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This meeting took place in 2017
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B Cells and T Follicular Helper Cells - Controlling Long-Lived Immunity (D2)
Organizer(s) Stuart G. Tangye, Ignacio Sanz and Hai Qi
April 23—27, 2017
Whistler Conference Centre • Whistler, BC Canada
Discounted Abstract Deadline: Dec 21, 2016
Abstract Deadline: Jan 24, 2017
Scholarship Deadline: Dec 21, 2016
Discounted Registration Deadline: Feb 23, 2017
Sponsored by Arena Pharmaceuticals, Inc., BioLegend, Inc. and Merck & Co., Inc.
Summary of Meeting:
B cells are fundamental for the development of long-lived immunological memory following exposure to infectious pathogens and, consequently, for the success of the vast majority of currently-available vaccines. The differentiation of B cells into the effector cells of serological memory – memory B cells and plasma cells – occurs in germinal centers. However this process critically requires a specialized subset of CD4+ T cells termed T follicular helper (Tfh) cells. The integration of signals required to generate germinal center B cells, memory and plasma cells, and Tfh cells are strictly controlled. This is to ensure the efficient selection of antigen-specific high-affinity effector cells, and to prevent the development of immune dyscrasias associated with GCs, such as autoimmunity, immune deficiency and malignancy – conditions that can develop when the complexities of lymphocyte differentiation in germinal centers are dysregulated. Despite the substantial advances that have been made in understanding the cellular, biochemical and molecular requirements for the generation of effective T-dependent B-cell responses, major questions regarding these processes remain. Answers to such questions are needed so as to be able to harness the intrinsic function of memory B cells, plasma cells and Tfh cells in order to enhance immunity in immunocompromised individuals, improve vaccine design and develop novel vaccines for infectious pathogens, as well as to attenuate humoral immune responses in the setting of autoantibody-mediated autoimmune diseases. This meeting will bring together basic and clinical immunologists to address unanswered questions and to discuss the latest cutting-edge breakthroughs in the biology of B cells and Tfh cells to facilitate development of new translational strategies of regulating their behavior in human immunopathologies.
View Scholarships/Awards
B cells are fundamental for the development of long-lived immunological memory following exposure to infectious pathogens and, consequently, for the success of the vast majority of currently-available vaccines. The differentiation of B cells into the effector cells of serological memory – memory B cells and plasma cells – occurs in germinal centers. However this process critically requires a specialized subset of CD4+ T cells termed T follicular helper (Tfh) cells. The integration of signals required to generate germinal center B cells, memory and plasma cells, and Tfh cells are strictly controlled. This is to ensure the efficient selection of antigen-specific high-affinity effector cells, and to prevent the development of immune dyscrasias associated with GCs, such as autoimmunity, immune deficiency and malignancy – conditions that can develop when the complexities of lymphocyte differentiation in germinal centers are dysregulated. Despite the substantial advances that have been made in understanding the cellular, biochemical and molecular requirements for the generation of effective T-dependent B-cell responses, major questions regarding these processes remain. Answers to such questions are needed so as to be able to harness the intrinsic function of memory B cells, plasma cells and Tfh cells in order to enhance immunity in immunocompromised individuals, improve vaccine design and develop novel vaccines for infectious pathogens, as well as to attenuate humoral immune responses in the setting of autoantibody-mediated autoimmune diseases. This meeting will bring together basic and clinical immunologists to address unanswered questions and to discuss the latest cutting-edge breakthroughs in the biology of B cells and Tfh cells to facilitate development of new translational strategies of regulating their behavior in human immunopathologies.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, April 23 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 27 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, April 28 in order to fully experience the meeting.
SUNDAY, APRIL 23
MONDAY, APRIL 24
TUESDAY, APRIL 25
WEDNESDAY, APRIL 26
THURSDAY, APRIL 27
FRIDAY, APRIL 28
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, April 23 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 27 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, April 28 in order to fully experience the meeting.
SUNDAY, APRIL 23
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
*
Stuart G. Tangye,
Garvan Institute of Medical Research, Australia
Christopher C. Goodnow,
Garvan Institute of Medical Research, Australia
Actively Acquired Tolerance in the Antibody System - The Iliad and The Odyssey
Actively Acquired Tolerance in the Antibody System - The Iliad and The Odyssey
09:00—11:00
B Cells, Infections and Vaccines
*
Hai Qi,
Tsinghua University, China
William Schief,
International AIDS Vaccine Initiative and The Scripps Research Institute, USA
HIV Vaccine Strategies to Guide B Cell Maturation
HIV Vaccine Strategies to Guide B Cell Maturation
Coffee Break
Stuart G. Tangye,
Garvan Institute of Medical Research, Australia
Molecular Requirements for Generating Long-Lived Humoral Immunity in Humans: Lessons from Human Genetic Diseases
Molecular Requirements for Generating Long-Lived Humoral Immunity in Humans: Lessons from Human Genetic Diseases
Jenny L. Johnson,
St. Jude Children's Research Hospital, USA
Short Talk: The Role of Germinal Centers in Generating Antibodies to Conserved Influenza Epitopes
Short Talk: The Role of Germinal Centers in Generating Antibodies to Conserved Influenza Epitopes
Deepak Rao,
Brigham and Women's Hospital, USA
Short Talk: Plasticity of Circulating PD-1hi Follicular and Peripheral Helper T Cells
Short Talk: Plasticity of Circulating PD-1hi Follicular and Peripheral Helper T Cells
14:30—16:30
Workshop 1: B Cell Memory and Plasma Cells
*
Kathryn A. Pape,
University of Minnesota, USA
*
Robert C. Rickert,
Pfizer Inc., USA
Kerstin Narr,
University of Basel, Switzerland
Interferon-Driven Deletion of Antiviral B Cells at the Onset of Chronic Infection
Interferon-Driven Deletion of Antiviral B Cells at the Onset of Chronic Infection
Daniel Lingwood,
Havard Medical School, USA
DC-Dependent Control Over the Initiation of Humoral Immunity
DC-Dependent Control Over the Initiation of Humoral Immunity
Mary M. Tomayko,
Yale University School of Medicine, USA
B Cell Memory Formation Requires Bone Morphogenetic Protein Receptor Ia
B Cell Memory Formation Requires Bone Morphogenetic Protein Receptor Ia
Deborah L. Burnett,
Garvan Institute of Medical Research, Australia
Somatic Hypermutation Serves Two Independent Functions: Antibody Maturation Away from Binding Self and towards Binding Foreign
Somatic Hypermutation Serves Two Independent Functions: Antibody Maturation Away from Binding Self and towards Binding Foreign
Joshua F. Koenig,
McMaster University, Canada
Long-Lived Memory B Cells Maintain Th2 Humoral Immunity for a Lifetime
Long-Lived Memory B Cells Maintain Th2 Humoral Immunity for a Lifetime
Sandra Nielsen,
Stanford University, USA
Human Immune Responses to Controlled Necator Americanus (Hookworm) Infection
Human Immune Responses to Controlled Necator Americanus (Hookworm) Infection
Deepta Bhattacharya,
Washington University School of Medicine, USA
Metabolic Control of Plasma Cell Lifespan and Antibody Secretion
Metabolic Control of Plasma Cell Lifespan and Antibody Secretion
Nicolas Hipp,
University of Rennes1, France
T Cell Help Mediated by IL-2 Orchestrates BACH2 Downregulation that Allows Plasma Cell Differentiation
T Cell Help Mediated by IL-2 Orchestrates BACH2 Downregulation that Allows Plasma Cell Differentiation
17:00—19:00
Transcriptional Regulation of B Cells and Tfh Cells
*
Betty Diamond,
Feinstein Institute for Medical Research, USA
Stephen L. Nutt,
Walter and Eliza Hall Institute, Australia
The Regulation of Gene Expression in B Cells
The Regulation of Gene Expression in B Cells
Amy Weinmann,
University of Alabama at Birmingham, USA
Molecular Regulators of CD4 T Cell Differentiation
Molecular Regulators of CD4 T Cell Differentiation
Jason Weinstein,
Rutgers New Jersey Medical School, USA
Short Talk: The Transcriptional Regulators STAT4 and T-bet Cooperate in Follicular Helper T Cells to Fine-Tune the Viral Specific Humoral Response
Short Talk: The Transcriptional Regulators STAT4 and T-bet Cooperate in Follicular Helper T Cells to Fine-Tune the Viral Specific Humoral Response
Ari M. Melnick,
Weill Cornell Medical College, USA
Epigenetic Switches Controlling the Germinal Center Reaction
Epigenetic Switches Controlling the Germinal Center Reaction
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Tfh Programming and Flexibility
*
Ignacio Sanz,
Emory University, School of Medicine, USA
Hai Qi,
Tsinghua University, China
Germinal Center T-B Communications
Germinal Center T-B Communications
Shane Crotty,
La Jolla Institute for Immunology, USA
Tfh Differentiation and B Cell Responses in the Context of Vaccines and Infections
Tfh Differentiation and B Cell Responses in the Context of Vaccines and Infections
Coffee Break
Elissa K. Deenick,
Garvan Institute of Medical Research, Australia
Short Talk: Over Activation of PI3K Causes Defects in B-Cell Development and Differentiation
Short Talk: Over Activation of PI3K Causes Defects in B-Cell Development and Differentiation
Silvia Preite,
National Institutes of Health, USA
Short Talk: Dissecting the Role of Phosphotidylinositol 3-Kinase (PI3K) δ in the Germinal Center Reaction through a Mouse Model of Hyperactivated PIK3CD
Short Talk: Dissecting the Role of Phosphotidylinositol 3-Kinase (PI3K) δ in the Germinal Center Reaction through a Mouse Model of Hyperactivated PIK3CD
Hideki Ueno,
Icahn School of Medicine at Mount Sinai, USA
Circulating Tfh1 Cells in Influenza Vaccination
Circulating Tfh1 Cells in Influenza Vaccination
Dirk Baumjohann,
Ludwig-Maximilians-University Munich, Germany
Short Talk: MicroRNAs are Essential for the Maintenance of Tfh Cell Identity and Germinal Centers
Short Talk: MicroRNAs are Essential for the Maintenance of Tfh Cell Identity and Germinal Centers
Luis Graca,
iMM-Instituto de Medicina Molecular, Portugal
Short Talk: T Follicular Helper (Tfh) and T Follicular Regulatory (Tfr) Cells Have Different TCR-Specificity
Short Talk: T Follicular Helper (Tfh) and T Follicular Regulatory (Tfr) Cells Have Different TCR-Specificity
17:00—19:00
Lymphocyte Signaling and Diseases
*
Robert Brink,
Garvan Institute of Medical Research, Australia
David J. Rawlings,
University of Washington, Seattle Children's Hospital Research Institute, USA
Signaling Defects Causing Immune Dysregulation
Signaling Defects Causing Immune Dysregulation
Gail A. Bishop,
University of Iowa, USA
TRAF3 Inhibits B Cell Survival and Differentiation via Multiple Mechanisms
TRAF3 Inhibits B Cell Survival and Differentiation via Multiple Mechanisms
Christopher D. C. Allen,
University of California, San Francisco, USA
Short Talk: IgE Responses Are Regulated by Constitutive Activity of the IgE B Cell Receptor
Short Talk: IgE Responses Are Regulated by Constitutive Activity of the IgE B Cell Receptor
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Autoimmunity and Immunodeficiency - Mice and Man
*
David M. Tarlinton,
Monash University, Australia
Robert Brink,
Garvan Institute of Medical Research, Australia
Circumvention of Normal Antigenic Controls by Rogue Germinal Center B Cells
Circumvention of Normal Antigenic Controls by Rogue Germinal Center B Cells
Qiang Pan-Hammarström,
Karolinska Institutet, Sweden
DNA Repair Defects and Primary Immunodeficiency
DNA Repair Defects and Primary Immunodeficiency
Coffee Break
David M. Tarlinton,
Monash University, Australia
Guiding B Cells In and Out of Germinal Centers: Many Are Called but Few Are Chosen
Guiding B Cells In and Out of Germinal Centers: Many Are Called but Few Are Chosen
Alessandra Pernis,
Weill Cornell Medicine, USA
Short Talk: Regulation of CD11c+ Tbet+ B Cells in Systemic Autoimmunity
Short Talk: Regulation of CD11c+ Tbet+ B Cells in Systemic Autoimmunity
Corey Tan,
University of California, San Francisco, USA
Short Talk: Nur77 Expression Marks Autoreactive B Cells in vivo and Enforces Tolerance
Short Talk: Nur77 Expression Marks Autoreactive B Cells in vivo and Enforces Tolerance
Mark J. Shlomchik,
University of Pittsburgh School of Medicine, USA
Unexpected Roles of Dendritic Cells in Regulating Extrafollicular (EF) Plasmablast Responses
Unexpected Roles of Dendritic Cells in Regulating Extrafollicular (EF) Plasmablast Responses
17:00—19:00
GCs, Tfh Cells and Disease
*
Kim Good-Jacobson,
Monash University, Australia
Laura Pasqualucci,
Columbia University, USA
Genetic-Driven Epigenetic Dysregulation in B Cell Non-Hodgkin Lymphoma
Genetic-Driven Epigenetic Dysregulation in B Cell Non-Hodgkin Lymphoma
Karin Tarte,
INSERM U917 Université de Rennes 1, France
GC B-Cell Malignancies and the Tumor Microenvironment
GC B-Cell Malignancies and the Tumor Microenvironment
Stephanie C. Eisenbarth,
Yale University, USA
Short Talk: Dock8 Deficiency Reveals the Role of Dendritic Cell Subsets in Tfh Cell Priming
Short Talk: Dock8 Deficiency Reveals the Role of Dendritic Cell Subsets in Tfh Cell Priming
Marcus R. Clark,
University of Chicago, USA
Quantifying adaptive cell networks in human inflammation
Quantifying adaptive cell networks in human inflammation
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
B Cell Regulation: Intrinsic and Extrinsic Mechanisms
*
Gail A. Bishop,
University of Iowa, USA
Peter Sage,
Harvard Medical School, USA
T Follicular Regulatory Cells and Regulation of Humoral Immunity
T Follicular Regulatory Cells and Regulation of Humoral Immunity
Ignacio Sanz,
Emory University, School of Medicine, USA
A New Effector B Cell Pathway with Defective Negative Regulation of TLR7 Signaling in Human SLE
A New Effector B Cell Pathway with Defective Negative Regulation of TLR7 Signaling in Human SLE
Coffee Break
Betty Diamond,
Feinstein Institute for Medical Research, USA
B Cell-Mediated Autoimmunity and Therapeutics
B Cell-Mediated Autoimmunity and Therapeutics
Kathryn A. Pape,
University of Minnesota, USA
Short Talk: A Single Heavy Chain Variable Segment Determines the Size, Quality, and Longevity of the Memory B Cell Response to a Protein Antigen
Short Talk: A Single Heavy Chain Variable Segment Determines the Size, Quality, and Longevity of the Memory B Cell Response to a Protein Antigen
Patrick C. Wilson,
University of Chicago, USA
Identification of Influenza-Induced Precursors for Long-Lived Plasma Cells in Humans
Identification of Influenza-Induced Precursors for Long-Lived Plasma Cells in Humans
Jenna Guthmiller,
University of Chicago, USA
Short Talk: B Cell-Intrinsic and -Extrinsic IL-10 Signaling Promotes Germinal Center B Cell Responses and Protective Anti-Plasmodium Humoral Immunity
Short Talk: B Cell-Intrinsic and -Extrinsic IL-10 Signaling Promotes Germinal Center B Cell Responses and Protective Anti-Plasmodium Humoral Immunity
14:30—16:30
Workshop 2: Molecular Regulation of the Germinal Center Response
*
Elissa K. Deenick,
Garvan Institute of Medical Research, Australia
*
Christopher D. C. Allen,
University of California, San Francisco, USA
Roza I. Nurieva,
University of Texas MD Anderson Cancer Center, USA
STAT1 Is Required for Tfh Lineage Maintenance through Regulation of IL-21 Expression
STAT1 Is Required for Tfh Lineage Maintenance through Regulation of IL-21 Expression
Amanda Mener,
Emory University, USA
Complement Serves as a Switch between CD4 Independent and Dependent Antibody Responses
Complement Serves as a Switch between CD4 Independent and Dependent Antibody Responses
Mark Andrew Noviski,
University of California, San Francisco, USA
Differential Responsiveness of IgM and IgD to Self-Antigens
Differential Responsiveness of IgM and IgD to Self-Antigens
Kira V. Rubtsova,
Eli Lilly and Company, USA
T-Bet Expression in B Cells Drives Lupus-Like Autoimmunity and the Formation of Spontaneous Germinal Centers
T-Bet Expression in B Cells Drives Lupus-Like Autoimmunity and the Formation of Spontaneous Germinal Centers
Ankur Saini,
Cincinnati Children's Hospital Medical Center, USA
Convergent Genomic Actions of NFATs and IRF4,8 in Activated B Lymphocytes
Convergent Genomic Actions of NFATs and IRF4,8 in Activated B Lymphocytes
Chris Scharer,
Emory University, USA
Ezh2 Is Required for the Division-Specific Epigenetic Programming of Plasma Cell Differentiation
Ezh2 Is Required for the Division-Specific Epigenetic Programming of Plasma Cell Differentiation
Mridu Acharya,
Benaroya Research Institute, USA
Alpha(v) Integrins Engage Autophagy Proteins to Regulate Toll-Like Receptor Signaling in B Cells
Alpha(v) Integrins Engage Autophagy Proteins to Regulate Toll-Like Receptor Signaling in B Cells
David R. Glass,
Stanford University, USA
Comprehensive Single Cell Phenotyping of Human B Cells Reveals Broad Heterogeneity within Previously Defined Compartments
Comprehensive Single Cell Phenotyping of Human B Cells Reveals Broad Heterogeneity within Previously Defined Compartments
17:00—19:00
Germinal Center Dynamics
*
Shane Crotty,
La Jolla Institute for Immunology, USA
Tri Giang Phan,
Garvan Institute of Medical Research, Australia
Optimal Search Strategies for B Cell Encounter with Antigen and T Cell Help in Primary and Secondary Antibody Responses
Optimal Search Strategies for B Cell Encounter with Antigen and T Cell Help in Primary and Secondary Antibody Responses
Kim Good-Jacobson,
Monash University, Australia
Transcriptional and Epigenetic Regulation of B Cell Differentiation
Transcriptional and Epigenetic Regulation of B Cell Differentiation
Jonatan Ersching,
Rockefeller University, USA
Short Talk: Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1
Short Talk: Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1
Jason G. Cyster,
HHMI/University of California, San Francisco, USA
Guidance Cues for T-Dependent B Cell Activation and Differentiation
Guidance Cues for T-Dependent B Cell Activation and Differentiation
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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