Keystone Symposia

Tivoli Hotel and Congress Center Floorplan

This meeting took place in 2017



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Neuronal Control of Appetite, Metabolism and Weight (Z5)


Organizer(s) Lora K. Heisler and Scott M. Sternson
May 9—13, 2017
Tivoli Hotel and Congress Center • Copenhagen, Denmark
Discounted Abstract Deadline: Jan 12, 2017
Abstract Deadline: Feb 9, 2017
Scholarship Deadline: Jan 12, 2017
Discounted Registration Deadline: Mar 9, 2017

Lead Sponsor: Novo Nordisk A/S. Sponsored by Arena Pharmaceuticals, Inc.


Summary of Meeting:
Obesity, a condition that is becoming a leading cause of human morbidity and mortality, is among the global healthcare challenges of the 21st century. Obesity is primarily a result of the cumulative effect of increased food intake beyond the body’s energetic requirements over time. Emerging research reveals critical integrative neuronal systems that control both energy and glucose homeostasis, which have encouraging implications for the future treatment of obesity. This symposium will fuse existing knowledge with the latest discoveries in the neural circuits underpinning nutrient sensation, satiety, food reward, developmental programming and glucoregulatory function. Furthermore, recent findings will be presented on the peripheral regulation of these neural circuits by gut and adipocyte-derived signals. The application of cutting-edge neuroscience approaches and the clinical relevance of basic science discoveries to obesity research will also be highlighted. Recent advances in emerging treatment options will be discussed, including surgical interventions and next-generation pharmacotherapies. In combination with a joint symposium on the” Gastrointestinal Control of Metabolism,” this exciting program will bring together breaking research from both basic science and translational realms on the etiology and treatment of obesity and type 2 diabetes.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Tuesday, May 9 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, May 13 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Sunday, May 14 in order to fully experience the meeting.

TUESDAY, MAY 9

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Brasserie 3

WEDNESDAY, MAY 10

07:30—08:30
Breakfast

Individual Hotel
08:30—10:00
Welcome and Keynote Session (Joint)

Tivoli Congress Hall
* Lora K. Heisler, Rowett Institute, University of Aberdeen, UK
Session Chair

* Randy J. Seeley, University of Michigan, USA
Session Chair

Stephen O'Rahilly, University of Cambridge, UK
Metabolic Disease: Lessons from Natural Human Variation

Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
The Intestinal Stem Cell Niche – At the Base of It All

Coffee Break

10:20—11:45
Nutrient Sensing and Gut Signaling (Joint)

Tivoli Congress Hall
* Andrew Butler, St. Louis University, USA
Session Chair

* Fiona M. Gribble, University of Cambridge, UK
Session Chair

Ronald M. Evans, The Salk Institute for Biological Studies, USA
Gut Feelings: Systemic Reach of Intestinal FXR

Kristina Schoonjans, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
Bile Acid Signaling in Metabolic Disease

Joshua Thaler, University of Washington, USA
Short Talk: Prevention of Microglial Inflammatory Signaling Reduces Susceptibility to Diet-Induced Obesity

11:45—14:30
On Own for Lunch

11:45—13:00
Poster Setup

Vandsalen
13:00—22:00
Poster Viewing

Vandsalen
14:30—16:30
Workshop 1: Disorders and Diseases Associated with Weight Loss
Anorexia nervosa, binge eating disorder, PTSD, cancer cachexia and others

Carstensen
* Thomas Alexander Lutz, University of Zürich, Switzerland
Session Chair

* Petra Kotzbeck, Medical University of Graz, Austria
Session Chair

Yong Xu, Baylor College of Medicine, USA
5-HT Neurons and Eating Disorders

Manon Duquenne, INSERM Université Lille 2, France
A Role for Tanycyte Exocytosis in the Central Control of Energy Homeostasis?

Christian Stockmann, University of Zurich, Switzerland
The Role of Vascular Endothelial Growth Factor-A in the Context of Cancer Cachexia and Chemotherapy

Kevin G. Murphy, Imperial College London, UK
Investigating Disorders Associated with Weight Loss

Serge Luquet, Université Paris Diderot, France
Palatability Can Drive Feeding Independent of AgRP Neurons

Christin Kosse, Francis Crick Institute, UK
Functional Properties of GAD65 Neurons in the Lateral Hypothalamus

Yunlei Yang, SUNY Upstate Medical University, USA
Deciphering Anorexigenic Septohypothalamic Feeding Circuits

14:30—16:30
Workshop 1

Ballonsalen/Blomstersalen
* Timo D. Müller, Institute for Diabetes and Obesity, Germany
Session Chair

Anne-Charlotte Jarry, Paris Diderot University, France
Neuromedin U Blocks Gastric Emptying through Vagal-Dependent Mechanisms and Improves Oral Glucose Tolerance

Geke Aline Boer, University of Copenhagen, Biomedical Institute, Denmark
Acute Reduction of GIP: Effects on Lipid and Bone Metabolism

Emily C. Bruggeman, University of Texas Southwestern Medical Center, USA
Ghrelin Receptor Deletion Increases Morbidity and Mortality in a Prader-Willi Syndrome Mouse Model

Natalia Petersen, University of Copenhagen, Denmark
"Tailoring" the Intestinal Epithelium for Type 2 Diabetes Treatment: Modulation of L-Cell Differentiation

Hai-Bin Ruan, University of Minnesota, USA
Diet- and Microbiota-Sensitive Intestinal O-GlcNAc Signaling Controls Enteroendocrine Cell Development and Function

Sara Lind Jepsen, University of Copenhagen, Denmark
Somatostatin Regulates GLP-1 Secretion through the Somatostatin Receptor Subtype 2

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Interactions between Ingestive Signals and Reward Circuits

Carstensen
* Matt Carter, Williams College, USA
Session Chair

* Agatha A. van der Klaauw, University of Cambridge, UK
Session Chair

Michael A. Cowley, Monash University, Australia
Leptin Receptor Expressing Neurons of the Dorsomedial Hypothalamus Play a Limited Role in Regulating Food Intake but a Critical Role in Regulating Metabolism

Suzanne Lee Dickson, Sahlgrenska Academy, Gothenburg University, Sweden
Brain Ghrelin Signaling and Food Reward Behavior

Christian Lüscher, University of Geneva, Switzerland
Feeding Circuits that Can Override Metabolic Needs

Claire J. Foldi, Monash University, Australia
Short Talk: CNS Reward Pathways in Anorexia Nervosa: Insights from a Rat Model

17:00—19:00
Gut Bacteria as Cause and Treatment of Metabolic Diseases
Gut bacteria as cause and treatment of metabolic diseases.

Ballonsalen/Blomstersalen
* Gilles Mithieux, INSERM, France
Session Chair

Fredrik Bäckhed, University of Gothenburg, Sweden
Microbial Signaling from the Gut and Resulting Effects on Host Metabolism

Martin J. Blaser, New York University School of Medicine, USA
Effects of the Early Life Microbiota on the Development of Metabolic Illnesses

Karine Clément, INSERM / Sorbonne Universite, France
Microbiome as Therapy

Edna A. Trujillo, University of Wisconsin-Madison, USA
Short Talk: Metabolite Profiling of Plasma and Cecum Elucidates the Impacts of Host Genetics and Environment on the Gut Microbiota

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Vandsalen
19:30—22:00
Poster Session 1

Vandsalen

THURSDAY, MAY 11

07:30—08:30
Breakfast

Individual Hotel
08:30—11:45
Emerging Energy Homeostasis Neurocircuitry

Tivoli Congress Hall
* Qingchun Tong, University of Texas Medical School, USA
Session Chair

* Matthew R. Hayes, University of Pennsylvania, USA

Sabrina Diano, Columbia University, USA
Mitochondrial Control of the Melanocortin System

Martin G. Myers, Jr., University of Michigan, USA
LepRb Signaling and the Regulation of Transcription

Coffee Break

Joseph T. Bass, Northwestern University, USA
Identification of an SCN-AgRP Circadian Neurocircuit Regulating Obesity and Systemic Metabolism

Lori M. Zeltser, Columbia University, USA
Gene X Environment Interactions that Promote Anorexia-Like Behavior

Ali Guler, University of Virginia, USA
Short Talk: Dopamine Signaling in the SCN Regulates Circadian Consumption of High-Fat Diet

Mathias Treier, Max-Delbrueck-Center for Molecular Medicine, Germany
Short Talk: Identification of the Hypothalamic Circuit Maintaining Food Foraging

08:30—11:45
Stem Cells, Gut-Pancreas Development I

Ballonsalen/Blomstersalen
* Praveen Sethupathy, Cornell University, USA
Session Chair

Fiona M. Gribble, University of Cambridge, UK
The Biology of Enteroendocrine Cells

Heiko Lickert, Institute of Diabetes and Regeneration, Germany
Dissecting Intestinal Stem Cell Lineage Decisions

Coffee Break

James M. Wells, Cincinnati Children's Hospital Research Foundation, USA
Human Pluripotent Stem Cell-Derived Gastrointestinal Organoids as New Models to Study Metabolic and Digestive Diseases

Lori Sussel, University of Colorado Anschutz Medical Campus, USA
Loss of Beta Cell Identity Related to Diabetes

John Furness, University of Melbourne, Australia
Short Talk: Diversity of Enteroendocrine Cells between Species and Regions Studied at a Cellular and Subcellular Level

Sandra Guilmeau, INSERM U1016 Institut Cochin, CNRS UMR 8104, France
Short Talk: Contribution of ChREBP in Intestinal GLP-1 Production

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Vandsalen
13:00—22:00
Poster Viewing

Vandsalen
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Signaling from Periphery to Brain to Modulate Energy Balance (Joint)

Tivoli Congress Hall
* Suzanne M. Appleyard, Washington State University, USA
Session Chair

* David Olson, University of Michigan, USA
Session Chair

Jeffrey M. Friedman, Rockefeller University, USA
Neural Control of Food Intake, Locomotion and Glucose Metabolism

Randy J. Seeley, University of Michigan, USA
How the Gut Regulates Metabolic Status

Ivan E. de Araujo, Icahn School of Medicine at Mount Sinai, USA
What Does Sugar Do to the Brain? Circuit Logic for Sugar Sensing

Celine E. Riera, Cedars Sinai Medical Center, USA
Short Talk: The Sense of Smell Impacts Metabolic Health and Obesity

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Tivoli Congress Hall
19:30—22:00
Poster Session 2

Vandsalen

FRIDAY, MAY 12

07:30—08:30
Breakfast

Individual Hotel
08:30—11:45
Hypothalamic Signals Modulating Hunger and Complex Behavior

Tivoli Congress Hall
* Clemence Blouet, University of Cambridge, UK
Session Chair

* J. Nicholas Betley, University of Pennsylvania, USA
Session Chair

Scott M. Sternson, HHMI/University of California, San Diego, USA
Motivational Mechanisms Controlling Hunger

Garret D. Stuber, University of North Carolina at Chapel Hill School of Medicine, USA
Lateral Hypothalamic Circuits for Feeding and Reward

Coffee Break

Tamas L. Horvath, Yale School of Medicine, USA
Appetite Circuits in the Regulation of Complex Behavior

Roger D. Cone, University of Michigan, USA
Melanocortins: From Pharmacology to Pharmacotherapy

Tatiana Korotkova, Max Planck Institute for Metabolism Research, Germany
Short Talk: Gamma Oscillations Organize Top-Down Signaling to Hypothalamus and Enable Food-Seeking

Marcelo O. Dietrich, Yale University, USA
Short Talk: Behavioral Ontogeny of Hypothalamic Neurons

08:30—11:30
Controversies in Obesity/Diabetes Treatment: Surgery vs. Devices vs. Medicines - What Does the Future Hold?

Ballonsalen/Blomstersalen
* Ruth E. Gimeno, Eli Lilly and Company, USA
Session Chair

Jens Juul Holst, University of Copenhagen the Panum Institute, Denmark
The Role of the Gut in the Development of Type 2 Diabetes

Tricia M. Tan, Imperial College London, UK
Triple Gut Hormones as Therapy

Coffee Break

David E. Cummings, University of Washington, USA
Metabolic Surgery: Mechanisms and Use of “Bariatric” Operations to Treat Type 2 Diabetes

Niels Vrang, Gubra, Denmark
Short Talk: The Effect of FXR, PPAR-α/δ and GLP-1 Agonism on Liver Disease in Diet-Induced Obese and Biopsy-Confirmed Mouse Models of NASH

Wendy M. McKimpson, Columbia University, USA
Short Talk: Foxo1-Expressing Cells in the Gut as a Source of Insulin for Diabetes Treatment

Makoto Fukuda, Baylor College of Medicine, USA
Short Talk: Gut Hormone GIP Drives Hypothalamic Pathogenesis of Obesity

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Vandsalen
13:00—22:00
Poster Viewing

Vandsalen
14:30—16:30
Workshop 2

Ballonsalen/Blomstersalen
* Lene Jessen, Zealand Pharma, Denmark
Session Chair

Maria H. Hauge, Copenhagen University, Denmark
Gq and Gs Signaling Acting in Synergy to Control GLP-1 Secretion

Youngjung Kim, Icahn School of Medicine at Mount Sinai, USA
Pyruvate Kinase as a Novel Metabolic Regulator of Beta Cell Loss in Diabetes

Alyce M. Martin, Flinders University, Australia
Gut Serotonin Is a Signaling Nexus between the Gut Microbiome and Host Metabolism

Louise Olofsson, University of Gothenburg, Sweden
Role of the Gut Microbiota in Diet-Induced Hypothalamic Inflammation

Anette Christ, University of Massachusetts Medical School, USA
Long-Term Epigenetic Re-Programming of Myeloid Precursor Cells in a Hyperlipidemic Environment

Nadja Gebert, Leibniz Institute on Aging, Germany
Age and Diet Affect the Intestinal Crypt Proteome

Jonathan D. Douros, Duke University, USA
Increased Glucose-Dependent Insulinotropic Polypeptide (GIP) Secretion and Signaling Improves Beta-Cell Function following Vertical Sleeve Gastrectomy (VSG)

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Cutting-Edge Approaches in Obesity Research

Tivoli Congress Hall
* Jeffrey M. Zigman, University of Texas Southwestern Medical Center, USA
Session Chair

* Daniela Cota, Neurocentre Magendie, France
Session Chair

Stephen Liberles, Harvard Medical School, USA
Molecular and Genetic Analysis of the Vagus Nerve

Andres Lozano, University of Toronto, Toronto Western Hospital, Canada
Deep Brain Stimulation to Treat Obesity or Anorexia

Kevin L. Grove, Novo Nordisk, USA
Obesity-Related Genes in the Rhesus Macaque

John N. Campbell, University of Virginia, USA
Short Talk: A Molecular Census of Arcuate Hypothalamus and Median Eminence Cell Types

17:00—19:00
Stem Cells, Gut-Pancreas Development II

Ballonsalen/Blomstersalen
* Lori Sussel, University of Colorado Anschutz Medical Campus, USA
Session Chair

Andrew B. Leiter, University of Massachusetts Medical School, USA
Differentiation of Enteroendocrine Cells

Praveen Sethupathy, Cornell University, USA
Microbiota, MicroRNAs, and Intestinal Stem Cell Function

Susumu Seino, Kobe University Graduate School of Medicine, Japan
Beta-Cell Glutamate Signaling Is Critical for Incretin-Induced Insulin Secretion

William L. Holland, University of Texas Southwestern Medical Center, USA
Short Talk: Glucagon Receptor Inhibition Restores Functional Beta Cell Mass and Reverses Hyperglycemia in Type-1 Diabetic Mice

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Tivoli Congress Hall
19:30—22:00
Poster Session 3

Vandsalen

SATURDAY, MAY 13

07:30—08:30
Breakfast

Individual Hotel
08:00—08:30
Poster Setup

Vandsalen
08:30—17:00
Poster Viewing

Vandsalen
08:30—11:45
Pharmacotherapies for Obesity and Type 2 Diabetes (Joint)

Tivoli Congress Hall
* Malcolm J. Low, University of Michigan, USA
Session Chair

* Roger A. Adan, Brain Center Rudolf Magnus, Netherlands
Session Chair

Daniel J. Drucker, Lunenfeld-Tanenbaum Research Institute, Canada
The Control of Gut Hormone Activity: Role of Dipeptidyl Peptidase-4

Matthias H. Tschöp, Helmholtz Munich, Germany
Gut Peptide Combination Therapy to Treat Obesity

Coffee Break

Lora K. Heisler, Rowett Institute, University of Aberdeen, UK
Modifying CNS 5-HT Circuits to Reverse Obesity and Type 2 Diabetes

Ruth E. Gimeno, Eli Lilly and Company, USA
Current and Emerging Targets for Obesity Treatment

Tamer Coskun, Eli Lilly & Company, USA
Short Talk: Confirming Efficacy of Celastrol and Withaferin A in a Diet-Induced Obese (DIO) Mouse Model

Shamina M. Rangwala, Pfizer, USA
Short Talk: Gdf15-Mediated Mechanisms of Food Intake Reduction and Weight Loss

11:45—12:30
Lunch

Tivoli Congress Hall
12:00—14:30
Poster Session 4

Vandsalen
14:30—16:30
Workshop 2: CNS Regulation of Adipose Tissue
CNS regulation of white and brown fat and browning of white fat

Tivoli Congress Hall
* Kate Ellacott, University of Exeter Medical School, UK
Session Chair

* Mads Tang-Christensen, Novo Nordisk A/S, Denmark
Session Chair

Justin J. Rochford, University of Aberdeen, UK
Inhibition of Gamma Synuclein Directly Alters Adipocyte Mitochondrial Function and Lipid Metabolism

Barbara Cannon, Stockholm University, Sweden
Peripheral and Central Regulation of UCP1-Dependent Thermogenesis

Miguel López, Universidad de Santiago de Compostela, Spain
Hypothalamic AMPK: A Canonical Regulator of Energy Balance

Sangho Yu, Pennington Biomedical Research Center, USA
Preoptic Leptin Function Modulates Diet-Induced Weight Gain

Claire H. Feetham, University of Manchester, UK
Prolactin-Releasing Peptide Neurones Project from Dorsomedial to Paraventricular Hypothalamic Nucleus to Affect Energy Expenditure

Pablo B. Martinez de Morentin, Rowett Institute of Nutrition and Health, UK
Raphe Pallidus Serotonin Cells Modulate Brown Adipose Tissue Thermogenesis

16:30—17:00
Coffee Available

Foyer
17:00—18:45
Programming Obesity: Early Environmental Influences

Tivoli Congress Hall
* Michael Krashes, NIDDK, National Institutes of Health, USA
Session Chair

* Alicja A. Skowronski, Columbia University, USA

Elinor L. Sullivan, Oregon National Primate Research Center, USA
Maternal Metabolic and Dietary Environmental Influences on Offspring Metabolic Health and Behavior

John Speakman, Institute of Genetics and Developmental Biology, CAS, China
The Impact of Maternal Diet on Hypothalamic Remodeling during Development and Subsequent Susceptibility to High Fat Diets in the Mouse

Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany
Effect of Insulin on Brain Development and Metabolic Programming

17:00—18:45
Novel Aspects of Gut Function

Ballonsalen/Blomstersalen
* John Furness, University of Melbourne, Australia
Session Chair

Thue W. Schwartz, University of Copenhagen, Denmark
Nutrient and Gut Microbiota Metabolite Sensing through GPCRs in the GI Tract

Gilles Mithieux, INSERM, France
Central Regulation of Metabolism Initiated by Intestinal Gluconeogenesis

Tony K.T. Lam, Toronto General Research Institute, Canada
Gut Nutrient Sensing

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Tivoli Congress Hall
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Balloonsalen/Blomstersalen
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Tivoli Congress Hall
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources. Novo Nordisk A/S funding is not being used for this function.

Tivoli Congress Hall

SUNDAY, MAY 14

11:00—11:00
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Lead Sponsor for generously supporting this meeting:

Novo Nordisk A/S
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

Arena Pharmaceuticals, Inc.

We gratefully acknowledge additional support for this conference from:

Research Diets, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Novo Nordisk A/S


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Molecular Metabolism (Elsevier GmbH) NeuroscientistNews

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: John Monson, Director of Corporate Relations, Email: johnm@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-1179