as an Evolutionarily Conserved Process Across Three Kingdoms
Discovery of Pan Autophagy Inhibitors through a High Throughput Screen Highlights Macroautophagy as an Evolutionarily Conserved Process Across Three Kingdoms
17:00—19:00
Autophagy in Neurons
*
Christian Behrends,
Ludwig Maximilians University München, Germany
Richard J. Youle,
NINDS, National Institutes of Health, USA
Molecular Basis of Parkinson's Disease
Molecular Basis of Parkinson's Disease
Patricia Boya,
Centro de Investigaciones Biológicas, CSIC, Spain
Mitophagy in Neurons: From Development to Degeneration
Mitophagy in Neurons: From Development to Degeneration
Erika L. F. Holzbaur,
University of Pennsylvania, USA
Autophagy in Neuronal Homeostasis and Neurodegeneration
Autophagy in Neuronal Homeostasis and Neurodegeneration
Nicholas F. Endres,
Genentech, Inc., USA
Short Talk: A Reversible Covalent Inhibitor of the Deubiquitinase USP30 Enhances Parkin Mediated Mitophagy
Short Talk: A Reversible Covalent Inhibitor of the Deubiquitinase USP30 Enhances Parkin Mediated Mitophagy
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Metabolism, Oncogenesis and Stem Cells
*
Patrice Codogno,
INSERM, France
*
Noboru Mizushima,
University of Tokyo, Japan
Eileen P. White,
Rutgers University, USA
Autophagy-mediated Recycling Sustains Survival of Cancer Cells
Autophagy-mediated Recycling Sustains Survival of Cancer Cells
Katja Simon,
University of Oxford, UK
Autophagy Determines Immune Metabolism
Autophagy Determines Immune Metabolism
Coffee Break
Alison Simmons,
Weatherall Institute of Molecular Medicine, UK
Innate Immunity and Autophagy in Rare Intestinal Cell Subsets
Innate Immunity and Autophagy in Rare Intestinal Cell Subsets
Martin Graef,
Max Planck Institute for Biology of Aging, Germany
Short Talk: Autophagosomal acyl-CoA Synthetases Activate Free Fatty Acids Essential for Autophagy
Short Talk: Autophagosomal acyl-CoA Synthetases Activate Free Fatty Acids Essential for Autophagy
17:00—18:45
Targeting Autophagy Networks
*
Sharon A. Tooze,
Francis Crick Institute, UK
Michel Desjardins,
University of Montreal, Canada
PINK1/Parkin are Key Regulators of Autophagy, Antigen Presentation and Autoimmune Diseases
PINK1/Parkin are Key Regulators of Autophagy, Antigen Presentation and Autoimmune Diseases
David C. Rubinsztein,
Cambridge Institute for Medical Research, UK
The Parkinson’s Disease-Associated Genes ATP13A2 and SYT11 Regulate Autophagy via a Common Pathway
The Parkinson’s Disease-Associated Genes ATP13A2 and SYT11 Regulate Autophagy via a Common Pathway
Johara Chouitar,
Takeda Boston, USA
Targeting Autophagy for Cancer Therapy
Targeting Autophagy for Cancer Therapy
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions
*
J. Wade Harper,
Harvard Medical School, USA
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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